-
1
-
-
33846405332
-
Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: A randomized controlled trial
-
Oettle H, Post S, Neuhaus P., et al Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: a randomized controlled trial. JAMA. 2007;297:267-277.
-
(2007)
JAMA
, vol.297
, pp. 267-277
-
-
Oettle, H.1
Post, S.2
Neuhaus, P.3
-
3
-
-
69949106925
-
The double-edged sword of autophagy modulation in cancer
-
White E, DiPaola RS The double-edged sword of autophagy modulation in cancer. Clin Cancer Res. 2009;15:5308-5316.
-
(2009)
Clin Cancer Res.
, vol.15
, pp. 5308-5316
-
-
White, E.1
DiPaola, R.S.2
-
4
-
-
80053634368
-
The dynamic nature of autophagy in cancer
-
Kimmelman AC. The dynamic nature of autophagy in cancer. Genes Dev. 2011;25:1999-2010.
-
(2011)
Genes Dev.
, vol.25
, pp. 1999-2010
-
-
Kimmelman, A.C.1
-
5
-
-
0344142468
-
Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21
-
Aita VM, Liang XH, Murty V.V., et al Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21. Genomics. 1999;59;59-65.
-
(1999)
Genomics.
, vol.59
, pp. 59-65
-
-
Aita, V.M.1
Liang, X.H.2
Murty, V.V.3
-
6
-
-
0000906170
-
Induction of autophagy and inhibition of tumorigenesis by beclin 1
-
Liang XH, Jackson S, Seaman M., et al Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature. 1999;402:672-676.
-
(1999)
Nature.
, vol.402
, pp. 672-676
-
-
Liang, X.H.1
Jackson, S.2
Seaman, M.3
-
7
-
-
50149095124
-
Autophagy is activated in pancreatic cancer cells and correlates with poor patient outcome
-
Fujii S, Mitsunaga S, Yamazaki M., et al Autophagy is activated in pancreatic cancer cells and correlates with poor patient outcome. Cancer Sci. 2008;99:1813-1819.
-
(2008)
Cancer Sci.
, vol.99
, pp. 1813-1819
-
-
Fujii, S.1
Mitsunaga, S.2
Yamazaki, M.3
-
8
-
-
79955166274
-
Clinicopathologic correlation of beclin-1 expression in pancreatic ductal adenocarcinoma
-
Kim HS, Lee SH, Do S.I., et al Clinicopathologic correlation of beclin-1 expression in pancreatic ductal adenocarcinoma. Pathol Res Pract. 2011;207:247-252.
-
(2011)
Pathol Res Pract.
, vol.207
, pp. 247-252
-
-
Kim, H.S.1
Lee, S.H.2
Do, S.I.3
-
9
-
-
79952229430
-
Pancreatic cancers require autophagy for tumor growth
-
Yang S, Wang X, Contino G., et al Pancreatic cancers require autophagy for tumor growth. Genes Dev. 2011;25:717-729.
-
(2011)
Genes Dev.
, vol.25
, pp. 717-729
-
-
Yang, S.1
Wang, X.2
Contino, G.3
-
10
-
-
37549063395
-
Expression of beclin-1, an autophagy-related protein, in gastric and colorectal cancers
-
Ahn CH, Jeong EG, Lee J.W., et al Expression of beclin-1, an autophagy-related protein, in gastric and colorectal cancers. APMIS. 2007;115:1344-1349.
-
(2007)
APMIS
, vol.115
, pp. 1344-1349
-
-
Ahn, C.H.1
Jeong, E.G.2
Lee, J.W.3
-
11
-
-
54849188100
-
LC3, an autophagosome marker, is highly expressed in gastrointestinal cancers
-
Yoshioka A, Miyata H, Doki Y., et al LC3, an autophagosome marker, is highly expressed in gastrointestinal cancers. Int J Oncol. 2008;33:461-468.
-
(2008)
Int J Oncol.
, vol.33
, pp. 461-468
-
-
Yoshioka, A.1
Miyata, H.2
Doki, Y.3
-
12
-
-
58149084586
-
Decreased expression of autophagy-related proteins in Malignant epithelial ovarian cancer
-
Shen Y, Li DD, Wang L.L., et al Decreased expression of autophagy-related proteins in malignant epithelial ovarian cancer. Autophagy. 2008;4:1067-1068.
-
(2008)
Autophagy.
, vol.4
, pp. 1067-1068
-
-
Shen, Y.1
Li, D.D.2
Wang, L.L.3
-
13
-
-
56449107131
-
Association of autophagy defect with a Malignant phenotype and poor prognosis of hepatocellular carcinoma
-
Ding ZB, Shi YH, Zhou J, et al Association of autophagy defect with a malignant phenotype and poor prognosis of hepatocellular carcinoma. Cancer Res. 2008;68:9167-9175.
-
(2008)
Cancer Res.
