Reversal of multidrug resistance in gastric cancer cells by CDX2 downregulation

World Journal of Gastroenterology

Volumn 19, Issue 26, 2013, Pages 4155-4165

  Yan, Lin Hai ^a   Wang, Xiao Tong ^a   Yang, Jie ^b   Lian, Chao ^a   Kong, Fan Biao ^a   Wei, Wei Yuan ^a   Luo, Wen ^a   Xiao, Qiang ^a   Xie, Yu Bo ^a  

^a FIRST AFFILIATED HOSPITAL OF GUANGXI MEDICAL UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF GUANGXI UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Drug resistance; Gastric cancer; Homeobox gene CDX2; Murine model; RNA interference

Indexed keywords

CISPLATIN; CYCLIN D1; DOXORUBICIN; FLUOROURACIL; SMALL INTERFERING RNA; SURVIVIN; TRANSCRIPTION FACTOR CDX2;

APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE; CELL CYCLE PROGRESSION; CELL VIABILITY; CHEMOLUMINESCENCE; CONTROLLED STUDY; DOWN REGULATION; DRUG SENSITIVITY; EFFUSION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; MULTIDRUG RESISTANCE; NICK END LABELING; ONCOGENE C MYC; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH CANCER; TUMOR VOLUME; WESTERN BLOTTING;

EID: 84880097674     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v19.i26.4155     Document Type: Article

References (30)

