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Volumn 4, Issue 4, 2013, Pages 186-

Unconventional vaccines: Progress and challenges

Author keywords

Immunogenicity; Infectious diseases; Vaccines

Indexed keywords


EID: 84879931604     PISSN: None     EISSN: 21577560     Source Type: Journal    
DOI: 10.4172/2157-7560.1000186     Document Type: Review
Times cited : (1)

References (44)
  • 1
    • 84861152662 scopus 로고    scopus 로고
    • Strategies to use immune modulators in therapeutic vaccines against cancer
    • Berzofsky JA, Terabe M, Wood LV (2012) Strategies to use immune modulators in therapeutic vaccines against cancer. Semin Oncol 39: 348-357.
    • (2012) Semin Oncol , vol.39 , pp. 348-357
    • Berzofsky, J.A.1    Terabe, M.2    Wood, L.V.3
  • 3
    • 80052461387 scopus 로고    scopus 로고
    • Therapeutic vaccines for chronic diseases: Successes and technical challenges
    • Bachmann MF, Jennings GT (2011) Therapeutic vaccines for chronic diseases: successes and technical challenges. Philos Trans R Soc Lond B Biol Sci 366: 2815-2822.
    • (2011) Philos Trans R Soc Lond B Biol Sci , vol.366 , pp. 2815-2822
    • Bachmann, M.F.1    Jennings, G.T.2
  • 4
    • 84874900846 scopus 로고    scopus 로고
    • Immunotherapy with Sipuleucel-T (APC8015) in patients with metastatic castration-refractory prostate cancer (mCRPC): A systematic review and meta-analysis
    • Botrel TE, Clark O, Pompeo AC, Bretas FF, Sadi MV, et al. (2012) Immunotherapy with Sipuleucel-T (APC8015) in patients with metastatic castration-refractory prostate cancer (mCRPC): a systematic review and meta-analysis. Int Braz J Urol 38: 717-727.
    • (2012) Int Braz J Urol , vol.38 , pp. 717-727
    • Botrel, T.E.1    Clark, O.2    Pompeo, A.C.3    Bretas, F.F.4    Sadi, M.V.5
  • 5
    • 84878786666 scopus 로고    scopus 로고
    • Clinical evaluation of therapeutic cancer vaccines
    • Ogi C, Aruga A (2013) Clinical evaluation of therapeutic cancer vaccines. Hum Vaccin Immunother 9.
    • (2013) Hum Vaccin Immunother , pp. 9
    • Ogi, C.1    Aruga, A.2
  • 7
    • 34447542505 scopus 로고    scopus 로고
    • Pollinex Quattro Ragweed: Safety evaluation of a new allergy vaccine adjuvanted with monophosphoryl lipid A (MPL) for the treatment of ragweed pollen allergy
    • Baldrick P, Richardson D, Woroniecki SR, Lees B (2007) Pollinex Quattro Ragweed: safety evaluation of a new allergy vaccine adjuvanted with monophosphoryl lipid A (MPL) for the treatment of ragweed pollen allergy. J Appl Toxicol 27: 399-409.
    • (2007) J Appl Toxicol , vol.27 , pp. 399-409
    • Baldrick, P.1    Richardson, D.2    Woroniecki, S.R.3    Lees, B.4
  • 8
    • 84879933837 scopus 로고    scopus 로고
    • Pollinex Quattro: An innovative four injections immunotherapy In allergic rhinitis
    • Rosewich M, Lee D, Zielen S (2013) Pollinex Quattro: An innovative four injections immunotherapy In allergic rhinitis. Hum Vaccin Immunother 9.
    • (2013) Hum Vaccin Immunother , pp. 9
    • Rosewich, M.1    Lee, D.2    Zielen, S.3
  • 9
    • 80051794923 scopus 로고    scopus 로고
    • Assessment of clinical efficacy of CYT003-QbG10 in patients with allergic rhinoconjunctivitis: A phase IIb study
    • Klimek L, Willers J, Hammann-Haenni A, Pfaar O, Stocker H, et al. (2011) Assessment of clinical efficacy of CYT003-QbG10 in patients with allergic rhinoconjunctivitis: a phase IIb study. Clin Exp Allergy 41: 1305-1312.
    • (2011) Clin Exp Allergy , vol.41 , pp. 1305-1312
    • Klimek, L.1    Willers, J.2    Hammann-Haenni, A.3    Pfaar, O.4    Stocker, H.5
  • 11
  • 12
    • 67849102202 scopus 로고    scopus 로고
    • Anti-amyloid-beta immunotherapy in Alzheimer's disease: ACC-001 clinical trials are ongoing
    • Ryan JM, Grundman M (2009) Anti-amyloid-beta immunotherapy in Alzheimer's disease: ACC-001 clinical trials are ongoing. J Alzheimers Dis 17: 243.
