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Volumn 20, Issue 8, 2013, Pages 1135-1144

Enzogenol for cognitive functioning in traumatic brain injury: A pilot placebo-controlled RCT

Author keywords

Brain injury; Neurological disorders; Randomized clinical trial; Rehabilitation; Trauma

Indexed keywords

ENZOGENOL; FLAVONOID; PLACEBO; UNCLASSIFIED DRUG;

EID: 84880132053     PISSN: 13515101     EISSN: 14681331     Source Type: Journal    
DOI: 10.1111/ene.12099     Document Type: Article
Times cited : (54)

References (45)
  • 1
    • 33748785730 scopus 로고    scopus 로고
    • The epidemiology and impact of traumatic brain injury: a brief overview
    • Langlois JA, Rutland-Brown W, Wald MM. The epidemiology and impact of traumatic brain injury: a brief overview. J Head Trauma Rehabil 2006; 21: 375-378.
    • (2006) J Head Trauma Rehabil , vol.21 , pp. 375-378
    • Langlois, J.A.1    Rutland-Brown, W.2    Wald, M.M.3
  • 2
    • 77949574614 scopus 로고    scopus 로고
    • The epidemiology of traumatic brain injury
    • Research Support, N.I.H., Extramural Review]
    • Corrigan JD, Selassie AW, Orman JA. The epidemiology of traumatic brain injury. J Head Trauma Rehabil [Research Support, N.I.H., Extramural Review] 2010; 25: 72-80.
    • (2010) J Head Trauma Rehabil , vol.25 , pp. 72-80
    • Corrigan, J.D.1    Selassie, A.W.2    Orman, J.A.3
  • 3
    • 1442306534 scopus 로고    scopus 로고
    • Mild traumatic brain injury after traffic collisions: a population-based inception cohort study
    • Research Support, Non-US Govt]
    • Cassidy JD, Carroll L, Cote P, Holm L, Nygren A. Mild traumatic brain injury after traffic collisions: a population-based inception cohort study. J Rehabil Med [Research Support, Non-US Govt] 2004; (43 Suppl.): 15-21.
    • (2004) J Rehabil Med , Issue.43 SUPPL. , pp. 15-21
    • Cassidy, J.D.1    Carroll, L.2    Cote, P.3    Holm, L.4    Nygren, A.5
  • 4
    • 0032938743 scopus 로고    scopus 로고
    • One year outcome in mild to moderate head injury: the predictive value of acute injury characteristics related to complaints and return to work
    • van der Naalt J, van Zomeren AH, Sluiter SW, Minderhoud JM. One year outcome in mild to moderate head injury: the predictive value of acute injury characteristics related to complaints and return to work. J Neurol Neurosurg Psychiatry 1999; 66: 207-213.
    • (1999) J Neurol Neurosurg Psychiatry , vol.66 , pp. 207-213
    • van der Naalt, J.1    van Zomeren, A.H.2    Sluiter, S.W.3    Minderhoud, J.M.4
  • 5
    • 43449126506 scopus 로고    scopus 로고
    • Working with a brain injury: personal experiences of returning to work following a mild or moderate brain injury
    • Gilworth G, Eyres S, Carey A, Bhakta B, Tennant A. Working with a brain injury: personal experiences of returning to work following a mild or moderate brain injury. J Rehabil Med 2008; 40: 334-339.
    • (2008) J Rehabil Med , vol.40 , pp. 334-339
    • Gilworth, G.1    Eyres, S.2    Carey, A.3    Bhakta, B.4    Tennant, A.5
  • 6
    • 38549148489 scopus 로고    scopus 로고
    • Consequences of mild traumatic brain injury on information processing assessed with attention and short-term memory tasks
    • Malojcic B, Mubrin Z, Coric B, Susnic M, Spilich GJ. Consequences of mild traumatic brain injury on information processing assessed with attention and short-term memory tasks. J Neurotrauma 2008; 25: 30-37.
    • (2008) J Neurotrauma , vol.25 , pp. 30-37
    • Malojcic, B.1    Mubrin, Z.2    Coric, B.3    Susnic, M.4    Spilich, G.J.5
  • 7
    • 79959707187 scopus 로고    scopus 로고
    • Long-term outcomes after uncomplicated mild traumatic brain injury: a comparison with trauma controls
    • Comparative Study Research Support, Non-US Govt]
    • Ponsford J, Cameron P, Fitzgerald M, Grant M, Mikocka-Walus A. Long-term outcomes after uncomplicated mild traumatic brain injury: a comparison with trauma controls. J Neurotrauma [Comparative Study Research Support, Non-US Govt] 2011; 28: 937-946.
