Toxin secretion systems

The Comprehensive Sourcebook of Bacterial Protein Toxins

Volumn , Issue , 2006, Pages 83-105

  Scott, Maria ^a   Sandkvist, Maria ^a  

^a HOLLAND LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 79955877385     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012088445-2/50010-X     Document Type: Chapter

References (222)

1. Akeda Y., Galan J.E. Genetic analysis of the Salmonella enterica type III secretion-associated ATPase InvC defines discrete functional domains. J. Bacteriol. 2004, 186:2402-2412.
2. Akrim M., Bally M., Ball G., Tommassen J., Teerink H., Filloux A., Lazdunski A. Xcp-mediated protein secretion in Pseudomonas aeruginosa: identification of two additional genes and evidence for regulation of xcp gene expression. Mol. Microbiol. 1993, 10:431-443.
3. Alley M.R., Maddock J.R., Shapiro L. Polar localization of a bacterial chemoreceptor. Genes Dev. 1992, 6:825-836.
4. Andersen C. Channel-tunnels: outer membrane components of type I secretion systems and multidrug efflux pumps of Gram-negative bacteria. Rev. Physiol Biochem. Pharmacol. 2003, 147:122-165.
5. Andersen C., Koronakis E., Bokma E., Eswaran J., Humphreys D., Hughes C., Koronakis V. Transition to the open state of the TolC periplasmic tunnel entrance. Proc. Natl. Acad. Sci. U.S.A 2002, 99:11103-11108.
6. Andersen C., Koronakis E., Hughes C., Koronakis V. An aspartate ring at the TolC tunnel entrance determines ion selectivity and presents a target for blocking by large cations. Mol. Microbiol. 2002, 44:1131-1139.
7. Anderson D.M., Schneewind O. Yersinia enterocolitica type III secretion: an mRNA signal that couples translation and secretion of YopQ. Mol. Microbiol. 1999, 31:1139-1148.
8. Anderson D.M., Schneewind O. A mRNA signal for the type III secretion of Yop proteins by Yersinia enterocolitica. Science 1997, 278:1140-1143.
9. Anderson L.B., Hertzel A.V., Das A. Agrobacterium tumefaciens VirB7 and VirB9 form a disulfide-linked protein complex. Proc. Natl. Acad. Sci. U. S. A 1996, 93:8889-8894.
10. Atmakuri K., Cascales E., Christie P.J. Energetic components VirD4, VirB11 and VirB4 mediate early DNA transfer reactions required for bacterial type IV secretion. Mol. Microbiol. 2004, 54:1199-1211.
11. Atmakuri K., Ding Z., Christie P.J. VirE2, a type IV secretion substrate, interacts with the VirD4 transfer protein at cell poles of Agrobacterium tumefaciens. Mol. Microbiol. 2003, 49:1699-1713.
12. Bachman M.A., Swanson M.S. RpoS co-operates with other factors to induce Legionella pneumophila virulence in the stationary phase. Mol. Microbiol. 2001, 40:1201-1214.
13. Balakrishnan L., Hughes C., Koronakis V. Substratetriggered recruitment of the TolC channel-tunnel during type I export of hemolysin by Escherichia coli. J. Mol. Biol. 2001, 313:501-510.
14. Ball G., Chapon-Herve V., Bleves S., Michel G., Bally M. Assembly of XcpR in the cytoplasmic membrane is required for extracellular protein secretion in Pseudomonas aeruginosa. J. Bacteriol. 1999, 181:382-388.
15. Baron C., Thorstenson Y.R., Zambryski P.C. The lipoprotein VirB7 interacts with VirB9 in the membranes of Agrobacterium tumefaciens. J. Bacteriol. 1997, 179:1211-1218.
16. Berks B.C. A common export pathway for proteins binding complex redox cofactors?. Mol. Microbiol. 1996, 22:393-404.
17. Berks B.C., Sargent F., De L.E., Hinsley A.P., Stanley N.R., Jack R.L., Buchanan G., Palmer T. A novel protein transport system involved in the biogenesis of bacterial electron transfer chains. Biochim. Biophys. Acta 2000, 1459:325-330.
18. Berks B.C., Sargent F., Palmer T. The Tat protein export pathway. Mol. Microbiol. 2000, 35:260-274.
19. Birtalan S.C., Phillips R.M., Ghosh P. Three-dimensional secretion signals in chaperone-effector complexes of bacterial pathogens. Mol. Cell 2002, 9:971-980.
20. Bitter W., Koster M., Latijnhouwers M., de C.H., Tommassen J. Formation of oligomeric rings by XcpQ and PilQ, which are involved in protein transport across the outer membrane of Pseudomonas aeruginosa. Mol. Microbiol. 1998, 27:209-219.
21. Blaudeck N., Sprenger G.A., Freudl R., Wiegert T. Specificity of signal peptide recognition in tat-dependent bacterial protein translocation. J. Bacteriol. 2001, 183:604-610.
22. Bleves S., Voulhoux R., Michel G., Lazdunski A., Tommassen J., Filloux A. The secretion apparatus of Pseudomonas aeruginosa: identification of a fifth pseudopilin, XcpX (GspK family). Mol. Microbiol. 1998, 27:31-40.
23. Blocker A., Jouihri N., Larquet E., Gounon P., Ebel F., Parsot C., Sansonetti P., Allaoui A. Structure and composition of the Shigella flexneri "needle complex", a part of its type III secreton. Mol. Microbiol. 2001, 39:652-663.
24. Bogsch E.G., Sargent F., Stanley N.R., Berks B.C., Robinson C., Palmer T. An essential component of a novel bacterial protein export system with homologues in plastids and mitochondria. J. Biol. Chem. 1998, 273:18003-18006.
25. Bolhuis A., Mathers J.E., Thomas J.D., Barrett C.M., Robinson C. TatB and TatC form a functional and structural unit of the twin-arginine translocase from Escherichia coli. J. Biol. Chem. 2001, 276:20213-20219.
26. Bortoli-German I., Brun E., Py B., Chippaux M., Barras F. Periplasmic disulphide bond formation is essential for cellulase secretion by the plant pathogen Erwinia chrysanthemi. Mol. Microbiol. 1994, 11:545-553.
