Interventions for replacing missing teeth: different times for loading dental implants

Cochrane Database of Systematic Reviews

Volumn 2013, Issue 3, 2013, Pages

  Esposito, Marco ^a   Grusovin, Maria Gabriella ^b   Maghaireh, Hassan ^a   Worthington, Helen V ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b Private practice   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN; NEXT GENERATION SEQUENCING; OSSEOINTEGRATION; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROSTHESIS COMPLICATION; RESOURCE ALLOCATION; REVIEW; RISK ASSESSMENT; SENSITIVITY ANALYSIS; SYSTEMATIC REVIEW; TOOTH DISEASE; TOOTH IMPLANTATION; BONE DENSITY; BONE REGENERATION; MANDIBLE; MATERIALS TESTING; META ANALYSIS; PERIODONTAL DISEASE; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL (TOPIC); TIME; TOOTH IMPLANT;

BONE DENSITY; DENTAL IMPLANTATION, ENDOSSEOUS; DENTAL IMPLANTS; HUMANS; IMMEDIATE DENTAL IMPLANT LOADING; MANDIBLE; MATERIALS TESTING; OSSEOINTEGRATION; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TIME FACTORS; TOOTH LOSS;

MLCS; MLOWN;

EID: 84880058221     PISSN: None     EISSN: 1469493X     Source Type: Journal    
DOI: 10.1002/14651858.CD003878.pub5     Document Type: Review

References (97)

1. Assad AS, Hassan SA, Shawky YM, Badawy MM. Clinical and radiographic evaluation of implant-retained mandibular overdentures with immediate loading. Implant Dentistry 2007;16(2):212-23.
2. Cannizzaro G, Leone M. Restoration of partially edentulous patients using dental implants with a microtextured surface: a prospective comparison of delayed and immediate full occlusal loading. International Journal of Oral and Maxillofacial Implants 2003;18(4):512-22.
3. Cannizzaro G, Leone M, Esposito M. Immediate versus early loading of two implants placed with a flapless technique supporting mandibular bar-retained overdentures: a single-blinded, randomised controlled clinical trial. European Journal of Oral Implantology 2008;1(1):33-43.
4. Cannizzaro G, Torchio C, Leone M, Esposito M. Immediate versus early loading of flapless-placed implants supporting maxillary full-arch prostheses: a randomised controlled clinical trial. European Journal of Oral Implantology 2008;1(2):127-39.
5. Cannizzaro G, Felice P, Leone M, Ferri V, Viola P, Esposito M. Immediate versus early loading of 6.5 mm-long flapless-placed single implants: a 4-year after loading report of a split-mouth randomised controlled trial. European Journal of Oral Implantology 2012;5(2):111-21.
6. Cannizzaro G, Leone M, Torchio C, Viola P, Esposito M. Immediate versus early loading of 7 mm long flapless-placed single implants: a split-mouth randomised controlled clinical trial. European Journal of Oral Implantology 2008;1(4):277-92.
7. Cannizzaro G, Torchio C, Felice P, Leone M, Esposito M. Immediate occlusal versus non-occlusal loading of single zirconia implants. A multicenter pragmatic randomised clinical trial. European Journal of Oral Implantology 2010;3(2):111-20.
8. Chiapasco M, Abati S, Romeo E, Vogel G. Implant-retained mandibular overdentures with Branemark System MKII implants: a prospective comparative study between delayed and immediate loading. The International Journal of Oral and Maxillofacial Implants 2001;16(4):537-46.
9. Crespi R, Capparé P, Gherlone E, Romanos GE. Immediate versus delayed loading of dental implants placed in fresh extraction sockets in the maxillary esthetic zone: a clinical comparative study. The International Journal of Oral and Maxillofacial Implants 2008;23(4):753-8.
10. den Hartog L, Raghoebar GM, Stellingsma K, Vissink A, Meijer HJ. Immediate non-occlusal loading of single implants in the aesthetic zone: a randomized clinical trial. Journal of Clinical Periodontology 2011;38(2):186-94.
11. De Rouck T, Collys K, Wyn I, Cosyn J. Instant provisionalization of immediate single-tooth implants is essential to optimize esthetic treatment outcome. Clinical Oral Implants Research 2009;20(6):566-70.
