Gastric autoimmunity: The role of Helicobacter pylori and molecular mimicry

Trends in Molecular Medicine

Volumn 10, Issue 7, 2004, Pages 316-323

  D'Elios, Mario M ^a   Appelmelk, Ben J ^b   Amedei, Amedeo ^a   Bergman, Mathijs P ^b   Del Prete, Gianfranco ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; FAS LIGAND; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HLA DR ANTIGEN; HYDROGEN POTASSIUM ADENOSINE TRIPHOSPHATASE; INTERLEUKIN 4; INTERLEUKIN 5; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ANTIBODY PRODUCTION; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; APOPTOSIS; ATROPHIC GASTRITIS; AUTOIMMUNE DISEASE; B LYMPHOCYTE; CELL DEATH; CELL DIFFERENTIATION; CELL INFILTRATION; CELL PROLIFERATION; CHRONIC GASTRITIS; CYTOKINE PRODUCTION; EPITOPE MAPPING; GASTRITIS; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; MACROPHAGE; MOLECULAR CLONING; MOLECULAR MECHANICS; NONHUMAN; PEPTIC ULCER; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REVIEW; STOMACH MUCOSA; STOMACH PARIETAL CELL; T LYMPHOCYTE; TH1 CELL; THYMECTOMY; UPREGULATION;

ANIMALS; AUTOANTIGENS; AUTOIMMUNE DISEASES; AUTOIMMUNITY; GASTRITIS; H(+)-K(+)-EXCHANGING ATPASE; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; MOLECULAR MIMICRY; PARIETAL CELLS, GASTRIC; TH1 CELLS;

HELICOBACTER; HELICOBACTER PYLORI;

EID: 3042790021     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmed.2004.06.001     Document Type: Review

References (67)