27. Braun P., Tommassen J., Filloux A. Role of the propeptide in folding and secretion of elastase of Pseudomonas aeruginosa. Mol. Microbiol. 1996, 19:297-306.
28. Brok R., Van G.P., Winterhalter M., Ziese U., Koster A.J., de C.H., Koster M., Tommassen J., Bitter W. The C-terminal domain of the Pseudomonas secretin XcpQ forms oligomeric rings with pore activity. J. Mol. Biol. 1999, 294:1169-1179.
29. Buchwald G., Friebel A., Galan J.E., Hardt W.D., Wittinghofer A., Scheffzek K. Structural basis for the reversible activation of a Rho protein by the bacterial toxin SopE. EMBO J. 2002, 21:3286-3295.
30. Buddelmeijer N., Beckwith J. Assembly of cell division proteins at the E. coli cell center. Curr. Opin. Microbiol. 2002, 5:553-557.
31. Burns D.L. Type IV transporters of pathogenic bacteria. Curr. Opin. Microbiol. 2003, 6:29-34.
32. Camberg J.L., Sandkvist M. Molecular Analysis of the Vibrio cholerae Type II Secretion ATPase EpsE. J. Bacteriol. 2005, 187:249-256.
33. Cascales E., Christie P.J. The versatile bacterial type IV secretion systems. Nat. Rev. Microbiol. 2003, 1:137-149.
34. Cascales E., Christie P.J. Definition of a bacterial type IV secretion pathway for a DNA substrate. Science 2004, 304:1170-1173.
35. Chang C.H., Winans S.C. Functional roles assigned to the periplasmic, linker, and receiver domains of the Agrobacterium tumefaciens VirA protein. J. Bacteriol. 1992, 174:7033-7039.
36. Chapon V., Czjzek M., El H.M., Py B., Juy M., Barras F. Type II protein secretion in gram-negative pathogenic bacteria: the study of the structure/secretion relationships of the cellulase Cel5 (formerly EGZ) from Erwinia chrysanthemi. J. Mol. Biol. 2001, 310:1055-1066.
37. Christie P.J. Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems. Biochim. Biophys. Acta 2004, 1694:219-234.
38. Clemons W.M., Menetret J.F., Akey C.W., Rapoport T.A. Structural insight into the protein translocation channel. Curr. Opin. Struct. Biol. 2004, 14:390-396.
39. Cline K., Mori H. Thylakoid DeltapH-dependent precursor proteins bind to a cpTatC-Hcf106 complex before Tha4-dependent transport. J. Cell Biol. 2001, 154:719-729.
40. Collier D.N., Bankaitis V.A., Weiss J.B., Bassford P.J. The antifolding activity of SecB promotes the export of the E. coli maltose-binding protein. Cell 1988, 53:273-283.
41. Connell T.D., Metzger D.J., Wang M., Jobling M.G., Holmes R.K. Initial studies of the structural signal for extracellular transport of cholera toxin and other proteins recognized by Vibrio cholerae. Infect. Immun. 1995, 63:4091-4098.
42. Coote J.G. Structural and functional relationships among the RTX toxin determinants of gram-negative bacteria. FEMS Microbiol. Rev. 1992, 8:137-161.
43. Cornelis G., Vanootegem J.C., Sluiters C. Transcription of the yop regulon from Y. enterocolitica requires trans acting pYV and chromosomal genes. Microb. Pathog. 1987, 2:367-379.
44. Cornelis G.R. How Yops find their way out of Yersinia. Mol. Microbiol. 2003, 50:1091-1094.
45. Cornelis G.R., Van G.F. Assembly and function of type III secretory systems. Annu. Rev. Microbiol. 2000, 54:735-774.
46. d'Enfert C., Pugsley A.P. Klebsiella pneumoniae pulS gene encodes an outer membrane lipoprotein required for pullulanase secretion. J. Bacteriol. 1989, 171:3673-3679.
47. d'Enfert C., Ryter A., Pugsley A.P. Cloning and expression in Escherichia coli of the Klebsiella pneumoniae genes for production, surface localization and secretion of the lipoprotein pullulanase. EMBO J. 1987, 6:3531-3538.
48. Dalbey R.E., Kuhn A. Evolutionarily related insertion pathways of bacterial, mitochondrial, and thylakoid membrane proteins. Annu. Rev. Cell Dev. Biol. 2000, 16:51-87.
49. Dalbey R.E., Lively M.O., Bron S., van Dijl J.M. The chemistry and enzymology of the type 1 signal peptidases. Protein Sci. 1997, 6:1129-1138.
50. Dang T.A., Christie P.J. The VirB4 ATPase of Agrobacterium tumefaciens is a cytoplasmic membrane protein exposed at the periplasmic surface. J. Bacteriol. 1997, 179:453-462.
51. Daniell S.J., Takahashi N., Wilson R., Friedberg D., Rosenshine I., Booy F.P., Shaw R.K., Knutton S., Frankel G., Aizawa S. The filamentous type III secretion translocon of enteropathogenic Escherichia coli. Cell Microbiol. 2001, 3:865-871.
52. Darwin A.J., Miller V.L. The psp locus of Yersinia enterocolitica is required for virulence and for growth in vitro when the Ysc type III secretion system is produced. Mol. Microbiol. 2001, 39:429-444.
53. Davidson A.L., Chen J. ATP-binding cassette transporters in bacteria. Annu. Rev. Biochem. 2004, 73:241-268.
54. de Gier J.W., Luirink J. The ribosome and YidC. New insights into the biogenesis of Escherichia coli inner membrane proteins. EMBO Rep. 2003, 4:939-943.
55. de G.A., Filloux A., Tommassen J. Conservation of xcp genes, involved in the two-step protein secretion process, in different Pseudomonas species and other gram-negative bacteria. Mol. Gen. Genet. 1991, 229:278-284.
56. de G.A., Koster M., Gerard-Vincent M., Gerritse G., Lazdunski A., Tommassen J., Filloux A. Exchange of Xcp (Gsp) secretion machineries between Pseudomonas aeruginosa and Pseudomonas alcaligenes: species specificity unrelated to substrate recognition. J. Bacteriol. 2001, 183:959-967.
