Development of a high-throughput screen and its use in the discovery of Streptococcus pneumoniae immunoglobulin A1 protease inhibitors

Journal of the American Chemical Society

Volumn 135, Issue 27, 2013, Pages 10014-10017

  Garner, Amanda L ^a   Fullagar, Jessica L ^b   Day, Joshua A ^b   Cohen, Seth M ^b   Janda, Kim D ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL CELL SURFACE; COLORIMETRIC ASSAYS; EPITHELIAL CELLS; HIGH-THROUGHPUT SCREENS; PROTEASE INHIBITOR; SCREENING ASSAYS; STREPTOCOCCUS PNEUMONIAE; VIRULENCE FACTORS;

CELL MEMBRANES;

BACTERIA;

IMMUNOGLOBULIN A1 PROTEASE; METALLOPROTEINASE; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

ARTICLE; BACTERIAL CELL; CELL SURFACE; COLORIMETRY; HIGH THROUGHPUT SCREENING; HINGE REGION; HUMAN; IMMUNE SYSTEM; NONHUMAN; PROTEIN DEGRADATION; STREPTOCOCCUS PNEUMONIAE;

BIOLOGICAL PRODUCTS; DOSE-RESPONSE RELATIONSHIP, DRUG; HIGH-THROUGHPUT SCREENING ASSAYS; MOLECULAR STRUCTURE; PROTEASE INHIBITORS; SERINE ENDOPEPTIDASES; STREPTOCOCCUS PNEUMONIAE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84880006286     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja404180x     Document Type: Article

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