Alkaline-stable peptide ligand affinity adsorbents for the purification of biomolecules

Journal of Chromatography A

Volumn 1245, Issue , 2012, Pages 55-64

  Menegatti, Stefano ^a   Naik, Amith D ^a   Gurgel, Patrick V ^a   Carbonell, Ruben G ^a  

^a North Carolina State University   (United States)

Author keywords

Affinity adsorbent; Cleaning in place; Modification of surface chemistry; NaOH stability; Peptide ligand; Solid phase peptide synthesis

Indexed keywords

ALKALINE CONDITIONS; AMIDE BOND; BASE RESIN; BIOPHARMACEUTICALS; BROAD APPLICATION; CELL CULTURE MEDIUMS; CHROMATOGRAPHIC MATRIX; CLEANING IN PLACE; COMPLEX MEDIA; ESTER BONDS; HYDROXYL GROUPS; PEPTIDE LIGAND; PEPTIDE SYNTHESIS; REPEATED CYCLE; SDS-PAGE ANALYSIS; SOLID PHASE PEPTIDE SYNTHESIS;

ADSORBENTS; AMIDES; BIOSYNTHESIS; CELL CULTURE; ESTERIFICATION; ESTERS; HYDROPHILICITY; LEACHING; LIGANDS; PURIFICATION; RESINS; SURFACE CHEMISTRY;

PEPTIDES;

ADSORBENT; ESTER; HISTIDYLTRYPTOPHYLARGINYLGLYCYLTRYPTOPHYLVALINE; IMMUNOGLOBULIN G; RESIN; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; BINDING AFFINITY; CELL CULTURE; CHEMICAL BOND; CHROMATOGRAPHY; CLEANING; CONTROLLED STUDY; HYDROPHILICITY; LEACHING; LIGAND BINDING; MOLECULAR STABILITY; PEPTIDE SYNTHESIS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PURIFICATION; REGENERATION;

ADSORPTION; ALKALIES; CHROMATOGRAPHY, AFFINITY; IMMUNOGLOBULIN G; LIGANDS; PEPTIDES; PROTEIN BINDING;

EID: 84861989875     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2012.04.072     Document Type: Article

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