    • (2011) J Neurotrauma , vol.28 , pp. 937-946
    • Ponsford, J.1    Cameron, P.2    Fitzgerald, M.3    Grant, M.4    Mikocka-Walus, A.5
  • 8
    • 57749114508 scopus 로고    scopus 로고
    • A systematic review of psychological treatments for mild traumatic brain injury: an update on the evidence
    • Snell DL, Surgenor LJ, Hay-Smith EJ, Siegert RJ. A systematic review of psychological treatments for mild traumatic brain injury: an update on the evidence. J Clin Exp Neuropsychol 2009; 31: 20-38.
    • (2009) J Clin Exp Neuropsychol , vol.31 , pp. 20-38
    • Snell, D.L.1    Surgenor, L.J.2    Hay-Smith, E.J.3    Siegert, R.J.4
  • 9
    • 84858379943 scopus 로고    scopus 로고
    • Interstitial F(2)-isoprostane 8-iso-PGF(2alpha) as a biomarker of oxidative stress after severe human traumatic brain injury
    • Research Support, Non-US Govt]
    • Clausen F, Marklund N, Lewen A, Enblad P, Basu S, Hillered L. Interstitial F(2)-isoprostane 8-iso-PGF(2alpha) as a biomarker of oxidative stress after severe human traumatic brain injury. J Neurotrauma [Research Support, Non-US Govt] 2012; 29: 766-775.
    • (2012) J Neurotrauma , vol.29 , pp. 766-775
    • Clausen, F.1    Marklund, N.2    Lewen, A.3    Enblad, P.4    Basu, S.5    Hillered, L.6
  • 10
    • 1042301370 scopus 로고    scopus 로고
    • Pathophysiology of cerebral ischemia and brain trauma: similarities and differences
    • Research Support, US Govt, Non-P.H.S. Research Support, US Govt, P.H.S. Review]
    • Bramlett HM, Dietrich WD. Pathophysiology of cerebral ischemia and brain trauma: similarities and differences. J Cereb Blood Flow Metab [Research Support, US Govt, Non-P.H.S. Research Support, US Govt, P.H.S. Review] 2004; 24: 133-150.
    • (2004) J Cereb Blood Flow Metab , vol.24 , pp. 133-150
    • Bramlett, H.M.1    Dietrich, W.D.2
  • 11
    • 0033597564 scopus 로고    scopus 로고
    • Long-term intracerebral inflammatory response after experimental focal brain injury in rat
    • Research Support, Non-US Govt]
    • Holmin S, Mathiesen T. Long-term intracerebral inflammatory response after experimental focal brain injury in rat. NeuroReport [Research Support, Non-US Govt] 1999; 10: 1889-1891.
    • (1999) NeuroReport , vol.10 , pp. 1889-1891
    • Holmin, S.1    Mathiesen, T.2
  • 12
    • 7944233053 scopus 로고    scopus 로고
    • Long-term intracerebral inflammatory response after traumatic brain injury
    • Research Support, N.I.H., Extramural]
    • Gentleman SM, Leclercq PD, Moyes L, et al. Long-term intracerebral inflammatory response after traumatic brain injury. Forensic Sci Int [Research Support, N.I.H., Extramural] 2004; 146: 97-104.
    • (2004) Forensic Sci Int , vol.146 , pp. 97-104
    • Gentleman, S.M.1    Leclercq, P.D.2    Moyes, L.3
  • 13
    • 21544437887 scopus 로고    scopus 로고
    • A review of the effectiveness of antioxidant therapy to reduce neuronal damage in acute traumatic brain injury
    • Rigg JL, Elovic EP, Greenwald BD. A review of the effectiveness of antioxidant therapy to reduce neuronal damage in acute traumatic brain injury. J Head Trauma Rehabil 2005; 20: 389-391.
