-
1
-
-
0034284550
-
Therapeutic approaches to bone disease
-
10968781 10.1126/science.289.5484.1508 1:CAS:528:DC%2BD3cXmt1Kgsb4%3D
-
Rodan GA, Martin TJ (2000) Therapeutic approaches to bone disease. Science 289:1508-1514
-
(2000)
Science
, vol.289
, pp. 1508-1514
-
-
Rodan, G.A.1
Martin, T.J.2
-
2
-
-
84255200563
-
Building strong bones: Molecular regulation of the osteoblast lineage
-
22189423 10.1038/nrm3254
-
Long F (2011) Building strong bones: molecular regulation of the osteoblast lineage. Nat Rev Mol Cell Biol 13:27-38
-
(2011)
Nat Rev Mol Cell Biol
, vol.13
, pp. 27-38
-
-
Long, F.1
-
3
-
-
0242668869
-
Bone morphogenetic proteins, their antagonists, and the skeleton
-
DOI 10.1210/er.2002-0023
-
Canalis E, Economides AN, Gazzerro E (2003) Bone morphogenetic proteins, their antagonists and the skeleton. Endor Rev 24:218-235 (Pubitemid 36515285)
-
(2003)
Endocrine Reviews
, vol.24
, Issue.2
, pp. 218-235
-
-
Canalis, E.1
Economides, A.N.2
Gazzerro, E.3
-
4
-
-
0030678549
-
Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation
-
Ducy P, Zhang R, Geoffroy V, Ridall AL, Karsenty G (1997) Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 89:747-754 (Pubitemid 27516177)
-
(1997)
Cell
, vol.89
, Issue.5
, pp. 747-754
-
-
Ducy, P.1
Zhang, R.2
Geoffroy, V.3
Ridall, A.L.4
Karsenty, G.5
-
5
-
-
0030684749
-
Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
-
10.1016/S0092-8674(00)80258-5
-
Komori T, Yagi H, Nomura S, Yamaguchi A, Sasaki K, Deguchi K, Shimizu Y, Bronson RT, Gao YH, Inada M, Sato M, Okamoto R, Kitamura Y, Yoshiki S, Kishimoto T (1997) Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 89:765-771
-
(1997)
Cell
, vol.89
, pp. 765-771
-
-
Komori, T.1
Yagi, H.2
Nomura, S.3
Yamaguchi, A.4
Sasaki, K.5
Deguchi, K.6
Shimizu, Y.7
Bronson, R.T.8
Gao, Y.H.9
Inada, M.10
Sato, M.11
Okamoto, R.12
Kitamura, Y.13
Yoshiki, S.14
Kishimoto, T.15
-
6
-
-
0034641606
-
A Pro250Arg substitution in mouse Fgfr1 causes increased expression of Cbfa1 and premature fusion of calvarial sutures
-
Zhou YX, Xu X, Chen L, Li C, Brodie SG, Deng CX (2000) A Pro250Arg substitution in mouse Fgfr1 causes increased expression of Cbfa1 and premature fusion of calvarial sutures. Hum Mol Genet 9:2001-2008 (Pubitemid 30642665)
-
(2000)
Human Molecular Genetics
, vol.9
, Issue.13
, pp. 2001-2008
-
-
Zhou, Y.-X.1
Xu, X.2
Chen, L.3
Li, C.4
Brodie, S.G.5
Deng, C.-X.6
-
7
-
-
0034460993
-
Runx2 is a common target of transforming growth factor β1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12
-
DOI 10.1128/MCB.20.23.8783-8792.2000
-
Lee KS, Kim HJ, Li QL, Chi XZ, Ueta C, Komori T, Wozney JM, Kim EG, Choi JY, Ryoo HM, Bae SC (2000) Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12. Mol Cell Biol 20:8783-8792 (Pubitemid 32245911)
-
(2000)
Molecular and Cellular Biology
, vol.20
, Issue.23
, pp. 8783-8792
-
-
Lee, K.-S.1
Kim, H.-J.2
Li, Q.-L.3
Chi, X.-Z.4
Ueta, C.5
Komori, T.6
Wozney, J.M.7
Kim, E.-G.8
Choi, J.-Y.9
Ryoo, H.-M.10
Bae, S.-C.11
-
8
-
-
0036774003
-