, vol.68
, pp. 9167-9175
-
-
Ding, Z.B.1
Shi, Y.H.2
Zhou, J.3
-
14
-
-
71049170526
-
Clinicopathologic correlation of beclin-1 and bcl-2 expression in human breast cancer
-
Won KY, Kim GY, Kim Y.W., et al Clinicopathologic correlation of beclin-1 and bcl-2 expression in human breast cancer. Hum Pathol. 2010;41:107-112.
-
(2010)
Hum Pathol.
, vol.41
, pp. 107-112
-
-
Won, K.Y.1
Kim, G.Y.2
Kim, Y.W.3
-
15
-
-
70349641918
-
Beclin-1 expression is a predictor of clinical outcome in patients with esophageal squamous cell carcinoma and correlated to hypoxia-inducible factor (HIF)-1alpha expression
-
Chen Y, Lu Y, Lu C., et al Beclin-1 expression is a predictor of clinical outcome in patients with esophageal squamous cell carcinoma and correlated to hypoxia-inducible factor (HIF)-1alpha expression. Pathol Oncol Res. 2009;15:487-493.
-
(2009)
Pathol Oncol Res.
, vol.15
, pp. 487-493
-
-
Chen, Y.1
Lu, Y.2
Lu, C.3
-
16
-
-
33744988159
-
Autophagy: Is it cancer's friend or foe?
-
Marx J. Autophagy: is it cancer's friend or foe? Science. 2006;312:1160-1161.
-
(2006)
Science
, vol.312
, pp. 1160-1161
-
-
Marx, J.1
-
17
-
-
79954423742
-
Down-regulation of bax-interacting factor 1 in human pancreatic ductal adenocarcinoma
-
Coppola D, Helm J, Ghayouri M., et al Down-regulation of bax-interacting factor 1 in human pancreatic ductal adenocarcinoma. Pancreas. 2011;40:433-437.
-
(2011)
Pancreas.
, vol.40
, pp. 433-437
-
-
Coppola, D.1
Helm, J.2
Ghayouri, M.3
-
18
-
-
33747592333
-
Decreased expression of tumour suppressor bax-interacting factor-1 (Bif-1), a bax activator, in gastric carcinomas
-
Lee JW, Jeong EG, Soung Y.H., et al Decreased expression of tumour suppressor Bax-interacting factor-1 (Bif-1), a Bax activator, in gastric carcinomas. Pathology. 2006;38:312-315.
-
(2006)
Pathology.
, vol.38
, pp. 312-315
-
-
Lee, J.W.1
Jeong, E.G.2
Soung, Y.H.3
-
19
-
-
55849126198
-
Down-regulation of bax-interacting factor-1 in colorectal adenocarcinoma
-
Coppola D, Khalil F, Eschrich S.A., et al Down-regulation of Bax-interacting factor-1 in colorectal adenocarcinoma. Cancer. 2008;113:2665-2670.
-
(2008)
Cancer.
, vol.113
, pp. 2665-2670
-
-
Coppola, D.1
Khalil, F.2
Eschrich, S.A.3
-
20
-
-
27144544082
-
Loss of bif-1 suppresses bax/Bak conformational change and mitochondrial apoptosis
-
Takahashi Y, Karbowski M, Yamaguchi H., et al Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis. Mol Cell Biol. 2005;25:9369-9382.
-
(2005)
Mol Cell Biol.
, vol.25
, pp. 9369-9382
-
-
Takahashi, Y.1
Karbowski, M.2
Yamaguchi, H.3
-
21
-
-
9144240441
-
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
-
Qu X, Yu J, Bhagat G., et al Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest. 2003;112:1809-1820.
-
(2003)
J Clin Invest.
, vol.112
, pp. 1809-1820
-
-
Qu, X.1
Yu, J.2
Bhagat, G.3
-
22
-
-
0345166111
-
Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
-
Yue Z, Jin S, Yang C., et al Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci U S A. 2003;100:15077-15082.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 15077-15082
-
-
Yue, Z.1
Jin, S.2
Yang, C.3
-
23
-
-
34347220473
-
Defining the role of mTOR in cancer
-
Guertin DA, Sabatini DM Defining the role of mTOR in cancer. Cancer Cell. 2007;12:9-22.
-
(2007)
Cancer Cell.
, vol.12
, pp. 9-22
-
-
Guertin, D.A.1
Sabatini, D.M.2
-
25
-
-
66449099090
-
Autophagy suppresses tumorigenesis through elimination of p62
-
Mathew R, Karp CM, Beaudoin B, et al Autophagy suppresses tumorigenesis through elimination of p62. Cell. 2009;137:1062-1075.
-
(2009)
Cell.
, vol.137
, pp. 1062-1075
-
-
Mathew, R.1
Karp, C.M.2
Beaudoin, B.3
-
26
-
-
78650890352
-
Regulation of autophagy by ROS: Physiology and pathology
-
Scherz-Shouval R., Elazar Z. Regulation of autophagy by ROS: physiology and pathology. Trends Biochem Sci. 2011;36:30-38.
