메뉴 건너뛰기




Volumn 183, Issue 2, 2013, Pages 760-766

Ginsenoside Rg1 improves survival in a murine model of polymicrobial sepsis by suppressing the inflammatory response and apoptosis of lymphocytes

Author keywords

Anti inflammation; Ginsenoside Rg1; Immune modulation; Sepsis

Indexed keywords

GINSENOSIDE RG 1;

EID: 84880300604     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2013.01.068     Document Type: Article
Times cited : (56)

References (36)
  • 1
    • 0037396875 scopus 로고    scopus 로고
    • 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
    • M.M. Levy, M.P. Fink, and J.C. Marshall 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference Intensive Care Med 29 2003 530
    • (2003) Intensive Care Med , vol.29 , pp. 530
    • Levy, M.M.1    Fink, M.P.2    Marshall, J.C.3
  • 2
    • 0037451929 scopus 로고    scopus 로고
    • The epidemiology of sepsis in the United States from 1979 through 2000
    • G.S. Martin, D.M. Mannino, S. Eaton, and M. Moss The epidemiology of sepsis in the United States from 1979 through 2000 N Engl J Med 348 2003 1546
    • (2003) N Engl J Med , vol.348 , pp. 1546
    • Martin, G.S.1    Mannino, D.M.2    Eaton, S.3    Moss, M.4
  • 3
    • 0026048714 scopus 로고
    • The pathogenesis of sepsis
    • R.C. Bone The pathogenesis of sepsis Ann Intern Med 115 1991 457
    • (1991) Ann Intern Med , vol.115 , pp. 457
    • Bone, R.C.1
  • 5
    • 81855185336 scopus 로고    scopus 로고
    • Advances in the management of sepsis and the understanding of key immunologic defects
    • L.P. Skrupky, P.W. Kerby, and R.S. Hotchkiss Advances in the management of sepsis and the understanding of key immunologic defects Anesthesiology 115 2011 1349
    • (2011) Anesthesiology , vol.115 , pp. 1349
    • Skrupky, L.P.1    Kerby, P.W.2    Hotchkiss, R.S.3
  • 6
    • 34347397197 scopus 로고    scopus 로고
    • Advances in pathogenesis and management of sepsis
    • I. Cinel, and R.P. Dellinger Advances in pathogenesis and management of sepsis Curr Opin Infect Dis 20 2007 345
    • (2007) Curr Opin Infect Dis , vol.20 , pp. 345
    • Cinel, I.1    Dellinger, R.P.2
  • 7
    • 84255193988 scopus 로고    scopus 로고
    • Immunosuppression in sepsis
    • P.A. Ward Immunosuppression in sepsis JAMA 306 2011 2618
    • (2011) JAMA , vol.306 , pp. 2618
    • Ward, P.A.1
  • 8
    • 77953307436 scopus 로고    scopus 로고
    • Pharmacology of ginsenosides: A literature review
    • K.W. Leung, and A.S. Wong Pharmacology of ginsenosides: a literature review Chin Med 5 2010 20
    • (2010) Chin Med , vol.5 , pp. 20
    • Leung, K.W.1    Wong, A.S.2
  • 9
    • 79251622569 scopus 로고    scopus 로고
    • Inhibitory effect of ginsenoside Rg1 on lipopolysaccharide-induced microglial activation in mice
    • J.F. Hu, X.Y. Song, and S.F. Chu Inhibitory effect of ginsenoside Rg1 on lipopolysaccharide-induced microglial activation in mice Brain Res 1374 2011 8
    • (2011) Brain Res , vol.1374 , pp. 8
    • Hu, J.F.1    Song, X.Y.2    Chu, S.F.3
  • 10
    • 79960481117 scopus 로고    scopus 로고
    • Ginsenoside Rg1, a novel glucocorticoid receptor agonist of plant origin, maintains glucocorticoid efficacy with reduced side effects
