Construction, affinity maturation, and biological characterization of an anti-tumor-associated glycoprotein-72 humanized antibody

Journal of Biological Chemistry

Volumn 281, Issue 11, 2006, Pages 6985-6992

  Sun, Ok Yoon ^a   Tae, Sup Lee ^b   Sang, Jick Kim ^a   Myung, Hee Jang ^a   Young, Jun Kang ^a   Jae, Hyun Park ^a   Kim, Keun Soo ^a   Hyun, Sil Lee ^a   Chun, Jeih Ryu ^a   Gonzales, Noreen R ^c   Kashmiri, Syed V S ^c   Sang, Moo Lim ^b   Chang, Woon Choi ^b   Hyo, Jeong Hong ^a  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b Korea Institute of Radiation and Medical Science   (South Korea)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; CARCINOGENS; DIAGNOSIS; GRAFTING (CHEMICAL); TISSUE; TUMORS;

BIOLOGICAL CHARACTERIZATION; GLYCOPROTEIN-72; HUMAN CANCERS; HUMANIZED ANTIBODY;

ONCOLOGY;

MONOCLONAL ANTIBODY CC49; PROTEIN ANTIBODY; TUMOR ASSOCIATED GLYCOPROTEIN 72 ANTIBODY; UNCLASSIFIED DRUG; ANTIBODY; GLYCOPROTEIN; IMMUNOGLOBULIN G; ISOPROTEIN; RECOMBINANT PROTEIN; TUMOR ANTIGEN; TUMOR ASSOCIATED ANTIGEN 72; TUMOR-ASSOCIATED ANTIGEN 72;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY AFFINITY; ARTICLE; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG DETERMINATION; DRUG INHIBITION; FEMALE; GERM LINE; HEAVY CHAIN; HUMAN; HUMAN CELL; IMMUNOGENICITY; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PROCESSING; SURFACE PLASMON RESONANCE; ADENOCARCINOMA; AMINO ACID SEQUENCE; ANIMAL; BAGG ALBINO MOUSE; BINDING COMPETITION; CANCER TRANSPLANTATION; CELL STRAIN COS1; CERCOPITHECUS; CHEMISTRY; CONFORMATION; DOSE RESPONSE; ESCHERICHIA COLI; GENETIC VARIABILITY; IMMUNOLOGY; KINETICS; METABOLISM; MOLECULAR GENETICS; POLYMERASE CHAIN REACTION; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; TIME; TISSUE DISTRIBUTION; TUMOR CELL LINE;

MURINAE;

ADENOCARCINOMA; AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES; ANTIGENS, NEOPLASM; BINDING, COMPETITIVE; CELL LINE, TUMOR; CERCOPITHECUS AETHIOPS; COMPLEMENTARITY DETERMINING REGIONS; COS CELLS; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; ESCHERICHIA COLI; FEMALE; GLYCOPROTEINS; HUMANS; IMMUNOGLOBULIN G; KINETICS; MICE; MICE, INBRED BALB C; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; NEOPLASM TRANSPLANTATION; POLYMERASE CHAIN REACTION; PROTEIN BINDING; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SURFACE PLASMON RESONANCE; TIME FACTORS; TISSUE DISTRIBUTION; VARIATION (GENETICS);

EID: 33646382846     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M511165200     Document Type: Article

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