12. Donati M, La Scala V, Billi M, Di Dino B, Torrisi P, Berglundh T. Immediate functional loading of implants in single tooth replacement: a prospective clinical multicenter study. Clinical Oral Implants Research 2008;19(8):740-8.
13. Albrecht D, Marki L, Fabiam M, Bayer S, Stark H, Mericske-Stern R, Enkling N. Impact of implant-retained-overdentures on OHRQoL: immediate- vs. delayed-loading (Abstract 076). Clinical Oral Implant Research. 2011; Vol. 22:913.
14. Enkling N, Albrecht D, Bayer S, Stark H, Mericske-Stern R. [Immediate loading of interforaminal implants using a chairside fabricated bur (oral presentation)]. Clinical Oral Implants Research. 2010; Vol. 21:1013.
15. Fischer K, Stenberg T. Early loading of ITI implants supporting a maxillary full-arch prosthesis: 1-year data of a prospective, randomized study. The International Journal of Oral and Maxillofacial Implants 2004;19(3):374-81.
16. Fischer K, Stenberg T. Three-year data from a randomized, controlled study of early loading of single-stage dental implants supporting maxillary full-arch prostheses. The International Journal of Oral and Maxillofacial Implants 2006;21(2):245-52.
17. Fischer K, Stenberg T, Hedin M, Sennerby L. Five-year results from a randomized, controlled trial on early and delayed loading of implants supporting full-arch prosthesis in the edentulous maxilla. Clinical Oral Implants Research 2008;19(5):433-41.
18. Güncü GN, Tozum TF, Güncü MB, Yamalik N. Relationships between implant stability, image-based measures and nitric oxide levels. Journal of Oral Rehabilitation 2008;35(10):745-53.
19. Güncü GN, Tözüm TF, Güncü MB, Yamalik N, Tumer C. A 12-month evaluation of nitrite oxide metabolism around immediate and conventionally loaded dental implants. Implant Dentistry 2009;18(1):27-37.
20. Güncü GN, Tozum TF, Güncü MB, Yamalik N, Tumer C, Karabulut E, et al.Myeloperoxidase as a measure of polymorphonuclear leukocyte response in inflammatory status around immediately and delayed loaded dental implants: a randomized controlled clinical trial. Clinical Implant Dentistry & Related Research 2008;10(1):30-9.
21. Güncü MB, Aslan Y, Tümer C, Güncü GN, Uysal S. In-patient comparison of immediate and conventional loaded implants in mandibular molar sites within 12 months. Clinical Oral Implants Research 2008;19(4):335-41.
22. Hall J, Payne AG, Purton DG, Torr B, Duncan WJ, De Silva RK. Immediately restored, single tapered implants in the anterior maxilla: prosthodontic and aesthetic outcome after one year. Clinical Implant Dentistry & Related Research 2007;9(1):34-45.
23. Hall JA, Payne AG, Purton DG, Torr B. A randomized controlled clinical trial of conventional and immediately loaded tapered implants with screw-retained crowns. International Journal of Prosthodontics 2006;19(1):17-9.
24. Tan D, Hall J, Duncan W, Thomson WH. Immediate-loading of single-tooth, narrow, tapered Southern implants. http://iadr.confex.com/iadr/anz05/techprogram/abstract_72085.htm 2005:(Abstract No 0099).
25. Lindeboom JA, Frenken JW, Dubois L, Frank M, Abbink I, Kroon FH. Immediate loading versus immediate provisionalization of maxillary single-tooth replacements: a prospective randomized study with BioComp implants. Journal of Oral and Maxillofacial Surgery 2006;64(6):936-42.
26. Meloni SM, De Riu G, Pisano M, De Riu N, Tullio A. Immediate versus delayed loading of single lower molars. One year results from a randomised controlled trial. The European Journal of Oral Implantology 2012;5(4):345-53.
27. Merli M, Bernardelli F, Esposito M. Immediate non-occlusal versus early loading of dental implants placed flapless in partially edentulous patients. Preliminary results from a randomized controlled clinical trial. The International Journal of Periodontics and Restorative Dentistry 2008;28(5):453-9.
28. Merli M, Merli A, Bernardelli F, Lombardini F, Esposito M. Immediate versus early non-occlusal loading of dental implants placed flapless in partially edentulous patients. One-year results from a randomized controlled clinical trial. European Journal of Oral Implantology 2008;1(3):207-20.
