In silico screening for compounds that match the pharmacophore of omega-hexatoxin-Hv1a leads to discovery and optimization of a novel class of insecticides

Pesticide Biochemistry and Physiology

Volumn 106, Issue 3, 2013, Pages 124-140

  Tedford, H William ^a   Steinbaugh, Bruce A ^a   Bao, Lin ^a   Tait, Bradley D ^e   Tempczyk Russell, Anna ^b,d   Smith, Whitney ^f   Benzon, Gary L ^c   Finkenbinder, Chad A ^c   Kennedy, Robert M ^a  

^a Vestaron Corporation   (United States)

^b ACCELRYS INC   (United States)

^c Benzon Research   (United States)

^d PFIZER INC   (United States)

^e Proteostasis Therapeutics Inc   (United States)

^f IDBS   (United Kingdom)

Author keywords

DUM neuron; Electrophysiology; In silico; Mosquito; Omega hexatoxin; Pharmacophore; Scanning mutagenesis; Screening; Triazine; Venom

Indexed keywords

AEDES AEGYPTI; BLATTARIA; HEXAPODA; LEPIDOPTERA; SPODOPTERA EXIGUA;

EID: 84879887847     PISSN: 00483575     EISSN: 10959939     Source Type: Journal    
DOI: 10.1016/j.pestbp.2013.01.009     Document Type: Article

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