Nanog expression is negatively regulated by protein kinase C activities in human cancer cell lines

Carcinogenesis

Volumn 34, Issue 7, 2013, Pages 1497-1509

  Chu, Wing Keung ^a   Dai, Pei Min ^a   Li, Hsin Lun ^a   Pao, Chia Chu ^a   Chen, Jan Kan ^a  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CHELERYTHRINE; MESSENGER RNA; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN KINASE C; STAUROSPORINE; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2;

ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; EMBRYONAL CARCINOMA; ENZYME INHIBITION; GENE EXPRESSION REGULATION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; NASOPHARYNX CARCINOMA; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSIENT TRANSFECTION;

CELL PROLIFERATION; DISEASE PROGRESSION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HEP G2 CELLS; HOMEODOMAIN PROTEINS; HUMANS; ISOENZYMES; MUTAGENESIS, SITE-DIRECTED; NASOPHARYNGEAL NEOPLASMS; OCTAMER TRANSCRIPTION FACTOR-3; PROMOTER REGIONS, GENETIC; PROTEIN KINASE C-ALPHA; PROTEIN KINASE C-DELTA; RNA, MESSENGER; SOXB1 TRANSCRIPTION FACTORS; TETRADECANOYLPHORBOL ACETATE; TRANSCRIPTION, GENETIC;

EID: 84880282047     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgt104     Document Type: Article

References (56)