    • J. Du, B. Cheng, X. Zhu, and C. Ling Ginsenoside Rg1, a novel glucocorticoid receptor agonist of plant origin, maintains glucocorticoid efficacy with reduced side effects J Immunol 187 2011 942
    • (2011) J Immunol , vol.187 , pp. 942
    • Du, J.1    Cheng, B.2    Zhu, X.3    Ling, C.4
  • 11
    • 10744231155 scopus 로고    scopus 로고
    • Ginsenoside Rg1 enhances CD4(+) T-cell activities and modulates Th1/Th2 differentiation
    • E.J. Lee, E. Ko, and J. Lee Ginsenoside Rg1 enhances CD4(+) T-cell activities and modulates Th1/Th2 differentiation Int Immunopharmacol 4 2004 235
    • (2004) Int Immunopharmacol , vol.4 , pp. 235
    • Lee, E.J.1    Ko, E.2    Lee, J.3
  • 12
    • 84862007373 scopus 로고    scopus 로고
    • Ginsenoside Rg1 protection against beta-amyloid peptide-induced neuronal apoptosis via estrogen receptor alpha and glucocorticoid receptor-dependent anti-protein nitration pathway
    • J. Wu, Z. Pan, and Z. Wang Ginsenoside Rg1 protection against beta-amyloid peptide-induced neuronal apoptosis via estrogen receptor alpha and glucocorticoid receptor-dependent anti-protein nitration pathway Neuropharmacology 63 2012 349
    • (2012) Neuropharmacology , vol.63 , pp. 349
    • Wu, J.1    Pan, Z.2    Wang, Z.3
  • 13
    • 69249148258 scopus 로고    scopus 로고
    • Ginsenoside Rg1 protects rat cardiomyocyte from hypoxia/reoxygenation oxidative injury via antioxidant and intracellular calcium homeostasis
    • D. Zhu, L. Wu, and C.R. Li Ginsenoside Rg1 protects rat cardiomyocyte from hypoxia/reoxygenation oxidative injury via antioxidant and intracellular calcium homeostasis J Cell Biochem 108 2009 117
    • (2009) J Cell Biochem , vol.108 , pp. 117
    • Zhu, D.1    Wu, L.2    Li, C.R.3
  • 14
    • 33646759609 scopus 로고    scopus 로고
    • Cecal ligation and puncture
    • W.J. Hubbard, M. Choudhry, and M.G. Schwacha Cecal ligation and puncture Shock 24 Suppl 1 2005 52
    • (2005) Shock , vol.24 , Issue.SUPPL. 1 , pp. 52
    • Hubbard, W.J.1    Choudhry, M.2    Schwacha, M.G.3
  • 15
    • 0036317919 scopus 로고    scopus 로고
    • Role of macrophage migration inhibitory factor in bleomycin-induced lung injury and fibrosis in mice
    • Y. Tanino, H. Makita, and K. Miyamoto Role of macrophage migration inhibitory factor in bleomycin-induced lung injury and fibrosis in mice Am J Physiol Lung Cell Mol Physiol 283 2002 L156
    • (2002) Am J Physiol Lung Cell Mol Physiol , vol.283 , pp. 156
    • Tanino, Y.1    Makita, H.2    Miyamoto, K.3
  • 16
    • 84857090358 scopus 로고    scopus 로고
    • Sepsis, systemic inflammatory response, and multiple organ dysfunction: The mystery continues
    • D.E. Fry Sepsis, systemic inflammatory response, and multiple organ dysfunction: the mystery continues Am Surg 78 2012 1
    • (2012) Am Surg , vol.78 , pp. 1
    • Fry, D.E.1
  • 17
    • 0037426726 scopus 로고    scopus 로고
    • The pathophysiology and treatment of sepsis
    • R.S. Hotchkiss, and I.E. Karl The pathophysiology and treatment of sepsis N Engl J Med 348 2003 138
    • (2003) N Engl J Med , vol.348 , pp. 138
    • Hotchkiss, R.S.1    Karl, I.E.2
  • 18
    • 42049117508 scopus 로고    scopus 로고
    • Inflammatory markers in SIRS, sepsis and septic shock
    • I. Herzum, and H. Renz Inflammatory markers in SIRS, sepsis and septic shock Curr Med Chem 15 2008 581