57. De L.E., Porcelli I., Sargent F., Palmer T., Berks B.C. Membrane interactions and self-association of the TatA and TatB components of the twin-arginine translocation pathway. FEBS Lett. 2001, 506:143-148.
58. DeLisa M.P., Tullman D., Georgiou G. Folding quality control in the export of proteins by the bacterial twin-arginine translocation pathway. Proc. Natl. Acad. Sci. U. S. A 2003, 100:6115-6120.
59. Desvaux M., Parham N.J., Henderson I.R. The autotransporter secretion system. Res. Microbiol. 2004, 155:53-60.
60. Desvaux M., Parham N.J., Scott-Tucker A., Henderson I.R. The general secretory pathway: a general misnomer?. Trends Microbiol. 2004, 12:306-309.
61. Dillard J.P., Seifert H.S. A variable genetic island specific for Neisseria gonorrhoeae is involved in providing DNA for natural transformation and is found more often in disseminated infection isolates. Mol. Microbiol. 2001, 41:263-277.
62. Douet V., Loiseau L., Barras F., Py B. Systematic analysis, by the yeast two-hybrid, of protein interaction between components of the type II secretory machinery of Erwinia chrysanthemi. Res. Microbiol. 2004, 155:71-75.
63. Dreusch A., Burgisser D.M., Heizmann C.W., Zumft W.G. Lack of copper insertion into unprocessed cytoplasmic nitrous oxide reductase generated by an R20D substitution in the arginine consensus motif of the signal peptide. Biochim. Biophys. Acta 1997, 1319:311-318.
64. Drew D., Sjostrand D., Nilsson J., Urbig T., Chin C.N., de Gier J.W., von H.G. Rapid topology mapping of Escherichia coli inner-membrane proteins by prediction and PhoA/GFP fusion analysis. Proc. Natl. Acad. Sci. U. S. A 2002, 99:2690-2695.
65. Duong F., Wickner W. The SecDFyajC domain of preprotein translocase controls preprotein movement by regulating SecA membrane cycling. EMBO J. 1997, 16:4871-4879.
66. Durand E., Bernadac A., Ball G., Lazdunski A., Sturgis J.N., Filloux A. Type II protein secretion in Pseudomonas aeruginosa: the pseudopilus is a multifibrillar and adhesive structure. J. Bacteriol. 2003, 185:2749-2758.
67. El K.M., Ockhuijsen C., Bitter W., Jaeger K.E., Tommassen J. Specificity of the lipase-specific foldases of gram-negative bacteria and the role of the membrane anchor. Mol. Gen. Genet. 1999, 261:770-776.
68. Errington J., Daniel R.A., Scheffers D.J. Cytokinesis in bacteria. Microbiol. Mol. Biol. Rev. 2003, 67:52-65. table.
69. Eswaran J., Hughes C., Koronakis V. Locking TolC entrance helices to prevent protein translocation by the bacterial type I export apparatus. J. Mol. Biol. 2003, 327:309-315.
70. Evans D.T., et al. Mucosal priming of simian immunodeficiency virus-specific cytotoxic T-lymphocyte responses in rhesus macaques by the Salmonella type III secretion antigen delivery system. J. Virol. 2003, 77:2400-2409.
71. Fekkes P., van der D.C., Driessen A.J. The molecular chaperone SecB is released from the carboxy-terminus of SecA during initiation of precursor protein translocation. EMBO J. 1997, 16:6105-6113.
72. Filloux A., Bally M., Ball G., Akrim M., Tommassen J., Lazdunski A. Protein secretion in gram-negative bacteria: transport across the outer membrane involves common mechanisms in different bacteria. EMBO J. 1990, 9:4323-4329.
73. Findlay G., Yu J., Hirst T.R. Analysis of enterotoxin synthesis in a Vibrio cholerae strain lacking DsbA, a periplasmic enzyme involved in disulphide bond formation. Biochem. Soc. Trans. 1993, 21:212S.
74. Fralick J.A. Evidence that TolC is required for functioning of the Mar/AcrAB efflux pump of Escherichia coli. J. Bacteriol. 1996, 178:5803-5805.
75. Francis M.S., Wolf-Watz H., Forsberg A. Regulation of type III secretion systems. Curr. Opin. Microbiol. 2002, 5:166-172.
76. Frithz-Lindsten E., Du Y., Rosqvist R., Forsberg A. Intracellular targeting of exoenzyme S of Pseudomonas aeruginosa via type III-dependent translocation induces phagocytosis resistance, cytotoxicity and disruption of actin microfilaments. Mol. Microbiol. 1997, 25:1125-1139.
77. Galan J.E. Salmonella interactions with host cells: type III secretion at work. Annu. Rev. Cell Dev. Biol. 2001, 17:53-86.
78. Goldberg M.B., Sansonetti P.J. Shigella subversion of the cellular cytoskeleton: a strategy for epithelial colonization. Infect. Immun. 1993, 61:4941-4946.
79. Gomis-Ruth F.X., Coll M. Structure of TrwB, a gatekeeper in bacterial conjugation. Int. J. Biochem. Cell Biol. 2001, 33:839-843.
80. Gomis-Ruth F.X., Moncalian G., de la C.F., Coll M. Conjugative plasmid protein TrwB, an integral membrane type IV secretion system coupling protein. Detailed structural features and mapping of the active site cleft. J. Biol. Chem. 2002, 277:7556-7566.
81. Gross R., Simon J., Kroger A. The role of the twin-arginine motif in the signal peptide encoded by the hydA gene of the hydrogenase from wolinella succinogenes. Arch. Microbiol. 1999, 172:227-232.
82. Halbig D., Wiegert T., Blaudeck N., Freudl R., Sprenger G.A. The efficient export of NADP-containing glucose-fructose oxidoreductase to the periplasm of Zymomonas mobilis depends both on an intact twin-arginine motif in the signal peptide and on the generation of a structural export signal induced by cofactor binding. Eur. J. Biochem. 1999, 263:543-551.
83. Hardie K.R., Seydel A., Guilvout I., Pugsley A.P. The secretin-specific, chaperone-like protein of the general secretory pathway: separation of proteolytic protection and piloting functions. Mol. Microbiol. 1996, 22:967-976.
