Ethanol induces TLR4/TLR2 association, triggering an inflammatory response in microglial cells

Journal of Neurochemistry

Volumn 126, Issue 2, 2013, Pages 261-273

  Fernandez Lizarbe, Sara ^a   Montesinos, Jorge ^a   Guerri, Consuelo ^a  

^a CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

Author keywords

apoptosis; ethanol; immunopathology; inflammation; lipid rafts; TLRs

Indexed keywords

ALCOHOL; AUTACOID; HETERODIMER; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; LIPOTEICHOIC ACID; MITOGEN ACTIVATED PROTEIN KINASE; REACTIVE OXYGEN METABOLITE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ALCOHOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CAVEOLA; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; ENZYME ACTIVATION; FEMALE; FLOW CYTOMETRY; FLUORESCENCE RESONANCE ENERGY TRANSFER; GLIA CELL; IMMUNOPRECIPITATION; KNOCKOUT MOUSE; LIPID RAFT; MICROGLIA; MOUSE; NERVE DEGENERATION; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; RAT; RECEPTOR UPREGULATION;

APOPTOSIS; ETHANOL; IMMUNOPATHOLOGY; INFLAMMATION; LIPID RAFTS; TLRS;

ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; CAVEOLAE; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CEREBRAL CORTEX; CYTOKINES; ENERGY TRANSFER; ETHANOL; FEMALE; GENE EXPRESSION REGULATION; INFLAMMATION; LIPOPOLYSACCHARIDES; MEMBRANE MICRODOMAINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NEUROGLIA; NEURONS; NITRIC OXIDE SYNTHASE; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

MUS;

EID: 84879992339     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12276     Document Type: Article

References (55)