-
(2011)
Trends Biochem Sci.
, vol.36
, pp. 30-38
-
-
Scherz-Shouval, R.1
Elazar, Z.2
-
27
-
-
79952228407
-
Activated ras requires autophagy to maintain oxidative metabolism and tumorigenesis
-
Guo JY, Chen HY, Mathew R, et al Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev. 2011;25:460-470.
-
(2011)
Genes Dev.
, vol.25
, pp. 460-470
-
-
Guo, J.Y.1
Chen, H.Y.2
Mathew, R.3
-
28
-
-
0024292722
-
Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes
-
Almoguera C, Shibata D, Forrester K., et al Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell. 1988;53:549-554.
-
(1988)
Cell.
, vol.53
, pp. 549-554
-
-
Almoguera, C.1
Shibata, D.2
Forrester, K.3
-
29
-
-
65249135974
-
Prognostic significance of beclin 1-dependent apoptotic activity in hepatocellular carcinoma
-
Shi YH, Ding ZB, Zhou J, et al Prognostic significance of Beclin 1-dependent apoptotic activity in hepatocellular carcinoma. Autophagy. 2009;5:380-382.
-
(2009)
Autophagy.
, vol.5
, pp. 380-382
-
-
Shi, Y.H.1
Ding, Z.B.2
Zhou, J.3
-
30
-
-
70349649219
-
The prognostic role of beclin 1 protein expression in high-grade gliomas
-
Pirtoli L, Cevenini G, Tini P., et al The prognostic role of Beclin 1 protein expression in high-grade gliomas. Autophagy. 2009;5:930-936.
-
(2009)
Autophagy.
, vol.5
, pp. 930-936
-
-
Pirtoli, L.1
Cevenini, G.2
Tini, P.3
-
31
-
-
79955606244
-
Beclin-1 and LC3A expression in cutaneous Malignant melanomas: A biphasic survival pattern for beclin-1
-
Sivridis E, Koukourakis MI, Mendrinos S.E., et al Beclin-1 and LC3A expression in cutaneous malignant melanomas: a biphasic survival pattern for beclin-1. Melanoma Res. 2011;21:188-195.
-
(2011)
Melanoma Res.
, vol.21
, pp. 188-195
-
-
Sivridis, E.1
Koukourakis, M.I.2
Mendrinos, S.E.3
-
32
-
-
77953708091
-
Elevated beclin 1 expression is correlated with HIF-1alpha in predicting poor prognosis of nasopharyngeal carcinoma
-
Wan XB, Fan XJ, Chen M.Y., et al Elevated Beclin 1 expression is correlated with HIF-1alpha in predicting poor prognosis of nasopharyngeal carcinoma. Autophagy. 2010;6:395-404.
-
(2010)
Autophagy.
, vol.6
, pp. 395-404
-
-
Wan, X.B.1
Fan, X.J.2
Chen, M.Y.3
-
33
-
-
77956524618
-
The role of autophagy in the treatment of pancreatic cancer with gemcitabine and ionizing radiation
-
Mukubou H, Tsujimura T, Sasaki R., et al The role of autophagy in the treatment of pancreatic cancer with gemcitabine and ionizing radiation. Int J Oncol. 2010;37:821-828.
-
(2010)
Int J Oncol.
, vol.37
, pp. 821-828
-
-
Mukubou, H.1
Tsujimura, T.2
Sasaki, R.3
-
34
-
-
0037451783
-
Autophagy: A barrier or an adaptive response to cancer
-
Ogier-Denis E., Codogno P. Autophagy: a barrier or an adaptive response to cancer. Biochim Biophys Acta. 2003;1603:113-128.
-
(2003)
Biochim Biophys Acta.
, vol.1603
, pp. 113-128
-
-
Ogier-Denis, E.1
Codogno, P.2
-
35
-
-
33644606050
-
Detection of autophagy in tissue by standard immunohistochemistry: Possibilities and limitations
-
Martinet W, De Meyer GR, Andries L, et al Detection of autophagy in tissue by standard immunohistochemistry: possibilities and limitations. Autophagy. 2006;2:55-57.
-
(2006)
Autophagy.
, vol.2
, pp. 55-57
-
-
Martinet, W.1
De Meyer, G.R.2
Andries, L.3
-
36
-
-
34250900953
-
LC3, an autophagosome marker, can be incorporated into protein aggregates independent of autophagy: Caution in the interpretation of LC3 localization
-
Kuma A, Matsui M, Mizushima N. LC3, an autophagosome marker, can be incorporated into protein aggregates independent of autophagy: caution in the interpretation of LC3 localization. Autophagy. 2007;3:323-328.
-
(2007)
Autophagy.
, vol.3
, pp. 323-328
-
-
Kuma, A.1
Matsui, M.2
Mizushima, N.3
|