Conditional estimation after a two-stage diagnostic biomarker study that allows early termination for futility

Statistics in Medicine

Volumn 31, Issue 5, 2012, Pages 420-435

  Koopmeiners, Joseph S ^a   Feng, Ziding ^b   Pepe, Margaret Sullivan ^b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

Author keywords

Conditional estimation; Diagnostic biomarkers, group sequential design; PPV curve; ROC curve

Indexed keywords

BIOLOGICAL MARKER;

ARTICLE; CONDITIONAL ESTIMATION; CONFIDENCE INTERVAL; DIAGNOSTIC TEST; EARLY TERMINATION FOR FUTILITY; NORMAL DISTRIBUTION; PREDICTIVE VALUE; PROBABILITY; RECEIVER OPERATING CHARACTERISTIC; SAMPLE SIZE; SIMULATION; STATISTICAL ANALYSIS; STATISTICAL CONCEPTS; VARIANCE;

BIAS (EPIDEMIOLOGY); BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; COMPUTER SIMULATION; CONFIDENCE INTERVALS; DATA INTERPRETATION, STATISTICAL; DIAGNOSIS; EARLY TERMINATION OF CLINICAL TRIALS; HUMANS; MEDICAL FUTILITY; MODELS, STATISTICAL; REPRODUCIBILITY OF RESULTS; ROC CURVE;

EID: 84856472139     PISSN: 02776715     EISSN: 10970258     Source Type: Journal    
DOI: 10.1002/sim.4430     Document Type: Article

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