29. Merli M, Moscatelli M, Mariotti G, Piemontese M, Nieri M. Immediate versus early non-occlusal loading of dental implants placed flapless in partially edentulous patients: a 3-year randomized clinical trial. Journal of Clinical Periodontology 2012;39(2):196-202.
30. Oh TJ, Shotwell JL, Billy EJ, Wang HL. Effect of flapless implant surgery on soft tissue profile: a randomized controlled clinical trial. Journal of Periodontololgy 2006;77(5):874-82.
31. Payne AG, Tawse-Smith A, Duncan WD, Kumara R. Conventional and early loading of unsplinted ITI implants supporting mandibular overdentures. Clinical Oral Implants Research 2002;13(16):603-9.
32. Romeo E, Chiapasco M, Lazza A, Casentini P, Ghisolfi M, Iorio M, et al.Implant-retained mandibular overdentures with ITI implants: A comparison of 2-year results between delayed and immediate loading. Clinical Oral Implants Research 2002;13(5):495-501.
33. Schincaglia GP, Marzola R, Fazi G, Scapoli C, Scotti R. Replacement of mandibular molars with single-unit restorations supported by wide-body implants: immediate versus delayed loading. A randomized controlled study. International Journal of Oral and Maxillofacial Implants 2008;23(3):474-80.
34. Tawse-Smith A, Payne AG, Kumara R, Thomson WM. Early loading of unsplinted implants supporting mandibular overdentures using a one-stage operative procedure with two different implant systems: a 2-year report. Clinical Implant Dentistry & Related Research 2002;4(1):33-42.
35. Capelli M, Esposito M, Zuffetti F, Galli F, Del Fabbro M, Testori T. A 5-year report from a multicentre randomised clinical trial: immediate non-occlusal versus early loading of dental implants in partially edentulous patients. European Journal of Oral Implantology 2010;3(3):209-19.
36. Galli F, Capelli M, Zuffetti F, Esposito M, Testori T. Immediate non-occlusal vs early loading of dental implants in partially edentulous patients: a multicentre randomized clinical trial. Peri-implant bone and soft-tissue levels. Clinical Oral implants Research 2008;19(6):546-52.
37. Testori T, Galli F, Capelli M, Zuffetti F, Esposito M. Immediate non-occlusal versus early loading of dental implants in partially edentulous patients: 1-year results from a multicenter, randomized controlled clinical trial. The International Journal of Oral and Maxillofacial Implants 2007;22(5):815-22.
38. Turkyilmaz I, Tumer C. Early versus late loading of unsplinted TiUnite surface implants supporting mandibular overdentures: a 2-year report from a prospective study. Journal of Oral Rehabilitation 2007;34(10):773-80.
39. Ganeles J, Zöllner A, Jackowski J, ten Bruggenkate C, Beagle J, Guerra F. Immediate and early loading of Straumann implants with a chemically modified surface (SLActive) in the posterior mandible and maxilla: 1-year results from a prospective multicenter study. Clinical Oral Implants Research 2008;19(11):1119-28.
40. Zöllner A, Ganeles J, Korostoff J, Guerra F, Krafft T, Brägger U. Immediate and early non-occlusal loading of Straumann implants with a chemically modified surface (SLActive) in the posterior mandible and maxilla: interim results from a prospective multicenter randomized-controlled study. Clinical Oral Implants Research 2008;19(5):442-50.
41. Appleton RS, Nummikoski, PV, Pigno MA, Cronin RJ, Chung KH. A radiographic assessment of progressive loading on bone around single osseointegrated implants in the posterior maxilla. Clinical Oral Implants Research 2005;16(2):161-7.
42. Barewal RM, Stanford C, Weesner TC. A randomized controlled clinical trial comparing the effects of three loading protocols on dental implant stability. The International Journal of Oral & Maxillofacial Implants 2012;27(4):945-56.
43. Cannizzaro G, Leone M, Consolo U, Ferri V, Esposito M. Immediate functional loading of implants placed with flapless surgery versus conventional implants in partially edentulous patients. A 3-year randomized controlled clinical trial. The International Journal of Oral and Maxillofacial Implants 2008;23(5):867-75.