    • (2005) J Head Trauma Rehabil , vol.20 , pp. 389-391
    • Rigg, J.L.1    Elovic, E.P.2    Greenwald, B.D.3
  • 14
    • 30444450708 scopus 로고    scopus 로고
    • Dietary curcumin counteracts the outcome of traumatic brain injury on oxidative stress, synaptic plasticity, and cognition
    • Wu A, Ying Z, Gomez-Pinilla F. Dietary curcumin counteracts the outcome of traumatic brain injury on oxidative stress, synaptic plasticity, and cognition. Exp Neurol 2006; 197: 309-317.
    • (2006) Exp Neurol , vol.197 , pp. 309-317
    • Wu, A.1    Ying, Z.2    Gomez-Pinilla, F.3
  • 15
    • 84864088071 scopus 로고    scopus 로고
    • Hydrogen-rich saline protects against oxidative damage and cognitive deficits after mild traumatic brain injury
    • Hou Z, Luo W, Sun X, et al. Hydrogen-rich saline protects against oxidative damage and cognitive deficits after mild traumatic brain injury. Brain Res Bull 2012; 88: 560-565.
    • (2012) Brain Res Bull , vol.88 , pp. 560-565
    • Hou, Z.1    Luo, W.2    Sun, X.3
  • 16
    • 0042236910 scopus 로고    scopus 로고
    • ® with vitamin C on protein oxidation and DNA damage in older human subjects
    • ® with vitamin C on protein oxidation and DNA damage in older human subjects. Nutr Res 2003; 23: 1199-1210.
    • (2003) Nutr Res , vol.23 , pp. 1199-1210
    • Senthilmohan, S.T.1    Zhang, J.2    Stanley, R.A.3
  • 17
    • 0037512459 scopus 로고    scopus 로고
    • Pilot study on the clinical effects of dietary supplementation with Enzogenol, a flavonoid extract of pine bark and vitamin C
    • Shand B, Strey C, Scott R, Morrison Z, Gieseg S. Pilot study on the clinical effects of dietary supplementation with Enzogenol, a flavonoid extract of pine bark and vitamin C. Phytother Res 2003; 17: 490-494.
    • (2003) Phytother Res , vol.17 , pp. 490-494
    • Shand, B.1    Strey, C.2    Scott, R.3    Morrison, Z.4    Gieseg, S.5
  • 19
    • 0036094703 scopus 로고    scopus 로고
    • Antioxidant activity of procyanidin-containing plant extracts at different pHs
    • Wood JE, Senthilmohan ST, Peskin AV. Antioxidant activity of procyanidin-containing plant extracts at different pHs. Food Chem 2002; 77: 155-161.
    • (2002) Food Chem , vol.77 , pp. 155-161
    • Wood, J.E.1    Senthilmohan, S.T.2    Peskin, A.V.3
  • 20
    • 29744441933 scopus 로고    scopus 로고
    • Comparative effects of enzogenol and vitamin C supplementation versus vitamin C alone on endothelial function and biochemical markers of oxidative stress and inflammation in chronic smokers
    • Young JM, Shand BI, McGregor PM, Scott RS, Frampton CM. Comparative effects of enzogenol and vitamin C supplementation versus vitamin C alone on endothelial function and biochemical markers of oxidative stress and inflammation in chronic smokers. Free Radic Res 2006; 40: 85-94.
    • (2006) Free Radic Res , vol.40 , pp. 85-94
    • Young, J.M.1    Shand, B.I.2    McGregor, P.M.3    Scott, R.S.4    Frampton, C.M.5
  • 21
    • 52649172732 scopus 로고    scopus 로고
    • Improved cognitive performance after dietary supplementation with a Pinus Radiata bark extract formulation
    • Pipingas A, Silberstein RB, Vitetta L, et al. Improved cognitive performance after dietary supplementation with a Pinus Radiata bark extract formulation. Phytother Res 2008; 22: 1168-1174.
    • (2008) Phytother Res , vol.22 , pp. 1168-1174
    • Pipingas, A.1    Silberstein, R.B.2    Vitetta, L.3
  • 22
    • 33645983596 scopus 로고    scopus 로고
    • Use of a pine bark extract and antioxidant vitamin combination product as therapy for migraine in patients refractory to pharmacologic medication
    • Chayasirisobhon S. Use of a pine bark extract and antioxidant vitamin combination product as therapy for migraine in patients refractory to pharmacologic medication. Headache 2006; 46: 788-793.
