Hyperlipidemia modifies innate immune responses to lipopolysaccharide via the TLR-NF-κB signaling pathway

Inflammation

Volumn 36, Issue 4, 2013, Pages 968-976

  Chen, Shuai ^a   Lin, Gengbing ^a   Lei, Lang ^a   You, Xiaoqing ^a   Wu, Chunfang ^a   Xu, Wenjing ^a   Huang, Min ^a   Luo, Lan ^a   Wang, Zhijun ^a   Li, Yanfen ^a   Zhao, Xin ^a   Yan, Fuhua ^a,b  

^a FUJIAN MEDICAL UNIVERSITY   (China)

^b NANJING UNIVERSITY   (China)

Author keywords

cytokine; hyperlipidemia; innate immunity; monocyte macrophage; NF B

Indexed keywords

BETA ACTIN; C REACTIVE PROTEIN; FAS LIGAND; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; PATTERN RECOGNITION RECEPTOR; PROTEIN BCL 2; SCAVENGER RECEPTOR A; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPERIMENTAL RABBIT; HISTONE ACETYLATION; HYPERLIPIDEMIA; IMMUNE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; INNATE IMMUNITY; LIPID DIET; MACROPHAGE; MALE; NONHUMAN; OBESITY; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGENS, CD95; C-REACTIVE PROTEIN; HYPERLIPIDEMIAS; IMMUNITY, INNATE; INFLAMMATION; INTERLEUKIN-6; LIPIDS; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; NF-KAPPA B; PROTO-ONCOGENE PROTEINS C-BCL-2; RABBITS; RNA, MESSENGER; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 84880253680     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-013-9628-9     Document Type: Article

References (43)

