Gastrointestinal weight-loss surgery: Glimpses at the molecular level

Drug Discovery Today

Volumn 18, Issue 13-14, 2013, Pages 625-636

  Freudenberg, Johannes M ^a   Rajpal, Neetu ^a   Way, James M ^a   Magid Slav, Michal ^a   Rajpal, Deepak K ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BARIATRIC SURGERY; BODY MASS; COMORBIDITY; GASTROINTESTINAL SURGERY; GASTROINTESTINAL WEIGHT LOSS SURGERY; GASTROPLASTY; HUMAN; LIFESTYLE MODIFICATION; METABOLOMICS; OBESITY; PROTEOMICS; REVIEW; STOMACH BYPASS; TRANSCRIPTOMICS; WEIGHT GAIN; WEIGHT REDUCTION;

ANIMALS; ANTI-OBESITY AGENTS; BARIATRIC SURGERY; COMPUTATIONAL BIOLOGY; DRUG DISCOVERY; GENE EXPRESSION PROFILING; GENETIC PREDISPOSITION TO DISEASE; HUMANS; METABOLOMICS; MOLECULAR TARGETED THERAPY; OBESITY; PHENOTYPE; PROTEOMICS; SIGNAL TRANSDUCTION; TREATMENT OUTCOME; WEIGHT LOSS;

EID: 84879919604     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2012.12.006     Document Type: Review

References (65)

