Targeting 3-phosphoinositide-dependent protein kinase 1 by N-acetyl-cysteine through activation of peroxisome proliferators activated receptor alpha in human lung cancer cells, the role of p53 and p65

Journal of Experimental and Clinical Cancer Research

Volumn 32, Issue 1, 2013, Pages

  Hann, Swei Sunny ^a   Zheng, Fang ^a   Zhao, Shunyu ^a  

^a GUANGDONG PROVINCIAL HOSPITAL OF CHINESE MEDICINE   (China)

Author keywords

3 phosphoinositide dependent protein kinase 1; Human non small cell lung carcinoma cells; N Acetyl Cysteine; Nuclear factor kappa B; p53; Peroxisome proliferators activated receptor alpha

Indexed keywords

ACETYLCYSTEINE; LUCIFERASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN P53; SMALL INTERFERING RNA; SYNAPTOTAGMIN I;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CELL GROWTH; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; EXPRESSION VECTOR; GENE ACTIVITY; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; LUNG CANCER; NITROBLUE TETRAZOLIUM TEST; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; TRANSIENT TRANSFECTION; WESTERN BLOTTING;

3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASES; ACETYLCYSTEINE; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL PROLIFERATION; ENZYME ACTIVATION; GENE SILENCING; HUMANS; LUNG NEOPLASMS; PPAR ALPHA; PROMOTER REGIONS, GENETIC; PROTEIN-SERINE-THREONINE KINASES; TRANSCRIPTION FACTOR RELA; TRANSCRIPTIONAL ACTIVATION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84880182929     PISSN: None     EISSN: 17569966     Source Type: Journal    
DOI: 10.1186/1756-9966-32-43     Document Type: Article

References (29)

