The cyclin-dependent kinase inhibitor roscovitine and the nucleoside analog sangivamycin induce apoptosis in caspase-3 deficient breast cancer cells independent of caspase mediated P-glycoprotein cleavage: Implications for therapy of drug resistant breast cancers

Cell Cycle

Volumn 8, Issue 9, 2009, Pages 1421-1425

  Cappellini, Alessandra ^a   Chiarini, Francesca ^b   Ognibene, Andrea ^c   McCubrey, James A ^d   Martelli, Alberto M ^b,e  

^a UNIVERSITY OF CASSINO AND SOUTHERN LAZIO   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

^d EAST CAROLINA UNIVERSITY   (United States)

^e CNR   (Italy)

Author keywords

Apoptosis; Breast cancer; Caspase 3; Cleavage; Drug resistance; P glycoprotein; Roscovitine

Indexed keywords

CASPASE 3; CASPASE 6; CASPASE 7; COMPLEMENTARY DNA; GLYCOPROTEIN P; RECOMBINANT ENZYME; ROSCOVITINE; SANGIVAMYCIN;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CANCER THERAPY; CELL STRAIN MCF 7; CONTROLLED STUDY; DNA TRANSFECTION; DRUG SENSITIVITY; ENZYME ACTIVATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; PROTEIN CLEAVAGE; STRAIN DIFFERENCE; WILD TYPE;

EID: 65949118693     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.8.9.8323     Document Type: Article

References (32)

