Helicobacter pylori HP0175 promotes the production of IL-23, IL-6, IL-1β and TGF-β

European Journal of Inflammation

Volumn 11, Issue 1, 2013, Pages 261-268

  Amedei, A ^a,b   Munari, F ^c   Della Bella, C ^a,b   Niccolai, E ^a,b   Benagiano, M ^a,b   Bencini, L ^d   Cianchi, F ^d   Silvestri, E ^a,b   D'Elios, S ^a   Farsi, M ^d   Prisco, D ^a,b   Zanotti, G ^c   De Bernard, M ^c   Kundu, M ^e   D'Elios, Mario M ^a,b  

^a UNIVERSITY OF FLORENCE   (Italy)

^b Institute of General Pathology   (Italy)

^c VENETIAN INSTITUTE OF MOLECULAR MEDICINE   (Italy)

^d UNIVERSITY OF FLORENCE   (Italy)

^e BOSE INSTITUTE   (India)

Author keywords

Cytokines; Helicobacter pylori; IL 1b; IL 23; IL 6; TGF b

Indexed keywords

INTERLEUKIN 1BETA; INTERLEUKIN 23; INTERLEUKIN 6; PEPTIDYLPROLYL ISOMERASE; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; BACTERIAL STRAIN; CYTOKINE PRODUCTION; HELICOBACTER PYLORI; HUMAN; HUMAN CELL; INNATE IMMUNITY; LYMPHOCYTE DIFFERENTIATION; MONOCYTE; NEUTROPHIL; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION; TH17 CELL;

EID: 84879973020     PISSN: 1721727X     EISSN: None     Source Type: Journal    
DOI: 10.1177/1721727X1301100127     Document Type: Article

References (28)