1. Akira S., and, Takeda K., (2004) Toll-like receptor signalling. Nat. Rev. Immunol. 4, 499-511.
2. Alfonso-Loeches S., Pascual-Lucas M., Blanco A. M., Sanchez-Vera I., and, Guerri C., (2010) Pivotal role of TLR4 receptors in alcohol-induced neuroinflammation and brain damage. J. Neurosci. 30, 8285-8295.
3. Alfonso-Loeches S., Pascual M., Gomez-Pinedo U., Pascual-Lucas M., Renau-Piqueras J., and, Guerri C., (2012) Toll-like receptor 4 participates in the myelin disruptions associated with chronic alcohol abuse. Glia 60, 948-964.
4. Amor S., Puentes F., Baker D., and, van der Valk P., (2010) Inflammation in neurodegenerative diseases. Immunology 129, 154-169.
5. Babcock A. A., Wirenfeldt M., Holm T., et al,. (2006) Toll-like receptor 2 signaling in response to brain injury: an innate bridge to neuroinflammation. J. Neurosci. 26, 12826-12837.
6. Blanco A. M., Valles S. L., Pascual M., and, Guerri C., (2005) Involvement of TLR4/type I IL-1 receptor signaling in the induction of inflammatory mediators and cell death induced by ethanol in cultured astrocytes. J. Immunol. 175, 6893-6899.
7. Blanco A. M., Perez-Arago A., Fernandez-Lizarbe S., and, Guerri C., (2008) Ethanol mimics ligand-mediated activation and endocytosis of IL-1RI/TLR4 receptors via lipid rafts caveolae in astroglial cells. J. Neurochem. 106, 625-639.
8. Block M. L., Zecca L., and, Hong J. S., (2007) Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat. Rev. Neurosci. 8, 57-69.
9. Brightbill H. D., Libraty D. H., Krutzik S. R., et al,. (1999) Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. Science 285, 732-736.
10. Buchanan M. M., Hutchinson M., Watkins L. R., and, Yin H., (2010) Toll-like receptor 4 in CNS pathologies. J. Neurochem. 114, 13-27.
11. Crews F. T., Qin L., Sheedy D., Vetreno R. P., and, Zou J., (2013) High mobility group box 1/toll-like receptor danger signaling increases brain neuroimmune activation in alcohol dependence. Biol. Psychiatry 73, 602-612.
12. Fernandez-Lizarbe S., Pascual M., Gascon M. S., Blanco A., and, Guerri C., (2008) Lipid rafts regulate ethanol-induced activation of TLR4 signaling in murine macrophages. Mol. Immunol. 45, 2007-2016.
13. Fernandez-Lizarbe S., Pascual M., and, Guerri C., (2009) Critical role of TLR4 response in the activation of microglia induced by ethanol. J. Immunol. 183, 4733-4744.
14. Flo T. H., Ryan L., Latz E., et al,. (2002) Involvement of toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers. J. Biol. Chem. 277, 35489-35495.
15. Gay N. J., and, Gangloff M., (2007) Structure and function of Toll receptors and their ligands. Annu. Rev. Biochem. 76, 141-165.
16. Goral J., and, Kovacs E. J., (2005) In vivo ethanol exposure down-regulates TLR2-, TLR4-, and TLR9-mediated macrophage inflammatory response by limiting p38 and ERK1/2 activation. J. Immunol. 174, 456-463.
17. Guerri C., Saez R., Sancho-Tello M., Martin de Aquilera E., and, Renau-Piqueras J., (1990) Ethanol alters astrocyte development: a study of critical periods using primary cultures. Neurochem. Res. 15, 559-565.
18. Harper C., and, Matsumoto I., (2005) Ethanol and brain damage. Curr. Opin. Pharmacol. 5, 73-78.
19. He J., and, Crews F. T., (2008) Increased MCP-1 and microglia in various regions of the human alcoholic brain. Exp. Neurol. 210, 349-358.
20. Hoebe K., Georgel P., Rutschmann S., et al,. (2005) CD36 is a sensor of diacylglycerides. Nature 433, 523-527.
21. Hong J., Cho I. H., Kwak K. I., et al,. (2010) Microglial Toll-like receptor 2 contributes to kainic acid-induced glial activation and hippocampal neuronal cell death. J. Biol. Chem. 285, 39447-39457.
22. Jin M. S., Kim S. E., Heo J. Y., Lee M. E., Kim H. M., Paik S. G., Lee H., and, Lee J. O., (2007) Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Cell 130, 1071-1082.
23. Kawai T., and, Akira S., (2010) The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat. Immunol. 11, 373-384.
24. Kim H. Y., Park S. J., Joe E. H., and, Jou I., (2006) Raft-mediated Src homology 2 domain-containing proteintyrosine phosphatase 2 (SHP-2) regulation in microglia. J. Biol. Chem. 281, 11872-11878.
25. Kim S. C., Ghanem A., Stapel H., Tiemann K., Knuefermann P., Hoeft A., Meyer R., Grohe C., Knowlton A. A., and, Baumgarten G., (2007) Toll-like receptor 4 deficiency: smaller infarcts, but no gain in function. BMC Physiol. 7, 5.
26. Kim M. J., Woo S. J., Yoon C. H., Lee J. S., An S., Choi Y. H., Hwang S. G., Yoon G., and, Lee S. J., (2011) Involvement of autophagy in oncogenic K-Ras-induced malignant cell transformation. J. Biol. Chem. 286, 12924-12932.
27. Koedel U., Merbt U. M., Schmidt C., Angele B., Popp B., Wagner H., Pfister H. W., and, Kirschning C. J., (2007) Acute brain injury triggers MyD88-dependent, TLR2/4-independent inflammatory responses. Am. J. Pathol. 171, 200-213.
28. Le Roy C., and, Wrana J. L., (2005) Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling. Nat. Rev. Mol. Cell Biol. 6, 112-126.
29. Lehnardt S., (2010) Innate immunity and neuroinflammation in the CNS: the role of microglia in Toll-like receptor-mediated neuronal injury. Glia 58, 253-263.