    • (2009) J Alzheimers Dis , vol.17 , pp. 243
    • Ryan, J.M.1    Grundman, M.2
  • 13
    • 84865005632 scopus 로고    scopus 로고
    • 2 immunotherapy CAD106 passes first safety test in patients with Alzheimer disease
    • 2 immunotherapy CAD106 passes first safety test in patients with Alzheimer disease. Nat Rev Neurol 8: 414.
    • (2012) Nat Rev Neurol , vol.8 , pp. 414
    • Kingwell, K.1
  • 14
    • 84862331908 scopus 로고    scopus 로고
    • 2 immunotherapy with CAD106 in patients with Alzheimer's disease: Randomised, double-blind, placebo-controlled, first-in-human study
    • 2 immunotherapy with CAD106 in patients with Alzheimer's disease: randomised, double-blind, placebo-controlled, first-in-human study. Lancet Neurol 11: 597-604.
    • (2012) Lancet Neurol , vol.11 , pp. 597-604
    • Winblad, B.1    Andreasen, N.2    Minthon, L.3    Floesser, A.4    Imbert, G.5
  • 15
    • 79959670013 scopus 로고    scopus 로고
    • 2 immunotherapy CAD106 reduces amyloid accumulation in APP transgenic mice while minimizing potential side effects
    • 2 immunotherapy CAD106 reduces amyloid accumulation in APP transgenic mice while minimizing potential side effects. J Neurosci 31: 9323-9331.
    • (2011) J Neurosci , vol.31 , pp. 9323-9331
    • Wiessner, C.1    Wiederhold, K.H.2    Tissot, A.C.3    Frey, P.4    Danner, S.5
  • 16
    • 63249137056 scopus 로고    scopus 로고
    • Development of AFFITOPE vaccines for Alzheimer's disease (AD)--from concept to clinical testing
    • Schneeberger A, Mandler M, Otawa O, Zauner W, Mattner F, et al. (2009) Development of AFFITOPE vaccines for Alzheimer's disease (AD)--from concept to clinical testing. J Nutr Health Aging 13: 264-267.
    • (2009) J Nutr Health Aging , vol.13 , pp. 264-267
    • Schneeberger, A.1    Mandler, M.2    Otawa, O.3    Zauner, W.4    Mattner, F.5
  • 21
    • 84877941277 scopus 로고    scopus 로고
    • Clinical perspectives for ghrelin-derived therapeutic products
    • Allas S, Abribat T (2013) Clinical perspectives for ghrelin-derived therapeutic products. Endocr Dev 25: 157-166.
    • (2013) Endocr Dev , vol.25 , pp. 157-166
    • Allas, S.1    Abribat, T.2
  • 22
    • 4043116249 scopus 로고    scopus 로고
    • Randomized double-blind placebo-controlled study of an angiotensin immunotherapeutic vaccine (PMD3117) in hypertensive subjects
    • Brown MJ, Coltart J, Gunewardena K, Ritter JM, Auton TR, et al. (2004) Randomized double-blind placebo-controlled study of an angiotensin immunotherapeutic vaccine (PMD3117) in hypertensive subjects. Clin Sci (Lond) 107: 167-173.
    • (2004) Clin Sci (Lond) , vol.107 , pp. 167-173
    • Brown, M.J.1    Coltart, J.2    Gunewardena, K.3    Ritter, J.M.4    Auton, T.R.5
  • 23
    • 33845362874 scopus 로고    scopus 로고
    • A vaccine for hypertension based on virus-like particles: Preclinical efficacy and phase I safety and immunogenicity
    • Ambühl PM, Tissot AC, Fulurija A, Maurer P, Nussberger J, et al. (2007) A vaccine for hypertension based on virus-like particles: preclinical efficacy and phase I safety and immunogenicity. J Hypertens 25: 63-72.
    • (2007) J Hypertens , vol.25 , pp. 63-72
    • Ambühl, P.M.1    Tissot, A.C.2    Fulurija, A.3    Maurer, P.4    Nussberger, J.5
  • 24
    • 40049106627 scopus 로고    scopus 로고
    • Effect of immunisation against angiotensin II with CYT006-AngQb on ambulatory blood pressure: A double-blind, randomised, placebo-controlled phase IIa study
    • Tissot AC, Maurer P, Nussberger J, Sabat R, Pfister T, et al. (2008) Effect of immunisation against angiotensin II with CYT006-AngQb on ambulatory blood pressure: a double-blind, randomised, placebo-controlled phase IIa study. Lancet 371: 821-827.
