Epigenetic regulation of the innate immune response to LPS in bovine peripheral blood mononuclear cells (PBMC)

Veterinary Immunology and Immunopathology

Volumn 154, Issue 3-4, 2013, Pages 102-110

  Doherty, R ^a,b   O'Farrelly, C ^b   Meade, K G ^a  

^a TEAGASC   (Ireland)

^b TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Acetylation; Bovine; DNMT; HDAC; Innate immunity; Trichostatin A

Indexed keywords

DNA METHYLTRANSFERASE; DNA METHYLTRANSFERASE 3A; GAMMA INTERFERON; HISTONE DEACETYLASE; HISTONE DEACETYLASE 6; HISTONE DEACETYLASE 7; HISTONE H3; INTERLEUKIN 2; LIPOPOLYSACCHARIDE; TRICHOSTATIN A; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; EPIGENETICS; GENE EXPRESSION; GENETIC REGULATION; HISTONE ACETYLATION; INNATE IMMUNITY; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION; STIMULATION;

ANIMALS; CATTLE; CELL SURVIVAL; COMPUTATIONAL BIOLOGY; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION; HISTONE DEACETYLASES; HYDROXAMIC ACIDS; IMMUNITY, INNATE; LEUKOCYTES, MONONUCLEAR; LIPOPOLYSACCHARIDES; PHYLOGENY;

ANIMALIA; BOS; BOVINAE;

EID: 84880135557     PISSN: 01652427     EISSN: 18732534     Source Type: Journal    
DOI: 10.1016/j.vetimm.2013.05.004     Document Type: Article

References (39)

