Membrane-bound TRAIL supplements natural killer cell cytotoxicity against neuroblastoma cells

Journal of Immunotherapy

Volumn 36, Issue 5, 2013, Pages 319-329

  Sheard, Michael A ^a   Asgharzadeh, Shahab ^a,b,c   Liu, Yin ^a   Lin, Tsen Yin ^a   Wu, Hong Wei ^a   Ji, Lingyun ^b   Groshen, Susan ^b   Lee, Dean A ^d   Seeger, Robert C ^a,b,c  

^a CHILDREN S HOSPITAL LOS ANGELES   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c CHILDREN S ONCOLOGY GROUP   (United States)

^d UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Cytotoxicity; Natural killer cells; Neuroblastoma; TRAIL

Indexed keywords

CASPASE 3; CASPASE 4; CASPASE 8; CD137 LIGAND; DEATH RECEPTOR 4; DEATH RECEPTOR 5; GAMMA INTERFERON; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 21; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR 3;

ARTICLE; CELL MEDIATED CYTOTOXICITY; CELL SURVIVAL; CYTOTOXICITY; EXOCYTOSIS; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; IN VITRO STUDY; NATURAL KILLER CELL; NEUROBLASTOMA CELL; NORMAL HUMAN; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE;

ANTIBODIES, BLOCKING; APOPTOSIS; CASPASE 8; CELL GROWTH PROCESSES; CYTOKINES; CYTOTOXICITY, IMMUNOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; K562 CELLS; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; MEMBRANE PROTEINS; MICROARRAY ANALYSIS; NEUROBLASTOMA; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TRANSCRIPTOME;

EID: 84880238142     PISSN: 15249557     EISSN: 15374513     Source Type: Journal    
DOI: 10.1097/CJI.0b013e31829b4493     Document Type: Article

References (39)