    • (2008) Lancet , vol.371 , pp. 821-827
    • Tissot, A.C.1    Maurer, P.2    Nussberger, J.3    Sabat, R.4    Pfister, T.5
  • 25
    • 43549115915 scopus 로고    scopus 로고
    • Tovaxin, radiation-attenuated, patient-specific T-cells for the therapeutic vaccination of multiple sclerosis
    • Hellings N, Stinissen P (2008) Tovaxin, radiation-attenuated, patient-specific T-cells for the therapeutic vaccination of multiple sclerosis. Curr Opin Investig Drugs 9: 534-540.
    • (2008) Curr Opin Investig Drugs , vol.9 , pp. 534-540
    • Hellings, N.1    Stinissen, P.2
  • 26
    • 34249809700 scopus 로고    scopus 로고
    • A virus-like particle-based vaccine selectively targeting soluble TNF-alpha protects from arthritis without inducing reactivation of latent tuberculosis
    • Spohn G, Guler R, Johansen P, Keller I, Jacobs M, et al. (2007) A virus-like particle-based vaccine selectively targeting soluble TNF-alpha protects from arthritis without inducing reactivation of latent tuberculosis. J Immunol 178: 7450-7457.
    • (2007) J Immunol , vol.178 , pp. 7450-7457
    • Spohn, G.1    Guler, R.2    Johansen, P.3    Keller, I.4    Jacobs, M.5
  • 27
    • 77951102828 scopus 로고    scopus 로고
    • GAD-alum (Diamyd)--a new concept for preservation of residual insulin secretion
    • Ludvigsson J (2010) GAD-alum (Diamyd)--a new concept for preservation of residual insulin secretion. Expert Opin Biol Ther 10: 787-799.
    • (2010) Expert Opin Biol Ther , vol.10 , pp. 787-799
    • Ludvigsson, J.1
  • 28
    • 53249140520 scopus 로고    scopus 로고
    • Diamyd, an alum-formulated recombinant human GAD65 for the prevention of autoimmune diabetes
    • Hinke SA (2008) Diamyd, an alum-formulated recombinant human GAD65 for the prevention of autoimmune diabetes. Curr Opin Mol Ther 10: 516-525.
    • (2008) Curr Opin Mol Ther , vol.10 , pp. 516-525
    • Hinke, S.A.1
  • 29
    • 84856402593 scopus 로고    scopus 로고
    • DIAPREV-IT study of diabetes therapy Diamyd® receives further funding and will continue despite disappointing Phase III trial results
    • (2011) DIAPREV-IT study of diabetes therapy Diamyd® receives further funding and will continue despite disappointing Phase III trial results. Immunotherapy 3: 923-924.
    • (2011) Immunotherapy , vol.3 , pp. 923-924
  • 30
    • 84872853977 scopus 로고    scopus 로고
    • Immune therapy in type 1 diabetes mellitus
    • Lernmark A, Larsson HE (2013) Immune therapy in type 1 diabetes mellitus. Nat Rev Endocrinol 9: 92-103.
    • (2013) Nat Rev Endocrinol , vol.9 , pp. 92-103
    • Lernmark, A.1    Larsson, H.E.2
  • 31
    • 84864692611 scopus 로고    scopus 로고
    • Proof-of-concept, randomized, controlled clinical trial of Bacillus-Calmette-Guerin for treatment of long-term type 1 diabetes
    • Faustman DL, Wang L, Okubo Y, Burger D, Ban L, et al. (2012) Proof-of-concept, randomized, controlled clinical trial of Bacillus-Calmette-Guerin for treatment of long-term type 1 diabetes. PLoS One 7: e41756.
    • (2012) PLoS One , vol.7
    • Faustman, D.L.1    Wang, L.2    Okubo, Y.3    Burger, D.4    Ban, L.5
  • 32
    • 1942474600 scopus 로고    scopus 로고
    • Prevention of autoimmune diabetes through immunostimulation with Q fever complement-fixing antigen
    • Silva DG, Charlton B, Cowden W, Petrovsky N (2003) Prevention of autoimmune diabetes through immunostimulation with Q fever complement-fixing antigen. Ann N Y Acad Sci 1005: 423-430.