Serine phosphorylation of RUNX2 with novel potential functions as negative regulatory mechanisms
-
DOI 10.1093/embo-reports/kvf193
-
Wee HJ, Huang G, Shigesada K, Ito Y (2002) Serine phosphorylation of RUNX2 with novel potential functions as negative regulatory mechanisms. EMBO Rep 3:967-974 (Pubitemid 35256471)
-
(2002)
EMBO Reports
, vol.3
, Issue.10
, pp. 967-974
-
-
Wee, H.-J.1
Huang, G.2
Shigesada, K.3
Ito, Y.4
-
9
-
-
41049108267
-
GSK-3β controls osteogenesis through regulating Runx2 activity
-
DOI 10.1371/journal.pone.0000837
-
Kugimiya F, Kawaguchi H, Ohba S, Kawamura N, Hirata M, Chikuda H, Azuma Y, Woodgett JR, Nakamura K, Chung UI (2007) GSK-3beta controls osteogenesis through regulating Runx2 activity. PLoS ONE 2:e837 (Pubitemid 351420082)
-
(2007)
PLoS ONE
, vol.2
, Issue.9
-
-
Kugimiya, F.1
Kawaguchi, H.2
Ohba, S.3
Kawamura, N.4
Hirata, M.5
Chikuda, H.6
Azuma, Y.7
Woodgett, J.R.8
Nakamura, K.9
Chung, U.-I.10
-
10
-
-
84859902202
-
C-Jun N-terminal kinase 1 negatively regulates osteoblastic differentiation induced by BMP-2 via phosphorylation of Runx2 at Ser104
-
22247071 10.1002/jbmr.1548 1:CAS:528:DC%2BC38Xls1aqtLg%3D
-
Huang YF, Lin JJ, Lin CH, Su Y, Hung SC (2012) c-Jun N-terminal kinase 1 negatively regulates osteoblastic differentiation induced by BMP-2 via phosphorylation of Runx2 at Ser104. J Bone Miner Res 27:1093-1105
-
(2012)
J Bone Miner Res
, vol.27
, pp. 1093-1105
-
-
Huang, Y.F.1
Lin, J.J.2
Lin, C.H.3
Su, Y.4
Hung, S.C.5
-
11
-
-
0037184027
-
Fibroblast growth factor 2 induction of the osteocalcin gene requires MAPK activity and phosphorylation of the osteoblast transcription factor, Cbfa1/Runx2
-
12110689 10.1074/jbc.M206057200 1:CAS:528:DC%2BD38XnsVCjsbk%3D
-
Xiao G, Jiang D, Gopalakrishnan R, Franceschi RT (2002) Fibroblast growth factor 2 induction of the osteocalcin gene requires MAPK activity and phosphorylation of the osteoblast transcription factor, Cbfa1/Runx2. J Biol Chem 277:36181-36187
-
(2002)
J Biol Chem
, vol.277
, pp. 36181-36187
-
-
Xiao, G.1
Jiang, D.2
Gopalakrishnan, R.3
Franceschi, R.T.4
-
12
-
-
0035865459
-
Dimerization with PEBP2β protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation
-
DOI 10.1093/emboj/20.4.723
-
Huang G, Shigesada K, Ito K, Wee HJ, Yokomizo T, Ito Y (2001) Dimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin-proteasome- mediated degradation. EMBO J 20:723-733 (Pubitemid 32167637)
-
(2001)
EMBO Journal
, vol.20
, Issue.4
, pp. 723-733
-
-
Huang, G.1
Shigesada, K.2
Ito, K.3
Wee, H.-J.4
Yokomizo, T.5
Ito, Y.6
-
13
-
-
33745184891
-
Cyclin D1-cdk4 induce runx2 ubiquitination and degradation
-
16613857 10.1074/jbc.M603439200 1:CAS:528:DC%2BD28XlsV2ls7s%3D
-
Shen R, Wang X, Drissi H, Liu F, O'Keefe RF, Chen D (2006) Cyclin D1-cdk4 induce runx2 ubiquitination and degradation. J Biol Chem 281:16347-16353
-
(2006)
J Biol Chem
, vol.281
, pp. 16347-16353
-
-
Shen, R.1
Wang, X.2
Drissi, H.3
Liu, F.4
O'Keefe, R.F.5
Chen, D.6
-
14
-
-
0032906633
-
P53 Sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage
-
