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Volumn 31, Issue 4, 2013, Pages 381-389

PCAF acetylates Runx2 and promotes osteoblast differentiation

Author keywords

Acetylation; Osteoblast differentiation; PCAF; Runx2

Indexed keywords

ALKALINE PHOSPHATASE; HISTONE ACETYLTRANSFERASE PCAF; MESSENGER RNA; TRANSCRIPTION FACTOR RUNX2; P300-CBP-ASSOCIATED FACTOR; PROTEIN BINDING; RUNX2 PROTEIN, MOUSE;

EID: 84880254069     PISSN: 09148779     EISSN: 14355604     Source Type: Journal    
DOI: 10.1007/s00774-013-0428-y     Document Type: Article
Times cited : (42)

References (34)
  • 1
    • 0034284550 scopus 로고    scopus 로고
    • Therapeutic approaches to bone disease
    • 10968781 10.1126/science.289.5484.1508 1:CAS:528:DC%2BD3cXmt1Kgsb4%3D
    • Rodan GA, Martin TJ (2000) Therapeutic approaches to bone disease. Science 289:1508-1514
    • (2000) Science , vol.289 , pp. 1508-1514
    • Rodan, G.A.1    Martin, T.J.2
  • 2
    • 84255200563 scopus 로고    scopus 로고
    • Building strong bones: Molecular regulation of the osteoblast lineage
    • 22189423 10.1038/nrm3254
    • Long F (2011) Building strong bones: molecular regulation of the osteoblast lineage. Nat Rev Mol Cell Biol 13:27-38
    • (2011) Nat Rev Mol Cell Biol , vol.13 , pp. 27-38
    • Long, F.1
  • 3
    • 0242668869 scopus 로고    scopus 로고
    • Bone morphogenetic proteins, their antagonists, and the skeleton
    • DOI 10.1210/er.2002-0023
    • Canalis E, Economides AN, Gazzerro E (2003) Bone morphogenetic proteins, their antagonists and the skeleton. Endor Rev 24:218-235 (Pubitemid 36515285)
    • (2003) Endocrine Reviews , vol.24 , Issue.2 , pp. 218-235
    • Canalis, E.1    Economides, A.N.2    Gazzerro, E.3
  • 4
    • 0030678549 scopus 로고    scopus 로고
    • Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation
    • Ducy P, Zhang R, Geoffroy V, Ridall AL, Karsenty G (1997) Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 89:747-754 (Pubitemid 27516177)
    • (1997) Cell , vol.89 , Issue.5 , pp. 747-754
    • Ducy, P.1    Zhang, R.2    Geoffroy, V.3    Ridall, A.L.4    Karsenty, G.5
  • 6
    • 0034641606 scopus 로고    scopus 로고
    • A Pro250Arg substitution in mouse Fgfr1 causes increased expression of Cbfa1 and premature fusion of calvarial sutures
    • Zhou YX, Xu X, Chen L, Li C, Brodie SG, Deng CX (2000) A Pro250Arg substitution in mouse Fgfr1 causes increased expression of Cbfa1 and premature fusion of calvarial sutures. Hum Mol Genet 9:2001-2008 (Pubitemid 30642665)
    • (2000) Human Molecular Genetics , vol.9 , Issue.13 , pp. 2001-2008
    • Zhou, Y.-X.1    Xu, X.2    Chen, L.3    Li, C.4    Brodie, S.G.5    Deng, C.-X.6
  • 7
    • 0034460993 scopus 로고    scopus 로고
    • Runx2 is a common target of transforming growth factor β1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12
    • DOI 10.1128/MCB.20.23.8783-8792.2000
    • Lee KS, Kim HJ, Li QL, Chi XZ, Ueta C, Komori T, Wozney JM, Kim EG, Choi JY, Ryoo HM, Bae SC (2000) Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12. Mol Cell Biol 20:8783-8792 (Pubitemid 32245911)
    • (2000) Molecular and Cellular Biology , vol.20 , Issue.23 , pp. 8783-8792
    • Lee, K.-S.1    Kim, H.-J.2    Li, Q.-L.3    Chi, X.-Z.4    Ueta, C.5    Komori, T.6    Wozney, J.M.7    Kim, E.-G.8    Choi, J.-Y.9    Ryoo, H.-M.10    Bae, S.-C.11
  • 8
