Effect of the light chain C-terminal serine residue on disulfide bond susceptibility of human immunoglobulin G1λ

Analytical Biochemistry

Volumn 408, Issue 2, 2011, Pages 277-283

  Liu, Hongcheng ^a   Zhong, Suju ^a   Chumsae, Chris ^a   Radziejewski, Czeslaw ^a   Hsieh, Chung Ming ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Alkylation; Disulfide bonds; Human IgG; Mass spectrometry

Indexed keywords

ALKYLATION; ANTIBODIES; CARBON DISULFIDE; COVALENT BONDS; MASS SPECTROMETRY; REDUCTION;

ALANINE RESIDUES; CYSTEINE RESIDUES; DISULFIDE BONDS; HUMAN IGG; HUMAN IMMUNOGLOBULIN; INTERCHAIN DISULFIDE BONDS; MASS SPECTROMETRY ANALYSIS; NATURAL ISOTOPES;

AMINO ACIDS;

ALANINE; CARBON 13; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G1 LAMBDA; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LAMBDA CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; IODOACETIC ACID; SERINE; UNCLASSIFIED DRUG;

ALKYLATION; AMINO ACID SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; MOLECULAR WEIGHT; PRIORITY JOURNAL; REDUCTION; TANDEM MASS SPECTROMETRY;

EID: 78149412950     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2010.09.025     Document Type: Article

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