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Volumn 11, Issue 1, 2012, Pages

N-acetylcysteine improves antitumoural response of Interferon alpha by NF-kB downregulation in liver cancer cells

Author keywords

Interferon alpha; Liver cancer cells; N acetylcysteine; NF kB

Indexed keywords

ACETYLCYSTEINE; ALPHA2A INTERFERON; ANNEXIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR RELA;

EID: 84870376274     PISSN: None     EISSN: 14765926     Source Type: Journal    
DOI: 10.1186/1476-5926-11-4     Document Type: Article
Times cited : (30)

References (54)
  • 2
    • 33748480133 scopus 로고    scopus 로고
    • Cyclooxygenases in hepatocellular carcinoma
    • Cervello M, Montalto G. Cyclooxygenases in hepatocellular carcinoma. World J Gastroenterol 2006, 12:5113-5121.
    • (2006) World J Gastroenterol , vol.12 , pp. 5113-5121
    • Cervello, M.1    Montalto, G.2
  • 3
    • 77953464861 scopus 로고    scopus 로고
    • Molecular genetics of hepatocellular neoplasia
    • 2826827, 20182587
    • Jain S, Singhal S, Lee P, Xu R. Molecular genetics of hepatocellular neoplasia. Am J Transl Res 2010, 2:105-118. 2826827, 20182587.
    • (2010) Am J Transl Res , vol.2 , pp. 105-118
    • Jain, S.1    Singhal, S.2    Lee, P.3    Xu, R.4
  • 4
    • 77349092851 scopus 로고    scopus 로고
    • Molecular Classification and Novel Targets in Hepatocellular Carcinoma: Recent Advancements
    • 10.1055/s-0030-1247131, 20175032
    • Hoshida Y, Toffanin S, Lachenmayer A, Villanueva A, Minguez B, Llovet J. Molecular Classification and Novel Targets in Hepatocellular Carcinoma: Recent Advancements. Semin Liver Dis 2010, 30:35-51. 10.1055/s-0030-1247131, 20175032.
    • (2010) Semin Liver Dis , vol.30 , pp. 35-51
    • Hoshida, Y.1    Toffanin, S.2    Lachenmayer, A.3    Villanueva, A.4    Minguez, B.5    Llovet, J.6
  • 5
    • 33745727578 scopus 로고    scopus 로고
    • Immunohistochemical expression of CD95 (Fas), c-myc and epidermal growth factor receptor in hepatitis C virus infection, cirrhotic liver disease and hepatocellular carcinoma
    • 10.1111/j.1600-0463.2006.apm_323.x, 16856963
    • El-Bassiouni A, Nosseir M, Zoheiry M, El-Ahwany E, Ghali A, El-Bassiouni N. Immunohistochemical expression of CD95 (Fas), c-myc and epidermal growth factor receptor in hepatitis C virus infection, cirrhotic liver disease and hepatocellular carcinoma. APMIS 2006, 114:420-427. 10.1111/j.1600-0463.2006.apm_323.x, 16856963.
    • (2006) APMIS , vol.114 , pp. 420-427
    • El-Bassiouni, A.1    Nosseir, M.2    Zoheiry, M.3    El-Ahwany, E.4    Ghali, A.5    El-Bassiouni, N.6
  • 6
    • 33748976352 scopus 로고    scopus 로고
    • Hepatitis C virus core protein induces expression of genes regulating immune evasion and anti-apoptosis in hepatocytes
    • 10.1016/j.virol.2006.04.028, 16876223
    • Nguyen H, Sankaran S, Dandekar S. Hepatitis C virus core protein induces expression of genes regulating immune evasion and anti-apoptosis in hepatocytes. Virology 2006, 354:58-68. 10.1016/j.virol.2006.04.028, 16876223.