1. Fong T.L., et al. Helicobacter pylori infection in pernicious anemia: a prospective controlled study. Gastroenterology. 100:1991;328-332
2. Strickland R.G. Gastritis. Springer Semin. Immunopathol. 12:1990;203-217
3. Toh B.H., et al. Pernicious anemia. N. Engl. J. Med. 337:1997;1441-1448
4. Toh B.H., et al. Autoimmune gastritis and pernicious anemia. Rose N.R., Mackay I.R. The Autoimmune Diseases. 3rd edn:1998;459-477 Academic Press
5. +-ATPase, the parietal cell antigen. Clin. Exp. Immunol. 70:1987;604-610
6. Goldkorn I., et al. Gastric parietal cell antigens of 60-90, 92, and 100-120 kDa associated with autoimmune gastritis and pernicious anemia. J. Biol. Chem. 264:1989;18768-18774
7. +-ATPase are concordantly targeted by parietal cell autoantibodies associated with autoimmune gastritis. Autoimmunity. 16:1993;289-295
8. +-ATPase (proton pump) is the target autoantigen of Th1-type cytotoxic T cells in autoimmune gastritis. Gastroenterology. 120:2001;377-386
9. +-ATPase T cell epitopes in human autoimmune gastritis. Eur. J. Immunol. 33:2003;539-545
10. Valnes K., et al. Relation between T cell number and epithelial HLA class II expression quantified by image analysis in normal and inflamed gastric mucosa. Gut. 31:1990;647-652
11. Ye G., et al. Expression of B7-1 and B7-2 costimulatory molecules by human gastric epithelial cells. J. Clin. Invest. 99:1997;1628-1636
12. Barrera C., et al. Expression of cathepsins B, L, S, and D by gastric epithelial cells implicates them as antigen presenting cells in local immune responses. Hum. Immunol. 62:2001;1081-1091
13. + ATPase antigen in the pathogenesis of autoimmune gastritis. Immunol. Today. 21:2000;348-354
14. Burman P., et al. A study of autoimmune gastritis in the postpartum period and at a 5-year follow-up. Gastroenterology. 103:1992;934-942
15. Gleeson P.A., et al. Organ-specific autoimmunity induced by lymphopenia. Immunol. Rev. 149:1996;97-125
16. Suri-Payer E., et al. Post-thymectomy autoimmune gastritis: fine specificity and pathogenicity of anti-H/K-ATPase-reactive T cells. Eur. J. Immunol. 29:1999;669-677
17. Andrada J.A., et al. Experimental autoimmune gastritis in the Rhesus monkey. Clin. Exp. Immunol. 4:1969;293-310
18. +-ATPase induces a reversible autoimmune gastritis. Immunology. 92:1997;91-98
19. Claeys D., et al. Neonatal injection of native proton pump induces autoimmune gastritis in mice. Gastroenterology. 113:1997;1136-1145
20. De Silva H.D., et al. Identification of a gastritogenic epitope of the H/K-ATPase β subunit. Immunology. 96:1999;145-151
21. Gleeson P.A., Toh B.H. Molecular targets in pernicious anemia. Immunol. Today. 12:1991;233-238
22. Martinelli T., et al. Analysis of mononuclear cell infiltrate and cytokine production in murine autoimmune gastritis. Gastroenterology. 110:1996;1791-1802
23. Suri-Payer E., et al. Pathogenesis of post-thymectomy autoimmune gastritis. Identification of anti-H/K adenosine triphosphatase-reactive T cells. J. Immunol. 157:1996;1799-1805
24. + T cells, are required for the development of experimental autoimmune gastritis. Immunology. 93:1998;405-408
25. Marshall A.C., et al. Fas/CD95 is required for gastric mucosal damage in autoimmune gastritis. Gastroenterology. 123:2002;780-789
26. Barrett S.P., et al. Interferon-γ is required during the initiation of an organ-specific autoimmune disease. Eur. J. Immunol. 26:1996;1652-1655
27. Katakai T., et al. Differential localization of Th1 and Th2 cells in autoimmune gastritis. Int. Immunol. 10:1998;1325-1334
28. Alderuccio F., et al. Tolerance and autoimmunity to a gastritogenic peptide in TCR transgenic mice. Int. Immunol. 12:2000;343-352
29. +-adenosine triphosphatase of parietal cells discerned by a murine gastritogenic T-cell clone. Gastroenterology. 107:1994;1408-1414
30. Nishio A., et al. A possible involvement of Fas-Fas ligand signaling in the pathogenesis of murine autoimmune gastritis. Gastroenterology. 111:1996;959-967
31. Lehmann P.V., et al. Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen. Nature. 358:1992;155-157
32. Miller S.D., et al. Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading. Nat. Med. 3:1997;1133-1136
33. + regulatory T cells is necessary but not sufficient, for induction of organ-specific autoimmune disease. J. Immunol. 168:2002;5979-5983
34. Suerbaum S., Michetti P. Helicobacter pylori infection. N. Engl. J. Med. 347:2002;1175-1186
35. Uemura N., et al. Helicobacter pylori infection and the development of gastric cancer. N. Engl. J. Med. 345:2001;784-789
36. Perez-Perez G.I. Role of Helicobacter pylori infection in the development of pernicious anemia. Clin. Infect. Dis. 25:1997;1020-1022
