Thioredoxin 1 is responsible for antibody disulfide reduction in CHO cell culture

Journal of Biotechnology

Volumn 157, Issue 1, 2012, Pages 261-267

  Koterba, Kristen L ^a   Borgschulte, Trissa ^b   Laird, Michael W ^a  

^a GENENTECH INC   (United States)

^b Sigma Aldrich Co   (United States)

Author keywords

CHO K1; Disulfide bonds; Manufacturing; Monoclonal antibodies; Thioredoxin

Indexed keywords

CHINESE HAMSTER OVARY CELLS; CHO-K1; DISULFIDE BONDS; DISULFIDE REDUCTION; LARGE-SCALE MANUFACTURING; SHORT HAIRPIN RNA; THIOREDOXINS;

CELLS; COVALENT BONDS; MAMMALS; MANUFACTURE; MONOCLONAL ANTIBODIES; RNA;

CELL CULTURE;

DISULFIDE; IMMUNOGLOBULIN G1; SHORT HAIRPIN RNA; THIOREDOXIN 1;

ANIMAL CELL; ARTICLE; CELL DENSITY; CHO CELL; DISULFIDE BOND; FEMALE; HUMAN; HUMAN CELL; LENTIVIRINAE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRAL GENE DELIVERY SYSTEM;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; BASE SEQUENCE; CELL PROLIFERATION; CELL SURVIVAL; CHO CELLS; CRICETINAE; CRICETULUS; DISULFIDES; HUMANS; IMMUNOGLOBULIN G; LENTIVIRUS; MOLECULAR SEQUENCE DATA; OXIDATION-REDUCTION; PROTEIN ENGINEERING; RNA INTERFERENCE; RNA, SMALL INTERFERING; THIOREDOXINS; TRANSFECTION;

CRICETULUS GRISEUS; LENTIVIRUS; MAMMALIA;

EID: 84855249027     PISSN: 01681656     EISSN: 18734863     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2011.11.009     Document Type: Article

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