84. Hardy S.J., Holmgren J., Johansson S., Sanchez J., Hirst T.R. Coordinated assembly of multisubunit proteins: oligomerization of bacterial enterotoxins in vivo and in vitro. Proc. Natl. Acad. Sci. U. S. A 1988, 85:7109-7113.
85. Hartl F.U., Lecker S., Schiebel E., Hendrick J.P., Wickner W. The binding cascade of SecB to SecA to SecY/E mediates preprotein targeting to the E. coli plasma membrane. Cell 1990, 63:269-279.
86. Henderson I.R., Nataro J.P. Virulence functions of autotransporter proteins. Infect. Immun. 2001, 69:1231-1243.
87. Henderson I.R., Navarro-Garcia F., Nataro J.P. The great escape: structure and function of the autotransporter proteins. Trends Microbiol. 1998, 6:370-378.
88. Hirst T.R., Holmgren J. Conformation of protein secreted across bacterial outer membranes: a study of enterotoxin translocation from Vibrio cholerae. Proc. Natl. Acad. Sci. U. S. A 1987, 84:7418-7422.
89. Hirst T.R., Holmgren J. Transient entry of enterotoxin subunits into the periplasm occurs during their secretion from Vibrio cholerae. J. Bacteriol. 1987, 169:1037-1045.
90. Hofreuter D., Odenbreit S., Haas R. Natural transformation competence in Helicobacter pyrlori is mediated by the basic components of a type IV secretion system. Mol. Microbiol. 2001, 41:379-391.
91. Hoiczyk E., Blobel G. Polymerization of a single protein of the pathogen Yersinia enterocolitica into needles punctures eukaryotic cells. Proc. Natl. Acad. Sci. U. S. A 2001, 98:4669-4674.
92. Howard S.P., Meiklejohn H.G., Shivak D., Jahagirdar R. A TonB-like protein and a novel membrane protein containing an ATP-binding cassette function together in exotoxin secretion. Mol. Microbiol. 1996, 22:595-604.
93. Hueck C.J. Type III protein secretion systems in bacterial pathogens of animals and plants. Microbiol. Mol. Biol. Rev. 1998, 62:379-433.
94. Hung L.W., Wang I.X., Nikaido K., Liu P.Q., Ames G.F., Kim S.H. Crystal structure of the ATP-binding subunit of an ABC transporter. Nature 1998, 396:703-707.
95. Hunt J.F., Weinkauf S., Henry L., Fak J.J., McNicholas P., Oliver D.B., Deisenhofer J. Nucleotide control of interdomain interactions in the conformational reaction cycle of SecA. Science 2002, 297:2018-2026.
96. Hwang J., Zhong X., Tai P.C. Interactions of dedicated export membrane proteins of the colicin V secretion system: CvaA, a member of the membrane fusion proteinfamily, interacts with CvaB and TolC. J. Bacteriol. 1997, 179:6264-6270.
97. Ignatova Z., Hornle C., Nurk A., Kasche V. Unusual signal peptide directs penicillin amidase from Escherichia coli to the Tat translocation machinery. Biochem. Biophys. Res. Commun. 2002, 291:146-149.
98. Iriarte M., Cornelis G.R. Identification of SycN, YscX, and YscY, three new elements of the Yersinia yop virulon. J. Bacteriol. 1999, 181:675-680.
99. Izadi-Pruneyre N., Wolff N., Redeker V., Wandersman C., Delepierre M., Lecroisey A. NMR studies of the C-terminal secretion signal of the haem-binding protein, HasA. Eur. J. Biochem. 1999, 261:562-568.
100. Jack R.L., Buchanan G., Dubini A., Hatzixanthis K., Palmer T., Sargent F. Coordinating assembly and export of complex bacterial proteins. EMBO J. 2004, 23:3962-3972.
101. Jack R.L., Sargent F., Berks B.C., Sawers G., Palmer T. Constitutive expression of Escherichia coli tat genes indicates an important role for the twin-arginine translocase during aerobic and anaerobic growth. J. Bacteriol. 2001, 183:1801-1804.
102. Jackson M.W., Day J.B., Plano G.V. YscB of Yersinia pestis functions as a specific chaperone for YopN. J. Bacteriol. 1998, 180:4912-4921.
103. Jacob-Dubuisson F., Locht C., Antoine R. Two-partner secretion in Gram-negative bacteria: a thrifty, specific pathway for large virulence proteins. Mol. Microbiol. 2001, 40:306-313.
104. Jahagirdar R., Howard S.P. Isolation and characterization of a second exe operon required for extracellular protein secretion in Aeromonas hydrophila. J. Bacteriol. 1994, 176:6819-6826.
105. Jakubowski S.J., Krishnamoorthy V., Cascales E., Christie P.J. Agrobacterium tumefaciens VirB6 domains direct the ordered export of a DNA substrate through a type IV secretion System. J. Mol. Biol. 2004, 341:961-977.
106. Jakubowski S.J., Krishnamoorthy V., Christie P.J. Agrobacterium tumefaciens VirB6 protein participates in formation of VirB7 and VirB9 complexes required for type IV secretion. J. Bacteriol. 2003, 185:2867-2878.
107. Jones P.M., George A.M. Subunit interactions in ABC transporters: towards a functional architecture. FEMS Microbiol. Lett. 1999, 179:187-202.
108. Journet L., Agrain C., Broz P., Cornelis G.R. The needle length of bacterial injectisomes is determined by a molecular ruler. Science 2003, 302:1757-1760.
109. Kagami Y., Ratliff M., Surber M., Martinez A., Nunn D.N. Type II protein secretion by Pseudomonas aeruginosa: genetic suppression of a conditional mutation in the pilin-like component XcpT by the cytoplasmic component XcpR. Mol. Microbiol. 1998, 27:221-233.
110. Kihara A., Akiyama Y., Ito K. FtsH is required for proteolytic elimination of uncomplexed forms of SecY, an essential protein translocase subunit. Proc. Natl. Acad. Sci. U. S. A 1995, 92:4532-4536.
111. Koronakis V., Eswaran J., Hughes C. Structure and function of TolC: the bacterial exit duct for proteins and drugs. Annu. Rev. Biochem. 2004, 73:467-489.