44. Degidi M, Nardi D, Piattelli A. Immediate versus one-stage restoration of small-diameter implants for a single missing maxillary lateral incisor: a 3-year randomized clinical trial. Journal of Periodontology 2009;80(9):1393-8.
45. Degidi M, Nardi D, Piattelli A. A comparison between immediate loading and immediate restoration in cases of partial posterior mandibular edentulism: a 3-year randomized clinical trial. Clinical Oral implants Research 2010;21(7):682-7.
46. Göthberg C, Slotte C, Bergendal T, Thomsen P, Suska F, Zoric N, et al.Tissue reactions around implants in fixed partial dentures and evaluation of healing times. A prospective, randomized, controlled study. Ongoing trial.
47. Jokstad A, Ellner S, Gussgard A. Comparison of two early loading protocols in full arch reconstructions in the edentulous maxilla using the Cresco prosthetic system: a three-arm parallel group randomized-controlled trial. Clinical Oral Implants Research 2011;22(5):455-63.
48. Kim YK, Kim SG, Park JY, Yi YJ, Bae JH. Comparison of clinical outcomes of sinus bone graft with simultaneous implant placement: 4-month and 6-month final prosthetic loading. Oral Surgery, Oral Medicine, Oral Pathotology, Oral Radiology, and Endodontics 2011;111(2):164-9.
49. Mackie A, Lyons K, Thomson WM, Payne AG. Mandibular two-implant overdentures: prosthodontic maintenance using different loading protocols and attachment systems. The International Journal of Prosthodontics 2011;24(5):405-16.
50. Ottoni JM, Oliveira ZF, Mansini R, Cabral AM. Correlation between placement torque and survival of single-tooth implants. International Journal of Oral and Maxillofacial Implants 2005;20(5):769-76.
51. Lee H, Polson AM, Salama H, Rose L, Minsk L, Sharkey D, et al.Safety and effectiveness of mandibular implants used in immediate loading: 5-year findings. Journal of Periodontology 2002;73(9, 2002 Annual Meeting Abstract):1091.
52. Lee I, Polson AM, Sharkey D, Polson AP, Salama H, Minsk L, et al.Five-year clinical status of dental implants after immediate loading. Journal of Dental Research 2003;Spec Issue A:(Abstract No 0850).
53. Polson AM, Lee I, Salama H, Minsk L, Sharkey D, Rose L, et al.3-year evaluation of safety and effectiveness of implants used in an immediate loading situation for the edentulous mandible (abstract). Journal of Periodontology 2000;71(12, 2000 Annual Meeting Abstract):1914.
54. Polson AM, Sharkey D, Lee I, Polson AP, Minsk L, Salama H, et al.Three year alveolar bone levels of dental implants after immediate loading. Journal of Dental Research 2001;80(AADR Abstracts):211 (Abstract No 1405).
55. Polson AM, Sharkey D, Minsk L, Lee I, Polson AP, Salama H, et al.Two year alveolar bone levels of dental implants after immediate loading. Journal of Dental Research 2000;79(IADR Abstracts):337 (Abstract No 1550).
56. Polson AM, Sharkey D, Polson AP, Salama H, Minsk L, Rose L, et al.Four year clinical status of dental implants after immediate loading. Journal of Dental Research 2002;81(Spec Issue A):A-101 (Abstract No 0616).
57. Roccuzzo M, Aglietta M, Bunino M, Bonino L. Early loading of sandblasted and acid-etched implants: a randomized-controlled double-blind split-mouth study. Five-year results. Clinical Oral Implants Research 2008;19(2):148-52.
58. Roccuzzo M, Bunino M, Prioglio F, Bianchi SD. Early loading of sandblasted and acid-etched (SLA) implants: a prospective split-mouth comparative study. Clinical Oral Implants Research 2001;12(6):572-8.
59. Romanos GE. Immediate loading in the posterior mandible. A clinical study. Clinical Oral Implants Research 2002;13(4):xxi (Abstract No 52).
60. Romanos GE, Nentwig G-H. Immediate versus delayed functional loading of implants in the posterior mandible: a 2-year prospective clinical study of 12 consecutive cases. The International Journal of Periodontics and Restorative Dentistry in press.