1. Warren JR, Marshall BJ. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulcer ulceration. Lancet 1984; 1:1311-15.
2. Parsonnet J, Friedman GD, Vandersteen DP, Chang Y, Vogelman JH, Orentreich N, Sibley RK. Helicobacter pylori infection and the risk of gastric carcinoma. N Engl J Med 1991; 325:1127-31.
3. Wotherspoon AC, Doglioni C, Diss TC, Pan L, Moschini A, de Boni M, Isaacson PG. Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori. Lancet 1993; 342:575-77. (Pubitemid 23259233)
4. D'Elios MM, Appelmelk BJ, Amedei A, Bergman MP, Del Prete G. Gastric autoimmunity: the role of Helicobacter pylori and molecular mimicry. Trends Mol Med 2004; 10:316323.
5. Fox JG, Wang TC. Inflammation, atrophy, and gastric cancer. J Clin Invest 2007; 117:60-69. (Pubitemid 46048450)
6. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Schistosomes, liver flukes and Helicobacter pylori. IARC Monogr Eval Carcinog. Risks Hum 1994; 61:1-241.
7. D'Elios MM, Manghetti M, De Carli M, Costa F, Baldari CT, Burroni D, Telford JL, Romagnani S, Del Prete G. Th1 effector cells specific for Helicobacter pylori in the gastric antrum of patients with peptic ulcer disease. J Immunol 1997; 158:962-67. (Pubitemid 127492677)
8. Kaparakis M, Philpott DJ, Ferrero RL. Mammalian NLR proteins; discriminating foe from friend. Immunol Cell Biol 2007; 85:495-502. (Pubitemid 47367515)
9. Amedei A, Cappon A, Codolo G, et al. The neutrophil-activating protein of Helicobacter pylori promotes Th1 immune responses. J Clin Invest 2006; 116:1092-101.
10. Luzza F, Parrello T, Monteleone G, Sebkova L, Romano M, Zarrilli R, Imeneo M, Pallone F. Upregulation of IL-17 is associated with bioactive IL-8 expression in Helicobacter pylori-infected human gastric mucosa. J Immunol 2000; 165:5332-37.
11. Shi Y, Liu XF, Zhuang Y, et al. Helicobacter pylori-induced Th17 response modulate Th1 cell responses, benefit bacterial growth, and contribute to pathology in mice. J Immunol 2011; 184:5121-29.
12. Caruso R, Fina D, Peluso I, et al. IL-21 is highly produced in Helicobacter pylori-infected gastric mucosa and promotes gelatinases synthesis. J Immunol 2007; 178:5957-65. (Pubitemid 46674393)
13. Volpe E, Servant N, Zollinger R, Bogiatzi SI, Hupe P, Barillot E, Soumelis VA. Critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human TH17 responses. Nat Immunol 2008; 9:650-57. (Pubitemid 351712635)
14. Korn T, Bettelli E, Oukkaì M, Kuchroo VK. IL-17 and Th17 Cells. Annu Rev Immunol 2009; 27:485-517.
15. Vivas J, Regnault B, Michel V, Bussière FI, Avé P, Huerre M, Labigne A, D'Elios MM, Touati E. Interferon gamma-signature transcript profiling and IL-23 upregulation in response to Helicobacter pylori infection. Int J Immunopathol Pharmacol 2008; 21:515-26.
16. Codolo G, Amedei A, Steere AC, et al. Borrelia burgdorferi-NapA driven Th17 cell inflammation in Lyme arthritis. Arthritis Rheum 2008; 58:3609-17.
17. Pathak SK, Basu S, Bhattacharyya A, Pathak S, Banerjee A, Basu J, Kundu M. TLR4-dependent NF-kappaB activation and mitogen- and stress-activated protein kinase 1-triggered phosphorylation events are central to Helicobacter pylori peptidyl prolyl cis-, trans-isomerase (HP0175)-mediated induction of IL-6 release from macrophages. J Immunol 2006; 177: 7950-58. (Pubitemid 44846311)
18. Basu S, Pathak SK, Chatterjee G, Pathak S, Basu J, Kundu M. Helicobacter pylori protein HP0175 transactivates epidermal growth factor receptor through TLR4 in gastric epithelial cells. J Biol Chem 2008; 283:32369-76.
19. Basak C, Pathak SK, Bhattacharyya A, Pathak S, Basu J, Kundu M. The secreted peptidyl prolyl cis,trans-isomerase HP0175 of Helicobacter pylori induces apoptosis of gastric epithelial cells in a TLR4- and apoptosis signal-regulating kinase 1-dependent manner. J Immunol 2005; 174:5672-80. (Pubitemid 40593209)
20. Oppmann B, Lesley R, Blom B, et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 2000; 13:715-25.
21. El-Omar EM, Carrington M, Chow WH, et al. Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature 2000; 404:398-402. (Pubitemid 30164342)
22. El-Omar EM, Carrington M, Chow WH, et al. The role of interleukin-1 polymorphisms in the pathogenesis of gastric cancer. Nature 2001; 412:499.
23. Ugai S, Shimozato O, Yu L, et al. Transduction of the IL-21 and IL-23 genes in human pancreatic carcinoma cells produces natural killer cell-dependent and -independent antitumour effects. Cancer Gene Ther 2003; 10:771-78. (Pubitemid 37243798)
24. Lo CH, Lee SC, Wu PY, et al. Antitumour and antimetastatic activity of IL-23. J Immunol 2003; 171:600-7.
25. Wu S, Rhee KJ, Albesiano E, et al. A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. Nat Med 2009; 15:1016-22.
26. Langowski JL, Zhang X, Wu L, et al. IL-23 promotes tumour incidence and growth. Nature 2006; 442:461-65. (Pubitemid 44264796)
27. Meulmeester E, Ten Dijke P. The dynamic roles of TGF-β in cancer. J Pathol 2011; 223:205-18.
28. Amedei A, Munari F, Delia Bella C, et al. Helicobacter pylori secreted peptidyl prolyl cis, trans-isomerase drives Th17 inflammation in gastric adenocarcinoma. Intern Emerg Med 2012; DOI 10.1007/s11739-012-0867-9.