112. Koronakis V., Koronakis E., Hughes C. Isolation and analysis of the C-terminal signal directing export of Escherichia coli hemolysin protein across both bacterial membranes. EMBO J. 1989, 8:595-605.
113. Koronakis V., Sharff A., Koronakis E., Luisi B., Hughes C. Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export. Nature 2000, 405:914-919.
114. Krall L., Wiedemann U., Unsin G., Weiss S., Domke N., Baron C. Detergent extraction identifies different VirB protein subassemblies of the type IV secretion machinery in the membranes of Agrobacterium tumefaciens. Proc. Natl. Acad. Sci. U. S. A 2002, 99:11405-11410.
115. Kubori T., Matsushima Y., Nakamura D., Uralil J., Lara-Tejero M., Sukhan A., Galan J.E., Aizawa S.I. Supramolecular structure of the Salmonella typhimurium type III protein secretion system. Science 1998, 280:602-605.
116. Kubori T., Sukhan A., Aizawa S.I., Galan J.E. Molecular characterization and assembly of the needle complex of the Salmonella typhimurium type III protein secretion system. Proc. Natl. Acad. Sci. U. S. A 2000, 97:10225-10230.
117. Kumamoto C.A., Beckwith J. Mutations in a new gene, secB, cause defective protein localization in Escherichia coli. J. Bacteriol. 1983, 154:253-260.
118. Kumar R.B., Das A. Polar location and functional domains of the Agrobacterium tumefaciens DNA transfer protein VirD4. Mol. Microbiol. 2002, 43:1523-1532.
119. Lai E.M., Eisenbrandt R., Kalkum M., Lanka E., Kado C.I. Biogenesis of T pili in Agrobacterium tumefaciens requires precise VirB2 propilin cleavage and cyclization. J. Bacteriol. 2002, 184:327-330.
120. Lambert de R.C., Sluiters C., Cornelis G.R. Role of the transcriptional activator, VirF, and temperature in the expression of the pYV plasmid genes of Yersinia enterocolitica. Mol. Microbiol. 1992, 6:395-409.
121. Lawley T.D., Klimke W.A., Gubbins M.J., Frost L.S. F factor conjugation is a true type IV secretion system. FEMS Microbiol. Lett. 2003, 224:1-15.
122. Lee S.H., Galan J.E. Salmonella type III secretion-associated chaperones confer secretion-pathway specificity. Mol. Microbiol. 2004, 51:483-495.
123. Lee V.T., Mazmanian S.K., Schneewind O. A program of Yersinia enterocolitica type III secretion reactions is activated by specific signals. J. Bacteriol. 2001, 183:4970-4978.
124. Linderoth N.A., Simon M.N., Russel M. The filamentous phage pIV multimer visualized by scanning transmission electron microscopy. Science 1997, 278:1635-1638.
125. Llosa M., Gomis-Ruth F.X., Coll M., de la Cruz F.F. Bacterial conjugation: a two-step mechanism for DNA transport. Mol. Microbiol. 2002, 45:1-8.
126. Llosa M., O'Callaghan D. Euroconference on the Biology of Type IV Secretion Processes: bacterial gates into the outer world. Mol. Microbiol. 2004, 53:1-8.
127. Llosa M., Zunzunegui S., de la C.F. Conjugative coupling proteinsinteract with cognate and heterologous VirB10-like proteins while exhibiting specificity for cognate relaxosomes. Proc. Natl. Acad. Sci. U. S. A 2003, 100:10465-10470.
128. Lloyd S.A., Norman M., Rosqvist R., Wolf-Watz H. Yersinia YopE is targeted for type III secretion by N-terminal, not mRNA, signals. Mol. Microbiol. 2001, 39:520-531.
129. Lu H.M., Lory S. A specific targeting domain in mature exotoxin A is required for its extracellular secretion from Pseudomonas aeruginosa. EMBO J. 1996, 15:429-436.
130. Luirink J., Sinning I. SRP-mediated protein targeting: structure and function revisited. Biochim. Biophys. Acta 2004, 1694:17-35.
131. Luo Z.Q., Isberg R.R. Multiple substrates of the Legionella pneumophila Dot/Icm system identified by interbacterial protein transfer. Proc. Natl. Acad. Sci. U. S. A 2004, 101:841-846.
132. Lupetti P., Heuser J.E., Manetti R., Massari P., Lanzavecchia S., Bellon P.L., Dallai R., Rappuoli R., Telford J.L. Oligomeric and subunit structure of the Helicobacter pylori vacuolating cytotoxin. J. Cell Biol. 1996, 133:801-807.
133. McVay C.S., Hamood A.N. Toxin A secretion in Pseudomonas aeruginosa: the role of the first 30 amino acids of the mature toxin. Mol. Gen. Genet. 1995, 249:515-525.
134. Melton A.R., Weiss A.A. Environmental regulation of expression of virulence determinants in Bordetella pertussis. J. Bacteriol. 1989, 171:6206-6212.
135. Michel G., Bleves S., Ball G., Lazdunski A., Filloux A. Mutual stabilization of the XcpZ and XcpY components of the secretory apparatus in Pseudomonas aeruginosa. Microbiology 1998, 144:3379-3386. (Pt 12).
136. Michiels T., Wattiau P., Brasseur R., Ruysschaert J.M., Cornelis G. Secretion of Yop proteins by Yersiniae. Infect. Immun. 1990, 58:2840-2849.
137. Nishiyama K., Suzuki T., Tokuda H. Inversion of the membrane topology of SecG coupled with SecA-dependent preprotein translocation. Cell 1996, 85:71-81.
138. Nouwen N., Stahlberg H., Pugsley A.P., Engel A. Domain structure of secretin PulD revealed by limited proteolysis and electron microscopy. EMBO J. 2000, 19:2229-2236.
139. Nunn D.N., Lory S. Cleavage, methylation, and localization of the Pseudomonas aeruginosa export proteins XcpT,-U,-V, and -W. J. Bacteriol. 1993, 175:4375-4382.
140. Ochsner U.A., Snyder A., Vasil A.I., Vasil M.L. Effects of the twin-arginine translocase on secretion of virulence factors, stress response, and pathogenesis. Proc. Natl. Acad. Sci. U. S. A 2002, 99:8312-8317.