1. Yuan H, Li X, Wu J, Li J, Qu X, Xu W, Tang W. Strategies to overcome or circumvent P-glycoprotein mediated multidrug resistance. Curr Med Chem 2008; 15:470-476
2. Sharom FJ. ABC multidrug transporters: structure, function and role in chemoresistance. Pharmacogenomics 2008; 9:105-127
3. Strizzi L, Abbott DE, Salomon DS, Hendrix MJ. Potential for cripto-1 in defining stem cell-like characteristics in human malignant melanoma. Cell Cycle 2008; 7:1931-1935.
4. Zhou J, Zhang Y. Cancer stem cells: Models, mechanisms and implications for improved treatment. Cell Cycle 2008; 7:1360-1370
5. Borst P, Jonkers J, Rottenberg S. What makes tumors multidrug resistant? Cell Cycle 2007; 6:2782-2787
6. Ruefli AA, Tainton KM, Darcy PK, Smyth MJ, Johnstone RW. P-glycoprotein inhibits caspase-8 activation but not formation of the death inducing signal complex (disc) following Fas ligation. Cell Death Differ 2002; 9:1266-1272 (Pubitemid 35331774)
7. Tainton KM, Smyth MJ, Jackson JT, Tanner JE, Cerruti L, Jane SM, et al. Mutational analysis of P-glycoprotein: suppression of caspase activation in the absence of ATP-dependent drug efflux. Cell Death Differ 2004; 11:1028-1037
8. Johnstone RW, Cretney E, Smyth MJ. P-glycoprotein protects leukemia cells against caspase-dependent, but not caspase-independent, cell death. Blood 1999; 93:1075-1085 (Pubitemid 29067874)
9. Taylor RC, Cullen SP, Martin SJ. Apoptosis: controlled demolition at the cellular level. Nat Rev Mol Cell Biol 2008; 9:231-241
10. Nica AF, Tsao CC, Watt JC, Jiffar T, Kurinna S, Jurasz P, et al. Ceramide promotes apoptosis in chronic myelogenous leukemia-derived K562 cells by a mechanism involving caspase-8 and JNK. Cell Cycle 2008; 7:3362-3370
11. Bin Hafeez B, Asim M, Siddiqui IA, Adhami VM, Murtaza I, Mukhtar H. Delphinidin, a dietary anthocyanidin in pigmented fruits and vegetables: a new weapon to blunt prostate cancer growth. Cell Cycle 2008; 7:3320-3326
12. Stegh AH, Chin L, Louis DN, DePinho RA. What drives intense apoptosis resistance and propensity for necrosis in glioblastoma? A role for Bcl2L12 as a multifunctional cell death regulator. Cell Cycle 2008; 7:2833-2839
13. Baptiste-Okoh N, Barsotti AM, Prives C. Caspase 2 is both required for p53-mediated apoptosis and downregulated by p53 in a p21-dependent manner. Cell Cycle 2008; 7:1133-1138
14. Mantovani I, Cappellini A, Tazzari PL, Papa V, Cocco L, Martelli AM. Caspase-dependent cleavage of 170-kDa P-glycoprotein during apoptosis of human T-lymphoblastoid CEM cells. J Cell Physiol 2006; 207:836-844 (Pubitemid 43668249)
15. Fantappie O, Solazzo M, Lasagna N, Platini F, Tessitore L, Mazzanti R. P-glycoprotein mediates celecoxib-induced apoptosis in multiple drug-resistant cell lines. Cancer Res 2007; 67:4915-4923 (Pubitemid 46910199)
16. Lavrik IN, Golks A, Krammer PH. Caspases: pharmacological manipulation of cell death. J Clin Invest 2005; 115:2665-2672 (Pubitemid 41434390)
17. Loo TW, Bartlett MC, Clarke DM. Transmembrane segment 1 of human P-glycoprotein contributes to the drug-binding pocket. Biochem J 2006; 396:537-545 (Pubitemid 44228168)
18. L- expressing MCF7-Fas cells: role for the bifunctional apoptosis regulator protein. J Biol Chem 2002; 277:4351-4360
19. Lee SA, Jung M. The nucleoside analog sangivamycin induces apoptotic cell death in breast carcinoma MCF7/adriamycin-resistant cells via protein kinase Cδ and JNK activation. J Biol Chem 2007; 282:15271-15283 (Pubitemid 47093380)
20. Hildinger M, Fehse B, Hegewisch-Becker S, John J, Rafferty JR, Ostertag W, Baum C. Dominant selection of hematopoietic progenitor cells with retroviral MDR1 co-expression vectors. Human Gene Ther 1998; 9:33-42. (Pubitemid 28050908)
21. Papa V, Tazzari PL, Chiarini F, Cappellini A, Ricci F, Billi AM, et al. Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells. Leukemia 2008; 22:147-160
22. Tazzari PL, Tabellini G, Bortul R, Papa V, Evangelisti C, Grafone T, et al. The insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 induces apoptosis in acute myeloid leukemia cells exhibiting autocrine insulin-like growth factor-I secretion. Leukemia 2007; 21:886-896 (Pubitemid 46672063)
23. Chiarini F, Del Sole M, Mongiorgi S, Gaboardi GC, Cappellini A, Mantovani I, et al. The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism. Leukemia 2008; 22:1106-1116
24. Fala F, Blalock WL, Tazzari PL, Cappellini A, Chiarini F, Martinelli G, et al. Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor (2S)-1-(1H-Indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl] oxyprop an2-amine (A443654) in T-cell acute lymphoblastic leukemia. Mol Pharmacol 2008; 74:884-895
25. Wesierska-Gadek J, Gueorguieva M, Horky M. Roscovitine-induced upregulation of p53AIP1 protein precedes the onset of apoptosis in human MCF-7 breast cancer cells. Mol Cancer Ther 2005; 4:113-124 (Pubitemid 40276781)
26. Janicke RU, Sprengart ML, Wati MR, Porter AG. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. J Biol Chem 1998; 273:9357-9360 (Pubitemid 28183012)
27. Devarajan E, Sahin AA, Chen JS, Krishnamurthy RR, Aggarwal N, Brun AM, et al. Downregulation of caspase 3 in breast cancer: a possible mechanism for chemoresistance. Oncogene 2002; 21:8843-8851
28. Bush JA, Li G. Regulation of the Mdr1 isoforms in a p53-deficient mouse model. Carcinogenesis 2002; 23:1603-1607 (Pubitemid 35214944)
29. Walther W, Stein U, Schlag PM. Use of the human MDR1 promoter for heat-inducible expression of therapeutic genes. Int J Cancer 2002; 98:291-296 (Pubitemid 34150816)
30. Bettayeb K, Oumata N, Echalier A, Ferandin Y, Endicott JA, Galons H, et al. CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases. Oncogene 2008; 27:5797-5807
31. Whittaker SR, Te Poele RH, Chan F, Linardopoulos S, Walton MI, Garrett MD, et al. The cyclin-dependent kinase inhibitor seliciclib (R-roscovitine; CYC202) decreases the expression of mitotic control genes and prevents entry into mitosis. Cell Cycle 2007; 6:3114-3131
32. Hunt T. You never know: Cdk inhibitors as anti-cancer drugs. Cell Cycle 2008; 7:3789-3790