메뉴 건너뛰기




Volumn 17, Issue 8, 2013, Pages 1399-1405

MLH1 as a Direct Target of MiR-155 and a Potential Predictor of Favorable Prognosis in Pancreatic Cancer

Author keywords

Expression; MiR 155; Mut L homologue 1; Pancreatic cancer; Survival

Indexed keywords

MESSENGER RNA; MICRORNA; MIRN155 MICRORNA, HUMAN; MLH1 PROTEIN, HUMAN; NUCLEAR PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TUMOR MARKER;

EID: 84880132922     PISSN: 1091255X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11605-013-2230-5     Document Type: Article
Times cited : (37)

References (35)
  • 1
    • 77951755278 scopus 로고    scopus 로고
    • Pancreatic cancer
    • Hidalgo M. Pancreatic cancer. N Engl J Med. 2010; 362: 1605-17.
    • (2010) N Engl J Med. , vol.362 , pp. 1605-1617
    • Hidalgo, M.1
  • 2
    • 78049466191 scopus 로고    scopus 로고
    • Therapeutic targeting of the DNA mismatch repair pathway
    • Martin SA, Lord CJ, Ashworth A. Therapeutic targeting of the DNA mismatch repair pathway. Clin Cancer Res. 2010; 16: 5107-13.
    • (2010) Clin Cancer Res. , vol.16 , pp. 5107-5113
    • Martin, S.A.1    Lord, C.J.2    Ashworth, A.3
  • 3
    • 0033987743 scopus 로고    scopus 로고
    • Reduced MLH1 expression in breast tumors after primary chemotherapy predicts disease-free survival
    • Mackay HJ, Cameron D, Rahilly M, et al. Reduced MLH1 expression in breast tumors after primary chemotherapy predicts disease-free survival. J Clin Oncol. 2000; 18: 87-93.
    • (2000) J Clin Oncol. , vol.18 , pp. 87-93
    • Mackay, H.J.1    Cameron, D.2    Rahilly, M.3
  • 4
    • 0036189776 scopus 로고    scopus 로고
    • Is reduced expression of mismatch repair genes MLH1 and MSH2 in patients with sporadic colorectal cancer related to their prognosis?
    • Kruschewski M, Noske A, Haier J, et al. Is reduced expression of mismatch repair genes MLH1 and MSH2 in patients with sporadic colorectal cancer related to their prognosis? Clin Exp Metastasis. 2002; 19: 71-7.
    • (2002) Clin Exp Metastasis. , vol.19 , pp. 71-77
    • Kruschewski, M.1    Noske, A.2    Haier, J.3
  • 5
    • 0141995086 scopus 로고    scopus 로고
    • Reduced MLH1 expression after chemotherapy is an indicator for poor prognosis in esophageal cancers
    • Kishi K, Doki Y, Yano M, et al. Reduced MLH1 expression after chemotherapy is an indicator for poor prognosis in esophageal cancers. Clin Cancer Res. 2003; 9: 4368-75.
    • (2003) Clin Cancer Res. , vol.9 , pp. 4368-4375
    • Kishi, K.1    Doki, Y.2    Yano, M.3
  • 6
    • 27644547870 scopus 로고    scopus 로고
    • Deficiency of hMLH1 and hMSH2 expression is a poor prognostic factor in esophageal squamous cell carcinoma
    • Uehara H, Miyamoto M, Kato K, et al. Deficiency of hMLH1 and hMSH2 expression is a poor prognostic factor in esophageal squamous cell carcinoma. J Surg Oncol. 2005; 92: 109-15.
    • (2005) J Surg Oncol. , vol.92 , pp. 109-115
    • Uehara, H.1    Miyamoto, M.2    Kato, K.3
  • 7
    • 48249117114 scopus 로고    scopus 로고
    • DLEC1 and MLH1 promoter methylation are associated with poor prognosis in non-small cell lung carcinoma
    • Seng TJ, Currey N, Cooper WA, et al. DLEC1 and MLH1 promoter methylation are associated with poor prognosis in non-small cell lung carcinoma. Br J Cancer. 2008; 99: 375-82.
    • (2008) Br J Cancer. , vol.99 , pp. 375-382
    • Seng, T.J.1    Currey, N.2    Cooper, W.A.3
  • 8
    • 54949109792 scopus 로고    scopus 로고
    • Frequent alterations of hMLH1 and RBSP3/HYA22 at chromosomal 3p22.3 region in early and late-onset breast carcinoma: clinical and prognostic significance
    • Sinha S, Singh RK, Alam N, et al. Frequent alterations of hMLH1 and RBSP3/HYA22 at chromosomal 3p22. 3 region in early and late-onset breast carcinoma: clinical and prognostic significance. Cancer Sci. 2008; 99: 1984-91.
    • (2008) Cancer Sci. , vol.99 , pp. 1984-1991
    • Sinha, S.1    Singh, R.K.2    Alam, N.3
  • 9
    • 77954145997 scopus 로고    scopus 로고