Liu L, Scolnick DM, Trievel RC, Zhang HB, Marmorstein R, Halazonetis TD, Berger SL (1999) p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage. Mol Cell Biol 19:1202-1209 (Pubitemid 29046862)
-
(1999)
Molecular and Cellular Biology
, vol.19
, Issue.2
, pp. 1202-1209
-
-
Liu, L.1
Scolnick, D.M.2
Trievel, R.C.3
Zhang, H.B.4
Marmorstein, R.5
Halazonetis, T.D.6
Berger, S.L.7
-
15
-
-
63049111216
-
PCAF acetylates beta-catenin and improves its stability
-
10.1091/mbc.E08-08-0792 1:CAS:528:DC%2BD1MXht1Srsrc%3D
-
Ge X, Jin Q, Zhang F, Yan T, Zhai Q (2009) PCAF acetylates beta-catenin and improves its stability. Mol Cell Biol 20:419-427
-
(2009)
Mol Cell Biol
, vol.20
, pp. 419-427
-
-
Ge, X.1
Jin, Q.2
Zhang, F.3
Yan, T.4
Zhai, Q.5
-
16
-
-
78149304022
-
Acetylation of Rb by PCAF is required for nuclear localization and keratinocyte differentiation
-
20940255 10.1242/jcs.068924 1:CAS:528:DC%2BC3cXhsFCit7nJ
-
Pickard A, Wong PP, McCance DJ (2010) Acetylation of Rb by PCAF is required for nuclear localization and keratinocyte differentiation. J Cell Sci 123:3718-3726
-
(2010)
J Cell Sci
, vol.123
, pp. 3718-3726
-
-
Pickard, A.1
Wong, P.P.2
McCance, D.J.3
-
17
-
-
79551500034
-
PCAF interacts with XBP-1S and mediates XBP-1S-dependent transcription
-
10.1093/nar/gkq785
-
Qiao JL, Chu KL, Lee J, Koh PL, Rajasegaran V, Teo JY, Chao SH (2011) PCAF interacts with XBP-1S and mediates XBP-1S-dependent transcription. Nucleic Acids Res 39:429-439
-
(2011)
Nucleic Acids Res
, vol.39
, pp. 429-439
-
-
Qiao, J.L.1
Chu, K.L.2
Lee, J.3
Koh, P.L.4
Rajasegaran, V.5
Teo, J.Y.6
Chao, S.H.7
-
18
-
-
84861314611
-
Biochemical stimulation of osteoblast gene expression requires phosphorylation of the RUNX2 transcription factor
-
22337141 10.1002/jbmr.1574 1:CAS:528:DC%2BC38XntFSgsLc%3D
-
Li Y, Ge C, Long JP, Begun DL, Rodriguez JA, Goldstein SA, Franceschi RT (2012) Biochemical stimulation of osteoblast gene expression requires phosphorylation of the RUNX2 transcription factor. J Bone Miner Res 27:1263-1274
-
(2012)
J Bone Miner Res
, vol.27
, pp. 1263-1274
-
-
Li, Y.1
Ge, C.2
Long, J.P.3
Begun, D.L.4
Rodriguez, J.A.5
Goldstein, S.A.6
Franceschi, R.T.7
-
19
-
-
77953854477
-
OP-1 (BMP-7) stimulates osteoprogenitor cell differentiation in the presence of polymethylmethacrylate particles
-
1:CAS:528:DC%2BC3cXnvVOgs7c%3D
-
Kann S, Chiu R, Ma T, Goodman SB (2010) OP-1 (BMP-7) stimulates osteoprogenitor cell differentiation in the presence of polymethylmethacrylate particles. J Biomed Mater Res Part A 94A:485-488
-
(2010)
J Biomed Mater Res Part A
, vol.94
, pp. 485-488
-
-
Kann, S.1
Chiu, R.2
Ma, T.3
Goodman, S.B.4
-
20
-
-
38449118017
-
Generation of osteoblasts in vitro, and assay of osteoclast activity
-
17951666 10.1007/978-1-59745-401-8-18 1:CAS:528:DC%2BD2sXptFGmsLw%3D
-
Takahashi N, Udagawa N, Kobayashi Y, Suda T (2007) Generation of osteoblasts in vitro, and assay of osteoclast activity. Methods Mol Med 135:285-301
-
(2007)
Methods Mol Med
, vol.135
, pp. 285-301
-
-
Takahashi, N.1
Udagawa, N.2
Kobayashi, Y.3
Suda, T.4
-
22
-
-
79952445351
-