    • 0036774003 scopus 로고    scopus 로고
    • Serine phosphorylation of RUNX2 with novel potential functions as negative regulatory mechanisms
    • DOI 10.1093/embo-reports/kvf193
    • Wee HJ, Huang G, Shigesada K, Ito Y (2002) Serine phosphorylation of RUNX2 with novel potential functions as negative regulatory mechanisms. EMBO Rep 3:967-974 (Pubitemid 35256471)
    • (2002) EMBO Reports , vol.3 , Issue.10 , pp. 967-974
    • Wee, H.-J.1    Huang, G.2    Shigesada, K.3    Ito, Y.4
  • 10
    • 84859902202 scopus 로고    scopus 로고
    • C-Jun N-terminal kinase 1 negatively regulates osteoblastic differentiation induced by BMP-2 via phosphorylation of Runx2 at Ser104
    • 22247071 10.1002/jbmr.1548 1:CAS:528:DC%2BC38Xls1aqtLg%3D
    • Huang YF, Lin JJ, Lin CH, Su Y, Hung SC (2012) c-Jun N-terminal kinase 1 negatively regulates osteoblastic differentiation induced by BMP-2 via phosphorylation of Runx2 at Ser104. J Bone Miner Res 27:1093-1105
    • (2012) J Bone Miner Res , vol.27 , pp. 1093-1105
    • Huang, Y.F.1    Lin, J.J.2    Lin, C.H.3    Su, Y.4    Hung, S.C.5
  • 11
    • 0037184027 scopus 로고    scopus 로고
    • Fibroblast growth factor 2 induction of the osteocalcin gene requires MAPK activity and phosphorylation of the osteoblast transcription factor, Cbfa1/Runx2
    • 12110689 10.1074/jbc.M206057200 1:CAS:528:DC%2BD38XnsVCjsbk%3D
    • Xiao G, Jiang D, Gopalakrishnan R, Franceschi RT (2002) Fibroblast growth factor 2 induction of the osteocalcin gene requires MAPK activity and phosphorylation of the osteoblast transcription factor, Cbfa1/Runx2. J Biol Chem 277:36181-36187
    • (2002) J Biol Chem , vol.277 , pp. 36181-36187
    • Xiao, G.1    Jiang, D.2    Gopalakrishnan, R.3    Franceschi, R.T.4
  • 12
    • 0035865459 scopus 로고    scopus 로고
    • Dimerization with PEBP2β protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation
    • DOI 10.1093/emboj/20.4.723
    • Huang G, Shigesada K, Ito K, Wee HJ, Yokomizo T, Ito Y (2001) Dimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin-proteasome- mediated degradation. EMBO J 20:723-733 (Pubitemid 32167637)
    • (2001) EMBO Journal , vol.20 , Issue.4 , pp. 723-733
    • Huang, G.1    Shigesada, K.2    Ito, K.3    Wee, H.-J.4    Yokomizo, T.5    Ito, Y.6
  • 13
    • 33745184891 scopus 로고    scopus 로고
    • Cyclin D1-cdk4 induce runx2 ubiquitination and degradation
    • 16613857 10.1074/jbc.M603439200 1:CAS:528:DC%2BD28XlsV2ls7s%3D
    • Shen R, Wang X, Drissi H, Liu F, O'Keefe RF, Chen D (2006) Cyclin D1-cdk4 induce runx2 ubiquitination and degradation. J Biol Chem 281:16347-16353
    • (2006) J Biol Chem , vol.281 , pp. 16347-16353
    • Shen, R.1    Wang, X.2    Drissi, H.3    Liu, F.4    O'Keefe, R.F.5    Chen, D.6
  • 15
    • 63049111216 scopus 로고    scopus 로고
    • PCAF acetylates beta-catenin and improves its stability
    • 10.1091/mbc.E08-08-0792 1:CAS:528:DC%2BD1MXht1Srsrc%3D
    • Ge X, Jin Q, Zhang F, Yan T, Zhai Q (2009) PCAF acetylates beta-catenin and improves its stability. Mol Cell Biol 20:419-427
    • (2009) Mol Cell Biol , vol.20 , pp. 419-427
    • Ge, X.1    Jin, Q.2    Zhang, F.3    Yan, T.4    Zhai, Q.5
  • 16
    • 78149304022 scopus 로고    scopus 로고
    • Acetylation of Rb by PCAF is required for nuclear localization and keratinocyte differentiation