141. Ohnishi Y., Nishiyama M., Horinouchi S., Beppu T. Involvement of the COOH-terminal pro-sequence of Serratia marcescens serine protease in the folding of the mature enzyme. J. Biol. Chem. 1994, 269:32800-32806.
142. Oliver D.B., Beckwith J. E. coli mutant pleiotropically defective in the export of secreted proteins. Cell 1981, 25:765-772.
143. Oliver D.C., Huang G., Fernandez R.C. Identification of secretion determinants of the Bordetella pertussis BrkA autotransporter. J. Bacteriol. 2003, 185:489-495.
144. Oliver D.C., Huang G., Nodel E., Pleasance S., Fernandez R.C. A conserved region within the Bordetella pertussis autotransporter BrkA is necessary for folding of its passenger domain. Mol. Microbiol. 2003, 47:1367-1383.
145. Oomen C.J., Van U.P., Van G.P., Feijen M., Tommassen J., Gros P. Structure of the translocator domain of a bacterial autotransporter. EMBO J. 2004, 23:1257-1266.
146. Oresnik I.J., Ladner C.L., Turner R.J. Identification of a twin-arginine leader-binding protein. Mol. Microbiol. 2001, 40:323-331.
147. Papish A.L., Ladner C.L., Turner R.J. The twin-arginine leader-binding protein, DmsD, interacts with the TatB and TatC subunits of the Escherichia coli twin-arginine translocase. J. Biol. Chem. 2003, 278:32501-32506.
148. Peabody C.R., Chung Y.J., Yen M.R., Vidal-Ingigliardi D., Pugsley A.P., Saier M.H. Type II protein secretion and its relationship to bacterial type IV pili and archaeal flagella. Microbiology 2003, 149:3051-3072.
149. Pettersson J., Nordfelth R., Dubinina E., Bergman T., Gustafsson M., Magnusson K.E., Wolf-Watz H. Modulation of virulence factor expression by pathogen target cell contact. Science 1996, 273:1231-1233.
150. Pimenta A.L., Young J., Holland I.B., Blight M.A. Antibody analysis of the localisation, expression and stability of HlyD, the MFP component of the E. coli haemolysin translocator. Mol. Gen. Genet. 1999, 261:122-132.
151. Pohlner J., Halter R., Beyreuther K., Meyer T.F. Gene structure and extracellular secretion of Neisseria gonorrhoeae IgA protease. Nature 1987, 325:458-462.
152. Possot O.M., Gerard-Vincent M., Pugsley A.P. Membrane association and multimerization of secreton component pulC. J. Bacteriol. 1999, 181:4004-4011.
153. Possot O.M., Vignon G., Bomchil N., Ebel F., Pugsley A.P. Multiple interactions between pullulanase secreton components involved in stabilization and cytoplasmic membrane association of PulE. J. Bacteriol. 2000, 182:2142-2152.
154. Pugsley A.P. The complete general secretory pathway in gram-negative bacteria. Microbiol. Rev. 1993, 57:50-108.
155. Pugsley A.P., Francetic O., Possot O.M., Sauvonnet N., Hardie K.R. Recent progress and future directions in studies of the main terminal branch of the general secretory pathway in Gram-negative bacteria-a review. Gene 1997, 192:13-19.
156. Py B., Chippaux M., Barras F. Mutagenesis of cellulase EGZ for studying the general protein secretory pathway in Erwinia chrysanthemi. Mol. Microbiol. 1993, 7:785-793.
157. Py B., Loiseau L., Barras F. Assembly of the type II secretion machinery of Erwinia chrysanthemi: direct interaction and associated conformational change between OutE, the putative ATP-binding component and the membrane protein OutL. J. Mol. Biol. 1999, 289:659-670.
158. Py B., Loiseau L., Barras F. An inner membrane platform in the type II secretion machinery of Gram-negative bacteria. EMBO Rep. 2001, 2:244-248.
159. Rabel C., Grahn A.M., Lurz R., Lanka E. The VirB4 family of proposed traffic nucleoside triphosphatases: common motifs in plasmid RP4 TrbE are essential for conjugation and phage adsorption. J. Bacteriol. 2003, 185:1045-1058.
160. Ray N., Oates J., Turner R.J., Robinson C. DmsD is required for the biogenesis of DMSO reductase in Escherichia coli but not for the interaction of the DmsA signal peptide with the Tat apparatus. FEBS Lett. 2003, 534:156-160.
161. Reyrat J.M., Pelicic V., Papini E., Montecucco C., Rappuoli R., Telford J.L. Towards deciphering the Helicobacter pylori cytotoxin. Mol. Microbiol. 1999, 34:197-204.
162. Ricci S., Rappuoli R., Scarlato V. The pertussis toxin liberation genes of Bordetella pertussis are transcriptionally linked to the pertussis toxin operon. Infect. Immun. 1996, 64:1458-1460.
163. Robien M.A., Krumm B.E., Sandkvist M., Hol W.G. Crystal structure of the extracellular protein secretion NTPase EpsE of Vibrio cholerae. J. Mol. Biol. 2003, 333:657-674.
164. Robinson C., Bolhuis A. Tat-dependent protein targeting in prokaryotes and chloroplasts. Biochim. Biophys. Acta 2004, 1694:135-147.
165. Rohde J.R., Luan X.S., Rohde H., Fox J.M., Minnich S.A. The Yersinia enterocolitica pYV virulence plasmid contains multiple intrinsic DNA bends which melt at 37 degrees C. J. Bacteriol. 1999, 181:4198-4204.
166. Rohde M., Puls J., Buhrdorf R., Fischer W., Haas R. A novel sheathed surface organelle of the Helicobacter pylori cag type IV secretion system. Mol. Microbiol. 2003, 49:219-234.
167. Rosch J., Caparon M. A microdomain for protein secretion in Gram-positive bacteria. Science 2004, 304:1513-1515.
168. Rosqvist R., Magnusson K.E., Wolf-Watz H. Target cell contact triggers expression and polarized transfer of Yersinia YopE cytotoxin into mammalian cells. EMBO J. 1994, 13:964-972.