30. Lehnardt S., Schott E., Trimbuch T., Laubisch D., Krueger C., Wulczyn G., Nitsch R., and, Weber J. R., (2008) A vicious cycle involving release of heat shock protein 60 from injured cells and activation of toll-like receptor 4 mediates neurodegeneration in the CNS. J. Neurosci. 28, 2320-2331.
31. Letiembre M., Liu Y., Walter S., Hao W., Pfander T., Wrede A., Schulz-Schaeffer W., and, Fassbender K., (2009) Screening of innate immune receptors in neurodegenerative diseases: a similar pattern. Neurobiol. Aging 30, 759-768.
32. Liu S., Liu Y., Hao W., et al,. (2012) TLR2 is a primary receptor for Alzheimer's amyloid beta peptide to trigger neuroinflammatory activation. J. Immunol. 188, 1098-1107.
33. Manukyan M., Triantafilou K., Triantafilou M., Mackie A., Nilsen N., Espevik T., Wiesmuller K. H., Ulmer A. J., and, Heine H., (2005) Binding of lipopeptide to CD14 induces physical proximity of CD14, TLR2 and TLR1. Eur. J. Immunol. 35, 911-921.
34. Nakamura Y., Si Q. S., and, Kataoka K., (1999) Lipopolysaccharide-induced microglial activation in culture: temporal profiles of morphological change and release of cytokines and nitric oxide. Neurosci. Res. 35, 95-100.
35. Nakata T., Yasuda M., Fujita M., Kataoka H., Kiura K., Sano H., and, Shibata K., (2006) CD14 directly binds to triacylated lipopeptides and facilitates recognition of the lipopeptides by the receptor complex of Toll-like receptors 2 and 1 without binding to the complex. Cell. Microbiol. 8, 1899-1909.
36. Napoli I., and, Neumann H., (2009) Microglial clearance function in health and disease. Neuroscience 158, 1030-1038.
37. Okun E., Griffioen K. J., Lathia J. D., Tang S. C., Mattson M. P., and, Arumugam T. V., (2009) Toll-like receptors in neurodegeneration. Brain Res. Rev. 59, 278-292.
38. Okun E., Griffioen K. J., and, Mattson M. P., (2011) Toll-like receptor signaling in neural plasticity and disease. Trends Neurosci. 34, 269-281.
39. Oliva J., Bardag-Gorce F., Li J., French B. A., and, French S. W., (2011) S-adenosylmethionine prevents the up regulation of Toll-like receptor (TLR) signaling caused by chronic ethanol feeding in rats. Exp. Mol. Pathol. 90, 239-243.
40. Pascual M., Fernandez-Lizarbe S., and, Guerri C., (2011) Role of TLR4 in ethanol effects on innate and adaptive immune responses in peritoneal macrophages. Immunol. Cell Biol. 89, 716-727.
41. Pfefferbaum A., (2004) Alcoholism damages the brain, but does moderate alcohol use? Lancet Neurol. 3, 143-144.
42. Pike L. J., (2003) Lipid rafts: bringing order to chaos. J. Lipid Res. 44, 655-667.
43. Rivest S., (2009) Regulation of innate immune responses in the brain. Nat. Rev. Immunol. 9, 429-439.
44. Simons K., and, Toomre D., (2000) Lipid rafts and signal transduction. Nat. Rev. Mol. Cell Biol. 1, 31-39.
45. Streit W. J., and, Xue Q. S., (2009) Life and death of microglia. J. Neuroimmune Pharmacol. 4, 371-379.
46. Syed M. M., Phulwani N. K., and, Kielian T., (2007) Tumor necrosis factor-alpha (TNF-alpha) regulates Toll-like receptor 2 (TLR2) expression in microglia. J. Neurochem. 103, 1461-1471.
47. Tanga F. Y., Nutile-McMenemy N., and, DeLeo J. A., (2005) The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy. Proc. Natl Acad. Sci. USA 102, 5856-5861.
48. Triantafilou M., Morath S., Mackie A., Hartung T., and, Triantafilou K., (2004) Lateral diffusion of Toll-like receptors reveals that they are transiently confined within lipid rafts on the plasma membrane. J. Cell Sci. 117, 4007-4014.
49. Triantafilou M., Gamper F. G., Haston R. M., Mouratis M. A., Morath S., Hartung T., and, Triantafilou K., (2006) Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting. J. Biol. Chem. 281, 31002-31011.
50. Triantafilou M., Gamper F. G., Lepper P. M., Mouratis M. A., Schumann C., Harokopakis E., Schifferle R. E., Hajishengallis G., and, Triantafilou K., (2007) Lipopolysaccharides from atherosclerosis-associated bacteria antagonize TLR4, induce formation of TLR2/1/CD36 complexes in lipid rafts and trigger TLR2-induced inflammatory responses in human vascular endothelial cells. Cell. Microbiol. 9, 2030-2039.
51. Triantafilou M., Lepper P. M., Olden R., Dias I. S., and, Triantafilou K., (2011) Location, location, location: is membrane partitioning everything when it comes to innate immune activation? Mediators Inflamm. 2011, 186093.
52. Yang R. B., Mark M. R., Gurney A. L., and, Godowski P. J., (1999) Signaling events induced by lipopolysaccharide-activated toll-like receptor 2. J. Immunol. 163, 639-643.
53. Zekki H., Feinstein D. L., and, Rivest S., (2002) The clinical course of experimental autoimmune encephalomyelitis is associated with a profound and sustained transcriptional activation of the genes encoding toll-like receptor 2 and CD14 in the mouse CNS. Brain Pathol. 12, 308-319.
54. Ziegler G., Harhausen D., Schepers C., Hoffmann O., Rohr C., Prinz V., Konig J., Lehrach H., Nietfeld W., and, Trendelenburg G., (2007) TLR2 has a detrimental role in mouse transient focal cerebral ischemia. Biochem. Biophys. Res. Commun. 359, 574-579.
55. Ziegler G., Freyer D., Harhausen D., Khojasteh U., Nietfeld W., and, Trendelenburg G., (2011) Blocking TLR2 in vivo protects against accumulation of inflammatory cells and neuronal injury in experimental stroke. J. Cereb. Blood Flow Metab. 31, 757-766.