Shrinkage estimation in two-stage adaptive designs with midtrial treatment selection

Statistics in Medicine

Volumn 32, Issue 10, 2013, Pages 1677-1690

  Carreras, Máximo ^a   Brannath, Werner ^b  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b UNIVERSITY OF BREMEN   (Germany)

Author keywords

Bayes risk; Best linear unbiased predictor (BLUP); Clinical trial; Empirical Bayes; Lindley's estimator; Random effects model; Seamless phase II III design; Selection bias; Selection mean squared error

Indexed keywords

ACCURACY; ALGORITHM; ARTICLE; BAYES THEOREM; LINEAR SYSTEM; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; MAXIMUM LIKELIHOOD METHOD; NORMAL DISTRIBUTION; PREDICTION; SAMPLE SIZE; SIMULATION; STUDY DESIGN; TREATMENT PLANNING;

BAYES THEOREM; BIAS (EPIDEMIOLOGY); BIOSTATISTICS; CLINICAL TRIALS AS TOPIC; CLINICAL TRIALS, PHASE II AS TOPIC; CLINICAL TRIALS, PHASE III AS TOPIC; HUMANS; LIKELIHOOD FUNCTIONS; MODELS, STATISTICAL;

EID: 84876448156     PISSN: 02776715     EISSN: 10970258     Source Type: Journal    
DOI: 10.1002/sim.5463     Document Type: Article

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