    • (2006) Virology , vol.354 , pp. 58-68
    • Nguyen, H.1    Sankaran, S.2    Dandekar, S.3
  • 7
    • 0024273530 scopus 로고
    • The role of interferon in cancer therapy: a current perspective
    • 10.3322/canjclin.38.5.258, 2458171
    • Goldstein D, Laszlo J. The role of interferon in cancer therapy: a current perspective. CA Cancer J Clin 1988, 38:258-277. 10.3322/canjclin.38.5.258, 2458171.
    • (1988) CA Cancer J Clin , vol.38 , pp. 258-277
    • Goldstein, D.1    Laszlo, J.2
  • 8
    • 78649325862 scopus 로고    scopus 로고
    • Long-term interferon-alpha treatment suppresses tumor growth but promotes metastasis capacity in hepatocellular carcinoma
    • 10.1007/s00432-010-0848-1, 20213095
    • Zhuang P, Zhang J, Zhang W, Zhu X, Liang Y, Xu H, Xiong Y, Kong L, Wang L, Wu W, Tang Z, Qin L, Sun H. Long-term interferon-alpha treatment suppresses tumor growth but promotes metastasis capacity in hepatocellular carcinoma. J Cancer Res Clin Oncol 2010, 136:1891-1900. 10.1007/s00432-010-0848-1, 20213095.
    • (2010) J Cancer Res Clin Oncol , vol.136 , pp. 1891-1900
    • Zhuang, P.1    Zhang, J.2    Zhang, W.3    Zhu, X.4    Liang, Y.5    Xu, H.6    Xiong, Y.7    Kong, L.8    Wang, L.9    Wu, W.10    Tang, Z.11    Qin, L.12    Sun, H.13
  • 9
    • 39049115413 scopus 로고    scopus 로고
    • Expression of tyrosine kinase Etk/Bmx and its relationship with AP-1- and NF-kappaB-associated proteins in hepatocellular carcinoma
    • 10.1159/000113491, 18196928
    • Guo L, Guo Y, Xiao S. Expression of tyrosine kinase Etk/Bmx and its relationship with AP-1- and NF-kappaB-associated proteins in hepatocellular carcinoma. Oncology 2007, 72:410-416. 10.1159/000113491, 18196928.
    • (2007) Oncology , vol.72 , pp. 410-416
    • Guo, L.1    Guo, Y.2    Xiao, S.3
  • 10
    • 0037247748 scopus 로고    scopus 로고
    • Nuclear factor-kappaB as a therapeutic target in critical care medicine
    • 10.1097/00003246-200301001-00015, 12544984
    • Zingarelli B, Sheehan M, Wong HR. Nuclear factor-kappaB as a therapeutic target in critical care medicine. Crit Care Med 2003, 31:S105-S111. 10.1097/00003246-200301001-00015, 12544984.
    • (2003) Crit Care Med , vol.31
    • Zingarelli, B.1    Sheehan, M.2    Wong, H.R.3
  • 11
    • 33750475618 scopus 로고    scopus 로고
    • Current insights into the regulation of programmed cell death by NF-kappaB
    • 10.1038/sj.onc.1209938, 17072329
    • Dutta J, Fan Y, Gupta N, Fan G, Gélinas C. Current insights into the regulation of programmed cell death by NF-kappaB. Oncogene 2006, 25:6800-6816. 10.1038/sj.onc.1209938, 17072329.
    • (2006) Oncogene , vol.25 , pp. 6800-6816
    • Dutta, J.1    Fan, Y.2    Gupta, N.3    Fan, G.4    Gélinas, C.5
  • 12
    • 70349575788 scopus 로고    scopus 로고
    • Gene therapy targeting nuclear factor-kappaB: towards clinical application in inflammatory diseases and cancer
    • 10.2174/156652309788488569, 2864453, 19519361
    • Tas S, Vervoordeldonk M, Tak P. Gene therapy targeting nuclear factor-kappaB: towards clinical application in inflammatory diseases and cancer. Curr Gene Ther 2009, 9:160-170. 10.2174/156652309788488569, 2864453, 19519361.