1. Boiani, M. et al. (2005) Regulatory networks in embryo-derived pluripotent stem cells. Nat. Rev. Mol. Cell Biol., 6, 872-884.
2. Loh, Y.H. et al. (2006) The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat. Genet., 38, 431-440.
3. Mitsui, K. et al. (2003) The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell, 113, 631-642.
4. Chambers, I. et al. (2003) Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell, 113, 643-655.
5. Yamaguchi, S. et al. (2005) Nanog expression in mouse germ cell development. Gene Expr. Patterns, 5, 639-646.
6. Kerr, C.L. et al. (2008) Expression of pluripotent stem cell markers in the human fetal testis. Stem Cells, 26, 412-421.
7. Rodda, D.J. et al. (2005) Transcriptional regulation of nanog by OCT4 and SOX2. J. Biol. Chem., 280, 24731-24737.
8. Zhang, J. et al. (2005) Expression of Nanog gene promotes NIH3T3 cell proliferation. Biochem. Biophys. Res. Commun., 338, 1098-1102.
9. Hart, A.H. et al. (2005) The pluripotency homeobox gene NANOG is expressed in human germ cell tumors. Cancer, 104, 2092-2098.
10. Meng, H.M. et al. (2010) Overexpression of nanog predicts tumor progression and poor prognosis in colorectal cancer. Cancer Biol. Ther., 9,.
11. Ezeh, U.I. et al. (2005) Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma. Cancer, 104, 2255-2265.
12. Chiou, S.H. et al. (2008) Positive correlations of Oct-4 and Nanog in oral cancer stem-like cells and high-grade oral squamous cell carcinoma. Clin. Cancer Res., 14, 4085-4095.
13. Zhang, S. et al. (2008) Identification and characterization of ovarian cancerinitiating cells from primary human tumors. Cancer Res., 68, 4311-4320.
14. Bussolati, B. et al. (2008) Identification of a tumor-initiating stem cell population in human renal carcinomas. FASEB J., 22, 3696-3705.
15. Ye, F. et al. (2008) Stem-cell-abundant proteins Nanog, Nucleostemin and Musashi1 are highly expressed in malignant cervical epithelial cells. BMC Cancer, 8, 108.
16. Nishizuka, Y. (1995) Protein kinase C and lipid signaling for sustained cellular responses. FASEB J., 9, 484-496.
17. Hug, H. et al. (1993) Protein kinase C isoenzymes: divergence in signal transduction? Biochem. J., 291 (Pt 2), 329-343.
18. Ways, D.K. et al. (1987) Dissimilar effects of phorbol ester and diacylglycerol derivative on protein kinase activity in the monoblastoid U937 cell. Cancer Res., 47, 3344-3350.
19. Collins, S.J. (1987) The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression. Blood, 70, 1233-1244.
20. Hong, Y. et al. (1996) Inhibition of protein kinase C suppresses megakaryocytic differentiation and stimulates erythroid differentiation in HEL cells. Blood, 87, 123-131.
21. Lumelsky, N.L. et al. (1997) Protein kinase C in erythroid and megakaryocytic differentiation: possible role in lineage determination. Biochim. Biophys. Acta, 1358, 79-92.
22. Abraham, I. et al. (1991) Increased PKA and PKC activities accompany neuronal differentiation of NT2/D1 cells. J. Neurosci. Res., 28, 29-39.
23. Lee, H.J. et al. (2010) PKC-delta inhibitors sustain self-renewal of mouse embryonic stem cells under hypoxia in vitro. Exp. Mol. Med., 42, 294-301.
24. Gao, Q.Y. et al. (2007) Expression of protein kinase C isoforms in retinoic acid-induced differentiation of mouse embryonic stem cells into neuronlike cells. Chin. Med. J. (Engl)., 120, 1639-1642.
25. Lin, T. et al. (2012) Overexpression of Nanog protein is associated with poor prognosis in gastric adenocarcinoma. Med Oncol., 29, 878-85.
26. Ku, W.C. et al. (1997) Inhibition of telomerase activity by PKC inhibitors in human nasopharyngeal cancer cells in culture. Biochem. Biophys. Res. Commun., 241, 730-736.
27. Suh, M.R. et al. (2004) Human embryonic stem cells express a unique set of microRNAs. Dev. Biol., 270, 488-498.
28. Schopperle, W.M. et al. (2007) The TRA-1-60 and TRA-1-81 human pluripotent stem cell markers are expressed on podocalyxin in embryonal carcinoma. Stem Cells, 25, 723-730.
29. Evans, M.J. et al. (1981) Establishment in culture of pluripotential cells from mouse embryos. Nature, 292, 154-156.
30. Smith, A.G. et al. (1988) Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides. Nature, 336, 688-690.
31. Ying, Q.L. et al. (2003) BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell, 115, 281-292.
32. Dahéron, L. et al. (2004) LIF/STAT3 signaling fails to maintain selfrenewal of human embryonic stem cells. Stem Cells, 22, 770-778.
33. Xu, R.H. et al. (2002) BMP4 initiates human embryonic stem cell differentiation to trophoblast. Nat. Biotechnol., 20, 1261-1264.
34. Xu, R.H. et al. (2005) Basic FGF and suppression of BMP signaling sustain undifferentiated proliferation of human ES cells. Nat. Methods, 2, 185-190.
35. Vallier, L. et al. (2005) Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells. J. Cell Sci., 118(Pt 19), 4495-4509.
36. James, D. et al. (2005) TGFbeta/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells. Development, 132, 1273-1282.
37. Xu, R.H. et al. (2008) NANOG is a direct target of TGFbeta/activin-mediated SMAD signaling in human ESCs. Cell Stem Cell, 3, 196-206.
38. Boyer, L.A. et al. (2005) Core transcriptional regulatory circuitry in human embryonic stem cells. Cell, 122, 947-956.
39. Lin, T. et al. (2005) p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression. Nat. Cell Biol., 7, 165-171.
40. Brieger, A. et al. (2002) Transient mismatch repair gene transfection for functional analysis of genetic hMLH1 and hMSH2 variants. Gut, 51, 677-684.
41. Liu, P.K. et al. (1994) Suppression of ischemia-induced fos expression and AP-1 activity by an antisense oligodeoxynucleotide to c-fos mRNA. Ann. Neurol., 36, 566-576.
42. Mongan, N.P. et al. (2006) The putative human stem cell marker, Rex-1 (Zfp42): structural classification and expression in normal human epithelial and carcinoma cell cultures. Mol. Carcinog., 45, 887-900.
43. Ben-Porath, I. et al. (2008) An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat. Genet., 40, 499-507.
44. Wong, D.J. et al. (2008) Module map of stem cell genes guides creation of epithelial cancer stem cells. Cell Stem Cell, 2, 333-344.
45. Wang, Q. et al. (2009) Oct3/4 and Sox2 are significantly associated with an unfavorable clinical outcome in human esophageal squamous cell carcinoma. Anticancer Res., 29, 1233-1241.
46. Saigusa, S. et al. (2009) Correlation of CD133, OCT4, and SOX2 in rectal cancer and their association with distant recurrence after chemoradiotherapy. Ann. Surg. Oncol., 16, 3488-3498.
47. Chang, C.C. et al. (2008) Oct-3/4 expression reflects tumor progression and regulates motility of bladder cancer cells. Cancer Res., 68, 6281-6291.
48. Chiou, S.H. et al. (2008) Positive correlations of Oct-4 and Nanog in oral cancer stem-like cells and high-grade oral squamous cell carcinoma. Clin. Cancer Res., 14, 4085-4095.
49. Huang, P. et al. (2011) Role of Sox2 and Oct4 in predicting survival of hepatocellular carcinoma patients after hepatectomy. Clin. Biochem., 44, 582-589.
50. Chen, Y. et al. (2008) The molecular mechanism governing the oncogenic potential of SOX2 in breast cancer. J. Biol. Chem., 283, 17969-17978.
51. Hu, T. et al. (2008) Octamer 4 small interfering RNA results in cancer stem cell-like cell apoptosis. Cancer Res., 68, 6533-6540.
52. Hochedlinger, K. et al. (2005) Ectopic expression of Oct-4 blocks progenitor- cell differentiation and causes dysplasia in epithelial tissues. Cell, 121, 465-477.
53. Kurie, J.M. et al. (1993) Cooperation between retinoic acid and phorbol esters enhances human teratocarcinoma differentiation. Differentiation., 54, 115-122.
54. Tay, Y. et al. (2008) MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation. Nature, 455, 1124-1128.
55. Tay, Y.M. et al. (2008) MicroRNA-134 modulates the differentiation of mouse embryonic stem cells, where it causes post-transcriptional attenuation of Nanog and LRH1. Stem Cells, 26, 17-29.
56. Xu, N. et al. (2009) MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. Cell, 137, 647-658.