1. Zhao J, Gregersen H. Relationships of CDXs and apical sodium-dependent bile acid transporter in Barrett's esophagus. World J Gastroenterol 2013; 19: 2736-2739 [PMID: 23687410 DOI: 10.3748/wjg. v19. i18.2736]
2. Guo RJ, Suh ER, Lynch JP. The role of Cdx proteins in intestinal development and cancer. Cancer Biol Ther 2004; 3: 593-601 [PMID: 15136761 DOI: 10.4161/cbt.3.7.91310.4161/cbt.3.7.913]
3. Guo M, House MG, Suzuki H, Ye Y, Brock MV, Lu F, Liu Z, Rustgi AK, Herman JG. Epigenetic silencing of CDX2 is a feature of squamous esophageal cancer. Int J Cancer 2007; 121: 1219-1226 [PMID: 17534889 DOI: 10.1002/ijc.22828]
4. Witek ME, Nielsen K, Walters R, Hyslop T, Palazzo J, Schulz S, Waldman SA. The putative tumor suppressor Cdx2 is overexpressed by human colorectal adenocarcinomas. Clin Cancer Res 2005; 11: 8549-8556 [PMID: 16361536 DOI: 10.1158/1078-0432. CCR-05-1624]
5. Grimminger P, Ling FC, Neiss S, Vallböhmer D, Lurje G, Schneider PM, Hölscher AH, Metzger R, Brabender J. The role of the homeobox genes BFT and CDX2 in the pathogenesis of non-small cell lung cancer. Anticancer Res 2009; 29: 1281-1286 [PMID: 19414376]
6. Dang LH, Chen F, Ying C, Chun SY, Knock SA, Appelman HD, Dang DT. CDX2 has tumorigenic potential in the human colon cancer cell lines LOVO and SW48. Oncogene 2006; 25: 2264-2272 [PMID: 16314840 DOI: 10.1038/sj. onc.1209247]
7. Barros R, da Costa LT, Pinto-de-Sousa J, Duluc I, Freund JN, David L, Almeida R. CDX2 autoregulation in human intestinal metaplasia of the stomach: impact on the stability of the phenotype. Gut 2011; 60: 290-298 [PMID: 21148572 DOI: 10.1136/gut.2010.222323]
8. Almeida R, Silva E, Santos-Silva F, Silberg DG, Wang J, De Bolós C, David L. Expression of intestine-specific transcription factors, CDX1 and CDX2, in intestinal metaplasia and gastric carcinomas. J Pathol 2003; 199: 36-40 [PMID: 12474224 DOI: 10.1002/path.1246]
9. Mutoh H, Sakurai S, Satoh K, Tamada K, Kita H, Osawa H, Tomiyama T, Sato Y, Yamamoto H, Isoda N, Yoshida T, Ido K, Sugano K. Development of gastric carcinoma from intestinal metaplasia in Cdx2-transgenic mice. Cancer Res 2004; 64: 7740-7747 [PMID: 15520178 DOI: 10.1158/0008-5472. CAN-04-1617]
10. Takakura Y, Hinoi T, Oue N, Sasada T, Kawaguchi Y, Okajima M, Akyol A, Fearon ER, Yasui W, Ohdan H. CDX2 regulates multidrug resistance 1 gene expression in malignant intestinal epithelium. Cancer Res 2010; 70: 6767-6778 [PMID: 20699370 DOI: 10.1158/0008-5472. CAN-09-4701]
11. Xie Y, Li L, Wang X, Qin Y, Qian Q, Yuan X, Xiao Q. Overexpression of Cdx2 inhibits progression of gastric cancer in vitro. Int J Oncol 2010; 36: 509-516 [PMID: 20043087]
12. Fan K, Fan D, Cheng LF, Li C. Expression of multidrug resistance-related markers in gastric cancer. Anticancer Res 2000; 20: 4809-4814 [PMID: 11205224]
13. Wang XT, Xie YB, Xiao Q. siRNA targeting of Cdx2 inhibits growth of human gastric cancer MGC-803 cells. World J Gastroenterol 2012; 18: 1903-1914 [PMID: 22563170 DOI: 10.3748/ wjg. v18. i16.1903]
14. Fan D, Liu X. New progresses in researches on multidrug resistance in gastric cancer. Chin J Digest 2000; 20: 77-78
15. Chuman Y, Sumizawa T, Takebayashi Y, Niwa K, Yamada K, Haraguchi M, Furukawa T, Akiyama S, Aikou T. Expression of the multidrug-resistance-associated protein (MRP) gene in human colorectal, gastric and non-small-cell lung carcinomas. Int J Cancer 1996; 66: 274-279 [PMID: 8603824 DOI: 10.1002/(SICI)1097-0215(19960410)66:]
16. Matsuhashi N, Saio M, Matsuo A, Sugiyama Y, Saji S. The evaluation of gastric cancer sensitivity to 5-FU/CDDP in terms of induction of apoptosis: time-and p53 expressiondependency of anti-cancer drugs. Oncol Rep 2005; 14: 609-615 [PMID: 16077963]
17. Han Y, Han ZY, Zhou XM, Shi R, Zheng Y, Shi YQ, Miao JY, Pan BR, Fan DM. Expression and function of classical protein kinase C isoenzymes in gastric cancer cell line and its drug-resistant sublines. World J Gastroenterol 2002; 8: 441-445 [PMID: 12046066]
18. Xiao B, Shi YQ, Zhao YQ, You H, Wang ZY, Liu XL, Yin F, Qiao TD, Fan DM. Transduction of Fas gene or Bcl-2 antisense RNA sensitizes cultured drug resistant gastric cancer cells to chemotherapeutic drugs. World J Gastroenterol 1998; 4: 421-425 [PMID: 11819336]
19. Minchinton AI, Tannock IF. Drug penetration in solid tumours. Nat Rev Cancer 2006; 6: 583-592 [PMID: 16862189 DOI: 10.1038/nrc1893]
20. Cappellini A, Chiarini F, Ognibene A, McCubrey JA, Martelli AM. The cyclin-dependent kinase inhibitor roscovitine and the nucleoside analog sangivamycin induce apoptosis in caspase-3 deficient breast cancer cells independent of caspase mediated P-glycoprotein cleavage: implications for therapy of drug resistant breast cancers. Cell Cycle 2009; 8: 1421-1425 [PMID: 19342873 DOI: 10.4161/cc.8.9.8323]
21. Sherbakova EA, Stromskaia TP, Rybalkina EIu, Kalita OV, Stavrovskaia AA. [Role of PTEN protein in multidrug resistance of prostate cancer cells]. Mol Biol (Mosk) 2008; 42: 487-493 [PMID: 18702307]
22. Ma L, Jüttner M, Kullak-Ublick GA, Eloranta JJ. Regulation of the gene encoding the intestinal bile acid transporter ASBT by the caudal-type homeobox proteins CDX1 and CDX2. Am J Physiol Gastrointest Liver Physiol 2012; 302: G123-G133 [PMID: 22016432 DOI: 10.1152/ajpgi.00102.2011]
23. Brabletz T, Spaderna S, Kolb J, Hlubek F, Faller G, Bruns CJ, Jung A, Nentwich J, Duluc I, Domon-Dell C, Kirchner T, Freund JN. Down-regulation of the homeodomain factor Cdx2 in colorectal cancer by collagen type I: an active role for the tumor environment in malignant tumor progression. Cancer Res 2004; 64: 6973-6977 [PMID: 15466189 DOI: 10.1158/0008-5472. CAN-04-1132]
24. Kornmann M, Danenberg KD, Arber N, Beger HG, Danenberg PV, Korc M. Inhibition of cyclin D1 expression in human pancreatic cancer cells is associated with increased chemosensitivity and decreased expression of multiple chemoresistance genes. Cancer Res 1999; 59: 3505-3511 [PMID: 10416617]
25. Sicari BM, Troxell R, Salim F, Tanwir M, Takane KK, Fiaschi-Taesch N. c-myc and skp2 coordinate p27 degradation, vascular smooth muscle proliferation, and neointima formation induced by the parathyroid hormone-related protein. Endocrinology 2012; 153: 861-872 [PMID: 22210745 DOI: 10.1210/en.2011-1590]
26. Tsubaki M, Satou T, Itoh T, Imano M, Komai M, Nishinobo M, Yamashita M, Yanae M, Yamazoe Y, Nishida S. Overexpression of MDR1 and survivin, and decreased Bim expression mediate multidrug-resistance in multiple myeloma cells. Leuk Res 2012; 36: 1315-1322 [PMID: 22819074 DOI: 10.1016/j. leukres.2012.07.003]
27. Hochhauser D, Schnieders B, Ercikan-Abali E, Gorlick R, Muise-Helmericks R, Li WW, Fan J, Banerjee D, Bertino JR. Effect of cyclin D1 overexpression on drug sensitivity in a human fibrosarcoma cell line. J Natl Cancer Inst 1996; 88: 1269-1275 [PMID: 8797766 DOI: 10.1093/jnci/88.18.1269]
28. Kornmann M, Arber N, Korc M. Inhibition of basal and mitogen-stimulated pancreatic cancer cell growth by cyclin D1 antisense is associated with loss of tumorigenicity and potentiation of cytotoxicity to cisplatinum. J Clin Invest 1998; 101: 344-352 [PMID: 9435306 DOI: 10.1172/JCI1323]
29. Wang X. The expanding role of mitochondria in apoptosis. Genes Dev 2001; 15: 2922-2933 [PMID: 11711427]
30. Hagenbuchner J, Kuznetsov AV, Obexer P, Ausserlechner MJ. BIRC5/Survivin enhances aerobic glycolysis and drug resistance by altered regulation of the mitochondrial fusion/ fission machinery. Oncogene 2012; Epub ahead of print [PMID: 23146905]