    • (2009) Curr Gene Ther , vol.9 , pp. 160-170
    • Tas, S.1    Vervoordeldonk, M.2    Tak, P.3
  • 13
    • 77953526775 scopus 로고    scopus 로고
    • Silibinin induced autophagic and apoptotic cell death in HT1080 cells through a reactive oxygen species pathway
    • 10.1254/jphs.09315FP, 20431246
    • Duan W, Jin X, Li Q, Tashiro S, Onodera S, Ikejima T. Silibinin induced autophagic and apoptotic cell death in HT1080 cells through a reactive oxygen species pathway. J Pharmacol Sci 2010, 113:48-56. 10.1254/jphs.09315FP, 20431246.
    • (2010) J Pharmacol Sci , vol.113 , pp. 48-56
    • Duan, W.1    Jin, X.2    Li, Q.3    Tashiro, S.4    Onodera, S.5    Ikejima, T.6
  • 14
    • 29444453188 scopus 로고    scopus 로고
    • The anti-death machinery in IKK/NF-kappaB signaling
    • 10.1007/s10875-005-8217-6, 16380818
    • Luo J, Kamata H, Karin M. The anti-death machinery in IKK/NF-kappaB signaling. J Clin Immunol 2005, 25:541-550. 10.1007/s10875-005-8217-6, 16380818.
    • (2005) J Clin Immunol , vol.25 , pp. 541-550
    • Luo, J.1    Kamata, H.2    Karin, M.3
  • 15
    • 16844366650 scopus 로고    scopus 로고
    • Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs
    • 10.1038/nrc1588, 15803156
    • Nakanishi C, Toi M. Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs. Nat Rev Cancer 2005, 5:297-309. 10.1038/nrc1588, 15803156.
    • (2005) Nat Rev Cancer , vol.5 , pp. 297-309
    • Nakanishi, C.1    Toi, M.2
  • 16
    • 72549111131 scopus 로고    scopus 로고
    • The NF-kappaB activation pathways, emerging molecular targets for cancer prevention and therapy
    • 10.1517/14728220903431069, 3043547, 20001209
    • Lin Y, Bai L, Chen W, Xu S. The NF-kappaB activation pathways, emerging molecular targets for cancer prevention and therapy. Expert Opin Ther Targets 2010, 14:45-55. 10.1517/14728220903431069, 3043547, 20001209.
    • (2010) Expert Opin Ther Targets , vol.14 , pp. 45-55
    • Lin, Y.1    Bai, L.2    Chen, W.3    Xu, S.4
  • 17
    • 34250902480 scopus 로고    scopus 로고
    • Glutamine inhibits over-expression of pro-inflammatory genes and down-regulates the nuclear factor kappaB pathway in an experimental model of colitis in the rat
    • 10.1016/j.tox.2007.04.012, 17543437
    • Fillmann H, Kretzmann N, San-Miguel B, Llesuy S, Marroni N, González-Gallego J, Tuñón M. Glutamine inhibits over-expression of pro-inflammatory genes and down-regulates the nuclear factor kappaB pathway in an experimental model of colitis in the rat. Toxicology 2007, 236:217-226. 10.1016/j.tox.2007.04.012, 17543437.
    • (2007) Toxicology , vol.236 , pp. 217-226
    • Fillmann, H.1    Kretzmann, N.2    San-Miguel, B.3    Llesuy, S.4    Marroni, N.5    González-Gallego, J.6    Tuñón, M.7
  • 18
    • 69149098551 scopus 로고    scopus 로고
    • N-acetylcysteine: multiple clinical applications
    • Millea P. N-acetylcysteine: multiple clinical applications. Am Fam Physician 2009, 80:265-269.
    • (2009) Am Fam Physician , vol.80 , pp. 265-269
    • Millea, P.1
  • 19
    • 77951435300 scopus 로고    scopus 로고
    • Hepatoprotective effects of antioxidants in chronic hepatitis C
    • 10.3748/wjg.v16.i15.1937, 2856839, 20397276
    • Moreno-Otero R, Trapero-Marugán M. Hepatoprotective effects of antioxidants in chronic hepatitis C. World J Gastroenterol 2010, 16:1937-1938. 10.3748/wjg.v16.i15.1937, 2856839, 20397276.