1. P.E. O'Brien Bariatric surgery: mechanisms, indications and outcomes J. Gastroenterol. Hepatol. 25 2010 1358 1365
2. World Health Organization Obesity and Overweight - Fact Sheet No. 311 2012 WHO
3. E.A. Finkelstein Annual medical spending attributable to obesity: payer-and service-specific estimates Health Aff. 28 2009 w822 w831
4. G. Derosa, and P. Maffioli Anti-obesity drugs: a review about their effects and their safety Expert Opin. Drug Saf. 11 2012 459 471
5. D. Wong The pharmaceutical market for obesity therapies Nat. Rev. Drug Discov. 11 2012 669 670
6. P.M. O'Neil Randomized placebo-controlled clinical trial of lorcaserin for weight loss in type 2 diabetes mellitus: the BLOOM-DM study Obesity 20 2012 1426 1436
7. L.M. Kaplan Pharmacologic therapies for obesity Gastroenterol. Clin. N. Am. 39 2010 69 79
8. S. Williams Surgical treatment of metabolic syndrome Med. Princ. Pract. 21 2012 301 309
9. W.J. Pories Who would have thought it? An operation proves to be the most effective therapy for adult-onset diabetes mellitus Ann. Surg. 222 1995 339 350
10. M.A. Stefater All bariatric surgeries are not created equal: insights from mechanistic comparisons Endocr. Rev. 33 2012 595 622
11. F.L. Greenway, and G.A. Bray Combination drugs for treating obesity Curr. Diab. Rep. 10 2010 108 115
12. C.S. Tam Could the mechanisms of bariatric surgery hold the key for novel therapies? Report from a Pennington Scientific Symposium Obes. Rev. 12 2011 984 994
13. J.J. Park GRB14, GPD1, and GDF8 as potential network collaborators in weight loss-induced improvements in insulin action in human skeletal muscle Physiol. Genomics 27 2006 114 121
14. D.M. Greenawalt A survey of the genetics of stomach, liver, and adipose gene expression from a morbidly obese cohort Genome Res. 21 2011 1008 1016
15. R. Edgar Gene Expression Omnibus: NCBI gene expression and hybridization array data repository Nucleic Acids Res. 30 2002 207 210
16. S.H. Jacobsen Changes in gastrointestinal hormone responses, insulin sensitivity, and beta-cell function within 2 weeks after gastric bypass in non-diabetic subjects Obes. Surg. 22 2012 1084 1096
17. S.N. Dankel Switch from stress response to homeobox transcription factors in adipose tissue after profound fat loss PLoS ONE 5 2010 e11033
18. M. Hulsmans Interleukin-1 receptor-associated kinase-3 is a key inhibitor of inflammation in obesity and metabolic syndrome PLoS ONE 7 2012 e30414
19. A. Oberbach Combined proteomic and metabolomic profiling of serum reveals association of the complement system with obesity and identifies novel markers of body fat mass changes J. Proteome Res. 10 2011 4769 4788
20. B. Laferrere Differential metabolic impact of gastric bypass surgery versus dietary intervention in obese diabetic subjects despite identical weight loss Sci. Transl. Med. 3 2011 80re2
21. R. Cancello Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss Diabetes 54 2005 2277 2286
22. C. Henegar Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity Genome Biol. 9 2008 R14
23. N. Hoggard Using gene expression to predict differences in the secretome of human omental vs. subcutaneous adipose tissue Obesity 20 2012 1158 1167
24. J.A. Houmard Severe obesity: evidence for a deranged metabolic program in skeletal muscle? Exerc. Sport Sci. Rev. 40 2012 204 210
25. S.Z. Berisha Changes in whole blood gene expression in obese subjects with type 2 diabetes following bariatric surgery: a pilot study PLoS ONE 6 2011 e16729
26. J.M. Freudenberg Acute depletion of Tet1-dependent 5- hydroxymethylcytosine levels impairs LIF/Stat3 signaling and results in loss of embryonic stem cell identity Nucleic Acids Res. 40 2012 3364 3377
27. G.K. Smyth Linear models and empirical Bayes methods for assessing differential expression in microarray experiments Stat. Appl. Genet. Mol. Biol. 3 2004 Article 3
28. Y. Benjamini, and Y. Hochberg Controlling the false discovery rate: a practical and powerful approach to multiple testing J. R. Stat. Soc. B 57 1995 289 300
29. J.M. Freudenberg CLEAN: CLustering Enrichment ANalysis BMC Bioinform. 10 2009 234
30. T. Rankinen The human obesity gene map: the 2005 update Obesity 14 2006 529 644
31. J.T. Eppig The Mouse Genome Database (MGD): comprehensive resource for genetics and genomics of the laboratory mouse Nucleic Acids Res. 40 2012 D881 D886
32. L.A. Hindorff Potential etiologic and functional implications of genome-wide association loci for human diseases and traits Proc. Natl. Acad. Sci. U.S.A. 106 2009 9362 9367
33. Y. Zhang Systematic analysis, comparison, and integration of disease based human genetic association data and mouse genetic phenotypic information BMC Med. Genomics 3 2010 1
34. Y.F. Ngai Ldlr-/- mice display decreased susceptibility to Western-type diet-induced obesity due to increased thermogenesis Endocrinology 151 2010 5226 5236
35. J. Wang ApoE and the role of very low density lipoproteins in adipose tissue inflammation Atherosclerosis 223 2012 342 349
36. R. Chaudhary Apolipoprotein E gene polymorphism: effects on plasma lipids and risk of type 2 diabetes and coronary artery disease Cardiovasc. Diabetol. 11 2012 36
37. M. Kanehisa KEGG for integration and interpretation of large-scale molecular data sets Nucleic Acids Res. 40 2012 D109 D114
38. L. Matthews Reactome knowledgebase of human biological pathways and processes Nucleic Acids Res. 37 2009 D619 D622
39. R.C. Gentleman Bioconductor: open software development for computational biology and bioinformatics Genome Biol. 5 2004 R80
40. M.F. Gregor, and G.S. Hotamisligil Inflammatory mechanisms in obesity Annu. Rev. Immunol. 29 2011 415 445
41. T.D. Baird, and R.C. Wek Eukaryotic initiation factor 2 phosphorylation and translational control in metabolism Adv. Nutr. 3 2012 307 321
42. J. Seo Atf4 regulates obesity, glucose homeostasis, and energy expenditure Diabetes 58 2009 2565 2573
43. M. Gaster Impaired TCA cycle flux in mitochondria in skeletal muscle from type 2 diabetic subjects: marker or maker of the diabetic phenotype? Arch. Physiol. Biochem. 118 2012 156 189
44. E. Hopps, and G. Caimi Matrix metalloproteinases in metabolic syndrome Eur. J. Intern. Med. 23 2012 99 104
45. G. Brandacher Potential applications of global protein expression analysis (proteomics) in morbid obesity and bariatric surgery Obes. Surg. 18 2008 905 910
46. A.D. Eckhart Metabolomics as a key integrator for 'omic' advancement of personalized medicine and future therapies Clin. Transl. Sci. 5 2012 285 288
47. P. She Obesity-related elevations in plasma leucine are associated with alterations in enzymes involved in branched-chain amino acid metabolism Am. J. Physiol Endocrinol. Metab. 293 2007 E1552 E1563
48. J.R. Bain Metabolomics applied to diabetes research: moving from information to knowledge Diabetes 58 2009 2429 2443
49. S.H. Shah Branching out for detection of type 2 diabetes Cell. Metab. 13 2011 491 492
50. S.H. Shah Branched-chain amino acid levels are associated with improvement in insulin resistance with weight loss Diabetologia 55 2012 321 330
51. R.E. Gerszten, and T.J. Wang Two roads diverge: weight loss interventions and circulating amino acids Sci. Transl. Med. 3 2011 80ps15
52. D.M. Culnan Apolipoprotein A-IV, a putative satiety/antiatherogenic factor, rises after gastric bypass Obesity 17 2009 46 52
53. S.R. Rao Inflammatory markers and bariatric surgery: a meta-analysis Inflamm. Res. 61 2012 789 807
54. B. Laferrere Diabetes remission after bariatric surgery: is it just the incretins? Int. J. Obes. 35 Suppl. 3 2011 S22 S25
55. L.M. Beckman Changes in gastrointestinal hormones and leptin after Roux-en-Y gastric bypass surgery J. Parenter. Enteral Nutr. 35 2011 169 180
56. Y. Falken Changes in glucose homeostasis after Roux-en-Y gastric bypass surgery for obesity at day three, two months, and one year after surgery: role of gut peptides J. Clin. Endocrinol. Metab. 96 2011 2227 2235
57. J.R. Brown Computational biology approaches for selecting host-pathogen drug targets Drug Discov. Today 16 2011 229 236
58. D.K. Rajpal Understanding biology through bioinformatics Int. J. Toxicol. 24 2005 147 152
59. N.S. Buchan The role of translational bioinformatics in drug discovery Drug Discov. Today 16 2011 426 434
60. A.L. Hopkins, and C.R. Groom The druggable genome Nat. Rev. Drug Discov. 1 2002 727 730
61. A.P. Russ, and S. Lampel The druggable genome: an update Drug Discov. Today 10 2005 1607 1610
62. P.M. Blake Toward an integrated knowledge environment to support modern oncology Cancer J. 17 2011 257 263
63. J. Faldt Reduced exercise endurance in interleukin-6-deficient mice Endocrinology 145 2004 2680 2686
64. A.D. Boran, and R. Iyengar Systems approaches to polypharmacology and drug discovery Curr. Opin. Drug Discov. Dev. 13 2010 297 309
65. J.C. Clemente The impact of the gut microbiota on human health: an integrative view Cell 148 2012 1258 1270