Aclacinomycin 10-hydroxylase is a novel substrate-assisted hydroxylase requiring S-adenosyl-L-methionine as cofactor

Journal of Biological Chemistry

Volumn 280, Issue 5, 2005, Pages 3636-3644

  Jansson, Anna ^a   Koskiniemi, Hanna ^b   Erola, Anna ^a   Wang, Jessy ^a   Mäntsälä, Pekka ^b   Schneider, Gunter ^a   Niemi, Jarmo ^b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF TURKU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; BIOSYNTHESIS; CARBON; CARBOXYLATION; CATALYST ACTIVITY; CRYSTAL STRUCTURE; HYDROXYLATION; MOLECULAR WEIGHT;

ACLACINOMYCIN 10-HYDROXYLASE; AROMATIC RING SYSTEM; THIOLS;

ENZYMES;

15 METHOXY EPSILON RHODOMYCIN; ACLANOMYCIN 10 HYDROXYLASE; GLUTATHIONE; METHYLTRANSFERASE; RHODOMYCIN A; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE; SINEFUNGIN; UNCLASSIFIED DRUG;

ANTIBIOTIC BIOSYNTHESIS; ARTICLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DECARBOXYLATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STRUCTURE; STRUCTURE ANALYSIS;

ADENOSINE; ANTHRACYCLINES; ANTIMALARIALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; COENZYMES; HYDROXYLATION; MASS SPECTROMETRY; MIXED FUNCTION OXYGENASES; MUTAGENESIS; OXYGEN; PROTEIN STRUCTURE, TERTIARY; S-ADENOSYLMETHIONINE; STREPTOMYCES; SUBSTRATE SPECIFICITY;

EID: 13544260883     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M412095200     Document Type: Article

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