    • (2010) World J Gastroenterol , vol.16 , pp. 1937-1938
    • Moreno-Otero, R.1    Trapero-Marugán, M.2
  • 20
    • 0024390065 scopus 로고
    • Effect of N-acetylcysteine on the antiproliferative action of X-rays or bleomycin in cultured human lung tumor cells
    • 10.1007/BF00400960, 2474548
    • Wanamarta A, van Rijn J, Blank L, Haveman J, van Zandwijk N, Joenje H. Effect of N-acetylcysteine on the antiproliferative action of X-rays or bleomycin in cultured human lung tumor cells. J Cancer Res Clin Oncol 1989, 115:340-344. 10.1007/BF00400960, 2474548.
    • (1989) J Cancer Res Clin Oncol , vol.115 , pp. 340-344
    • Wanamarta, A.1    van Rijn, J.2    Blank, L.3    Haveman, J.4    van Zandwijk, N.5    Joenje, H.6
  • 21
    • 0345530904 scopus 로고    scopus 로고
    • N-acetyl-L-cysteine prevents DNA damage induced by UVA, UVB and visible radiation in human fibroblasts
    • 10.1016/j.jphotobiol.2003.06.004, 14644566
    • Morley N, Curnow A, Salter L, Campbell S, Gould D. N-acetyl-L-cysteine prevents DNA damage induced by UVA, UVB and visible radiation in human fibroblasts. J Photochem Photobiol B 2003, 72:55-60. 10.1016/j.jphotobiol.2003.06.004, 14644566.
    • (2003) J Photochem Photobiol B , vol.72 , pp. 55-60
    • Morley, N.1    Curnow, A.2    Salter, L.3    Campbell, S.4    Gould, D.5
  • 22
    • 0030002735 scopus 로고    scopus 로고
    • Synergism between N-acetylcysteine and doxorubicin in the prevention of tumorigenicity and metastasis in murine models
    • 10.1002/(SICI)1097-0215(19960917)67:6<842::AID-IJC14>3.0.CO;2-3, 8824557
    • De Flora S, D'Agostini F, Masiello L, Giunciuglio D, Albini A. Synergism between N-acetylcysteine and doxorubicin in the prevention of tumorigenicity and metastasis in murine models. Int J Cancer 1996, 67:842-848. 10.1002/(SICI)1097-0215(19960917)67:6<842::AID-IJC14>3.0.CO;2-3, 8824557.
    • (1996) Int J Cancer , vol.67 , pp. 842-848
    • De Flora, S.1    D'Agostini, F.2    Masiello, L.3    Giunciuglio, D.4    Albini, A.5
  • 24
    • 33646232728 scopus 로고    scopus 로고
    • Oxidative stress induced by Cremophor EL is not accompanied by changes in NF-kappaB activation or iNOS expression
    • 10.1016/j.tox.2006.02.002, 16533553
    • Gutierrez MB, Miguel BS, Villares C, Gallego JG, Tunon MJ. Oxidative stress induced by Cremophor EL is not accompanied by changes in NF-kappaB activation or iNOS expression. Toxicology 2006, 222:125-131. 10.1016/j.tox.2006.02.002, 16533553.
    • (2006) Toxicology , vol.222 , pp. 125-131
    • Gutierrez, M.B.1    Miguel, B.S.2    Villares, C.3    Gallego, J.G.4    Tunon, M.J.5
  • 26
    • 77949264843 scopus 로고    scopus 로고
    • Quality control for quantitative PCR based on amplification compatibility test
    • 10.1016/j.ymeth.2010.01.028, 20109549
    • Tichopad A, Bar T, Pecen L, Kitchen R, Kubista M, Pfaffl M. Quality control for quantitative PCR based on amplification compatibility test. Methods 2010, 50:308-312. 10.1016/j.ymeth.2010.01.028, 20109549.