Acerogenin A, a natural compound isolated from Ace nikoense Maxim, stimulates osteoblast differentiation through bone morphogenetic protein action
-
21303661 10.1016/j.bbrc.2011.02.017 1:CAS:528:DC%2BC3MXjtFKjtrk%3D
-
Kihara T, Ichikawa S, Yonezawa T, Lee JW, Akihisa T, Woo JT, Michi Y, Amagasa T, Yamaguchi A (2011) Acerogenin A, a natural compound isolated from Ace nikoense Maxim, stimulates osteoblast differentiation through bone morphogenetic protein action. Biochem Biophys Res Commun 406:211-217
-
(2011)
Biochem Biophys Res Commun
, vol.406
, pp. 211-217
-
-
Kihara, T.1
Ichikawa, S.2
Yonezawa, T.3
Lee, J.W.4
Akihisa, T.5
Woo, J.T.6
Michi, Y.7
Amagasa, T.8
Yamaguchi, A.9
-
23
-
-
79957918508
-
Harmine promotes osteoblasts differentiation through bone morphogenetic protein signaling
-
21570953 10.1016/j.bbrc.2011.05.001 1:CAS:528:DC%2BC3MXntFCmtLs%3D
-
Yonezawa T, Lee JW, Hibino A, Asai M, Hojo H, Cha BY, Teruya T, Nagai K, Chung UI, Yagasaki K, Woo JT (2011) Harmine promotes osteoblasts differentiation through bone morphogenetic protein signaling. Biochem Biophys Res Commun 409:260-265
-
(2011)
Biochem Biophys Res Commun
, vol.409
, pp. 260-265
-
-
Yonezawa, T.1
Lee, J.W.2
Hibino, A.3
Asai, M.4
Hojo, H.5
Cha, B.Y.6
Teruya, T.7
Nagai, K.8
Chung, U.I.9
Yagasaki, K.10
Woo, J.T.11
-
24
-
-
79960015376
-
A program of microRNAs controls osteogenic lineage progression by targeting transcriptional factor Runx2
-
21628588 10.1073/pnas.1018493108 1:CAS:528:DC%2BC3MXnvVygu7k%3D
-
Zhang Y, Xie RL, Croce CM, Stein JL, Lian JB, van Wijnen AJ, Stein GS (2011) A program of microRNAs controls osteogenic lineage progression by targeting transcriptional factor Runx2. Proc Natl Acad Sci USA 108:9863-9868
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 9863-9868
-
-
Zhang, Y.1
Xie, R.L.2
Croce, C.M.3
Stein, J.L.4
Lian, J.B.5
Van Wijnen, A.J.6
Stein, G.S.7
-
25
-
-
79956221794
-
Xanthohumol from the hop plant stimulates osteoblast differentiation by RUNX2 activation
-
21565172 10.1016/j.bbrc.2011.04.113 1:CAS:528:DC%2BC3MXmvFSqs7c%3D
-
Jeong HM, Han EH, Jin YH, Choi YH, Lee KY, Jeong HG (2011) Xanthohumol from the hop plant stimulates osteoblast differentiation by RUNX2 activation. Biochem Biophys Res Commun 409:82-89
-
(2011)
Biochem Biophys Res Commun
, vol.409
, pp. 82-89
-
-
Jeong, H.M.1
Han, E.H.2
Jin, Y.H.3
Choi, Y.H.4
Lee, K.Y.5
Jeong, H.G.6
-
26
-
-
70349342805
-
Post-translational regulation of Runx2 in bone and cartilage
-
19734454 10.1177/0022034509341629 1:CAS:528:DC%2BD1MXhtlSjtLrK
-
Jonason JH, Xiao G, Zhang M, Xing L, Chen D (2009) Post-translational regulation of Runx2 in bone and cartilage. J Dent Res 88:693-703
-
(2009)
J Dent Res
, vol.88
, pp. 693-703
-
-
Jonason, J.H.1
Xiao, G.2
Zhang, M.3
Xing, L.4
Chen, D.5
-
28
-
-
77954972964
-
The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice
-
20551513 10.1172/JCI42285 1:CAS:528:DC%2BC3cXovFartrY%3D
-
Greenblatt MB, Shim JH, Zou W, Sitara D, Schweitzer M, Hu D, Lotinun S, Sano Y, Baron R, Park JM, Arthur S, Xie M, Schneider MD, Zhai B, Gygi S, Davis R, Glimcher LH (2010) The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice. J Clin Invest 120:2457-2473
