Swertiamarin: An active lead from enicostemma littorale regulates hepatic and adipose tissue gene expression by targeting PPAR-γ and improves insulin sensitivity in experimental niddm rat model

Evidence-based Complementary and Alternative Medicine

Volumn 2013, Issue , 2013, Pages

  Patel, Tushar P ^a   Soni, Sanket ^a   Parikh, Pankti ^a   Gosai, Jeetendra ^a   Chruvattil, Ragitha ^a   Gupta, Sarita ^a  

^a M S UNIVERSITY OF BARODA   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; BETA ACTIN; ENICOSTEMA LITTORALE EXTRACT; GLUCOKINASE; GLUCOSE; GLUCOSE 6 PHOSPHATASE; GLUTAMATE RECEPTOR 2; GLUTAMATE RECEPTOR 4; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; INSULIN; LEPTIN; LIPID; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METFORMIN; MEVALONIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PLANT EXTRACT; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; SWERTIAMARIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBOHYDRATE METABOLISM; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG EFFECT; DRUG ISOLATION; ENICOSTEMA LITTORALE; ENZYME ACTIVITY; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE TARGETING; GENETIC TRANSCRIPTION; GLUCOSE BLOOD LEVEL; HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHY; HYPOLIPEMIA; IMMUNOBLOTTING; IMMUNOPRECIPITATION; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID BLOOD LEVEL; LIPID METABOLISM; LIVER; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUCLEOTIDE SEQUENCE; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; RAT; RNA ISOLATION; SPECTROMETRY; TISSUE METABOLISM; ULTRAVIOLET RADIATION;

EID: 84880163170     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2013/358673     Document Type: Article

References (34)