    • (2003) Ann N Y Acad Sci , vol.1005 , pp. 423-430
    • Silva, D.G.1    Charlton, B.2    Cowden, W.3    Petrovsky, N.4
  • 33
    • 84870462302 scopus 로고    scopus 로고
    • The efficacy and safety of a nicotine conjugate vaccine (NicVAX®) or placebo co-administered with varenicline (Champix®) for smoking cessation: Study protocol of a phase IIb, double blind, randomized, placebo controlled trial
    • Hoogsteder PH, Kotz D, van Spiegel PI, Viechtbauer W, Brauer R, et al. (2012) The efficacy and safety of a nicotine conjugate vaccine (NicVAX®) or placebo co-administered with varenicline (Champix®) for smoking cessation: study protocol of a phase IIb, double blind, randomized, placebo controlled trial. BMC Public Health 12: 1052.
    • (2012) BMC Public Health , vol.12 , pp. 1052
    • Hoogsteder, P.H.1    Kotz, D.2    van Spiegel, P.I.3    Viechtbauer, W.4    Brauer, R.5
  • 34
    • 0345832345 scopus 로고    scopus 로고
    • NicVAX (Nabi Biopharmaceuticals)
    • Heading CE (2003) NicVAX (Nabi Biopharmaceuticals). IDrugs 6: 1178-1181.
    • (2003) IDrugs , vol.6 , pp. 1178-1181
    • Heading, C.E.1
  • 36
    • 22544431937 scopus 로고    scopus 로고
    • A therapeutic vaccine for nicotine dependence: Preclinical efficacy, and Phase I safety and immunogenicity
    • Maurer P, Jennings GT, Willers J, Rohner F, Lindman Y, et al. (2005) A therapeutic vaccine for nicotine dependence: preclinical efficacy, and Phase I safety and immunogenicity. Eur J Immunol 35: 2031-2040.
    • (2005) Eur J Immunol , vol.35 , pp. 2031-2040
    • Maurer, P.1    Jennings, G.T.2    Willers, J.3    Rohner, F.4    Lindman, Y.5
  • 37
    • 41649085639 scopus 로고    scopus 로고
    • TA-CD Xenova
    • Heading CE (2002) TA-CD. Xenova. IDrugs 5: 1070-1074.
    • (2002) IDrugs , vol.5 , pp. 1070-1074
    • Heading, C.E.1
  • 38
    • 7044263390 scopus 로고    scopus 로고
    • Vaccine adjuvants: Current state and future trends
    • Petrovsky N, Aguilar JC (2004) Vaccine adjuvants: current state and future trends. Immunol Cell Biol 82: 488-496.
    • (2004) Immunol Cell Biol , vol.82 , pp. 488-496
    • Petrovsky, N.1    Aguilar, J.C.2
  • 40
    • 79953874296 scopus 로고    scopus 로고
    • 2-D-[2-> 1] poly(fructo-furanosyl) α-D-glucose polymers
    • 2-D-[2-> 1] poly(fructo-furanosyl) α-D-glucose polymers. Glycobiology 21: 595-606.
    • (2011) Glycobiology , vol.21 , pp. 595-606
    • Cooper, P.D.1    Petrovsky, N.2
  • 41
  • 42
    • 84864000393 scopus 로고    scopus 로고
    • Advax™, a polysaccharide adjuvant derived from delta inulin, provides improved influenza vaccine protection through broad-based enhancement of adaptive immune responses
    • Honda-Okubo Y, Saade F, Petrovsky N (2012) Advax™, a polysaccharide adjuvant derived from delta inulin, provides improved influenza vaccine protection through broad-based enhancement of adaptive immune responses. Vaccine 30: 5373-5381.
    • (2012) Vaccine , vol.30 , pp. 5373-5381
    • Honda-Okubo, Y.1    Saade, F.2    Petrovsky, N.3
  • 43
    • 84875257910 scopus 로고    scopus 로고
    • A novel hepatitis B vaccine containing Advaxâ"¢, a polysaccharide adjuvant derived from delta inulin, induces robust humoral and cellular immunity with minimal reactogenicity in preclinical testing
    • Saade F, Honda-Okubo Y, Trec S, Petrovsky N (2013) A novel hepatitis B vaccine containing Advaxâ"¢, a polysaccharide adjuvant derived from delta inulin, induces robust humoral and cellular immunity with minimal reactogenicity in preclinical testing. Vaccine 31: 1999-2007.
    • (2013) Vaccine , vol.31 , pp. 1999-2007
    • Saade, F.1    Honda-Okubo, Y.2    Trec, S.3    Petrovsky, N.4
  • 44
    • 40549113071 scopus 로고    scopus 로고
    • Freeing vaccine adjuvants from dangerous immunological dogma
    • Petrovsky N (2008) Freeing vaccine adjuvants from dangerous immunological dogma. Expert Rev Vaccines 7: 7-10.
    • (2008) Expert Rev Vaccines , vol.7 , pp. 7-10
    • Petrovsky, N.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.