Rasip1 mediates Rap1 regulation of Rho in endothelial barrier function through ArhGAP29

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 28, 2013, Pages 11427-11432

  Post, Anneke ^a   Pannekoek, Willem Jan ^a   Ross, Sarah H ^a   Verlaan, Ingrid ^a   Brouwer, Patricia M ^a   Bos, Johannes L ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; ADAPTOR PROTEIN; RAP1 PROTEIN; RAS INTERACTING PROTEIN 1; UNCLASSIFIED DRUG;

ARTICLE; CELL ADHESION; CELL SPREADING; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION;

CELLS, CULTURED; ENDOTHELIUM, VASCULAR; GTPASE-ACTIVATING PROTEINS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; PROTEIN BINDING; RAP1 GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION;

EID: 84879993509     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1306595110     Document Type: Article

References (40)

1. Katagiri K, Maeda A, Shimonaka M, Kinashi T (2003) RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1. Nat Immunol 4(8):741-748. (Pubitemid 36986757)
2. Lafuente EM, et al. (2004) RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion. Dev Cell 7(4):585-595. (Pubitemid 39341843)
3. Lee HS, Lim CJ, Puzon-McLaughlin W, Shattil SJ, Ginsberg MH (2009) RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences. J Biol Chem 284(8):5119-5127.
4. Lyle KS, Raaijmakers JH, Bruinsma W, Bos JL, de Rooij J (2008) cAMP-induced Epac-Rap activation inhibits epithelial cell migration by modulating focal adhesion and leading edge dynamics. Cell Signal 20(6):1104-1116.
5. Ross SH, et al. (2012) Rap1 can bypass the FAK-Src-Paxillin cascade to induce cell spreading and focal adhesion formation. PLoS ONE 7(11):e50072.
6. Cullere X, et al. (2005) Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase. Blood 105(5):1950-1955. (Pubitemid 40731777)
7. Kooistra MR, Corada M, Dejana E, Bos JL (2005) Epac1 regulates integrity of endothelial cell junctions through VE-cadherin. FEBS Lett 579(22):4966-4972. (Pubitemid 41242837)
8. Pannekoek WJ, et al. (2011) Epac1 and PDZ-GEF cooperate in Rap1 mediated endothelial junction control. Cell Signal 23(12):2056-2064.
9. Wittchen ES, Aghajanian A, Burridge K (2011) Isoform-specific differences between Rap1A and Rap1B GTPases in the formation of endothelial cell junctions. Small GTPases 2(2):65-76.
10. Wittchen ES, et al. (2005) Rap1 GTPase inhibits leukocyte transmigration by promoting endothelial barrier function. J Biol Chem 280(12):11675-11682. (Pubitemid 40418482)
11. Knox AL, Brown NH (2002) Rap1 GTPase regulation of adherens junction positioning and cell adhesion. Science 295(5558):1285-1288. (Pubitemid 34157618)
12. Baluk P, Hashizume H, McDonald DM (2005) Cellular abnormalities of blood vessels as targets in cancer. Curr Opin Genet Dev 15(1):102-111. (Pubitemid 40127638)
13. Bazzoni G, Dejana E (2004) Endothelial cell-to-cell junctions: Molecular organization and role in vascular homeostasis. Physiol Rev 84(3):869-901. (Pubitemid 38823769)
14. Weis SM (2008) Vascular permeability in cardiovascular disease and cancer. Curr Opin Hematol 15(3):243-249.
15. Glading A, Han J, Stockton RA, Ginsberg MH (2007) KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell cell junctions. J Cell Biol 179(2):247-254. (Pubitemid 350004889)
16. Glading AJ, Ginsberg MH (2010) Rap1 and its effector KRIT1/CCM1 regulate beta-catenin signaling. Dis Model Mech 3(1-2):73-83.
17. Lorenowicz MJ, Fernandez-Borja M, Kooistra MR, Bos JL, Hordijk PL (2008) PKA and Epac1 regulate endothelial integrity and migration through parallel and independent pathways. Eur J Cell Biol 87(10):779-792.