1. Akira S., Uematsu S., Takeuchi O. Pathogen recognition and innate immunity. Cell 2006, 124:783-801.
2. Bertos N.R., Wang A.H., Yang X.J. Class II histone deacetylases: structure, function, and regulation. Biochem. Cell Biol. 2001, 79:243-252.
3. Bestor T.H. The DNA methyltransferases of mammals. Hum. Mol. Genet. 2000, 9:2395-2402.
4. Buggy J.J., Sideris M.L., Mak P., Lorimer D.D., McIntosh B., Clark J.M. Cloning and characterization of a novel human histone deacetylase, HDAC8. Biochem. J. 2000, 350(Pt 1):199-205.
5. Cantley M.D., Haynes D.R. Epigenetic regulation of inflammation: progressing from broad acting histone deacetylase (HDAC) inhibitors to targeting specific HDACs. Inflammopharmacology 2013.
6. Chen L., Fischle W., Verdin E., Greene W.C. Duration of nuclear NF-kappaB action regulated by reversible acetylation. Science 2001, 293:1653-1657.
7. de Ruijter A.J., van Gennip A.H., Caron H.N., Kemp S., van Kuilenburg A.B. Histone deacetylases (HDACs): characterization of the classical HDAC family. Biochem. J. 2003, 370:737-749.
8. Denu J.M. The Sir 2 family of protein deacetylases. Curr. Opin. Chem. Biol. 2005, 9:431-440.
9. Gao L., Cueto M.A., Asselbergs F., Atadja P. Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family. J. Biol. Chem. 2002, 277:25748-25755.
10. Glozak M.A., Sengupta N., Zhang X., Seto E. Acetylation and deacetylation of non-histone proteins. Gene 2005, 363:15-23.
11. Grunstein M. Histone acetylation in chromatin structure and transcription. Nature 1997, 389:349-352.
12. Halili M.A., Andrews M.R., Labzin L.I., Schroder K., Matthias G., Cao C., Lovelace E., Reid R.C., Le G.T., Hume D.A., Irvine K.M., Matthias P., Fairlie D.P., Sweet M.J. Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS. J. Leukoc. Biol. 2010, 87:1103-1114.
13. Huang L. Targeting histone deacetylases for the treatment of cancer and inflammatory diseases. J. Cell. Physiol. 2006, 209:611-616.
14. Hubner M.R., Eckersley-Maslin M.A., Spector D.L. Chromatin organization and transcriptional regulation. Curr. Opin. Genet. Dev. 2013, 23:89-95.
15. Jones B., Chen J. Inhibition of IFN-gamma transcription by site-specific methylation during T helper cell development. EMBO J. 2006, 25:2443-2452.
16. Joo M., Park G.Y., Wright J.G., Blackwell T.S., Atchison M.L., Christman J.W. Transcriptional regulation of the cyclooxygenase-2 gene in macrophages by PU.1. J. Biol. Chem. 2004, 279:6658-6665.
17. Li C.J., Li R.W., Elsasser T.H., Kahl S. Lipopolysaccharide-induced early response genes in bovine peripheral blood mononuclear cells implicate GLG1/E-selectin as a key ligand-receptor interaction. Funct. Integr. Genomics 2009, 9:335-349.
18. Licciardi P.V., Ververis K., Tang M.L., El-Osta A., Karagiannis T.C. Immunomodulatory effects of histone deacetylase inhibitors. Curr. Mol. Med. 2013, 13:640-647.
19. Liu Y., Peng L., Seto E., Huang S., Qiu Y. Modulation of histone deacetylase 6 (HDAC6) nuclear import and tubulin deacetylase activity through acetylation. J. Biol. Chem. 2012, 287:29168-29174.
20. Murphy M., Ahn J., Walker K.K., Hoffman W.H., Evans R.M., Levine A.J., George D.L. Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a. Genes Dev. 1999, 13:2490-2501.
21. Nakano K., Boyle D.L., Firestein G.S. Regulation of DNA methylation in rheumatoid arthritis synoviocytes. J. Immunol. 2013, 190:1297-1303.
22. Newton K., Dixit V.M. Signaling in innate immunity and inflammation. Cold Spring Harb. Perspect. Biol. 2012, 4:a006049.
23. Palsson-McDermott E.M., O'Neill L.A. Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4. Immunology 2004, 113:153-162.
24. Park G.Y., Joo M., Pedchenko T., Blackwell T.S., Christman J.W. Regulation of macrophage cyclooxygenase-2 gene expression by modifications of histone H3. Am. J. Physiol. Lung Cell Mol. Physiol. 2004, 286:L956-L962.
25. Placek K., Coffre M., Maiella S., Bianchi E., Rogge L. Genetic and epigenetic networks controlling T helper 1 cell differentiation. Immunology 2009, 127:155-162.
26. Rahman I., Marwick J., Kirkham P. Redox modulation of chromatin remodeling: impact on histone acetylation and deacetylation, NF-kappaB and pro-inflammatory gene expression. Biochem. Pharmacol. 2004, 68:1255-1267.
27. Roger T., Lugrin J., Le Roy D., Goy G., Mombelli M., Koessler T., Ding X.C., Chanson A.L., Reymond M.K., Miconnet I., Schrenzel J., Francois P., Calandra T. Histone deacetylase inhibitors impair innate immune responses to Toll-like receptor agonists and to infection. Blood 2011, 117:1205-1217.
28. Shuttleworth S.J., Bailey S.G., Townsend P.A. Histone Deacetylase inhibitors: new promise in the treatment of immune and inflammatory diseases. Curr. Drug Targets 2010, 11:1430-1438.
29. Struhl K. Histone acetylation and transcriptional regulatory mechanisms. Genes Dev. 1998, 12:599-606.
30. Sullivan K.E., Reddy A.B., Dietzmann K., Suriano A.R., Kocieda V.P., Stewart M., Bhatia M. Epigenetic regulation of tumor necrosis factor alpha. Mol. Cell. Biol. 2007, 27:5147-5160.
31. Sun H., Taneja R. Stra13 expression is associated with growth arrest and represses transcription through histone deacetylase (HDAC)-dependent and HDAC-independent mechanisms. Proc. Natl. Acad. Sci. U. S. A. 2000, 97:4058-4063.
32. Thiagalingam S., Cheng K.H., Lee H.J., Mineva N., Thiagalingam A., Ponte J.F. Histone deacetylases: unique players in shaping the epigenetic histone code. Ann. N. Y. Acad. Sci. 2003, 983:84-100.
33. Vanhaecke T., Papeleu P., Elaut G., Rogiers V. Trichostatin A-like hydroxamate histone deacetylase inhibitors as therapeutic agents: toxicological point of view. Curr. Med. Chem. 2004, 11:1629-1643.
34. Verdone L., Agricola E., Caserta M., Di Mauro E. Histone acetylation in gene regulation. Brief Funct. Genomic Proteomic 2006, 5:209-221.
35. Yoshida M., Kijima M., Akita M., Beppu T. Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. J. Biol. Chem. 1990, 265:17174-17179.
36. Young H.A., Ghosh P., Ye J., Lederer J., Lichtman A., Gerard J.R., Penix L., Wilson C.B., Melvin A.J., McGurn M.E., et al. Differentiation of the T helper phenotypes by analysis of the methylation state of the IFN-gamma gene. J. Immunol. 1994, 153:3603-3610.
37. Zhong S., Fields C.R., Su N., Pan Y.X., Robertson K.D. Pharmacologic inhibition of epigenetic modifications, coupled with gene expression profiling, reveals novel targets of aberrant DNA methylation and histone deacetylation in lung cancer. Oncogene 2007, 26:2621-2634.
38. Ziesche E., Kettner-Buhrow D., Weber A., Wittwer T., Jurida L., Soelch J., Muller H., Newel D., Kronich P., Schneider H., Dittrich-Breiholz O., Bhaskara S., Hiebert S.W., Hottiger M.O., Li H., Burstein E., Schmitz M.L., Kracht M. The coactivator role of histone deacetylase 3 in IL-1-signaling involves deacetylation of p65 NF-kappaB. Nucleic Acids Res. 2013, 41:90-109.
39. Zika E., Ting J.P. Epigenetic control of MHC-II: interplay between CIITA and histone-modifying enzymes. Curr. Opin. Immunol. 2005, 17:58-64.