Distinct role of Pyk2 in mediating thromboxane generation downstream of both G12/13 and integrin αIIbβ3 in platelets

Journal of Biological Chemistry

Volumn 288, Issue 25, 2013, Pages 18194-18203

  Kim, Soochong ^a   Cipolla, Lina ^a   Guidetti, Gianni ^a,c   Okigaki, Mitsuhiko ^b   Jin, Jianguo ^a   Torti, Mauro ^a   Kunapuli, Satya P ^a,b  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PAVIA   (Italy)

^c KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRINS; SIGNALING EVENTS; TYROSINE KINASE;

AMINO ACIDS; INDIUM PLATING;

PLATELETS;

2 METHYLTHIOADENOSINE DIPHOSPHATE; ADENOSINE DIPHOSPHATE; ALANINYLTYROSYLPROLYLGLYCYLLYSYLPHENYLALANINE; FIBRINOGEN RECEPTOR ANTAGONIST; FOCAL ADHESION KINASE 2; FOCAL ADHESION KINASE INHIBITOR; INTEGRIN; INTEGRIN ALPHA2BETA3; PROTEIN G12; PROTEIN G13; REGULATOR PROTEIN; THROMBOXANE A2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME INHIBITION; FATTY ACID SYNTHESIS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LIPID INTERACTION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; THROMBOCYTE;

ADP; G12/13; INTEGRIN; PLATELETS; PYK2; SIGNAL TRANSDUCTION; THROMBIN; THROMBOXANE;

ADENOSINE DIPHOSPHATE; ANIMALS; BLOOD PLATELETS; BLOTTING, WESTERN; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; FOCAL ADHESION KINASE 2; GTP-BINDING PROTEIN ALPHA SUBUNITS, G12-G13; HUMANS; MICE; MICE, KNOCKOUT; OLIGOPEPTIDES; PHOSPHORYLATION; PLATELET AGGREGATION; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; SIGNAL TRANSDUCTION; THIONUCLEOTIDES; THROMBOXANE A2; TIME FACTORS; TYRPHOSTINS;

EID: 84880066605     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.461087     Document Type: Article

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