37. Ma J.Y., et al. Positive correlation between H, K-adenosine triphosphatase autoantibodies and Helicobacter pylori antibodies in patients with pernicious anemia. Scand. J. Gastroenterol. 29:1994;961-965
38. Annibale B., et al. Role of Helicobacter pylori infection in pernicious anaemia. Dig. Liver Dis. 32:2000;756-762
39. Karnes W.E. Positive serum antibody and negative tissue staining for Helicobacter pylori in subjects with atrophic body gastritis. Gastroenterology. 101:1991;167-174
40. Varis O., et al. Is Helicobacter pylori involved in the pathogenesis of the gastritis characteristic of pernicious anaemia? Comparison between pernicious anaemia relatives and duodenal ulcer relatives. Scand. J. Gastroenterol. 28:1993;705-708
41. Annibale B., et al. Two-thirds of atrophic body gastritis patients have evidence of Helicobacter pylori infection. Helicobacter. 6:2001;225-233
42. Valle J., et al. Long-term course and consequences of Helicobacter pylori gastritis. Results of a 32-year follow-up study. Scand. J. Gastroenterol. 31:1996;546-550
43. Mattapallil J.J., et al. A predominant Th1 type of immune response is induced early during acute Helicobacter pylori infection in rhesus macaques. Gastroenterology. 118:2000;307-315
44. + lymphocytes in Helicobacter pylori gastritis display a Th1 phenotype. Infect. Immun. 66:1998;5543-5546
45. Mardh S., Song Y.H. Characterization of antigenic structures in autoimmune atrophic gastritis with pernicious anaemia. The parietal cell H, K-ATPase and the chief cell pepsinogen are the two major antigens. Acta Physiol. Scand. 136:1989;581-587
46. Biondo M., et al. Local transgenic expression of granulocyte macrophage-colony stimulating factor initiates autoimmunity. J. Immunol. 166:2001;2090-2099
47. Oldstone M.B.A. Molecular mimicry and immune-mediated diseases. FASEB J. 12:1998;1255-1265
48. Theofilopoulos A.N., Kono D.H. Mechanisms and genetics of autoimmunity. Ann. N.Y. Acad. Sci. 841:1998;225-235
49. Lori J.A., Inman R.D. Molecular mimicry and autoimmunity. N. Engl. J. Med. 341:1999;2068-2074
50. Benoist C., Mathis D. Autoimmunity provoked by infection: how good is the case for T cell epitope mimicry? Nat. Immunol. 2:2001;797-801
51. Wucherpfennig K.W. Mechanisms for the induction of autoimmunity by infectious agents. J. Clin. Invest. 108:2001;1097-1104
52. Schrer M.T., et al. Superantigens: bacterial and viral proteins that manipulate the immune system. Annu. Rev. Cell Biol. 9:1993;101-128
53. Murali-Krishna K., et al. Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity. 8:1998;177-187
54. Bachmaier K., et al. Chlamydia infections and heart disease linked through antigenic mimicry. Science. 283:1999;1335-1339
55. Rose N.R., Mackay I.R. Molecular mimicry: a critical look at exemplary instances in human diseases. Cell. Mol. Life Sci. 57:2000;542-551
56. Hemmer B., et al. Identification of candidate T-cell epitopes and molecular mimics in chronic Lyme disease. Nat. Med. 5:1999;1375-1382
57. Martin R., et al. Molecular mimicry and antigen-specific T cell responses in multiple sclerosis and chronic CNS Lyme disease. J. Autoimmun. 16:2001;187-192
58. +-ATPase in human gastric autoimmunity. J. Exp. Med. 198:2003;1147-1156
59. D'Elios M.M., et al. Th1 effector cells specific for Helicobacter pylori in the gastric antrum of patients with peptic ulcer disease. J. Immunol. 158:1997;962-967
60. D'Elios M.M., et al. Different cytokine profile and antigen-specificity repertoire in Helicobacter pylori-specific T cell clones from the antrum of chronic gastritis patients with or without peptic ulcer. Eur. J. Immunol. 27:1997;1751-1755
61. Wucherpfennig K.W., et al. Structure of human T-cell receptors specific for an immunodominant myelin basic protein peptide: positioning of T-cell receptors on HLA-DR2/peptide complexes. Proc. Natl. Acad. Sci. U. S. A. 92:1995;8896-8900
62. Wucherpfennig K.W., et al. Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones. J. Exp. Med. 179:1994;279-290
63. McDevitt H.O. Discovering the role of the major histocompatibility complex in the immune response. Annu. Rev. Immunol. 18:2000;1-17
64. Rose N.R., Bona C. Defining criteria for autoimmune diseases (Witebsky's postulates revisited). Immunol. Today. 14:1993;426-430
65. Faller G., et al. Evidence of novel pathogenic pathways for the formation of antigastric autoantibodies in Helicobacter pylori gastritis. J. Clin. Pathol. 51:1998;244-245
66. Appelmelk B.J., et al. Molecular mimicry between Helicobacter pylori and the host. Trends Microbiol. 5:1997;70-73
67. De Block C.E., et al. Helicobacter pylori, parietal cell antibodies and autoimmune gastropathy in type 1 diabetes mellitus. Aliment. Pharmacol. Ther. 16:2002;281-289