    • Frequent alterations of the candidate genes hMLH1, ITGA9 and RBSP3 in early dysplastic lesions of head and neck: clinical and prognostic significance
    • Ghosh A, Ghosh S, Maiti GP, et al. Frequent alterations of the candidate genes hMLH1, ITGA9 and RBSP3 in early dysplastic lesions of head and neck: clinical and prognostic significance. Cancer Sci. 2010; 101: 1511-20.
    • (2010) Cancer Sci. , vol.101 , pp. 1511-1520
    • Ghosh, A.1    Ghosh, S.2    Maiti, G.P.3
  • 10
    • 13144256735 scopus 로고    scopus 로고
    • Prognostic implications of hMLH1 and p53 immunohistochemical status in right-sided colon cancer
    • Smyth EF, Sharma A, Sivarajasingham N, et al. Prognostic implications of hMLH1 and p53 immunohistochemical status in right-sided colon cancer. Dis Colon Rectum. 2004; 47: 2086-91.
    • (2004) Dis Colon Rectum. , vol.47 , pp. 2086-2091
    • Smyth, E.F.1    Sharma, A.2    Sivarajasingham, N.3
  • 11
    • 33748781163 scopus 로고    scopus 로고
    • Loss of hMLH1 expression is associated with less aggressive clinicopathological features in sporadic endometrioid endometrial adenocarcinoma
    • Ju W, Park HM, Lee SN, et al. Loss of hMLH1 expression is associated with less aggressive clinicopathological features in sporadic endometrioid endometrial adenocarcinoma. J Obstet Gynaecol Res. 2006; 32: 454-60.
    • (2006) J Obstet Gynaecol Res. , vol.32 , pp. 454-460
    • Ju, W.1    Park, H.M.2    Lee, S.N.3
  • 12
    • 48849098718 scopus 로고    scopus 로고
    • Expression of the hMLH1 gene is a possible predictor for the clinical response to 5-fluorouracil after a surgical resection in colorectal cancer
    • Ide T, Kitajima Y, Ohtaka K, et al. Expression of the hMLH1 gene is a possible predictor for the clinical response to 5-fluorouracil after a surgical resection in colorectal cancer. Oncol Rep. 2008; 19: 1571-6.
    • (2008) Oncol Rep. , vol.19 , pp. 1571-1576
    • Ide, T.1    Kitajima, Y.2    Ohtaka, K.3
  • 13
    • 77951030494 scopus 로고    scopus 로고
    • Modulation of mismatch repair and genomic stability by miR-155
    • Valeri N, Gasparini P, Fabbri M, et al. Modulation of mismatch repair and genomic stability by miR-155. Proc Natl Acad Sci U S A. 2010; 107: 6982-7.
    • (2010) Proc Natl Acad Sci U S A. , vol.107 , pp. 6982-6987
    • Valeri, N.1    Gasparini, P.2    Fabbri, M.3
  • 14
    • 33646399145 scopus 로고    scopus 로고
    • HOXA5 regulates hMLH1 expression in breast cancer cells
    • Duriseti S, Winnard PT Jr, Mironchik Y, et al. HOXA5 regulates hMLH1 expression in breast cancer cells. Neoplasia. 2006; 8: 250-8.
    • (2006) Neoplasia. , vol.8 , pp. 250-258
    • Duriseti, S.1    Winnard Jr., P.T.2    Mironchik, Y.3
  • 15
    • 47049105096 scopus 로고    scopus 로고
    • Human mismatch repair gene, MLH1, is transcriptionally repressed by the hypoxia-inducible transcription factors, DEC1 and DEC2
    • Nakamura H, Tanimoto K, Hiyama K, et al. Human mismatch repair gene, MLH1, is transcriptionally repressed by the hypoxia-inducible transcription factors, DEC1 and DEC2. Oncogene. 2008; 27: 4200-9.
    • (2008) Oncogene. , vol.27 , pp. 4200-4209
    • Nakamura, H.1    Tanimoto, K.2    Hiyama, K.3
  • 16
    • 69249142193 scopus 로고    scopus 로고
    • Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer
    • Edwards RA, Witherspoon M, Wang K, et al. Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer. Cancer Res. 2009; 69: 6423-9.
    • (2009) Cancer Res. , vol.69 , pp. 6423-6429
    • Edwards, R.A.1    Witherspoon, M.2    Wang, K.3
  • 17
    • 0034264425 scopus 로고    scopus 로고
    • Not hMSH2 but hMLH1 is frequently silenced by hypermethylation in endometrial cancer but rarely silenced in pancreatic cancer with microsatellite instability
    • Kondo E, Furukawa T, Yoshinaga K, et al. Not hMSH2 but hMLH1 is frequently silenced by hypermethylation in endometrial cancer but rarely silenced in pancreatic cancer with microsatellite instability. Int J Oncol. 2000; 17: 535-41.