    • (2008) Curr Med Chem , vol.15 , pp. 581
    • Herzum, I.1    Renz, H.2
  • 19
    • 33748072117 scopus 로고    scopus 로고
    • Mechanisms of mortality in early and late sepsis
    • H. Xiao, J. Siddiqui, and D.G. Remick Mechanisms of mortality in early and late sepsis Infect Immun 74 2006 5227
    • (2006) Infect Immun , vol.74 , pp. 5227
    • Xiao, H.1    Siddiqui, J.2    Remick, D.G.3
  • 20
    • 70350502827 scopus 로고    scopus 로고
    • Genetic polymorphisms in sepsis
    • A. Namath, and A.J. Patterson Genetic polymorphisms in sepsis Crit Care Clin 25 2009 835
    • (2009) Crit Care Clin , vol.25 , pp. 835
    • Namath, A.1    Patterson, A.J.2
  • 21
    • 77956628404 scopus 로고    scopus 로고
    • Sepsis biomarkers: A review
    • C. Pierrakos, and J.L. Vincent Sepsis biomarkers: a review Crit Care 14 2010 R15
    • (2010) Crit Care , vol.14 , pp. 15
    • Pierrakos, C.1    Vincent, J.L.2
  • 22
    • 33746190736 scopus 로고    scopus 로고
    • Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality
    • M.F. Osuchowski, K. Welch, J. Siddiqui, and D.G. Remick Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality J Immunol 177 2006 1967
    • (2006) J Immunol , vol.177 , pp. 1967
    • Osuchowski, M.F.1    Welch, K.2    Siddiqui, J.3    Remick, D.G.4
  • 23
    • 79957649524 scopus 로고    scopus 로고
    • Mild versus strong anti-inflammatory therapy during early sepsis in mice: A matter of life and death
    • J.W. van den Berg, M. van der Zee, and R.W. de Bruin Mild versus strong anti-inflammatory therapy during early sepsis in mice: a matter of life and death Crit Care Med 39 2011 1275
    • (2011) Crit Care Med , vol.39 , pp. 1275
    • Van Den Berg, J.W.1    Van Der Zee, M.2    De Bruin, R.W.3
  • 24
    • 0029900294 scopus 로고    scopus 로고
    • Treatment of septic shock with the tumor necrosis factor receptor:Fc fusion protein. The Soluble TNF Receptor Sepsis Study Group
    • C.J. Fisher Jr., J.M. Agosti, and S.M. Opal Treatment of septic shock with the tumor necrosis factor receptor:Fc fusion protein. The Soluble TNF Receptor Sepsis Study Group N Engl J Med 334 1996 1697
    • (1996) N Engl J Med , vol.334 , pp. 1697
    • Fisher Jr., C.J.1    Agosti, J.M.2    Opal, S.M.3
  • 25
    • 8544262221 scopus 로고    scopus 로고
    • Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab')2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels
    • E.A. Panacek, J.C. Marshall, and T.E. Albertson Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab')2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels Crit Care Med 32 2004 2173
    • (2004) Crit Care Med , vol.32 , pp. 2173
    • Panacek, E.A.1    Marshall, J.C.2    Albertson, T.E.3
  • 27
    • 0033929552 scopus 로고    scopus 로고
    • Role of nitric oxide in the failure of neutrophil migration in sepsis
    • C.F. Benjamim, S.H. Ferreira, and F.Q. Cunha Role of nitric oxide in the failure of neutrophil migration in sepsis J Infect Dis 182 2000 214
    • (2000) J Infect Dis , vol.182 , pp. 214
    • Benjamim, C.F.1    Ferreira, S.H.2    Cunha, F.Q.3
  • 28
    • 81555198007 scopus 로고    scopus 로고
    • Ginsenoside-Rg1 protects the liver against Exhaustive exercise-induced oxidative stress in tats