    • (2010) Methods , vol.50 , pp. 308-312
    • Tichopad, A.1    Bar, T.2    Pecen, L.3    Kitchen, R.4    Kubista, M.5    Pfaffl, M.6
  • 27
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • 10.1093/nar/29.9.e45, 55695, 11328886
    • Pfaffl M. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001, 29:e45. 10.1093/nar/29.9.e45, 55695, 11328886.
    • (2001) Nucleic Acids Res , vol.29
    • Pfaffl, M.1
  • 28
    • 58149089795 scopus 로고    scopus 로고
    • Inhibitory function of interferon on hepatocarcinogenesis
    • Yano H. Inhibitory function of interferon on hepatocarcinogenesis. Oncology 2008, 75(Suppl 1):22-29.
    • (2008) Oncology , vol.75 , Issue.SUPPL. 1 , pp. 22-29
    • Yano, H.1
  • 30
    • 0036866501 scopus 로고    scopus 로고
    • Prediction of therapy response to interferon-alpha in chronic viral hepatitis-B by liver and hepatobiliary scintigraphy
    • 10.1007/BF02988654, 12508847
    • Caglar M, Sari O, Akcan Y. Prediction of therapy response to interferon-alpha in chronic viral hepatitis-B by liver and hepatobiliary scintigraphy. Ann Nucl Med 2002, 16:511-514. 10.1007/BF02988654, 12508847.
    • (2002) Ann Nucl Med , vol.16 , pp. 511-514
    • Caglar, M.1    Sari, O.2    Akcan, Y.3
  • 31
    • 74249099955 scopus 로고    scopus 로고
    • N-acetyl cysteine and penicillamine induce apoptosis via the ER stress response-signaling pathway
    • Guan D, Xu Y, Yang M, Wang H, Wang X, Shen Z. N-acetyl cysteine and penicillamine induce apoptosis via the ER stress response-signaling pathway. Mol Carcinog 2010, 49:68-74.
    • (2010) Mol Carcinog , vol.49 , pp. 68-74
    • Guan, D.1    Xu, Y.2    Yang, M.3    Wang, H.4    Wang, X.5    Shen, Z.6
  • 32
    • 59149106939 scopus 로고    scopus 로고
    • IFN-alpha-induced apoptosis in hepatocellular carcinoma involves promyelocytic leukemia protein and TRAIL independently of p53
    • 10.1158/0008-5472.CAN-08-2831, 19141642
    • Herzer K, Hofmann T, Teufel A, Schimanski C, Moehler M, Kanzler S, Schulze-Bergkamen H, Galle P. IFN-alpha-induced apoptosis in hepatocellular carcinoma involves promyelocytic leukemia protein and TRAIL independently of p53. Cancer Res 2009, 69:855-862. 10.1158/0008-5472.CAN-08-2831, 19141642.
    • (2009) Cancer Res , vol.69 , pp. 855-862
    • Herzer, K.1    Hofmann, T.2    Teufel, A.3    Schimanski, C.4    Moehler, M.5    Kanzler, S.6    Schulze-Bergkamen, H.7    Galle, P.8
  • 33
    • 33846179993 scopus 로고    scopus 로고
    • Induction of cell cycle arrest and apoptosis in HT-29 human colon cancer cells by the dietary compound luteolin
    • Lim D, Jeong Y, Tyner A, Park J. Induction of cell cycle arrest and apoptosis in HT-29 human colon cancer cells by the dietary compound luteolin. Am J Physiol Gastrointest Liver Physiol 2007, 292:G66-G75.
    • (2007) Am J Physiol Gastrointest Liver Physiol , vol.292
    • Lim, D.1    Jeong, Y.2    Tyner, A.3    Park, J.4
  • 36
    • 69249234626 scopus 로고    scopus 로고
    • Ribavirin enhances interferon signaling via stimulation of mTOR and p53 activities
    • 10.1016/j.febslet.2009.07.027, 19619545
    • Su W, Liu W, Cheng C, Chou Y, Hung K, Huang W, Wu C, Li Y, Shiau A, Lai M. Ribavirin enhances interferon signaling via stimulation of mTOR and p53 activities. FEBS Lett 2009, 583:2793-2798. 10.1016/j.febslet.2009.07.027, 19619545.