    • (2000) Int J Oncol. , vol.17 , pp. 535-541
    • Kondo, E.1    Furukawa, T.2    Yoshinaga, K.3
  • 18
    • 0037910331 scopus 로고    scopus 로고
    • Expression of the DNA mismatch repair proteins (hMLH1 and hMSH2) in infiltrating pancreatic cancer and its relation to some phenotypic features
    • Tomaszewska R, Okoń K, Stachura J. Expression of the DNA mismatch repair proteins (hMLH1 and hMSH2) in infiltrating pancreatic cancer and its relation to some phenotypic features. Pol J Pathol. 2003; 54: 31-7.
    • (2003) Pol J Pathol. , vol.54 , pp. 31-37
    • Tomaszewska, R.1    Okoń, K.2    Stachura, J.3
  • 19
    • 19944390234 scopus 로고    scopus 로고
    • Defective DNA mismatch repair in long-term (> or =3 years) survivors with pancreatic cancer
    • Maple JT, Smyrk TC, Boardman LA, et al. Defective DNA mismatch repair in long-term (> or =3 years) survivors with pancreatic cancer. Pancreatology. 2005; 5: 220-7.
    • (2005) Pancreatology. , vol.5 , pp. 220-227
    • Maple, J.T.1    Smyrk, T.C.2    Boardman, L.A.3
  • 20
    • 33745068434 scopus 로고    scopus 로고
    • Molecular characterisation of pancreatic ductal adenocarcinoma in patients under 40
    • Bergmann F, Aulmann S, Wente MN, et al. Molecular characterisation of pancreatic ductal adenocarcinoma in patients under 40. J Clin Pathol. 2006; 59: 580-4.
    • (2006) J Clin Pathol. , vol.59 , pp. 580-584
    • Bergmann, F.1    Aulmann, S.2    Wente, M.N.3
  • 21
    • 1542787474 scopus 로고    scopus 로고
    • Negative hMSH2 protein expression in pancreatic carcinoma may predict a better prognosis of patients
    • Nakata B, Wang YQ, Yashiro M, et al. Negative hMSH2 protein expression in pancreatic carcinoma may predict a better prognosis of patients. Oncol Rep. 2003; 10: 997-1000.
    • (2003) Oncol Rep. , vol.10 , pp. 997-1000
    • Nakata, B.1    Wang, Y.Q.2    Yashiro, M.3
  • 22
    • 79959588396 scopus 로고    scopus 로고
    • Tissue and serum microRNAs in the Kras(G12D) transgenic animal model and in patients with pancreatic cancer
    • LaConti JJ, Shivapurkar N, Preet A, et al. Tissue and serum microRNAs in the Kras(G12D) transgenic animal model and in patients with pancreatic cancer. PLoS One. 2011; 6: e20687.
    • (2011) PLoS One. , vol.6
    • LaConti, J.J.1    Shivapurkar, N.2    Preet, A.3
  • 23
    • 0037648597 scopus 로고    scopus 로고
    • Differential expression of hMLH1 and hMSH2 is related to bladder cancer grade, stage and prognosis but not microsatellite instability
    • Catto JW, Xinarianos G, Burton JL, et al. Differential expression of hMLH1 and hMSH2 is related to bladder cancer grade, stage and prognosis but not microsatellite instability. Int J Cancer. 2003; 105: 484-90.
    • (2003) Int J Cancer. , vol.105 , pp. 484-490
    • Catto, J.W.1    Xinarianos, G.2    Burton, J.L.3
  • 24
    • 33645818985 scopus 로고    scopus 로고
    • MLH1 mismatch repair gene product is associated with apoptotic potential of urothelial bladder carcinomas
    • Lazaris AC, Zarogiannos A, Kavantzas N, et al. MLH1 mismatch repair gene product is associated with apoptotic potential of urothelial bladder carcinomas. Anticancer Res. 2006; 26: 1535-42.
    • (2006) Anticancer Res. , vol.26 , pp. 1535-1542
    • Lazaris, A.C.1    Zarogiannos, A.2    Kavantzas, N.3
  • 25
    • 55949099916 scopus 로고    scopus 로고
    • Microsatellite instability due to hMLH1 deficiency is associated with increased cytotoxicity to irinotecan in human colorectal cancer cell lines
    • Vilar E, Scaltriti M, Balmaña J, et al. Microsatellite instability due to hMLH1 deficiency is associated with increased cytotoxicity to irinotecan in human colorectal cancer cell lines. Br J Cancer. 2008; 99: 1607-12.
    • (2008) Br J Cancer. , vol.99 , pp. 1607-1612
    • Vilar, E.1    Scaltriti, M.2    Balmaña, J.3
  • 26
    • 67650621413 scopus 로고    scopus 로고
    • MLH1 expression sensitises ovarian cancer cells to cell death mediated by XIAP inhibition