1. Shaw J. E., Sicree R. A., Zimmet P. Z., Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Research and Clinical Practice 2010 87 1 4 14 2-s2.0-73749083481 10.1016/j.diabres.2009.10.007
2. Yajnik C. S., Ganpule-Rao A. V., The obesity-diabetes association: what is different in Indians? International Journal of Lower Extremity Wounds 2010 9 3 113 115 2-s2.0-77955678734 10.1177/1534734610380028
3. Nakamura T., Terajima T., Ogata T., Ueno K., Hashimoto N., Ono K., Yano S., Establishment and pathophysiological characterization of type 2 diabetic mouse model produced by streptozotocin and nicotinamide. Biological and Pharmaceutical Bulletin 2006 29 6 1167 1174 2-s2.0-33744918517 10.1248/bpb.29.1167 (Pubitemid 43845477)
4. Srinivasan K., Ramarao P., Animal models in type 2 diabetes research: an overview. Indian Journal of Medical Research 2007 125 3 451 472 2-s2.0-34249279490 (Pubitemid 46805458)
5. O'Brien R. M., Streeper R. S., Ayala J. E., Stadelmaier B. T., Hornbuckle L. A., Insulin-regulated gene expression. Biochemical Society Transactions 2001 29 4 552 558 2-s2.0-0034873371 10.1042/BST0290552 (Pubitemid 32783656)
6. Postic C., Dentin R., Girard J., Role of the liver in the control of carbohydrate and lipid homeostasis. Diabetes and Metabolism 2004 30 5 398 408 2-s2.0-10644256593 (Pubitemid 39648006)
7. O'Brien R. M., Granner D. K., Regulation of gene expression by insulin. Biochemical Journal 1991 278 3 609 619 2-s2.0-0025826137
8. Collier J. J., Scott D. K., Sweet changes: glucose homeostasis can be altered by manipulating genes controlling hepatic glucose metabolism. Molecular Endocrinology 2004 18 5 1051 1063 2-s2.0-2342484517 10.1210/me.2003-0357 (Pubitemid 38591274)
9. Ferré P., The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity. Diabetes 2004 53 1 S43 S50 2-s2.0-0842263981 (Pubitemid 38168692)
10. Sheng X., Zhang Y., Gong Z., Huang C., Zang Y. Q., Improved insulin resistance and lipid metabolism by cinnamon extract through activation of peroxisome proliferator-activated receptors. PPAR Research 2008 2008 9 2-s2.0-58149170595 10.1155/2008/581348 581348
11. Cefalu W. T., Ye J., Wang Z. Q., Efficacy of dietary supplementation with botanicals on carbohydrate metabolism in humans. Endocrine, Metabolic and Immune Disorders 2008 8 2 78 81 2-s2.0-47249156463 10.2174/187153008784534376
12. Joseph B., Raj S. J., A comparative study on various properties of five medicinally important plants. International Journal of Pharmacology 2011 7 2 206 211 10.3923/ijp.2011.206.211
13. Maroo J., Ghosh A., Mathur R., Vasu V. T., Gupta S., Antidiabetic efficacy of Enicostemma littorale methanol extract in alloxan-induced diabetic rats. Pharmaceutical Biology 2003 41 5 388 391 2-s2.0-0141427905 10.1076/phbi.41.5.388.15943 (Pubitemid 37159457)
14. Vasu V. T., Modi H., Thaikoottathil J. V., Gupta S., Hypolipidaemic and antioxidant effect of Enicostemma littorale Blume aqueous extract in cholesterol fed rats. Journal of Ethnopharmacology 2005 101 1-3 277 282 2-s2.0-24644458974 10.1016/j.jep.2005.05.007 (Pubitemid 41265633)
15. Dadheech N., Soni S., Srivastava A., Dadheech S., Gupta S., Gopurappilly R., Bhonde R. R., Gupta S., A small molecule swertisin from Enicostemma littorale differentiates NIH3T3 cells into Islet-Like clusters and restores normoglycemia upon transplantation in diabetic balb/c mice. Evidence-Based Complementary and Alternative Medicine 2013 2013 20 280392 10.1155/2013/280392
16. Li H. L., Peng X. J., He C. J., Feng E. F., Xu G. L., Rao G. X., Development and validation of a LC-ESI-MS/MS method for the determination of swertiamarin in rat plasma and its application in pharmacokinetics. Journal of Chromatography B 2011 879 1653 1658 10.1016/j.jchromb.2011.04.003
17. Vaidya H., Rajani M., Sudarsanam V., Padh H., Goyal R., Antihyperlipidaemic activity of swertiamarin, a secoiridoid glycoside in poloxamer-407-induced hyperlipidaemic rats. Journal of Natural Medicines 2009 63 4 437 442 2-s2.0-69949139796 10.1007/s11418-009-0350-8
18. Vaidya H., Prajapati A., Rajani M., Sudarsanam V., Padh H., Goyal R. K., Beneficial effects of swertiamarin on dyslipidaemia in streptozotocin-induced type 2 diabetic rats. Phytotherapy Research 2012 26 8 1259 1261 10.1002/ptr.3708