169. Rouot B., varez-Martinez M.T., Marius C., Menanteau P., Guilloteau L., Boigegrain R.A., Zumbihl R., O'Callaghan D., Domke N., Baron C. Production of the type IV secretion system differs among Brucella species as revealed with VirB5-and VirB8-specific antisera. Infect. Immun. 2003, 71:1075-1082.
170. Sanders C., Wethkamp N., Lill H. Transport of cytochrome c derivatives by the bacterial Tat protein translocation system. Mol. Microbiol. 2001, 41:241-246.
171. Sandkvist M. Type II secretion and pathogenesis. Infect. Immun. 2001, 69:3523-3535.
172. Sandkvist M. Biology of type II secretion. Mol. Microbiol. 2001, 40:271-283.
173. Sandkvist M., Bagdasarian M., Howard S.P., DiRita V.J. Interaction between the autokinase EpsE and EpsL in the cytoplasmic membrane is required for extracellular secretion in Vibrio cholerae. EMBO J. 1995, 14:1664-1673.
174. Sandkvist M., Hough L.P., Bagdasarian M.M., Bagdasarian M. Direct interaction of the EpsL and EpsM proteins of the general secretion apparatus in Vibrio cholerae. J. Bacteriol. 1999, 181:3129-3135.
175. Sargent F., Berks B.C., Palmer T. Assembly of membrane-bound respiratory complexes by the Tat protein-transport system. Arch. Microbiol. 2002, 178:77-84.
176. Sargent F., Bogsch E.G., Stanley N.R., Wexler M., Robinson C., Berks
177. Sargent F., Gohlke U., De L.E., Stanley N.R., Palmer T., Saibil H.R., Berks B.C. Purified components of the Escherichia coli Tat protein transport system form a double-layered ring structure. Eur. J. Biochem. 2001, 268:3361-3367.
178. Saurin W., Hofnung M., Dassa E. Getting in or out: early segregation between importers and exporters in the evolution of ATP-binding cassette (ABC) transporters. J. Mol. Evol. 1999, 48:22-41.
179. Sauvonnet N., Pugsley A.P. Identification of two regions of Klebsiella oxytoca pullulanase that together are capable of promoting beta-lactamase secretion by the general secretory pathway. Mol. Microbiol. 1996, 22:1-7.
180. Sauvonnet N., Vignon G., Pugsley A.P., Gounon P. Pilus formation and protein secretion by the same machinery in Escherichia coli. EMBO J. 2000, 19:2221-2228.
181. Savvides S.N., Yeo H.J., Beck M.R., Blaesing F., Lurz R., Lanka E., Buhrdorf R., Fischer W., Haas R., Waksman G. VirB11 ATPases are dynamic hexameric assemblies: new insights into bacterial type IV secretion. EMBO J. 2003, 22:1969-1980.
182. Schiebel E., Driessen A.J., Hartl F.U., Wickner W. Delta mu H+ and ATP function at different steps of the catalytic cycle of preprotein translocase. Cell 1991, 64:927-939.
183. Schrammeijer B., den Dulk-Ras A., Vergunst A.C., Jurado J.E., Hooykaas P.J. Analysis of Vir protein translocation from Agrobacterium tumefaciens using Saccharomyces cerevisiae as a model: evidence for transport of a novel effector protein VirE3. Nucleic Acids Res. 2003, 31:860-868.
184. Scott M.E., Dossani Z.Y., Sandkvist M. Directed polar secretion of protease from single cells of Vibrio cholerae via the type II secretion pathway. Proc. Natl. Acad. Sci. U. S. A 2001, 98:13978-13983.
185. Serruto D., du-Bobie J., Scarselli M., Veggi D., Pizza M., Rappuoli R., Arico B. Neisseria meningitidis App, a new adhesin with autocatalytic serine protease activity. Mol. Microbiol. 2003, 48:323-334.
186. Settles A.M., Yonetani A., Baron A., Bush D.R., Cline K., Martienssen R. Sec-independent protein translocation by the maize Hcf106 protein. Science 1997, 278:1467-1470.
187. Shere K.D., Sallustio S., Manessis A., D'Aversa T.G., Goldberg M.B. Disruption of IcsP, the major Shigella protease that cleaves IcsA, accelerates actin-based motility. Mol. Microbiol. 1997, 25:451-462.
188. Shevchik V.E., Robert-Baudouy J., Condemine G. Specific interaction between OutD, and Erwinia chrysanthemi outer membrane protein of the general secretory pathway, and secreted proteins. EMBO J. 1997, 16:3007-3016.
189. Shirasu K., Koukolikova-Nicola Z., Hohn B., Kado C.I. An inner-membrane-associated virulence protein essential for T-DNA transfer from Agrobacterium tumefaciens to plants exhibits ATPase activity and similarities to conjugative transfer genes. Mol. Microbiol. 1994, 11:581-588.
190. Sijbrandi R., Urbanus M.L., ten Hagen-Jongman C.M., Bernstein H.D., Oudega B., Otto B.R., Luirink J. Signal recognition particle (SRP)-mediated targeting and Sec-dependent translocation of an extracellular Escherichia coli protein. J. Biol. Chem. 2003, 278:4654-4659.
191. Soderberg M.A., Rossier O., Cianciotto N.P. The type II protein secretion system of Legionella pneumophila promotes growth at low temperatures. J. Bacteriol. 2004, 186:3712-3720.
192. Sory M.P., Boland A., Lambermont I., Cornelis G.R. Identification of the YopE and YopH domains required for secretion and internalization into the cytosol of macrophages, using the cyaA gene fusion approach. Proc. Natl. Acad. Sci. U. S. A 1995, 92:11998-12002.
193. Spudich G.M., Fernandez D., Zhou X.R., Christie P.J. Intermolecular disulfide bonds stabilize VirB7 homodimers and VirB7/VirB9 heterodimers during biogenesis of the Agrobacterium tumefaciens T-complex transport apparatus. Proc. Natl. Acad. Sci. U. S. A 1996, 93:7512-7517.
194. Stanley N.R., Palmer T., Berks B.C. The twin arginine consensus motif of Tat signal peptides is involved in Sec-independent protein targeting in Escherichia coli. J. Biol. Chem. 2000, 275:11591-11596.
195. Stanley P., Koronakis V., Hughes C. Mutational analysis supports a role for multiple structural features in the C-terminal secretion signal of Escherichia coli haemolysin. Mol. Microbiol. 1991, 5:2391-2403.