    • Ding X, Mohd AB, Huang Z, et al. MLH1 expression sensitises ovarian cancer cells to cell death mediated by XIAP inhibition. Br J Cancer. 2009; 101: 269-77.
    • (2009) Br J Cancer. , vol.101 , pp. 269-277
    • Ding, X.1    Mohd, A.B.2    Huang, Z.3
  • 27
    • 82455174374 scopus 로고    scopus 로고
    • Down-regulation of DNA mismatch repair enhances initiation and growth of neuroblastoma and brain tumour multicellular spheroids
    • Collins SL, Hervé R, Keevil CW, et al. Down-regulation of DNA mismatch repair enhances initiation and growth of neuroblastoma and brain tumour multicellular spheroids. PLoS One. 2011; 6: e28123.
    • (2011) PLoS One. , vol.6
    • Collins, S.L.1    Hervé, R.2    Keevil, C.W.3
  • 28
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: genomics, biogenesis, mechanism, and function
    • Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004; 116: 281-97.
    • (2004) Cell. , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 29
    • 33846813656 scopus 로고    scopus 로고
    • Expression profiling identifies microRNA signature in pancreatic cancer
    • Lee EJ, Gusev Y, Jiang J, et al. Expression profiling identifies microRNA signature in pancreatic cancer. Int J Cancer. 2007; 120: 1046-54.
    • (2007) Int J Cancer. , vol.120 , pp. 1046-1054
    • Lee, E.J.1    Gusev, Y.2    Jiang, J.3
  • 30
    • 84859216070 scopus 로고    scopus 로고
    • Inactivation of Ink4a/Arf leads to deregulated expression of miRNAs in K-Ras transgenic mouse model of pancreatic cancer
    • Ali S, Banerjee S, Logna F, et al. Inactivation of Ink4a/Arf leads to deregulated expression of miRNAs in K-Ras transgenic mouse model of pancreatic cancer. J Cell Physiol. 2012; 227: 3373-80.
    • (2012) J Cell Physiol. , vol.227 , pp. 3373-3380
    • Ali, S.1    Banerjee, S.2    Logna, F.3
  • 31
    • 36048952786 scopus 로고    scopus 로고
    • Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development
    • Gironella M, Seux M, Xie MJ, et al. Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development. Proc Natl Acad Sci U S A. 2007; 104: 16170-5.
    • (2007) Proc Natl Acad Sci U S A. , vol.104 , pp. 16170-16175
    • Gironella, M.1    Seux, M.2    Xie, M.J.3
  • 32
    • 54549108057 scopus 로고    scopus 로고
    • Clinical and pathologic prognostic factors for curative resection for pancreatic cancer
    • Perini MV, Montagnini AL, Jukemura J, et al. Clinical and pathologic prognostic factors for curative resection for pancreatic cancer. HPB (Oxford). 2008; 10: 356-62.
    • (2008) HPB (Oxford). , vol.10 , pp. 356-362
    • Perini, M.V.1    Montagnini, A.L.2    Jukemura, J.3
  • 33
    • 80052967341 scopus 로고    scopus 로고
    • Prognostic implications of lymph node metastases in carcinoma of the body and tail of the pancreas
    • Sahin TT, Fujii T, Kanda M, et al. Prognostic implications of lymph node metastases in carcinoma of the body and tail of the pancreas. Pancreas. 2011; 40: 1029-33.
    • (2011) Pancreas. , vol.40 , pp. 1029-1033
    • Sahin, T.T.1    Fujii, T.2    Kanda, M.3
  • 34
    • 79960006148 scopus 로고    scopus 로고
    • Systematic review of immunohistochemical biomarkers to identify prognostic subgroups of patients with pancreatic cancer
    • Ansari D, Rosendahl A, Elebro J, et al. Systematic review of immunohistochemical biomarkers to identify prognostic subgroups of patients with pancreatic cancer. Br J Surg. 2011; 98: 1041-55.
    • (2011) Br J Surg. , vol.98 , pp. 1041-1055
    • Ansari, D.1    Rosendahl, A.2    Elebro, J.3
  • 35
    • 73449134501 scopus 로고    scopus 로고
    • Elevated expression of microRNAs 155, 203, 210 and 222 in pancreatic tumors is associated with poorer survival
    • Greither T, Grochola LF, Udelnow A, et al. Elevated expression of microRNAs 155, 203, 210 and 222 in pancreatic tumors is associated with poorer survival. Int J Cancer. 2010; 126: 73-80.
    • (2010) Int J Cancer. , vol.126 , pp. 73-80
    • Greither, T.1    Grochola, L.F.2    Udelnow, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.