    • 20940255 10.1242/jcs.068924 1:CAS:528:DC%2BC3cXhsFCit7nJ
    • Pickard A, Wong PP, McCance DJ (2010) Acetylation of Rb by PCAF is required for nuclear localization and keratinocyte differentiation. J Cell Sci 123:3718-3726
    • (2010) J Cell Sci , vol.123 , pp. 3718-3726
    • Pickard, A.1    Wong, P.P.2    McCance, D.J.3
  • 18
    • 84861314611 scopus 로고    scopus 로고
    • Biochemical stimulation of osteoblast gene expression requires phosphorylation of the RUNX2 transcription factor
    • 22337141 10.1002/jbmr.1574 1:CAS:528:DC%2BC38XntFSgsLc%3D
    • Li Y, Ge C, Long JP, Begun DL, Rodriguez JA, Goldstein SA, Franceschi RT (2012) Biochemical stimulation of osteoblast gene expression requires phosphorylation of the RUNX2 transcription factor. J Bone Miner Res 27:1263-1274
    • (2012) J Bone Miner Res , vol.27 , pp. 1263-1274
    • Li, Y.1    Ge, C.2    Long, J.P.3    Begun, D.L.4    Rodriguez, J.A.5    Goldstein, S.A.6    Franceschi, R.T.7
  • 19
    • 77953854477 scopus 로고    scopus 로고
    • OP-1 (BMP-7) stimulates osteoprogenitor cell differentiation in the presence of polymethylmethacrylate particles
    • 1:CAS:528:DC%2BC3cXnvVOgs7c%3D
    • Kann S, Chiu R, Ma T, Goodman SB (2010) OP-1 (BMP-7) stimulates osteoprogenitor cell differentiation in the presence of polymethylmethacrylate particles. J Biomed Mater Res Part A 94A:485-488
    • (2010) J Biomed Mater Res Part A , vol.94 , pp. 485-488
    • Kann, S.1    Chiu, R.2    Ma, T.3    Goodman, S.B.4
  • 20
    • 38449118017 scopus 로고    scopus 로고
    • Generation of osteoblasts in vitro, and assay of osteoclast activity
    • 17951666 10.1007/978-1-59745-401-8-18 1:CAS:528:DC%2BD2sXptFGmsLw%3D
    • Takahashi N, Udagawa N, Kobayashi Y, Suda T (2007) Generation of osteoblasts in vitro, and assay of osteoclast activity. Methods Mol Med 135:285-301
    • (2007) Methods Mol Med , vol.135 , pp. 285-301
    • Takahashi, N.1    Udagawa, N.2    Kobayashi, Y.3    Suda, T.4
  • 22
    • 79952445351 scopus 로고    scopus 로고
    • Acerogenin A, a natural compound isolated from Ace nikoense Maxim, stimulates osteoblast differentiation through bone morphogenetic protein action
    • 21303661 10.1016/j.bbrc.2011.02.017 1:CAS:528:DC%2BC3MXjtFKjtrk%3D
    • Kihara T, Ichikawa S, Yonezawa T, Lee JW, Akihisa T, Woo JT, Michi Y, Amagasa T, Yamaguchi A (2011) Acerogenin A, a natural compound isolated from Ace nikoense Maxim, stimulates osteoblast differentiation through bone morphogenetic protein action. Biochem Biophys Res Commun 406:211-217
    • (2011) Biochem Biophys Res Commun , vol.406 , pp. 211-217
    • Kihara, T.1    Ichikawa, S.2    Yonezawa, T.3    Lee, J.W.4    Akihisa, T.5    Woo, J.T.6    Michi, Y.7    Amagasa, T.8    Yamaguchi, A.9
  • 24
    • 79960015376 scopus 로고    scopus 로고
    • A program of microRNAs controls osteogenic lineage progression by targeting transcriptional factor Runx2
    • 21628588 10.1073/pnas.1018493108 1:CAS:528:DC%2BC3MXnvVygu7k%3D
    • Zhang Y, Xie RL, Croce CM, Stein JL, Lian JB, van Wijnen AJ, Stein GS (2011) A program of microRNAs controls osteogenic lineage progression by targeting transcriptional factor Runx2. Proc Natl Acad Sci USA 108:9863-9868
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 9863-9868
    • Zhang, Y.1    Xie, R.L.2    Croce, C.M.3    Stein, J.L.4    Lian, J.B.5    Van Wijnen, A.J.6    Stein, G.S.7