    • (2009) FEBS Lett , vol.583 , pp. 2793-2798
    • Su, W.1    Liu, W.2    Cheng, C.3    Chou, Y.4    Hung, K.5    Huang, W.6    Wu, C.7    Li, Y.8    Shiau, A.9    Lai, M.10
  • 37
    • 71549173131 scopus 로고    scopus 로고
    • N-Nitrosopiperidine and N-Nitrosodibutylamine induce apoptosis in HepG2 cells via the caspase dependent pathway
    • 10.1016/j.cellbi.2009.08.015, 19748591
    • García A, Morales P, Rafter J, Haza A. N-Nitrosopiperidine and N-Nitrosodibutylamine induce apoptosis in HepG2 cells via the caspase dependent pathway. Cell Biol Int 2009, 33:1280-1286. 10.1016/j.cellbi.2009.08.015, 19748591.
    • (2009) Cell Biol Int , vol.33 , pp. 1280-1286
    • García, A.1    Morales, P.2    Rafter, J.3    Haza, A.4
  • 38
    • 84865109737 scopus 로고    scopus 로고
    • Viral and host inflammation-related factors that can predict the prognosis of hepatocellular carcinoma
    • Chen L, Zhang Q, Chang W, Du Y, Zhang H, Cao G. Viral and host inflammation-related factors that can predict the prognosis of hepatocellular carcinoma. Eur J Cancer 2012, .
    • (2012) Eur J Cancer
    • Chen, L.1    Zhang, Q.2    Chang, W.3    Du, Y.4    Zhang, H.5    Cao, G.6
  • 39
    • 80255131066 scopus 로고    scopus 로고
    • Interferon-α2b and transforming growth factor-β1 treatments on HCC cell lines: Are Wnt/β-catenin pathway and Smads signaling connected in hepatocellular carcinoma?
    • 10.1016/j.bcp.2011.08.001, 21843516
    • Ceballos MP, Parody JP, Alvarez ML, Ingaramo PI, Carnovale CE, Carrillo MC. Interferon-α2b and transforming growth factor-β1 treatments on HCC cell lines: Are Wnt/β-catenin pathway and Smads signaling connected in hepatocellular carcinoma?. Biochem Pharmacol 2011, 82:1682-1691. 10.1016/j.bcp.2011.08.001, 21843516.
    • (2011) Biochem Pharmacol , vol.82 , pp. 1682-1691
    • Ceballos, M.P.1    Parody, J.P.2    Alvarez, M.L.3    Ingaramo, P.I.4    Carnovale, C.E.5    Carrillo, M.C.6
  • 40
    • 79951670840 scopus 로고    scopus 로고
    • Pegylated interferon alpha targets Wnt signaling by inducing nuclear export of β-catenin
    • 10.1016/j.jhep.2010.07.020, 3052972, 21093092
    • Thompson MD, Dar MJ, Monga SP. Pegylated interferon alpha targets Wnt signaling by inducing nuclear export of β-catenin. J Hepatol 2011, 54:506-512. 10.1016/j.jhep.2010.07.020, 3052972, 21093092.