19. Maroo J., Vasu V. T., Aalinkeel R., Gupta S., Glucose lowering effect of aqueous extract of Enicostemma littorale Blume in diabetes: a possible mechanism of action. Journal of Ethnopharmacology 2002 81 3 317 320 2-s2.0-0035996864 10.1016/S0378-8741(02)00095-8 (Pubitemid 34786315)
20. Vishwakarma S. L., Rajani M., Bagul M. S., Goyal R. K., A rapid method for the isolation of swertiamarin from Enicostemma littorale. Pharmaceutical Biology 2004 42 6 400 403 2-s2.0-11244316511 10.1080/13880200490885095 (Pubitemid 40066056)
21. Masiello P., Broca C., Gross R., Roye M., Manteghetti M., Hillaire-Buys D., Novelli M., Ribes G., Experimental NIDDM: development of a new model in adult rats administered streptozotocin and nicotinamide. Diabetes 1998 47 2 224 229 2-s2.0-0031939587 (Pubitemid 28079978)
22. Bhatt N. M., Barua S., Gupta S., Protective effect of Enicostemma littorale Blume on rat model of diabetic neuropathy. American Journal of Infectious Diseases 2009 5 2 99 105 2-s2.0-70349664291 10.3844/ajidsp.2009.99. 105
23. Bhatt N. M., Chauhan K., Gupta S., Pillai P., Pandya C., Thaikoottathil J. V., Gupta S. S., Protective effect of Enicostemma littorale Blume methanolic extract on gentamicin-induced nephrotoxicity in rats. American Journal of Infectious Diseases 2011 7 4 83 90 10.3844/ajidsp.2011.83.90
24. Jaishree V., Badami S., Rupesh Kumar M., Tamizhmani T., Antinociceptive activity of swertiamarin isolated from Enicostemma axillare. Phytomedicine 2009 16 2-3 227 232 2-s2.0-59849123053 10.1016/j.phymed.2008.09.010
25. Vasu V. T., Ashwinikumar C., Maroo J., Gupta S., Gupta S., Antidiabetic effect of Enicostemma littorale Blume aqueous extract in newly diagnosed non-insulin-dependent diabetes mellitus patients (NIDDM): a preliminary investigation. Oriental Pharmacy and Experimental Medicine 2003 3 84 89
26. Hanson R. W., Reshef L., Regulation of phosphoenolpyruvate carboxykinase (GTP) gene expression. Annual Review of Biochemistry 1997 66 581 611 2-s2.0-0030998776 10.1146/annurev.biochem.66.1.581 (Pubitemid 27274668)
27. Davies G. F., Khandelwal R. L., Roesler W. J., Troglitazone inhibits expression of the phosphoenolpyruvate carboxykinase gene by an insulin-independent mechanism. Biochimica et Biophysica Acta 1999 1451 1 122 131 2-s2.0-0032856254 10.1016/S0167-4889(99)00080-4 (Pubitemid 29364252)
28. Ribnicky D. M., Poulev A., Watford M., Cefalu W. T., Raskin I., Antihyperglycemic activity of Tarralin, an ethanolic extract of Artemisia dracunculus L. Phytomedicine 2006 13 8 550 557 2-s2.0-33747139651 10.1016/j.phymed.2005.09.007 (Pubitemid 44224045)
29. Vaidya H., Rajani M., Sudarsanam V., Padh H., Goyal R., Swertiamarin: a lead from Enicostemma littorale Blume. for anti-hyperlipidaemic effect. European Journal of Pharmacology 2009 617 1-3 108 112 2-s2.0-68749118431 10.1016/j.ejphar.2009.06.053
30. Suh Y. H., Kim Y., Bang J. H., Choi K. S., Lee J. W., Kim W. H., Oh T. J., An S., Jung M. H., Analysis of gene expression profiles in insulin-sensitive tissues from pre-diabetic and diabetic Zucker diabetic fatty rats. Journal of Molecular Endocrinology 2005 34 2 299 315 2-s2.0-17844407927 10.1677/jme.1.01679 (Pubitemid 40585183)
31. Huang H. L., Hong Y. W., Wong Y. H., Chen Y. N., Chyuan J. H., Huang C. J., Chao P. M., Bitter melon (Momordica charantia L.) inhibits adipocyte hypertrophy and down regulates lipogenic gene expression in adipose tissue of diet-induced obese rats. British Journal of Nutrition 2008 99 2 230 239 2-s2.0-38049123030 10.1017/S0007114507793947
32. Vaidya H., Goyal R. K., Cheema S. K., Anti-diabetic activity of swertiamarin is due to an active metabolite, gentianine, that upregulates PPAR-gamma gene expression in 3T3-L1 cells. Phytotherapy Research 2012 27 4 624 627 10.1002/ptr.4763
33. Qin B., Nagasaki M., Ren M., Bajotto G., Oshida Y., Sato Y., Cinnamon extract (traditional herb) potentiates in vivo insulin-regulated glucose utilization via enhancing insulin signaling in rats. Diabetes Research and Clinical Practice 2003 62 3 139 148 2-s2.0-0242559087 10.1016/S0168-8227(03) 00173-6 (Pubitemid 37414980)
34. Kadowaki T., Hara K., Yamauchi T., Terauchi Y., Tobe K., Nagai R., Molecular mechanism of insulin resistance and obesity. Experimental Biology and Medicine 2003 228 10 1111 1117 2-s2.0-0242694056 (Pubitemid 37413667)