MLH1 mismatch repair gene product is associated with apoptotic potential of urothelial bladder carcinomas

Anticancer Research

Volumn 26, Issue 2 B, 2006, Pages 1535-1542

  Lazaris, Andreas C ^a   Zarogiannos, Aristeidis ^b   Kavantzas, Nikolaus ^c   Zervas, Anastasios ^b   Giannopoulos, Aris ^b   Nakopoulou, Lydia ^a,c  

^a NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS   (Greece)

^b UNIVERSITY OF ATHENS   (Greece)

^c UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Apoptosis; Bladder cancer; Immunohistochemistry; MLH1

Indexed keywords

CASPASE 3; GENE PRODUCT; KI 67 ANTIGEN; PROTEIN MLH1;

ADULT; AGED; APOPTOSIS; ARTICLE; BLADDER CARCINOMA; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; MALE; MISMATCH REPAIR; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; TUMOR CELL;

ADULT; AGED; AGED, 80 AND OVER; APOPTOSIS; CARRIER PROTEINS; CELL NUCLEUS; DNA REPAIR; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NEOPLASM STAGING; NUCLEAR PROTEINS; URINARY BLADDER NEOPLASMS; UROTHELIUM;

EID: 33645818985     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Stone JG, Robertson D and Huolston RS: Immunohistochemistry for MSH2 and MHL1: a method for identifying mismatch repair deficient colorectal cancer. J Clin Pathol 54: 484-487, 2001.
2. Kassem HS, Varley JM, Hamam SM and Margison GP: Immunohistochemical analysis of expression and allelotype of mismatch repair genes (hMLH1 and hMSH2) in bladder cancer. Br J Cancer 84: 321-328, 2001.
3. Warnick C, Dabbas B, Illstrup S, Ford C and Strait K: Cell type-dependent regulation of hMLH1 promoter activity is influenced by the presence of multiple redundant elements. Mol Cancer Res 7: 610-618, 2003.
4. Bonnal Ch, Ravery V, Toublanc M, Bertrand G, Boccon-Gibod L, Henin D and Grandchamp B: Absence of microsatellite instability in transitional cell carcinoma of the bladder. Urology 55: 287-290, 2000.
5. Jin T-X, Furihata M, Yamasaki I, Kamada M, Liang S-B, Ohtsuki Y and Shuin T: Human mismatch repair gene (hMSH2) product expression in relation to recurrence of transitional cell carcinoma of the urinary bladder. Cancer 85: 478-484, 1999.
6. Catto J, Xinarianos G, Burton J, Meuth M and Hamdy F: Differential expression of hMLH1 and hMSH2 is related to bladder cancer, stage and prognosis but not microsatellite instability. Int J Cancer 105: 484-490, 2003.
7. Liya Gu, Jianxin Wu, Bei-Bei Zhu and Guo-Min Li: Deficiency of a novel mismatch repair activity in a bladder tumor cell line. Nucleic Acids Res 30: 2758-2763, 2002.
8. Amira N, Rivet J, Soliman H, Cancel-tassin G, Le Due A, Janin A and Cussenot O: Microsatellite instability in urothelial carcinoma of the upper urinary tract. J Urol 170: 1151-1154, 2003.
9. Aarnio M, Sankila R, Pukkala E, Salovaara R, Aaltonen LA, de la Chapelle A, Peltomaki P, Mecklin JP and Jarvinen HJ: Cancer risk in mutation carriers of DNA-mismatch-repair genes. Int J Cancer 81: 214-218, 1999.
10. Leach F: Molecular genetics of urothelial malignancies: mismatch repair genes as markers for detection and prognosis? Urol Oncol 6: 211-219, 2001.
11. Thykjaer T, Christensen M, Clark AB, Hansen LRT, Kunkel TA and Orntoft TF: Functional analysis of the mismatch repair system in bladder cancer. Br J Cancer 85: 568-575, 2001.
12. World Health Organization Classification of Tumours: Pathology and Genetics. Tumours of the Urinary System and Male Genital Organs. Eble JN, Sauter G, Epstein JI and Sesterhenn IA (eds.). IARC Press, Lyon, 2004.
13. Christensen M, Jensen M, Wolf H and Orntoft T: Pronounced microsatellite instability in transitional cell carcinomas from young patients with bladder cancer. Int J Cancer 79: 396-401, 1998.
14. Murata H, Khattar N, Kang Y, Gu L and Li G-M: Genetic and epigenetic modification of mismatch repair genes hMSH2 and hMLH1 in sporadic breast cancer with microsatellite instability. Oncogene 21: 5696-5703, 2002.
15. Marcus VA, Mandlensky L, Gryfe R, Kim H, So K, Millar A, Temple LK, Hsieh E, Hiruki T, Narod S, Bapat BV, Gallinger S and Redston M: Immunohistochemistry for hMLH1 and hMSH2: a practical test for DNA mismatch repair-deficient tumors. Am J Surg Pathol 23: 1248-1255, 1999.
16. Maruyma A, Miyamoto S, Saito T, Kondo H, Baba H and Tsukamoto N: Clinicopathologic and familial characteristics of endometrial carcinoma with multiple primary carcinomas in relation to the loss of protein expression of MSH2 and MLH1. Cancer 91: 2056-2064, 2001.
17. Tada Y, Wada M, Taguchi K, Mochida Y, Kinugawa N, Tsuneyoshi M, Naito S and Kuwano M: The association of death-associated protein kinase hypermethylation with early recurrence in superficial bladder cancers. Cancer Res 62: 4048-4053, 2002.
18. Sardi I, Bartoletti R, Occhini I, Piazzini M, Travaglini F, Guazzelli R and Montali E: Microsatellite alterations in superficial and locally advanced transitional cell carcinoma of the bladder. Oncol Rep 6: 901-905, 1999.
19. Giannopoulou I, Nakopoulou L, Zervas A, Lazaris AC, Stravodimos C, Giannopoulos A and Davaris PS: Immunohistochemical study of proapoptotic factors Bax, Fas and CPP32 in urinary bladder cancer: prognostic implications. Urol Res 30: 342-345, 2002.
20. Yanamadala S and Ljungman M: Potential role of MLH1 in the induction of p53 and apoptosis by blocking transcription on damaged DNA templates. Mol Cancer Res 1: 747-754, 2003.