    • M. Korivi, C.W. Hou, and C.Y. Huang Ginsenoside-Rg1 protects the liver against Exhaustive exercise-induced oxidative stress in tats Evid Based Complement Alternat Med 2012 2012 932165
    • (2012) Evid Based Complement Alternat Med , vol.2012 , pp. 932165
    • Korivi, M.1    Hou, C.W.2    Huang, C.Y.3
  • 29
    • 84255194001 scopus 로고    scopus 로고
    • Immunosuppression in patients who die of sepsis and multiple organ failure
    • J.S. Boomer, K. To, and K.C. Chang Immunosuppression in patients who die of sepsis and multiple organ failure JAMA 306 2011 2594
    • (2011) JAMA , vol.306 , pp. 2594
    • Boomer, J.S.1    To, K.2    Chang, K.C.3
  • 30
    • 0033120115 scopus 로고    scopus 로고
    • Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis
    • R.S. Hotchkiss, P.E. Swanson, and C.M. Knudson Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis J Immunol 162 1999 4148
    • (1999) J Immunol , vol.162 , pp. 4148
    • Hotchkiss, R.S.1    Swanson, P.E.2    Knudson, C.M.3
  • 31
    • 65549100987 scopus 로고    scopus 로고
    • Silencing of fas-associated death domain protects mice from septic lung inflammation and apoptosis
    • N. Matsuda, S. Yamamoto, and K. Takano Silencing of fas-associated death domain protects mice from septic lung inflammation and apoptosis Am J Respir Crit Care Med 179 2009 806
    • (2009) Am J Respir Crit Care Med , vol.179 , pp. 806
    • Matsuda, N.1    Yamamoto, S.2    Takano, K.3
  • 33
    • 36248985145 scopus 로고    scopus 로고
    • Role of T cells in a murine model of Escherichia coli sepsis
    • S.M. van Schaik, and A.K. Abbas Role of T cells in a murine model of Escherichia coli sepsis Eur J Immunol 37 2007 3101
    • (2007) Eur J Immunol , vol.37 , pp. 3101
    • Van Schaik, S.M.1    Abbas, A.K.2
  • 34
    • 77951207151 scopus 로고    scopus 로고
    • Ginsenoside-Rg1 from Panax notoginseng prevents hepatic fibrosis induced by thioacetamide in rats
    • J. Geng, W. Peng, Y. Huang, H. Fan, and S. Li Ginsenoside-Rg1 from Panax notoginseng prevents hepatic fibrosis induced by thioacetamide in rats Eur J Pharmacol 634 2010 162
    • (2010) Eur J Pharmacol , vol.634 , pp. 162
    • Geng, J.1    Peng, W.2    Huang, Y.3    Fan, H.4    Li, S.5
  • 35
    • 78049430530 scopus 로고    scopus 로고
    • Ginsenoside Rg1 modulation on thrombospondin-1 and vascular endothelial growth factor expression in early renal fibrogenesis in unilateral obstruction
    • X.S. Xie, H.C. Liu, and F.P. Wang Ginsenoside Rg1 modulation on thrombospondin-1 and vascular endothelial growth factor expression in early renal fibrogenesis in unilateral obstruction Phytother Res 24 2010 1581
    • (2010) Phytother Res , vol.24 , pp. 1581
    • Xie, X.S.1    Liu, H.C.2    Wang, F.P.3
  • 36
    • 67650113346 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase (MAPK) pathway mediates the oestrogen-like activities of ginsenoside Rg1 in human breast cancer (MCF-7) cells
    • W.S. Lau, W.F. Chen, R.Y. Chan, D.A. Guo, and M.S. Wong Mitogen-activated protein kinase (MAPK) pathway mediates the oestrogen-like activities of ginsenoside Rg1 in human breast cancer (MCF-7) cells Br J Pharmacol 156 2009 1136
    • (2009) Br J Pharmacol , vol.156 , pp. 1136
    • Lau, W.S.1    Chen, W.F.2    Chan, R.Y.3    Guo, D.A.4    Wong, M.S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.