Diazido mixed-amine platinum(IV) anticancer complexes activatable by visible-light form novel DNA adducts

Chemistry - A European Journal

Volumn 19, Issue 29, 2013, Pages 9578-9591

  Zhao, Yao ^a   Woods, Julie A ^b   Farrer, Nicola J ^a   Robinson, Kim S ^b   Pracharova, Jitka ^c   Kasparkova, Jana ^c   Novakova, Olga ^d   Li, Huilin ^a   Salassa, Luca ^a   Pizarro, Ana M ^a   Clarkson, Guy J ^a   Song, Lijiang ^a   Brabec, Viktor ^c   Sadler, Peter J ^a  

^a UNIVERSITY OF WARWICK   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

^c PALACKÝ UNIVERSITY   (Czech Republic)

^d INSTITUTE OF BIOPHYSICS   (Czech Republic)

Author keywords

antitumor agents; DNA binding; medicinal chemistry; photoactivity; platinum

Indexed keywords

ANTI-TUMOR AGENTS; CISPLATIN-RESISTANT CELL; DNA BINDING; INTERSTRAND CROSS-LINKS; MEDICINAL CHEMISTRY; PHOTOACTIVITY; PHOTOPHYSICAL PROPERTIES; SIGNIFICANT DIFFERENCES;

CELL CULTURE; CELLS; CHEMICAL BONDS; CRYSTAL ORIENTATION; DRUG PRODUCTS; LIGHT; OLIGONUCLEOTIDES; PLATINUM; PLATINUM COMPOUNDS; SYNTHESIS (CHEMICAL); X RAY CRYSTALLOGRAPHY;

DNA;

ANTINEOPLASTIC AGENT; AZIDE; CALF THYMUS DNA; CISPLATIN; DNA; PLATINUM; PLATINUM COMPLEX; PRODRUG; PYRIDINE DERIVATIVE; TRANSPLATIN;

ANTITUMOR AGENTS; ARTICLE; CHEMISTRY; DNA ADDUCT; DNA BINDING; HUMAN; LIGHT; MEDICINAL CHEMISTRY; PHOTOACTIVITY; X RAY CRYSTALLOGRAPHY;

ANTITUMOR AGENTS; DNA BINDING; MEDICINAL CHEMISTRY; PHOTOACTIVITY; PLATINUM;

ANTINEOPLASTIC AGENTS; AZIDES; CHEMISTRY, PHARMACEUTICAL; CISPLATIN; CRYSTALLOGRAPHY, X-RAY; DNA; DNA ADDUCTS; HUMANS; LIGHT; ORGANOPLATINUM COMPOUNDS; PLATINUM; PRODRUGS; PYRIDINES;

EID: 84879918023     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.201300374     Document Type: Article

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