1. Cameron, A.J.; J.E. Shaw, and P.Z. Zimmet. 2004. The metabolic syndrome: prevalence in worldwide populations. Endocrinology and Metabolism Clinics of North America 33: 351-375. table of contents.
2. Kassi, E.; P. Pervanidou, G. Kaltsas, and G. Chrousos. 2011. Metabolic syndrome: definitions and controversies. BMC Medicine 9: 48.
3. Wellen, K.E.; and G.S. Hotamisligil. 2003. Obesity-induced inflammatory changes in adipose tissue. The Journal of Clinical Investigation 112: 1785-1788.
4. Lawrence, C.B.; D. Brough, and E.M. Knight. 2012. Obese mice exhibit an altered behavioural and inflammatory response to lipopolysaccharide. Disease Models & Mechanisms 5: 649-659.
5. Yang, Z.H.; H. Miyahara, J. Takeo, and M. Katayama. 2012. Diet high in fat and sucrose induces rapid onset of obesity-related metabolic syndrome partly through rapid response of genes involved in lipogenesis, insulin signalling and inflammation in mice. Diabetology and Metabolic Syndrome 4: 32.
6. Ghanim, H.; S. Abuaysheh, C.L. Sia, et al. 2009. Increase in plasma endotoxin concentrations and the expression of Toll-like receptors and suppressor of cytokine signaling-3 in mononuclear cells after a high-fat, high-carbohydrate meal: implications for insulin resistance. Diabetes Care 32: 2281-2287.
7. Huang, H.; T. Liu, J.L. Rose, R.L. Stevens, and D.G. Hoyt. 2007. Sensitivity of mice to lipopolysaccharide is increased by a high saturated fat and cholesterol diet. J Inflamm (Lond) 4: 22.
8. Kim, M.S.; M.S. Choi, and S.N. Han. 2011. High fat diet-induced obesity leads to proinflammatory response associated with higher expression of NOD2 protein. Nutrition Research Practice 5: 219-223.
9. Borges, M.C.; Vinolo, M.A.; Crisma, A.R.; et al. 2012. High-fat diet blunts activation of the nuclear factor-kappaB signaling pathway in lipopolysaccharide-stimulated peritoneal macrophages of Wistar rats. LID - 10.1016/j.nut.2012.06.008 [doi]. Nutrition.
10. Janssens, S.; and R. Beyaert. 2003. Role of Toll-like receptors in pathogen recognition. Clinical Microbiology Reviews 16: 637-646.
11. Xu, X.H.; P.K. Shah, E. Faure, et al. 2001. Toll-like receptor-4 is expressed by macrophages in murine and human lipid-rich atherosclerotic plaques and upregulated by oxidized LDL. Circulation 104: 3103-3108.
12. Shi, H.; M.V. Kokoeva, K. Inouye, I. Tzameli, H. Yin, and J.S. Flier. 2006. TLR4 links innate immunity and fatty acid-induced insulin resistance. The Journal of Clinical Investigation 116: 3015-3025.
13. Kerttula, Y.; M. Vaara, L. Pyhala, H. Sariola, E. Kostiainen, and J.K. Huttunen. 1986. Effect of bacterial lipopolysaccharide on serum lipids and on the development of aortic atherosclerosis in rabbits. Atherosclerosis 59: 307-312.
14. Ebersole, J.L.; J. Stevens, M.J. Steffen, I.D. Dawson, and M.J. Novak. 2010. Systemic endotoxin levels in chronic indolent periodontal infections. Journal of Periodontal Research 45: 1-7.
15. de Almeida, M.C.; A.C. Silva, A. Barral, and N.M. Barral. 2000. A simple method for human peripheral blood monocyte isolation. Memórias do Instituto Oswaldo Cruz 95: 221-223.
16. Martin, M.J.; S.B. Hulley, W.S. Browner, L.H. Kuller, and D. Wentworth. 1986. Serum cholesterol, blood pressure, and mortality: implications from a cohort of 361,662 men. Lancet 2: 933-936.
17. Assmann, G.; H. Schulte, E.A. Von, and Y. Huang. 1996. High-density lipoprotein cholesterol as a predictor of coronary heart disease risk. The PROCAM experience and pathophysiological implications for reverse cholesterol transport. Atherosclerosis 124: 11-20.
18. Austin, M.A.; J.E. Hokanson, and K.L. Edwards. 1998. Hypertriglyceridemia as a cardiovascular risk factor. The American Journal of Cardiology 81: 7B-12B.
19. Zhang, L.; W.H. Zhang, L. Zhang, and P.Y. Wang. 2011. Prevalence of overweight/obesity and its associations with hypertension, diabetes, dyslipidemia, and metabolic syndrome: a survey in the suburban area of Beijing, 2007. Obesity Facts 4: 284-289.
20. Safwat, G.M.; S. Pisano, E. D'Amore, et al. 2009. Induction of non-alcoholic fatty liver disease and insulin resistance by feeding a high-fat diet in rats: does coenzyme Q monomethyl ether have a modulatory effect. Nutrition 25: 1157-1168.
21. Kolovou, G.; K. Anagnostopoulou, D.P. Mikhailidis, and D.V. Cokkinos. 2008. Apolipoprotein E knockout models. Current Pharmaceutical Design 14: 338-351.