18. Noda K, et al. (2010) Vascular endothelial-cadherin stabilizes at cell-cell junctions by anchoring to circumferential actin bundles through alpha- and beta-catenins in cyclic AMP-Epac-Rap1 signal-activated endothelial cells. Mol Biol Cell 21(4):584-596.
19. Birukova AA, et al. (2010) Rac GTPase is a hub for protein kinase A and Epac signaling in endothelial barrier protection by cAMP. Microvasc Res 79(2):128-138.
20. Fukuhara S, et al. (2005) Cyclic AMP potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathway. Mol Cell Biol 25(1):136-146. (Pubitemid 40039806)
21. Sehrawat S, Cullere X, Patel S, Italiano J, Jr., Mayadas TN (2008) Role of Epac1, an exchange factor for Rap GTPases, in endothelial microtubule dynamics and barrier function. Mol Biol Cell 19(3):1261-1270. (Pubitemid 351481837)
22. Stockton RA, Shenkar R, Awad IA, Ginsberg MH (2010) Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity. J Exp Med 207(4):881-896.
23. Ross SH, et al. (2011) Ezrin is required for efficient Rap1-induced cell spreading. J Cell Sci 124(Pt 11):1808-1818.
24. Mitin NY, et al. (2004) Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization. J Biol Chem 279(21):22353-22361. (Pubitemid 38679432)
25. Ohba Y, Kurokawa K, Matsuda M (2003) Mechanism of the spatio-temporal regulation of Ras and Rap1. EMBO J 22(4):859-869. (Pubitemid 36227788)
26. Xu K, et al. (2011) Blood vessel tubulogenesis requires Rasip1 regulation of GTPase signaling. Dev Cell 20(4):526-539.
27. Saras J, et al. (1997) A novel GTPase-activating protein for Rho interacts with a PDZ domain of the protein-tyrosine phosphatase PTPL1. J Biol Chem 272(39):24333-24338. (Pubitemid 27418638)
28. Carey SP, Charest JM, and Reinhart-King CA (2011) Forces during cell adhesion and spreading: Implications for cellular homeostasis. Cellular and Biomolecular Mechanics and Mechanobiology, ed Gefen A (Springer, Berlin), pp 29-69.
29. Arthur WT, Burridge K (2001) RhoA inactivation by p190RhoGAP regulates cell spreading and migration by promoting membrane protrusion and polarity. Mol Biol Cell 12(9):2711-2720. (Pubitemid 33051936)
30. Ahmed SM, et al. (2012) KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression. J Cell Biol 199(6):951-967.
31. Ahmed SM, Daulat AM, Meunier A, Angers S (2010) G protein betagamma subunits regulate cell adhesion through Rap1a and its effector Radil. J Biol Chem 285(9):6538-6551.
32. Huveneers S, et al. (2012) Vinculin associates with endothelial VE-cadherin junctions to control force-dependent remodeling. J Cell Biol 196(5):641-652.
33. Millán J, et al. (2010) Adherens junctions connect stress fibres between adjacent endothelial cells. BMC Biol 8:11.
34. Xu K, Chong DC, Rankin SA, Zorn AM, Cleaver O (2009) Rasip1 is required for endothelial cell motility, angiogenesis and vessel formation. Dev Biol 329(2):269-279.
35. Ratheesh A, et al. (2012) Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens. Nat Cell Biol 14(8):818-828.
36. Terry SJ, et al. (2011) Spatially restricted activation of RhoA signalling at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis. Nat Cell Biol 13(2):159-166.
37. Pertz O, Hodgson L, Klemke RL, Hahn KM (2006) Spatiotemporal dynamics of RhoA activity in migrating cells. Nature 440(7087):1069-1072.
38. Kher SS, Worthylake RA (2012) Nuanced junctional RhoA activity. Nat Cell Biol 14(8):784-786.
39. Machacek M, et al. (2009) Coordination of Rho GTPase activities during cell protrusion. Nature 461(7260):99-103.
40. Smutny M, et al. (2010) Myosin II isoforms identify distinct functional modules that support integrity of the epithelial zonula adherens. Nat Cell Biol 12(7):696-702.