1. Cancer statistics, 2013. Siegel R, Naishadham D, Jemal A, CA Cancer J Clin 2013 63 1 11 30 10.3322/caac.21166 23335087
2. N-Acetylcysteine interacts with copper to generate hydrogen peroxide and selectively induce cancer cell death. Zheng J, Lou JR, Zhang XX, Benbrook DM, Hanigan MH, Lind SE, Ding WQ, Cancer Lett 2010 298 2 186 194 10.1016/j.canlet.2010.07.003 20667650
3. N-acetylcysteine inhibits RhoA and promotes apoptotic cell clearance during intense lung inflammation. Moon C, Lee YJ, Park HJ, Chong YH, Kang JL, Am J Respir Crit Care Med 2010 181 4 374 387 10.1164/rccm.200907-1061OC 19965809
4. Targeting PDK1 in cancer. Raimondi C, Falasca M, Curr Med Chem 2011 18 18 2763 2769 10.2174/092986711796011238 21568903
5. Down-regulation of 3-phosphoinositide-dependent protein kinase-1 levels inhibits migration and experimental metastasis of human breast cancer cells. Liu Y, Wang J, Wu M, Wan W, Sun R, Yang D, Sun X, Ma D, Ying G, Zhang N, Mol Cancer Res 2009 7 6 944 954 10.1158/1541-7786.MCR-08-0368 19531564
6. 3-phosphoinositide-dependent protein kinase-1 regulates proliferation and survival of cancer cells with an activated mitogen-activated protein kinase pathway. Lu Z, Cox-Hipkin MA, Windsor WT, Boyapati A, Mol Cancer Res 2010 8 3 421 432 10.1158/1541-7786.MCR-09-0179 20197379
7. The anti-tumorigenic properties of peroxisomal proliferator-activated receptor alpha are arachidonic acid epoxygenase-mediated. Pozzi A, Popescu V, Yang S, Mei S, Shi M, Puolitaival SM, Caprioli RM, Capdevila JH, J Biol Chem 2010 285 17 12840 12850 10.1074/jbc.M109.081554 20178979
8. Modulation of peroxisome proliferator-activated receptor-alpha activity by N-acetyl cysteine attenuates inhibition of oligodendrocyte development in lipopolysaccharide stimulated mixed glial cultures. Paintlia MK, Paintlia AS, Khan M, Singh I, Singh AK, J Neurochem 2008 105 3 956 970 10.1111/j.1471-4159. 2007.05199.x 18205750 (Pubitemid 351562737)
9. COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. Johannessen CM, Boehm JS, Kim SY, Thomas SR, Wardwell L, Johnson LA, Emery CM, Stransky N, Cogdill AP, Barretina J, et al. Nature 2010 468 7326 968 972 10.1038/nature09627 21107320
10. Antiapoptotic role of PPARbeta in keratinocytes via transcriptional control of the Akt1 signaling pathway. Di-Poi N, Tan NS, Michalik L, Wahli W, Desvergne B, Mol Cell 2002 10 4 721 733 10.1016/S1097-2765(02)00646-9 12419217 (Pubitemid 35335629)
11. The 65-kDa subunit of human NF-kappa B functions as a potent transcriptional activator and a target for v-Rel-mediated repression. Ballard DW, Dixon EP, Peffer NJ, Bogerd H, Doerre S, Stein B, Greene WC, Proc Natl Acad Sci U S A 1992 89 5 1875 1879 10.1073/pnas.89.5.1875 1542686
12. Fenofibrate suppresses growth of the human hepatocellular carcinoma cell via PPARalpha-independent mechanisms. Yamasaki D, Kawabe N, Nakamura H, Tachibana K, Ishimoto K, Tanaka T, Aburatani H, Sakai J, Hamakubo T, Kodama T, et al. Eur J Cell Biol 2011 90 8 657 664 10.1016/j.ejcb.2011.02.005 21514001
13. N-acetyl cysteine mitigates curcumin-mediated telomerase inhibition through rescuing of Sp1 reduction in A549 cells. Hsin IL, Sheu GT, Chen HH, Chiu LY, Wang HD, Chan HW, Hsu CP, Ko JL, Mut Res 2010 688 1-2 72 77
14. Ameliorative effects of dimetylthiourea and N-acetylcysteine on nanoparticles induced cyto-genotoxicity in human lung cancer cells-A549. Srivastava RK, Rahman Q, Kashyap MP, Lohani M, Pant AB, PLoS One 2011 6 9 25767 10.1371/journal.pone.0025767 21980536
15. Small-molecule inhibitors of PDK1. Peifer C, Alessi DR, ChemMedChem 2008 3 12 1810 1838 10.1002/cmdc.200800195 18972468
16. Peroxisomal proliferator-activated receptor-alpha-dependent inhibition of endothelial cell proliferation and tumorigenesis. Pozzi A, Ibanez MR, Gatica AE, Yang S, Wei S, Mei S, Falck JR, Capdevila JH, J Biol Chem 2007 282 24 17685 17695 10.1074/jbc.M701429200 17405874 (Pubitemid 47100312)
17. Clofibric acid, a peroxisome proliferator-activated receptor alpha ligand, inhibits growth of human ovarian cancer. Yokoyama Y, Xin B, Shigeto T, Umemoto M, Kasai-Sakamoto A, Futagami M, Tsuchida S, Al-Mulla F, Mizunuma H, Mol Cancer Ther 2007 6 4 1379 1386 10.1158/1535-7163.MCT-06-0722 17431116 (Pubitemid 46712001)
18. ROS accumulation and IGF-IR inhibition contribute to fenofibrate/ PPARalpha -mediated inhibition of glioma cell motility in vitro. Drukala J, Urbanska K, Wilk A, Grabacka M, Wybieralska E, Del Valle L, Madeja Z, Reiss K, Mol Cancer 2010 9 159 10.1186/1476-4598-9-159 20569465
19. Retinoic acid induces neurogenesis by activating both retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta). Yu S, Levi L, Siegel R, Noy N, J Biol Chem 2012 287 50 42195 42205 10.1074/jbc.M112.410381 23105114
20. Peroxisome proliferator-activated receptor beta/delta expression and activation in lung cancer. Pedchenko TV, Gonzalez AL, Wang D, DuBois RN, Massion PP, Am J Respir Cell Mol Biol 2008 39 6 689 696 10.1165/rcmb.2007-0426OC 18566335
21. Targeting the p53-family in cancer and chemosensitivity: triple threat. Chung J, Irwin MS, Curr Drug Targets 2010 11 6 667 681 10.2174/ 138945010791170833 20298155
22. NF-kappaB and the link between inflammation and cancer. DiDonato JA, Mercurio F, Karin M, Immunol Rev 2012 246 1 379 400 10.1111/j.1600-065X.2012. 01099.x 22435567
23. Glycolysis links p53 function with NF-kappaB signaling: impact on cancer and aging process. Salminen A, Kaarniranta K, J Cell Physiol 2010 224 1 1 6 20301205
24. Cardioprotective effects of 3-phosphoinositide-dependent protein kinase-1 on hypoxic injury in cultured neonatal rat cardiomyocytes and myocardium in a rat myocardial infarct model. Shim TJ, Bae JW, Kim YJ, Kim DJ, Hwang KK, Kim DW, Cho MC, Biosci Biotechnol Biochem 2012 76 1 101 107 10.1271/bbb.110562 22232248
25. PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation. Lee KY, D'Acquisto F, Hayden MS, Shim JH, Ghosh S, Science 2005 308 5718 114 118 10.1126/science.1107107 15802604 (Pubitemid 40471010)
26. Pro-oxidant and antioxidant effects of N-acetylcysteine regulate doxorubicin-induced NF-kappa B activity in leukemic cells. Finn NA, Kemp ML, Mol Biosyst 2012 8 2 650 662 10.1039/c1mb05315a 22134636
27. N-acetylcysteine potentiates doxorubicin-induced ATM and p53 activation in ovarian cancer cells. Brum G, Carbone T, Still E, Correia V, Szulak K, Calianese D, Best C, Cammarata G, Higgins K, Ji F, et al. Int J Oncol 2013 42 1 211 218 23128467
28. Inhibition of calcium-independent phospholipase A2 activates p38 MAPK signaling pathways during cytostasis in prostate cancer cells. Sun B, Zhang X, Yonz C, Cummings BS, Biochem Pharmacol 2010 79 12 1727 1735 10.1016/j.bcp.2010. 02.005 20171194
29. N-acetylcysteine improves antitumoural response of Interferon alpha by NF-kB downregulation in liver cancer cells. Kretzmann NA, Chiela E, Matte U, Marroni N, Marroni CA, Comp Hepatol 2012 11 1 4 10.1186/1476-5926-11-4 23206959