    • (2006) Headache , vol.46 , pp. 788-793
    • Chayasirisobhon, S.1
  • 23
    • 77955498539 scopus 로고    scopus 로고
    • Beyond antioxidants: the cellular and molecular interactions of flavonoids and how these underpin their actions on the brain
    • Research Support, Non-US Govt Review]
    • Spencer JPE. Beyond antioxidants: the cellular and molecular interactions of flavonoids and how these underpin their actions on the brain. Proc Nutr Soc [Research Support, Non-US Govt Review] 2010; 69: 244-260.
    • (2010) Proc Nutr Soc , vol.69 , pp. 244-260
    • Spencer, J.P.E.1
  • 24
    • 77956585898 scopus 로고    scopus 로고
    • Methodological issues and research recommendations for mild traumatic brain injury: the WHO Collaborating Centre Task Force on Mild Traumatic Brain Injury
    • WHO Collaborating Centre Task Force on Mild Traumatic Brain I
    • Carroll LJ, Cassidy JD, Holm L, Kraus J, Coronado VG, WHO Collaborating Centre Task Force on Mild Traumatic Brain I. Methodological issues and research recommendations for mild traumatic brain injury: the WHO Collaborating Centre Task Force on Mild Traumatic Brain Injury. J Rehabil Med 2004; (43 Suppl.): 113-125.
    • (2004) J Rehabil Med , Issue.43 SUPPL. , pp. 113-125
    • Carroll, L.J.1    Cassidy, J.D.2    Holm, L.3    Kraus, J.4    Coronado, V.G.5
  • 26
    • 0016391336 scopus 로고
    • Assessment of coma and impaired consciousness: a practical scale
    • Teasdale G, Jennett B. Assessment of coma and impaired consciousness: a practical scale. Lancet 1974; 2: 81-84.
    • (1974) Lancet , vol.2 , pp. 81-84
    • Teasdale, G.1    Jennett, B.2
  • 27
    • 2342481159 scopus 로고    scopus 로고
    • Use of the Westmead PTA scale to monitor recovery of memory after mild head injury
    • Ponsford J, Willmott C, Rothwell A, Kelly A-M, Nelms R, Ng KT. Use of the Westmead PTA scale to monitor recovery of memory after mild head injury. Brain Inj 2004; 18: 603-614.
    • (2004) Brain Inj , vol.18 , pp. 603-614
    • Ponsford, J.1    Willmott, C.2    Rothwell, A.3    Kelly, A.-M.4    Nelms, R.5    Ng, K.T.6
  • 28
    • 0022462489 scopus 로고
    • Preliminary validation of a scale for measuring the duration of post-traumatic amnesia
    • Shores EA, Marosszeky JE, Sandanam J, Batchelor J. Preliminary validation of a scale for measuring the duration of post-traumatic amnesia. Med J Aust 1986; 144: 569-572.
    • (1986) Med J Aust , vol.144 , pp. 569-572
    • Shores, E.A.1    Marosszeky, J.E.2    Sandanam, J.3    Batchelor, J.4
  • 29
    • 56749157609 scopus 로고    scopus 로고
    • Ischemic stroke subtypes and associated risk factors: a French population-based study
    • Bejot Y, Caillier M, Ben Salem D, et al. Ischemic stroke subtypes and associated risk factors: a French population-based study. J Neurol Neurosurg Psychiatry 2008; 79: 1344-1348.
    • (2008) J Neurol Neurosurg Psychiatry , vol.79 , pp. 1344-1348
    • Bejot, Y.1    Caillier, M.2    Ben Salem, D.3
  • 31
    • 55449088675 scopus 로고    scopus 로고
    • Trends in head injury incidence in New Zealand: a hospital-based study from 1997/1998 to 2003/2004
    • Barker-Collo SL, Wilde NJ, Feigin VL. Trends in head injury incidence in New Zealand: a hospital-based study from 1997/1998 to 2003/2004. Neuroepidemiology 2009; 32: 32-39.
    • (2009) Neuroepidemiology , vol.32 , pp. 32-39
    • Barker-Collo, S.L.1    Wilde, N.J.2    Feigin, V.L.3
  • 33
    • 0036654806 scopus 로고    scopus 로고
    • The cognitive failures questionnaire revisited: dimensions and correlates
    • Wallace JC, Kass SJ, Stanny CJ. The cognitive failures questionnaire revisited: dimensions and correlates. J Gen Psychol 2002; 129: 238-256.
