Selective roles for toll-like receptors 2, 4, and 9 in systemic inflammation and immune dysfunction following peripheral tissue injury

Journal of Trauma and Acute Care Surgery

Volumn 74, Issue 6, 2013, Pages 1454-1461

  Darwiche, Sophie S ^a   Ruan, Xiangcai ^a,b   Hoffman, Marcus K ^a   Zettel, Kent R ^a   Tracy, Aaron P ^a   Schroeder, Linda M I ^a,c   Cai, Changchun ^a   Hoffman, Rosemary A ^a   Scott, Melanie J ^a   Pape, Hans Christoph ^a,c   Billiar, Timothy R ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b GUANGZHOU FIRST PEOPLE'S HOSPITAL   (China)

^c UNIVERSITY OF AACHEN MEDICAL CENTER   (Germany)

Author keywords

Immune dysfunction; Injury; Lymphocyte; Mouse; Toll like receptor

Indexed keywords

BIOLOGICAL MARKER; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE RELEASE; INFLAMMATION; LIVER INJURY; MOUSE; MUSCLE INJURY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SPLEEN CELL; SUPPRESSOR CELL; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; T LYMPHOCYTE; TISSUE INJURY; UPREGULATION;

ANIMALS; IMMUNITY; INTERLEUKIN-6; LIVER; MALE; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, KNOCKOUT; SIGNAL TRANSDUCTION; SOFT TISSUE INJURIES; SPLEEN; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTOR 9;

EID: 84880108827     PISSN: 21630755     EISSN: 21630763     Source Type: Journal    
DOI: 10.1097/TA.0b013e3182905ed2     Document Type: Article

References (38)