1. Parks SM, Schikel R, Peter ME. Nonapoptotic functions of FADD-binding death receptors and their signaling molecules. Curr Opin Cell Biol. 2005;17:610-616.
2. Guicciardi ME, Gores GJ. Life and death by death receptors. FASEB J. 2009;6:1625-1637.
3. Wajant H, Moosmayer D, Wü est T, et al. Differential activation of TRAIL-R1 and -2 by soluble and membrane TRAIL allows selective surface antigen-directed activation of TRAIL-R2 by a soluble TRAIL derivative. Oncogene. 2001; 20:4101-4106.
4. Ehrhardt H, Fulda S, Schmid I, et al. TRAIL induced survival and proliferation in cancer cells resistant towards TRAILinduced apoptosis mediated by NF-kappaB. Oncogene. 2003; 22:3842-3852.
5. Baader E, Toloczko A, Fuchs U, et al. Tumor necrosis factorrelated apoptosis-inducing ligand-mediated proliferation of tumor cells with receptor-proximal apoptosis defects. Cancer Res. 2005;65:7888-7895.
6. Mirandola P, Ponti C, Gobbi G, et al. Activated human NK and CD8+ T cells express both TNF-related apoptosisinducing ligand (TRAIL) and TRAIL receptors but are resistant to TRAIL-mediated cytotoxicity. Blood. 2004;104: 2418-2424.
7. Lampson LA, Fisher CA, Whelan JP. Striking paucity of HLA-A, B, C and beta 2-microglobulin on human neuroblastoma cell lines. J Immunol. 1983;130:2471-2478.
8. Raffaghello L, Prigione I, Bocca P, et al. Multiple defects of the antigen-processing machinery components in human neuroblastoma: immunotherapeutic implications. Oncogene. 2005;24:4634-4644.
9. Wö lfl M, Jungbluth AA, Garrido F, et al. Expression of MHC class I, MHC class II, and cancer germline antigens in neuroblastoma. Cancer Immunol Immunother. 2005;54: 400-406.
10. Main EK, Lampson LA, Hart MK, et al. Human neuroblastoma cell lines are susceptible to lysis by natural killer cells but not by cytotoxic T lymphocytes. J Immunol. 1985;135: 242-246.
11. Joncker NT, Raulet DH. Regulation of NK cell responsiveness to achieve self-tolerance and maximal responses to diseased target cells. Immunol Rev. 2008;224:85-97.
12. Delgado DC, Hank JA, Kolesar J, et al. Genotypes of NK cell KIR receptors, their ligands, and Fcg receptors in the response of neuroblastoma patients to Hu14.18-IL2 immunotherapy. Cancer Res. 2010;70:9554-9561.
13. Kayagaki N, Yamaguchi N, Nakayama M, et al. Expression and function of TNF-related apoptosis-inducing ligand on murine activated NK cells. J Immunol. 1999;163:1906-1913.
14. Takeda K, Smyth MJ, Cretney E, et al. Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development. J Exp Med. 2002; 195:161-169.
15. Takeda K, Hayakawa Y, Smyth MJ, et al. Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells. Nat Med. 2001;7:94-100.
16. Smyth MJ, Cretney E, Takeda K, et al. Tumor necrosis factorrelated apoptosis-inducing ligand (TRAIL) contributes to interferon gamma-dependent natural killer cell protection from tumor metastasis. J Exp Med. 2001;193:661-670.
17. Hopkins-Donaldson S, Bodmer JL, Bourloud KB, et al. Loss of caspase-8 expression in highly malignant human neuroblastoma cells correlates with resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis. Cancer Res. 2000;60:4315-4319.
18. Eggert A, Grotzer MA, Zuzak TJ, et al. Resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression. Cancer Res. 2001;61: 1314-1319.
19. Teitz T, Wei T, Valentine MB, et al. Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN. Nat Med. 2000;6:529-535.
20. Yang X, Merchant MS, Romero ME, et al. Induction of caspase 8 by interferon gamma renders some neuroblastoma (NB) cells sensitive to tumor necrosis factor-related apoptosisinducing ligand (TRAIL) but reveals that a lack of membrane TR1/TR2 also contributes to TRAIL resistance in NB. Cancer Res. 2003;63:1122-1129.
21. Harada K, Toyooka S, Shivapurkar N, et al. Deregulation of caspase 8 and 10 expression in pediatric tumors and cell lines. Cancer Res. 2002;62:5897-5901.
22. Mü hlethaler-Mottet A, Flahaut M, Bourloud KB, et al. Individual caspase-10 isoforms play distinct and opposing roles in the initiation of death receptor-mediated tumour cell apoptosis. Cell Death Dis. 2011;2:e125. doi:10.1038/cddis. 2011.8.
23. Denman CJ, Senyukov VV, Somanchi SS, et al. Membranebound IL-21 promotes sustained ex vivo proliferation of human natural killer cells. PLoS One. 2012;7:e30264. doi:10.1371/journal.pone.0030624.
24. Somanchi SS, Senyukov VV, Denman CJ, et al. Expansion, purification, and functional assessment of human peripheral blood NK cells. J Vis Exp. 2011;2:2540. doi: 10.3791/2540.
25. Asgharzadeh S, Pique-Regi R, Sposto R, et al. Prognostic significance of gene expression profiles of metastatic neuroblastomas lacking MYCN gene amplification. J Natl Cancer Inst. 2006;98:1193-1203.
26. Li C, Wong WH. Model-based analysis of oligonucleotide arrays: model validation, design issues and standard error application. Genome Biol. 2001;2:1-11.
27. Proffitt RT, Tran JV, Reynolds CP. A fluorescence digital image microscopy system for quantifying relative cell numbers in tissue culture plates. Cytometry. 1996;24:204-213.
28. Frgala T, Kalous O, Proffitt RT, et al. A fluorescence microplate cytotoxicity assay with a 4 log dynamic range that identifies synergistic drug combinations. Mol Cancer Ther. 2007;6:886-897.
29. StataCorp. Stata Statistical Software: Release
30. College Station, TX: StataCorp LP; 2009.
31. Berg D, Lehne M, Mü ller N, et al. Enforced covalent trimerization increases the activity of the TNF ligand family members TRAIL and CD95L. Cell Death Differ. 2007;14: 2021-2034.
32. Liu L, Wu HW, Sheard MA, et al. Growth and activation of natural killer cells ex vivo from children with neuroblastoma for adoptive cell therapy. Clin Cancer Res. 2013;19:2132-2143.
33. Fulda S, Debatin KM. INFgamma sensitizes for apoptosis by upregulating caspase-8 expression through the Stat1 pathway. Oncogene. 2002;21:2295-2308.
34. Sheard MA, Asgharzadeh S, Ji L, et al. Stimulation of neuroblastoma cell proliferation by soluble TRAIL. Manuscript in preparation.
35. Raguénez G, Mü hlethaler-Mottet A, Meier R, et al. Fenretinide-induced caspase-8 activation and apoptosis in an established model of metastatic neuroblastoma. BMC Cancer. 2009;9:97. doi:10.1186/1471-2407-9-97.
36. Holler N, Zaru R, Micheau O, et al. Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nat Immunol. 2000;1: 489-495.
37. Berg D, Stü hmer T, Siegmund D, et al. Oligomerized tumor necrosis factor-related apoptosis inducing ligand strongly induces cell death in myeloma cells, but also activated proinflammatory signaling pathways. FEBS J. 2009;276:6912-6927.
38. Wilson CA, Browning JL. Death of HT29 adenocarcinoma cells induced by TNF family receptor activation is caspaseindependent and displays features of both apoptosis and necrosis. Cell Death Differ. 2002;9:1321-1333.
39. Yu AL, Gilman AL, Ozkaynak MF, et al. Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma. N Engl J Med. 2010;363:1324-1334.