    • (2002) J Gen Psychol , vol.129 , pp. 238-256
    • Wallace, J.C.1    Kass, S.J.2    Stanny, C.J.3
  • 37
    • 28544439044 scopus 로고    scopus 로고
    • Construct validity and reliability of the rivermead post-concussion symptoms questionnaire
    • Eyres S, Carey A, Gilworth G, Neumann V, Tennant A. Construct validity and reliability of the rivermead post-concussion symptoms questionnaire. Clin Rehabil 2005; 19: 878-887.
    • (2005) Clin Rehabil , vol.19 , pp. 878-887
    • Eyres, S.1    Carey, A.2    Gilworth, G.3    Neumann, V.4    Tennant, A.5
  • 38
    • 0029166124 scopus 로고
    • The rivermead post concussion symptoms questionnaire: a measure of symptoms commonly experienced after head injury and its reliability
    • King NS, Crawford S, Wenden FJ, Moss NE, Wade DT. The rivermead post concussion symptoms questionnaire: a measure of symptoms commonly experienced after head injury and its reliability. J Neurol 1995; 242: 587-592.
    • (1995) J Neurol , vol.242 , pp. 587-592
    • King, N.S.1    Crawford, S.2    Wenden, F.J.3    Moss, N.E.4    Wade, D.T.5
  • 39
    • 0020527558 scopus 로고
    • The hospital anxiety and depression scale
    • Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand 1983; 67: 361-370.
    • (1983) Acta Psychiatr Scand , vol.67 , pp. 361-370
    • Zigmond, A.S.1    Snaith, R.P.2
  • 40
    • 59649127338 scopus 로고    scopus 로고
    • Validity of the hospital anxiety & depression scale to assess depression & anxiety following traumatic brain injury as compared with the structured clinical interview for DSM-IV
    • Whelan-Goodinson R, Ponsford J, Schonberger M. Validity of the hospital anxiety & depression scale to assess depression & anxiety following traumatic brain injury as compared with the structured clinical interview for DSM-IV. J Affect Disord 2009; 114: 94-102.
    • (2009) J Affect Disord , vol.114 , pp. 94-102
    • Whelan-Goodinson, R.1    Ponsford, J.2    Schonberger, M.3
  • 42
    • 0033883484 scopus 로고    scopus 로고
    • Estimation of skeletal muscle mass by bioelectrical impedance analysis
    • Janssen I, Heymsfield SB, Baumgartner RN, Ross R. Estimation of skeletal muscle mass by bioelectrical impedance analysis. J Appl Physiol 2000; 89: 465-471.
    • (2000) J Appl Physiol , vol.89 , pp. 465-471
    • Janssen, I.1    Heymsfield, S.B.2    Baumgartner, R.N.3    Ross, R.4
  • 43
    • 84880131625 scopus 로고    scopus 로고
    • Quantifying treatment effects when flexibly modeling individual change in a nonlinear mixed effects model
    • Gallop RJ, Dimidjian S, Atkins DC, Muggeo V. Quantifying treatment effects when flexibly modeling individual change in a nonlinear mixed effects model. J Data Sci 2011; 9: 221-241.
    • (2011) J Data Sci , vol.9 , pp. 221-241
    • Gallop, R.J.1    Dimidjian, S.2    Atkins, D.C.3    Muggeo, V.4
  • 44
    • 79961135005 scopus 로고    scopus 로고
    • R Development Core Team. R Vienna, Austria: R Foundation for Statistical Computing
    • R Development Core Team. R: A Language and Environment for Statistical Computing. R Vienna, Austria: R Foundation for Statistical Computing, 2011.
    • (2011) R: A Language and Environment for Statistical Computing
  • 45
    • 84880135989 scopus 로고    scopus 로고
    • the R Development Core Team. nlme: linear and nonlinear mixed effects models. R package version 3
    • Pinheiro J, Bates D, DebRoy S, Sarkar D, the R Development Core Team. nlme: linear and nonlinear mixed effects models. R package version 3. 2011: 1-102.
    • (2011) , pp. 1-102
    • Pinheiro, J.1    Bates, D.2    DebRoy, S.3    Sarkar, D.4


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