61. Salvi GE, Gallini G, Lang NP. Early loading (2 or 6 weeks) of sandblasted and acid-etched (SLA) ITI(R) implants in the posterior mandible. Clinical Oral Implants Research 2004;15(2):142-9.
62. Shibly O, Kutkut A, Patel N, Albandar JM. Immediate Implants with Immediate Loading vs. Conventional Loading: 1-Year Randomized Clinical Trial. Clinical Implant Dentistry and Related Research 2010;14(5):663-71.
63. Shibly O, Patel N, Albandar JM, Kutkut A. Bone regeneration around implants in periodontally compromised patients: a randomized clinical trial of the effect of immediate implant with immediate loading. Journal of Periodontology 2010;81(12):1743-51.
64. Tealdo T, Bevilacqua M, Menini M, Pera F, Ravera G, Drago C, Pera P. Immediate versus delayed loading of dental implants in edentulous maxillae: a 36-month prospective study. International Journal of Prosthodontics 2011;24(4):294-302.
65. Testori T, Bianchi F, Del Fabbro M, Szmukler-Moncler S, Francetti L, Weinstein RL. Immediate non-occlusal loading vs. early loading in partially edentulous patients. Practical Procedures and Aesthetic Dentistry 2003;15(10):787-94.
66. Turkyilmaz I. Clinical and radiological results of patients treated with two loading protocols for mandibular overdentures on Branemark implants. Journal of Clinical Periodontology 2006;33(3):233-8.
67. Turkyilmaz I, Sennerby L, Tumer C, Yenigul M, Avci M. Stability and marginal bone level measurements of unsplinted implants used for mandibular overdentures: a 1-year randomized prospective clinical study comparing early and conventional loading protocols. Clinical Oral Implants Research 2006;17(5):501-5.
68. Turkyilmaz I, Tözüm TF, Tumer C, Ozbek EN. A 2-year clinical report of patients treated with two loading protocols for mandibular overdentures: early versus conventional loading. Journal of Periodontology 2006;77(12):1998-2004.
69. Van de Velde T, Sennerby L, De Bruyn H. The clinical and radiographic outcome of implants placed in the posterior maxilla with a guided flapless approach and immediately restored with a provisional rehabilitation: a randomized clinical trial. Clinical Oral Implants Research 2010;21(11):1223-33.
70. Albrektsson T, Brånemark PI, Hansson HA, Lindström J. Osseointegrated titanium implants. Requirements for ensuring a long-lasting, direct bone-to-implant anchorage in man. Acta Orthopaedica Scandinavica 1981;52(2):155-70.
71. Alsabeeha N, Atieh M, Payne AG. Loading protocols for mandibular implant overdentures: a systematic review with meta-analysis. Clinical Implant Dentistry and Related Research 2010; Vol. 12 Suppl 1:e28-38.
72. Brunski JB, Moccia AF Jr, Pollack SR, Korostoff E, Trachtenberg DI. The influence of functional use of endosseous dental implants on the tissue-implant interface. I. Histological aspects. Journal of Dental Research 1979;58(10):1953-69.
73. Brånemark P-I, Hansson BO, Adell R, Breine U, Lindström J, Hallén O, et al.Osseointegrated implants in the treatment of the edentulous jaw. Experience from a 10-year period. Stockholm: Almqvist & Wiksell International, 1977.
74. Brånemark PI, Engstrand P, Öhrnell LO, Gröndahl K, Nilsson P, Hagberg K, et al.Brånemark Novum: a new treatment concept for rehabilitation of the edentulous mandible. Preliminary results from a prospective clinical follow-up study. Clinical Implant Dentistry & Related Research 1999;1(1):2-16.
75. Cannizzaro G, Leone M, Ferri V, Viola P, Federico G, Esposito M. Immediate loading of single implants inserted flapless with medium or high insertion torque: a 6-month follow-up of a split-mouth randomised controlled trial. The European Journal of Oral Implantology 2012;5(4):333-42.
76. Chung S, McCullagh A, Irinakis T. Immediate loading in the maxillary arch: evidence-based guidelines to improve success rates: a review. The Journal of Oral Implantology 2011; Vol. 37, issue 5:610-21.
77. Curtin F, Elbourne D, Altman DG. Meta-analysis combining parallel and cross-over clinical trials. II: Binary outcomes. Statistics in Medicine 2002;21(15):2145-59.