  • 25
    • 79956221794 scopus 로고    scopus 로고
    • Xanthohumol from the hop plant stimulates osteoblast differentiation by RUNX2 activation
    • 21565172 10.1016/j.bbrc.2011.04.113 1:CAS:528:DC%2BC3MXmvFSqs7c%3D
    • Jeong HM, Han EH, Jin YH, Choi YH, Lee KY, Jeong HG (2011) Xanthohumol from the hop plant stimulates osteoblast differentiation by RUNX2 activation. Biochem Biophys Res Commun 409:82-89
    • (2011) Biochem Biophys Res Commun , vol.409 , pp. 82-89
    • Jeong, H.M.1    Han, E.H.2    Jin, Y.H.3    Choi, Y.H.4    Lee, K.Y.5    Jeong, H.G.6
  • 26
    • 70349342805 scopus 로고    scopus 로고
    • Post-translational regulation of Runx2 in bone and cartilage
    • 19734454 10.1177/0022034509341629 1:CAS:528:DC%2BD1MXhtlSjtLrK
    • Jonason JH, Xiao G, Zhang M, Xing L, Chen D (2009) Post-translational regulation of Runx2 in bone and cartilage. J Dent Res 88:693-703
    • (2009) J Dent Res , vol.88 , pp. 693-703
    • Jonason, J.H.1    Xiao, G.2    Zhang, M.3    Xing, L.4    Chen, D.5
  • 29
    • 77950482656 scopus 로고    scopus 로고
    • FGF2-activated ERK mitogen-activated protein kinase enhances Runx2 acetylation and stabilization
    • 20007706 10.1074/jbc.M109.055053 1:CAS:528:DC%2BC3cXht1Wmsb0%3D
    • Park OJ, Kim HJ, Woo KM, Baek JH, Ryoo HM (2010) FGF2-activated ERK mitogen-activated protein kinase enhances Runx2 acetylation and stabilization. J Biol Chem 285:3568-3574
    • (2010) J Biol Chem , vol.285 , pp. 3568-3574
    • Park, O.J.1    Kim, H.J.2    Woo, K.M.3    Baek, J.H.4    Ryoo, H.M.5
  • 30
    • 78449244722 scopus 로고    scopus 로고
    • BMP2-activated Erk/MAP kinase stabilizes Runx2 by increasing p300 levels and histone acetyltransferase activity
    • 20851880 10.1074/jbc.M110.142307 1:CAS:528:DC%2BC3cXhsVWgsr%2FK
    • Jun JH, Yoon WJ, Seo SB, Woo KM, Kim GS, Ryoo HM, Baek JH (2010) BMP2-activated Erk/MAP kinase stabilizes Runx2 by increasing p300 levels and histone acetyltransferase activity. J Biol Chem 285:36410-36419
    • (2010) J Biol Chem , vol.285 , pp. 36410-36419
    • Jun, J.H.1    Yoon, W.J.2    Seo, S.B.3    Woo, K.M.4    Kim, G.S.5    Ryoo, H.M.6    Baek, J.H.7
  • 32
    • 28144448363 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors promote osteoblast maturation
    • DOI 10.1359/JBMR.050813
    • Schroeder TM, Westendorf JJ (2005) Histone deacetylase inhibitors promote osteoblast maturation. J Bone Miner Res 20:2254-2263 (Pubitemid 41698788)
    • (2005) Journal of Bone and Mineral Research , vol.20 , Issue.12 , pp. 2254-2263
    • Schroeder, T.M.1    Westendorf, J.J.2
  • 33
    • 84859974018 scopus 로고    scopus 로고
    • Resveratrol mediated modulation of Sirt-1/Runx2 promotes osteogenic differentiation of mesenchymal stem cells: Potential role of Runx2 deacetylation
    • 22539994 10.1371/journal.pone.0035712 1:CAS:528:DC%2BC38Xms1ClsL8%3D
    • Shakibaei M, Shayan P, Busch F, Aldinger C, Buhrmann C, Lueders C, Mobasheri A (2012) Resveratrol mediated modulation of Sirt-1/Runx2 promotes osteogenic differentiation of mesenchymal stem cells: potential role of Runx2 deacetylation. PLoS ONE 7:e35712
    • (2012) PLoS ONE , vol.7 , pp. 35712
    • Shakibaei, M.1    Shayan, P.2    Busch, F.3    Aldinger, C.4    Buhrmann, C.5    Lueders, C.6    Mobasheri, A.7
  • 34


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.