    • (2011) J Hepatol , vol.54 , pp. 506-512
    • Thompson, M.D.1    Dar, M.J.2    Monga, S.P.3
  • 41
    • 78049314065 scopus 로고    scopus 로고
    • PGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury
    • 10.1073/pnas.1008209107, 2951415, 20855591
    • North TE, Babu IR, Vedder LM, Lord AM, Wishnok JS, Tannenbaum SR, Zon LI, Goessling W. PGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury. Proc Natl Acad Sci U S A 2010, 107:17315-17320. 10.1073/pnas.1008209107, 2951415, 20855591.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 17315-17320
    • North, T.E.1    Babu, I.R.2    Vedder, L.M.3    Lord, A.M.4    Wishnok, J.S.5    Tannenbaum, S.R.6    Zon, L.I.7    Goessling, W.8
  • 42
    • 0345256337 scopus 로고    scopus 로고
    • Transfection of a dominant-negative mutant NF-kB inhibitor (IkBm) represses p53-dependent apoptosis in acute lymphoblastic leukemia cells: interaction of IkBm and p53
    • 10.1038/sj.onc.1206911, 14603254
    • Zhou M, Gu L, Zhu N, Woods W, Findley H. Transfection of a dominant-negative mutant NF-kB inhibitor (IkBm) represses p53-dependent apoptosis in acute lymphoblastic leukemia cells: interaction of IkBm and p53. Oncogene 2003, 22:8137-8144. 10.1038/sj.onc.1206911, 14603254.
    • (2003) Oncogene , vol.22 , pp. 8137-8144
    • Zhou, M.1    Gu, L.2    Zhu, N.3    Woods, W.4    Findley, H.5
  • 43
    • 58149202128 scopus 로고    scopus 로고
    • Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls
    • 10.1038/nrd2781, 2729321, 19116625
    • Baud V, Karin M. Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls. Nat Rev Drug Discov 2009, 8:33-40. 10.1038/nrd2781, 2729321, 19116625.
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 33-40
    • Baud, V.1    Karin, M.2
  • 44
    • 33947586159 scopus 로고    scopus 로고
    • Aberrant NF-kappaB signaling in lymphoma: mechanisms, consequences, and therapeutic implications
    • Jost P, Ruland J. Aberrant NF-kappaB signaling in lymphoma: mechanisms, consequences, and therapeutic implications. Blood 2007, 109:2700-2707.
    • (2007) Blood , vol.109 , pp. 2700-2707
    • Jost, P.1    Ruland, J.2
  • 45
    • 34547934035 scopus 로고    scopus 로고
    • N-acetyl cysteine inhibits human signet ring cell gastric cancer cell line (SJ-89) cell growth by inducing apoptosis and DNA synthesis arrest
    • 10.1097/MEG.0b013e3282202bda, 17700262
    • Li J, Tu H, Dai G, Dai Y, Wu Q, Shi Q, Cao Q, Li Z. N-acetyl cysteine inhibits human signet ring cell gastric cancer cell line (SJ-89) cell growth by inducing apoptosis and DNA synthesis arrest. Eur J Gastroenterol Hepatol 2007, 19:769-774. 10.1097/MEG.0b013e3282202bda, 17700262.
    • (2007) Eur J Gastroenterol Hepatol , vol.19 , pp. 769-774
    • Li, J.1    Tu, H.2    Dai, G.3    Dai, Y.4    Wu, Q.5    Shi, Q.6    Cao, Q.7    Li, Z.8
  • 46
    • 0035798603 scopus 로고    scopus 로고
    • N-acetylcysteine induces cell cycle arrest in hepatic stellate cells through its reducing activity
    • 10.1074/jbc.M100975200, 11509553
    • Kim K, Rhim T, Choi I, Kim S. N-acetylcysteine induces cell cycle arrest in hepatic stellate cells through its reducing activity. J Biol Chem 2001, 276:40591-40598. 10.1074/jbc.M100975200, 11509553.
    • (2001) J Biol Chem , vol.276 , pp. 40591-40598
    • Kim, K.1    Rhim, T.2    Choi, I.3    Kim, S.4
  • 47
    • 79951580422 scopus 로고    scopus 로고
    • Construction of NF-kappaB-targeting RNAi adenovirus vector and the effect of NF-kappaB pathway on proliferation and apoptosis of vascular endothelial cells
    • Chen GQY, Yao J, Jiang Q, Lin X, Chen F, Lin F, Lin M, Lin L, Zhu P. Construction of NF-kappaB-targeting RNAi adenovirus vector and the effect of NF-kappaB pathway on proliferation and apoptosis of vascular endothelial cells. Mol Bio Rep 2010, 38:3089-3094.