1. Xiao W, Mindrinos MN, Seok J, Cuschieri J, Cuenca AG, Gao H, Hayden DL, Hennessy L, Moore EE, Minei JP, et al. Inflammation and Host Response to Injury Large-Scale Collaborative Research Program. A genomic storm in critically injured humans. J Exp Med. 2011;208:2581-2590.
2. Flohé SB, Flohé S, Schade FU. Invited review: deterioration of the immune system after trauma: signals and cellular mechanisms. Innate Immun. 2008;14:333-344.
3. Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol. 2010;11:373-384.
4. Kaczorowski DJ, Mollen KP, Edmonds R, Billiar TR. Early events in the recognition of danger signals after tissue injury. J Leukoc Biol. 2008;83: 546-552.
5. Stoecklein VM, Osuka A, Lederer JA. Trauma equals dangerVdamage control by the immune system. J Leukoc Biol. 2012;92:539-551.
6. Manson J, Thiemermann C, Brohi K. Trauma alarmins as activators of damage-induced inflammation. Br J Surg. 2012;99(Suppl 1):12-20.
7. Hoth JJ, Hudson WP, Brownlee NA, Yoza BK, Hiltbold EM, Meredith JW, McCall CE. Toll-like receptor 2 participates in the response to lung injury in a murine model of pulmonary contusion. Shock. 2007;28:447-452.
8. DeMaria EJ, Pellicane JV, Lee RB. Hemorrhagic shock in endotoxinresistant mice: improved survival unrelated to deficient production of tumor necrosis factor. J Trauma. 1993;35:720-724.
9. Gill R, Ruan X, Menzel CL, Namkoong S, Loughran P, Hackam DJ, Billiar TR. Systemic inflammation and liver injury following hemorrhagic shock and peripheral tissue trauma involve functional TLR9 signaling on bone marrowYderived cells and parenchymal cells. Shock. 2011;35:164-170.
10. Tabeta K, Georgel P, Janssen E, Du X, Hoebe K, Crozat K, Mudd S, Shamel L, Sovath S, Goode J, et al. Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc Natl Acad Sci U S A. 2004;101:3516-3521.
11. Menzel CL, Pfeifer R, Darwiche SS, Kobbe P, Gill R, Shapiro RA, Loughran P, Vodovotz Y, Scott MJ, Zenati MS, et al. Models of lower extremity damage in mice: time course of organ damage and immune response. J Surg Res. 2011;166:e149-e156.
12. Darwiche SS, Kobbe P, Pfeifer R, Kohut L, Pape H, Billiar T. Pseudofracture: an acute peripheral tissue trauma model. J Vis Exp. 2011;50:2074. Available at: http://www.jove.com/details.php?id=2074.
13. Darwiche SS, Pfeifer R, Menzel C, Ruan X, Hoffman M, Cai C, Chanthaphavong RS, Loughran P, Pitt BR, Hoffman R, et al. Inducible nitric oxide synthase contributes to immune dysfunction following trauma. Shock. 2012;38:499-507.
14. Kobbe P, Kaczorowski DJ, Vodovotz Y, Tzioupis CH, Mollen KP, Billiar TR, Pape HC. Local exposure of bone components to injured soft tissue induces Toll-like receptor 4Ydependent systemic inflammation with acute lung injury. Shock. 2008;30:686-691.
15. Brune IB, Wilke W, Hensler T, Holzmann B, Siewert JR. Downregulation of T helper type 1 immune response and altered pro-inflammatory and antiinflammatory T cell cytokine balance following conventional but not laparoscopic surgery. Am J Surg. 1999;177:55-60.
16. Prince JM, Levy RM, Yang R, Mollen KP, Fink MP, Vodovotz Y, Billiar TR. Toll-like receptor-4 signaling mediates hepatic injury and systemic inflammation in hemorrhagic shock. J Am Coll Surg. 2006;202:407-417.
17. Levy RM, Prince JM, Yang R, Mollen KP, Liao H, Watson GA, Fink MP, Vodovotz Y, Billiar TR. Systemic inflammation and remote organ damage following bilateral femur fracture requires Toll-like receptor 4. Am J Physiol Regul Integr Comp Physiol. 2006;291:R970-R976.
18. Kaczorowski DJ, Nakao A, Vallabhaneni R, Mollen KP, Sugimoto R, Kohmoto J, Zuckerbraun BS, McCurry KR, Billiar TR. Mechanisms of Toll-like receptor 4 (TLR4)Ymediated inflammation after cold ischemia/reperfusion in the heart. Transplantation. 2009;87:1455-1463.
19. Barsness KA, Arcaroli J, Harken AH, Abraham E, Banerjee A, Reznikov L, McIntyre RC. Hemorrhage-induced acute lung injury is TLR-4 dependent. Am J Physiol Regul Integr Comp Physiol. 2004;287:R592-R599.
20. Tsung A, Hoffman RA, Izuishi K, Critchlow ND, Nakao A, Chan MH, Lotze MT, Geller DA, Billiar TR. Hepatic ischemia/reperfusion injury involves functional TLR4 signaling in nonparenchymal cells. J Immunol. 2005;175:7661-7668.
21. Oyama J, Blais C Jr, Liu X, Pu M, Kobzik L, Kelly RA, Bourcier T. Reduced myocardial ischemia-reperfusion injury in toll-like receptor 4-deficient mice. Circulation. 2004;109:784-789.
22. Cairns BA, Barnes CM, Mlot S, Meyer AA, Maile R. Toll-like receptor 2 and 4 ligation results in complex altered cytokine profiles early and late after burn injury. J Trauma. 2008;64:1069-1077.
23. Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo H, Matsumoto M, Hoshino K, Wagner H, Takeda K, et al. A Toll-like receptor recognizes bacterial DNA. Nature. 2000;408:740-745.
24. Zhang Q, Raoof M, Chen Y, Sumi Y, Sursal T, Junger W, Brohi K, Itagaki K, Hauser CJ. Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature. 2010;464:104-107.
25. Abdelsadik A, Trad A. Toll-like receptors on the fork roads between innate and adaptive immunity. Hum Immunol. 2011;72:1188-1193.
26. Medzhitov R. Toll-like receptors and innate immunity. Nat Rev Immunol. 2001;1:135-145.
27. Kabelitz D. Expression and function of Toll-like receptors in T lymphocytes. Curr Opin Immunol. 2007;19:39-45.
28. Caramalho I, Lopes-Carvalho T, Ostler D, Zelenay S, Haury M, Demengeot J. Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide. J Exp Med. 2003;197:403-411.
29. Gelman AE, Zhang J, Choi Y, Turka LA. Toll-like receptor ligands directly promote activated CD4+ T cell survival. J Immunol. 2004;172:6065-6073.
30. Imanishi T, Hara H, Suzuki S, Suzuki N, Akira S, Saito T. Cutting edge: TLR2 directly triggers Th1 effector functions. J Immunol. 2007;178: 6715-6719.
31. Landrigan A, Wong MT, Utz PJ. CpG and non-CpG oligodeoxynucleotides directly costimulate mouse and human CD4+ T cells through a TLR9- and MyD88-independent mechanism. J Immunol. 2011;187:3033-3043.
32. Kawasaki T, Choudhry MA, Schwacha MG, Bland KI, Chaudry IH. Effect of interleukin-15 on depressed splenic dendritic cell functions following trauma-hemorrhage. Am J Physiol Cell Physiol. 2009;296:C124-C130.
33. Versteeg D, Dol E, Hoefer IE, Flier S, Buhre WF, de Kleijn D, van Dongen EP, Pasterkamp G, de Vries JP. Toll-like receptor 2 and 4 response and expression on monocytes decrease rapidly in patients undergoing arterial surgery and are related to preoperative smoking. Shock. 2009;31:21-27.
34. Patenaude J, D'Elia M, Hamelin C, Bernier J. Selective effect of burn injury on splenic CD11c(+) dendritic cells and CD8alpha(+)CD4(-) CD11c(+) dendritic cell subsets. Cell Mol Life Sci. 2010;67:1315-1329.
35. Bunt SK, Clements VK, Hanson EM, Sinha P, Ostrand-Rosenberg S. Inflammation enhances myeloid-derived suppressor cell cross-talk by signaling through Toll-like receptor 4. J Leukoc Biol. 2009;85:996-1004.
36. Zoglmeier C, Bauer H, Nörenberg D, Wedekind G, Bittner P, Sandholzer N, Rapp M, Anz D, Endres S, Bourquin C. CpG blocks immunosuppression by myeloid-derived suppressor cells in tumor-bearing mice. Clin Cancer Res. 2011;17:1765-1775.
37. Shirota H, Klinman DM. Effect of CpG ODN on monocytic myeloid derived suppressor cells. Oncoimmunology. 2012;1:780-782.
38. Makarenkova VP, Bansal V, Matta BM, Perez LA, Ochoa JB. CD11b+/Gr-1+ myeloid suppressor cells cause T cell dysfunction after traumatic stress. J Immunol. 2006;176:2085-2094.