196. Stebbins C.E., Galan J.E. Maintenance of an unfolded polypeptide by a cognate chaperone in bacterial type III secretion. Nature 2001, 414:77-81.
197. Straley S.C., Plano G.V., Skrzypek E., Haddix P.L., Fields K.A. Regulation by Ca2+ in the Yersinia low-Ca2+ response. Mol. Microbiol. 1993, 8:1005-1010.
198. Strom M.S., Bergman P., Lory S. Identification of active-site cysteines in the conserved domain of PilD, the bifunctional type IV pilin leader peptidase/N-methyltransferase of Pseudomonas aeruginosa. J. Biol. Chem. 1993, 268:15788-15794.
199. Sulavik M.C., et al. Antibiotic susceptibility profiles of Escherichia coli strains lacking multidrug efflux pump genes. Antimicrob. Agents Chemother. 2001, 45:1126-1136.
200. Thanabalu T., Koronakis E., Hughes C., Koronakis V. Substrate-induced assembly of a contiguous channel for protein export from E.coli: reversible bridging of an inner-membrane translocase to an outer membrane exit pore. EMBO J. 1998, 17:6487-6496.
201. Thayer M.M., Flaherty K.M., McKay D.B. Three-dimensional structure of the elastase of Pseudomonas aeruginosa at 1.5-A resolution. J. Biol. Chem. 1991, 266:2864-2871.
202. van den B.B., Clemons W.M., Collinson I., Modis Y., Hartmann E., Harrison S.C., Rapoport T.A. X-ray structure of a protein-conducting channel. Nature 2004, 427:36-44.
203. Veenendaal A.K., van der D.C., Driessen A.J. Mapping the sites of interaction between SecY and SecE by cysteine scanning mutagenesis. J. Biol. Chem. 2001, 276:32559-32566.
204. Veiga E., Sugawara E., Nikaido H., de L.V., Fernandez L.A. Export of autotransported proteins proceeds through an oligomeric ring shaped by C-terminal domains. EMBO J. 2002, 21:2122-2131.
205. Velarde J.J., Nataro J.P. Hydrophobic residues of the autotransporter EspP linker domain are important for outer membrane translocation of its passenger. J. Biol. Chem. 2004, 279:31495-31504.
206. Vergunst A.C., Schrammeijer B., den Dulk-Ras A., de Vlaam C.M., Regensburg-Tuink T.J., Hooykaas P.J. VirB/D4-dependent protein translocation from Agrobacterium into plant cells. Science 2000, 290:970-982.
207. Vergunst A.C., van Lier M.C., den Dulk-Ras A., Hooykaas P.J. Recognition of the Agrobacterium tumefaciens VirE2 translocation signal by the VirB/D4 transport system does not require VirE1. Plant Physiol 2003, 133:978-988.
208. Voulhoux R., Ball G., Ize B., Vasil M.L., Lazdunski A., Wu L.F., Filloux A. Involvement of the twin-arginine translocation system in protein secretion via the type II pathway. EMBO J. 2001, 20:6735-6741.
209. Voulhoux R., Bos M.P., Geurtsen J., Mols M., Tommassen J. Role of a highly conserved bacterial protein in outer membrane protein assembly. Science 2003, 299:262-265.
210. Voulhoux R., Taupiac M.P., Czjzek M., Beaumelle B., Filloux A. Influence of deletions within domain II of exotoxin A on its extracellular secretion from Pseudomonas aeruginosa. J. Bacteriol. 2000, 182:4051-4058.
211. Vrontou E., Economou A. Structure and function of SecA, the preprotein translocase nanomotor. Biochim. Biophys. Acta 2004, 1694:67-80.
212. Wang L., Miller A., Rusch S.L., Kendall D.A. Demonstration of a specific Escherichia coli SecY-signal peptide interaction. Biochemistry 2004, 43:13185-13192.
213. Ward D.V., Draper O., Zupan J.R., Zambryski P.C. Peptide linkage mapping of the Agrobacterium tumefaciens virencoded type IV secretion system reveals protein subassemblies. Proc. Natl. Acad. Sci. U. S. A 2002, 99:11493-11500.
214. Watarai M., Andrews H.L., Isberg R.R. Formation of a fibrous structure on the surface of Legionella pneumophila associated with exposure of DotH and DotO proteins after intracellular growth. Mol. Microbiol. 2001, 39:313-329.
215. Wattiau P., Bernier B., Deslee P., Michiels T., Cornelis G.R. Individual chaperones required for Yop secretion by Yersinia. Proc. Natl. Acad. Sci. U. S. A 1994, 91:10493-10497.
216. Wattiau P., Woestyn S., Cornelis G.R. Customized secretion chaperones in pathogenic bacteria. Mol. Microbiol. 1996, 20:255-262.
217. Weiner J.H., Bilous P.T., Shaw G.M., Lubitz S.P., Frost L., Thomas G.H., Cole J.A., Turner R.J. A novel and ubiquitous system for membrane targeting and secretion of cofactor-containing proteins. Cell 1998, 93:93-101.
218. Yeo H.J., Savvides S.N., Herr A.B., Lanka E., Waksman G. Crystal structure of the hexameric traffic ATPase of the Helicobacter pylori type IV secretion system. Mol. Cell 2000, 6:1461-1472.
219. Yoshida T., Furuya N., Ishikura M., Isobe T., Haino-Fukushima K., Ogawa T., Komano T. Purification and characterization of thin pili of IncI1 plasmids ColIb-P9 and R64: formation of PilV-specific cell aggregates by type IV pili. J. Bacteriol. 1998, 180:2842-2848.
220. Zhang F., Greig D.I., Ling V. Functional replacement of the hemolysin A transport signal by a different primary sequence. Proc. Natl. Acad. Sci. U. S. A 1993, 90:4211-4215.
221. Zheng M., Aslund F., Storz G. Activation of the OxyR transcription factor by reversible disulfide bond formation. Science 1998, 279:1718-1721.
222. Zupan J., Muth T.R., Draper O., Zambryski P. The transfer of DNA from agrobacterium tumefaciens into plants: a feast of fundamental insights. Plant J. 2000, 23:11-28.