-
(2010)
J Clin Invest
, vol.120
, pp. 2457-2473
-
-
Greenblatt, M.B.1
Shim, J.H.2
Zou, W.3
Sitara, D.4
Schweitzer, M.5
Hu, D.6
Lotinun, S.7
Sano, Y.8
Baron, R.9
Park, J.M.10
Arthur, S.11
Xie, M.12
Schneider, M.D.13
Zhai, B.14
Gygi, S.15
Davis, R.16
Glimcher, L.H.17
-
29
-
-
77950482656
-
FGF2-activated ERK mitogen-activated protein kinase enhances Runx2 acetylation and stabilization
-
20007706 10.1074/jbc.M109.055053 1:CAS:528:DC%2BC3cXht1Wmsb0%3D
-
Park OJ, Kim HJ, Woo KM, Baek JH, Ryoo HM (2010) FGF2-activated ERK mitogen-activated protein kinase enhances Runx2 acetylation and stabilization. J Biol Chem 285:3568-3574
-
(2010)
J Biol Chem
, vol.285
, pp. 3568-3574
-
-
Park, O.J.1
Kim, H.J.2
Woo, K.M.3
Baek, J.H.4
Ryoo, H.M.5
-
30
-
-
78449244722
-
BMP2-activated Erk/MAP kinase stabilizes Runx2 by increasing p300 levels and histone acetyltransferase activity
-
20851880 10.1074/jbc.M110.142307 1:CAS:528:DC%2BC3cXhsVWgsr%2FK
-
Jun JH, Yoon WJ, Seo SB, Woo KM, Kim GS, Ryoo HM, Baek JH (2010) BMP2-activated Erk/MAP kinase stabilizes Runx2 by increasing p300 levels and histone acetyltransferase activity. J Biol Chem 285:36410-36419
-
(2010)
J Biol Chem
, vol.285
, pp. 36410-36419
-
-
Jun, J.H.1
Yoon, W.J.2
Seo, S.B.3
Woo, K.M.4
Kim, G.S.5
Ryoo, H.M.6
Baek, J.H.7
-
31
-
-
33745196250
-
Bone morphogenetic protein-2 stimulates Runx2 acetylation
-
16613856 10.1074/jbc.M512494200 1:CAS:528:DC%2BD28XlsV2lsb0%3D
-
Jeon EJ, Lee KY, Choi NS, Lee MH, Kim HN, Jin YH, Ryoo HM, Choi JY, Yoshida M, Nishino N, Oh BC, Lee KS, Lee YH, Bae SC (2006) Bone morphogenetic protein-2 stimulates Runx2 acetylation. J Biol Chem 281:16502-16511
-
(2006)
J Biol Chem
, vol.281
, pp. 16502-16511
-
-
Jeon, E.J.1
Lee, K.Y.2
Choi, N.S.3
Lee, M.H.4
Kim, H.N.5
Jin, Y.H.6
Ryoo, H.M.7
Choi, J.Y.8
Yoshida, M.9
Nishino, N.10
Oh, B.C.11
Lee, K.S.12
Lee, Y.H.13
Bae, S.C.14
-
32
-
-
28144448363
-
Histone deacetylase inhibitors promote osteoblast maturation
-
DOI 10.1359/JBMR.050813
-
Schroeder TM, Westendorf JJ (2005) Histone deacetylase inhibitors promote osteoblast maturation. J Bone Miner Res 20:2254-2263 (Pubitemid 41698788)
-
(2005)
Journal of Bone and Mineral Research
, vol.20
, Issue.12
, pp. 2254-2263
-
-
Schroeder, T.M.1
Westendorf, J.J.2
-
33
-
-
84859974018
-
Resveratrol mediated modulation of Sirt-1/Runx2 promotes osteogenic differentiation of mesenchymal stem cells: Potential role of Runx2 deacetylation
-
22539994 10.1371/journal.pone.0035712 1:CAS:528:DC%2BC38Xms1ClsL8%3D
-
Shakibaei M, Shayan P, Busch F, Aldinger C, Buhrmann C, Lueders C, Mobasheri A (2012) Resveratrol mediated modulation of Sirt-1/Runx2 promotes osteogenic differentiation of mesenchymal stem cells: potential role of Runx2 deacetylation. PLoS ONE 7:e35712
-
(2012)
PLoS ONE
, vol.7
, pp. 35712
-
-
Shakibaei, M.1
Shayan, P.2
Busch, F.3
Aldinger, C.4
Buhrmann, C.5
Lueders, C.6
Mobasheri, A.7
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