22. Kamimura, R.; S. Suzuki, H. Sakamoto, N. Miura, K. Misumi, and K. Miyahara. 1999. Development of atherosclerotic lesions in cholesterol-loaded rabbits. Experimental Animals 48: 1-7.
23. Kolodgie, F.D.; A.S. Katocs Jr.; E.E. Largis, et al. 1996. Hypercholesterolemia in the rabbit induced by feeding graded amounts of low-level cholesterol. Methodological considerations regarding individual variability in response to dietary cholesterol and development of lesion type. Arteriosclerosis, Thrombosis, and Vascular Biology 16: 1454-1464.
24. Yanni, A.E. 2004. The laboratory rabbit: an animal model of atherosclerosis research. Laboratory Animals 38: 246-256.
25. Arner, P.; S. Bernard, M. Salehpour, et al. 2011. Dynamics of human adipose lipid turnover in health and metabolic disease. Nature 478: 110-113.
26. Franssen, R.; H. Monajemi, E.S. Stroes, and J.J. Kastelein. 2011. Obesity and dyslipidemia. The Medical Clinics of North America 95: 893-902.
27. Amar, S.; Q. Zhou, Y. Shaik-Dasthagirisaheb, and S. Leeman. 2007. Diet-induced obesity in mice causes changes in immune responses and bone loss manifested by bacterial challenge. Proceedings of the National Academy of Sciences of the United States of America 104: 20466-20471.
28. Cousin, B.; M. Andre, L. Casteilla, and L. Penicaud. 2001. Altered macrophage-like functions of preadipocytes in inflammation and genetic obesity. Journal of Cellular Physiology 186: 380-386.
29. Ross, R. 1999. Atherosclerosis - an inflammatory disease. The New England Journal of Medicine 340: 115-126.
30. Libby, P. 2002. Inflammation in atherosclerosis. Nature 420: 868-874.
31. Li, Q.; and I.M. Verma. 2002. NF-kappaB regulation in the immune system. Nature Reviews Immunology 2: 725-734.
32. Baker, R.G.; M.S. Hayden, and S. Ghosh. 2011. NF-kappaB, inflammation, and metabolic disease. Cell Metabolism 13: 11-22.
33. Zhou, Q.; S.E. Leeman, and S. Amar. 2009. Signaling mechanisms involved in altered function of macrophages from diet-induced obese mice affect immune responses. Proceedings of the National Academy of Sciences of the United States of America 106: 10740-10745.
34. Zhou, Q.; S.E. Leeman, and S. Amar. 2011. Signaling mechanisms in the restoration of impaired immune function due to diet-induced obesity. Proceedings of the National Academy of Sciences of the United States of America 108: 2867-2872.
35. Yu, H.; T. Ha, L. Liu, et al. 2012. Scavenger receptor A (SR-A) is required for LPS-induced TLR4 mediated NF-kappaB activation in macrophages. Biochimica et Biophysica Acta 1823: 1192-1198.
36. Seimon, T.A.; A. Obstfeld, K.J. Moore, D.T. Golenbock, and I. Tabas. 2006. Combinatorial pattern recognition receptor signaling alters the balance of life and death in macrophages. Proceedings of the National Academy of Sciences of the United States of America 103: 19794-19799.
37. Amiel, E.; A. Alonso, S. Uematsu, S. Akira, M.E. Poynter, and B. Berwin. 2009. Pivotal advance: toll-like receptor regulation of scavenger receptor-A-mediated phagocytosis. Journal of Leukocyte Biology 85: 595-605.
38. Xu, W.Y.; L. Wang, H.M. Wang, et al. 2007. TLR2 and TLR4 agonists synergistically up-regulate SR-A in RAW264.7 through p38. Molecular Immunology 44: 2315-2323.
39. Cotena, A.; S. Gordon, and N. Platt. 2004. The class A macrophage scavenger receptor attenuates CXC chemokine production and the early infiltration of neutrophils in sterile peritonitis. Journal of Immunology 173: 6427-6432.
40. Chen, Y.; F. Wermeling, J. Sundqvist, et al. 2010. A regulatory role for macrophage class A scavenger receptors in TLR4-mediated LPS responses. European Journal of Immunology 40: 1451-1460.
41. Ben-Hur, H.; P. Gurevich, A. Ben-Arie, et al. 2000. Apoptosis and apoptosis-related proteins (Fas, Fas ligand, bcl-2, p53) in macrophages of human ovarian epithelial tumors. European Journal of Gynaecological Oncology 21: 141-145.
42. Van Parijs, L.; D.A. Peterson, and A.K. Abbas. 2009. Retraction. The Fas/Fas ligand pathway and Bcl-2 regulate T cell responses to model self and foreign antigens. Immunity 30: 611.
43. Liang, C.Z.; J.K. Zhang, Z. Shi, B. Liu, C.Q. Shen, and H.M. Tao. 2012. Matrine induces caspase-dependent apoptosis in human osteosarcoma cells in vitro and in vivo through the upregulation of Bax and Fas/FasL and downregulation of Bcl-2. Cancer Chemotherapy and Pharmacology 69: 317-331.