Conditionally unbiased estimation in phase II/III clinical trials with early stopping for futility

Statistics in Medicine

Volumn 32, Issue 17, 2013, Pages 2893-2910

  Kimani, Peter K ^a   Todd, Susan ^b   Stallard, Nigel ^a  

^a UNIVERSITY OF WARWICK   (United Kingdom)

^b UNIVERSITY OF READING   (United Kingdom)

Author keywords

Adaptive seamless designs; Estimation; Phase II III clinical trials

Indexed keywords

ADAPTIVE SEAMLESS DESIGN; ARTICLE; CALCULATION; EARLY TERMINATION OF CLINICAL TRIAL; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; MAXIMUM LIKELIHOOD METHOD; OUTCOME ASSESSMENT; PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); PROBABILITY; PROCESS MODEL; SIMULATION; STUDY DESIGN; SYSTEMATIC ERROR;

EID: 84880046856     PISSN: 02776715     EISSN: 10970258     Source Type: Journal    
DOI: 10.1002/sim.5757     Document Type: Article

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