Inhibitory effects of low molecular weight polyphenolics from Inonotus obliquus on human DNA topoisomerase activity and cancer cell proliferation

Molecular Medicine Reports

Volumn 8, Issue 2, 2013, Pages 535-542

  Kuriyama, Isoko ^a   Nakajima, Yuki ^b   Nishida, Hiroshi ^b   Konishi, Tetsuya ^b   Takeuchi, Toshifumi ^c   Sugawara, Fumio ^c   Yoshida, Hiromi ^a   Mizushina, Yoshiyuki ^a  

^a KOBE GAKUIN UNIVERSITY   (Japan)

^b NIIGATA UNIVERSITY OF PHARMACY AND APPLIED LIFE SCIENCES   (Japan)

^c TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

3,4 dihydroxybenzalacetone; Anticancer agents; Caffeic acid; Cell cycle arrest; Cytotoxicity; DNA topoisomerase; Enzyme inhibitor; Inonotus obliquus; Low molecular weight polyphenolics

Indexed keywords

2 5 DIHYDROXYTEREPHTHALIC ACID; 3 4 DIHYDROXYBENZALACETONE; BENZYLIDENEACETONE; CAFFEIC ACID; CATECHOL; DEOXYRIBONUCLEASE I; DNA POLYMERASE; DNA TOPOISOMERASE; GALLIC ACID; INOSINATE DEHYDROGENASE; LOW MOLECULAR WEIGHT POLYPHENOLIC; POLYNUCLEOTIDE 5' HYDROXYL KINASE; POLYPHENOL DERIVATIVE; PROTOCATECHUALDEHYDE; PROTOCATECHUIC ACID; RNA POLYMERASE; SYRINGIC ACID; T7 RNA POLYMERASE; TEREPHTHALIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CANCER CELL; CANCER GROWTH; CARCINOMA CELL; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; INONOTUS OBLIQUUS; LD 50; MOUSE; NONHUMAN;

ANIMALS; ANTINEOPLASTIC AGENTS; BASIDIOMYCOTA; CATTLE; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; COMPUTERS, MOLECULAR; DNA POLYMERASE BETA; DNA POLYMERASE I; DNA TOPOISOMERASES, TYPE I; ENZYME ACTIVATION; HCT116 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR WEIGHT; POLYPHENOLS; RATS; TOPOISOMERASE INHIBITORS;

BASIDIOMYCOTA; BOVINAE; INONOTUS OBLIQUUS; MAMMALIA;

EID: 84879951600     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2013.1547     Document Type: Article

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