78. Del Fabbro M, Testori T, Francetti L, Taschieri S, Weinstein R. Systematic review of survival rates for immediately loaded dental implants. The International Journal of Periodontics and Restorative Dentistry 2006;26(3):249-63.
79. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997;315(7109):629-34.
80. Elbourne DR, Altman DG, Higgins JP, Curtin F, Worthington HV, Vail A. Meta-analyses involving cross-over trials: methodological issues. International Journal of Epidemiology 2002;31(1):140-9.
81. Esposito M, Murray-Curtis L, Grusovin MG, Coulthard P, Worthington HV. Interventions for replacing missing teeth: different types of dental implants. Cochrane Database of Systematic Reviews 2007, Issue 4. [DOI: 10.1002/14651858.CD003815.pub3]
82. Follmann D, Elliott P, Suh I, Cutler J. Variance imputation for overviews of clinical trials with continuous response. Journal of Clinical Epidemiology 1992;45(7):769-73.
83. Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
84. Ioannidou E, Doufexi A. Does loading time affect implant survival? A meta-analysis of 1, 266 implants. Journal of Periodontology 2005;76(8):1252-8.
85. Javed F, Romanos GE. The role of primary stability for successful immediate loading of dental implants. A literature review. Journal of Dentistry 2010; Vol. 38, issue 8:612-20.
86. Jemt T. Regeneration of gingival papillae after single-implant treatment. The International Journal of Periodontics and Restorative Dentistry 1997;17(4):326-33.
87. Lekholm U, Zarb GA. Patient selection and preparation. In: Brånemark P-I, Zarb GA, Albrektsson T editor(s). Tissue integrated prostheses - osseointegration in clinical dentistry. Chicago: Quintessence Publishing Co, 1985:199-209.
88. Romanos G, Froum S, Hery C, Cho SC, Tarnow D. Survival rate of immediately vs delayed loaded implants: analysis of the current literature. The Journal of Oral Implantology 2010; Vol. 36, issue 4:315-24.
89. Schnitman PA, Wöhrle PS, Rubenstein JE. Immediate fixed interim prostheses supported by two-stage threaded implants: methodology and results. Journal of Oral Implantology 1990;16(2):96-105.
90. Schropp L, Isidor F, Kostopoulos L, Wenzel A. Patient experience of, and satisfaction with, delayed-immediate vs. delayed single-tooth implant placement. Clinical Oral Implants Research 2004;15(4):498-503.
91. Sennerby L, Gottlow J. Clinical outcomes of immediate/early loading of dental implants. A literature review of recent controlled prospective clinical studies. Australian Dental Journal 2008;53 Suppl 1:S82-88.
92. Thorlund K, Imberger G, Walsh M, Chu R, Gluud C, Wetterslev J, et al.The number of patients and events required to limit the risk of overestimation of intervention effects in meta-analysis - a simulation study. PLoS One 2011; Vol. 6, issue 10:e25491.
93. Esposito M, Worthington HV, Coulthard P. Interventions for replacing missing teeth: different times for loading dental implants. Cochrane Database of Systematic Reviews 2003, Issue 1. [DOI: 10.1002/14651858.CD003878]
94. Esposito M, Worthington HV, Thomsen P, Coulthard P. Interventions for replacing missing teeth: different times for loading dental implants. Cochrane Database of Systematic Reviews 2004, Issue 3. [DOI: 10.1002/14651858.CD003878.pub2]
95. Esposito M, Grusovin MG, Willings M, Coulthard P, Worthington HV. Interventions for replacing missing teeth: different times for loading dental implants. Cochrane Database of Systematic Reviews 2007, Issue 2. [DOI: 10.1002/14651858.CD003878.pub3]
96. Esposito M, Grusovin MG, Willings M, Coulthard P, Worthington HV. The effectiveness of immediate, early, and conventional loading of dental implants. A Cochrane systematic review of randomized controlled clinical trials. The International Journal of Oral and Maxillofacial Implants 2007;22(6):893-904.
97. Esposito M, Grusovin MG, Achille H, Coulthard P, Worthington HV. Interventions for replacing missing teeth: different times for loading dental implants. Cochrane Database of Systematic Reviews 2009, Issue 1. [DOI: 10.1002/14651858.CD003878.pub4]