    • (2010) Mol Bio Rep , vol.38 , pp. 3089-3094
    • Chen, G.Q.Y.1    Yao, J.2    Jiang, Q.3    Lin, X.4    Chen, F.5    Lin, F.6    Lin, M.7    Lin, L.8    Zhu, P.9
  • 48
    • 0036884292 scopus 로고    scopus 로고
    • A novel mechanism for the inhibition of NF-kappaB activation in vascular endothelial cells by natural antioxidants
    • Schubert S, Neeman I, Resnick N. A novel mechanism for the inhibition of NF-kappaB activation in vascular endothelial cells by natural antioxidants. FASEB J 2002, 16:1931-1933.
    • (2002) FASEB J , vol.16 , pp. 1931-1933
    • Schubert, S.1    Neeman, I.2    Resnick, N.3
  • 50
    • 0036494570 scopus 로고    scopus 로고
    • Transformed and tumor-derived human cells exhibit preferential sensitivity to the thiol antioxidants, N-acetyl cysteine and penicillamine
    • Havre P, O'Reilly S, McCormick J, Brash D. Transformed and tumor-derived human cells exhibit preferential sensitivity to the thiol antioxidants, N-acetyl cysteine and penicillamine. Cancer Res 2002, 62:1443-1449.
    • (2002) Cancer Res , vol.62 , pp. 1443-1449
    • Havre, P.1    O'Reilly, S.2    McCormick, J.3    Brash, D.4
  • 51
    • 0142200342 scopus 로고    scopus 로고
    • Interferon alpha inhibits the nuclear factor kappa B activation triggered by X gene product of hepatitis B virus in human hepatoma cells
    • 10.1016/S0014-5793(03)01034-2, 14572641
    • Ohata K, Ichikawa T, Nakao K, Shigeno M, Nishimura D, Ishikawa H, Hamasaki K, Eguchi K. Interferon alpha inhibits the nuclear factor kappa B activation triggered by X gene product of hepatitis B virus in human hepatoma cells. FEBS Lett 2003, 553:304-308. 10.1016/S0014-5793(03)01034-2, 14572641.
    • (2003) FEBS Lett , vol.553 , pp. 304-308
    • Ohata, K.1    Ichikawa, T.2    Nakao, K.3    Shigeno, M.4    Nishimura, D.5    Ishikawa, H.6    Hamasaki, K.7    Eguchi, K.8
  • 52
    • 0035909372 scopus 로고    scopus 로고
    • Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
    • 10.1038/35099560, 11607032
    • Alexopoulou L, Holt A, Medzhitov R, Flavell R. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 2001, 413:732-738. 10.1038/35099560, 11607032.
    • (2001) Nature , vol.413 , pp. 732-738
    • Alexopoulou, L.1    Holt, A.2    Medzhitov, R.3    Flavell, R.4
  • 53
    • 0034327721 scopus 로고    scopus 로고
    • IFN-alpha suppresses activation of nuclear transcription factors NF-kappa B and activator protein 1 and potentiates TNF-induced apoptosis
    • Manna S, Mukhopadhyay A, Aggarwal B. IFN-alpha suppresses activation of nuclear transcription factors NF-kappa B and activator protein 1 and potentiates TNF-induced apoptosis. J Immunol 2000, 165:4927-4934.
    • (2000) J Immunol , vol.165 , pp. 4927-4934
    • Manna, S.1    Mukhopadhyay, A.2    Aggarwal, B.3
  • 54
    • 33750432183 scopus 로고    scopus 로고
    • Nuclear factor-kappaB and inhibitor of kappaB kinase pathways in oncogenic initiation and progression
    • 10.1038/sj.onc.1209942, 17072330
    • Bassères D, Baldwin A. Nuclear factor-kappaB and inhibitor of kappaB kinase pathways in oncogenic initiation and progression. Oncogene 2006, 25:6817-6830. 10.1038/sj.onc.1209942, 17072330.
    • (2006) Oncogene , vol.25 , pp. 6817-6830
    • Bassères, D.1    Baldwin, A.2


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