Thiol-dependent recovery of catalytic activity from oxidized protein tyrosine phosphatases

Biochemistry

Volumn 52, Issue 37, 2013, Pages 6412-6423

  Parsons, Zachary D ^a   Gates, Kent S ^a,b  

^a UNIVERSITY OF MISSOURI   (United States)

^b University of Missouri   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APPARENT RATE CONSTANT; ENZYMATIC ACTIVITIES; LOW-MOLECULAR WEIGHT; PROTEIN-TYROSINE PHOSPHATASE; REACTIVATION PROCESS; SECOND-ORDER RATE CONSTANTS; STRUCTURAL DIFFERENCES; TRIS(2 CARBOXYETHYL)PHOSPHINE;

AMINO ACIDS; BYPRODUCTS; CATALYTIC OXIDATION; MAMMALS; MOLECULAR WEIGHT; OXIDATION; PHOSPHATASES; PHOSPHORUS COMPOUNDS; PROTEINS; RATE CONSTANTS; SIGNAL TRANSDUCTION;

CATALYST ACTIVITY;

DISULFIDE; DITHIOTHREITOL; GLUTAREDOXIN; GLUTATHIONE; PROTEIN TYROSINE PHOSPHATASE 1B; PROTEIN TYROSINE PHOSPHATASE SHP 2; THIOL; THIOL GROUP; THIOREDOXIN; TRIS(2 CARBOXYETHYL)PHOSPHINE;

ARTICLE; BIOCATALYSIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME METABOLISM; ENZYME REACTIVATION; ENZYME STRUCTURE; INTRACELLULAR SIGNALING; MOLECULAR WEIGHT; PH; PKA; PRIORITY JOURNAL;

CATALYTIC DOMAIN; DISULFIDES; DITHIOTHREITOL; ENZYME REACTIVATORS; GLUTATHIONE; HYDROGEN PEROXIDE; OXIDATION-REDUCTION; PHOSPHINES; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 11; SIGNAL TRANSDUCTION; SULFHYDRYL COMPOUNDS; THIOREDOXINS;

EID: 84880275000     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi400451m     Document Type: Article

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