Recent advances in the study of testicular nuclear receptor 4

Journal of Zhejiang University: Science B

Volumn 14, Issue 3, 2013, Pages 171-177

  Ding, Xian Fan ^a   Yu, Shi Cheng ^a   Chen, Bi De ^a   Lin, Shin Jen ^b   Chang, Chawnshang ^b   Li, Gong Hui ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b UNIVERSITY OF ROCHESTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD36 ANTIGEN; ESTRADIOL; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; HEMOGLOBIN; NUCLEAR RECEPTOR NR2C2; PROGESTERONE; RETINOID;

ADIPOCYTE; AGING; ANIMAL TISSUE; BONE MASS; BREAST CANCER; CARBOHYDRATE METABOLISM; DUAL ENERGY X RAY ABSORPTIOMETRY; ERYTHROCYTE; FEMALE FERTILITY; GEL MOBILITY SHIFT ASSAY; GENE CONTROL; GENE EXPRESSION; GENE INACTIVATION; GLUCONEOGENESIS; HUMAN; HUMAN TISSUE; HYPOTHALAMUS; IN VIVO STUDY; INSULIN SENSITIVITY; LIPID METABOLISM; LIVER CELL; MALE FERTILITY; METABOLIC SYNDROME X; NONHUMAN; OSTEOBLAST; OSTEOPOROSIS; OVARY FUNCTION; OXIDATIVE STRESS; PREMATURE AGING; PRIORITY JOURNAL; PROMOTER REGION; PROSTATE; PROSTATIC INTRAEPITHELIAL NEOPLASIA; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SEXUAL BEHAVIOR; SICKLE CELL ANEMIA; SPERMATOCYTE; STRESS; SUBFERTILITY; TESTIS; TISSUE DISTRIBUTION;

AGING, PREMATURE; ANIMALS; DISEASE MODELS, ANIMAL; HUMANS; INFERTILITY; MALE; MICE; MICE, KNOCKOUT; NUCLEAR RECEPTOR SUBFAMILY 2, GROUP C, MEMBER 2; PROSTATIC INTRAEPITHELIAL NEOPLASIA; SPINAL CURVATURES;

ANIMALIA; MUS; RATTUS;

EID: 84879857938     PISSN: 16731581     EISSN: 18621783     Source Type: Journal    
DOI: 10.1631/jzus.B1200357     Document Type: Review

References (41)

1. Aranda, A., Pascual, A., 2001. Nuclear hormone receptors and gene expression. Physiol. Rev., 81(3):1269-1304. (Pubitemid 32606670)
2. Bowen, R.L., Atwood, C.S., 2004. Living and dying for sex. A theory of aging based on the modulation of cell cycle signaling by reproductive hormones. Gerontology, 50(5):265-290. [doi:10.1159/000079125] (Pubitemid 39194344)
3. Campbell, A.D., Cui, S., Shi, L., Urbonya, R., Mathias, A., Bradley, K., Bonsu, K.O., Douglas, R.R., Halford, B., Schmidt, L., et al., 2011. Forced TR2/TR4 expression in sickle cell disease mice confers enhanced fetal hemoglobin synthesis and alleviated disease phenotypes. PNAS, 108(46):18808-18813. [doi:10.1073/pnas.1104964108]
4. Chang, C., da Silva, S.L., Ideta, R., Lee, Y., Yeh, S., Burbach, J.P., 1994. Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily. PNAS, 91(13):6040-6044. [doi:10.1073/pnas.91.13.6040] (Pubitemid 24188278)
5. Chen, L.M., Wang, R.S., Lee, Y.F., Liu, N.C., Chang, Y.J., Wu, C.C., Xie, S., Hung, Y.C., Chang, C., 2008. Subfertility with defective folliculogenesis in female mice lacking testicular orphan nuclear receptor 4. Mol. Endocrinol., 22(4):858-867. [doi:10.1210/me.2007-0181] (Pubitemid 351482822)
6. Chen, Y.T., Collins, L.L., Chang, S.S., Chang, C., 2008. The roles of testicular orphan nuclear receptor 4 (TR4) in cerebellar development. Cerebellum, 7(1):9-17. [doi:10.1007/s12311-008-0006-3]
7. Choi, H., Kim, S.J., Park, S.S., Chang, C., Kim, E., 2011. TR4 activates FATP1 gene expression to promote lipid accumulation in 3T3-L1 adipocytes. FEBS Lett., 585(17):2763-2767. [doi:10.1016/j.febslet.2011.08.002]
8. Collins, L.L., Lee, Y.F., Heinlein, C.A., Liu, N.C., Chen, Y.T., Shyr, C.R., Meshul, C.K., Uno, H., Platt, K.A., Chang, C., 2004. Growth retardation and abnormal maternal behavior in mice lacking testicular orphan nuclear receptor 4. PNAS, 101(42):15058-15063. [doi:10.1073/pnas.0405700101] (Pubitemid 39391718)
9. Collins, L.L., Lee, Y.F., Ting, H.J., Lin, W.J., Liu, N.C., Meshul, C.K., Uno, H., Bao, B.Y., Chen, Y.T., Chang, C., 2011. The roles of testicular nuclear receptor 4 (TR4) in male fertility-priapism and sexual behavior defects in TR4 knockout mice. Reprod. Biol. Endocrinol., 9(1):138. [doi:10.1186/1477- 7827-9-138]
10. Cui, S., Kolodziej, K.E., Obara, N., Amaral-Psarris, A., Demmers, J., Shi, L., Engel, J.D., Grosveld, F., Strouboulis, J., Tanabe, O., 2011. Nuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic β-type globin promoters in differentiated adult erythroid cells. Mol. Cell. Biol., 31(16):3298-3311. [doi:10.1128/MCB.05310-11]
11. Harada, H., Kuboi, Y., Miki, R., Honda, C., Masushige, S., Nakatsuka, M., Koga, Y., Kato, S., 1998. Cloning of rabbit TR4 and its bone cell-specific activity to suppress estrogen receptor-mediated transactivation. Endocrinology, 139(1):204-212. [doi:10.1210/en.139.1.204] (Pubitemid 28166310)
12. Hirose, T., Fujimoto, W., Tamaai, T., Kim, K.H., Matsuura, H., Jetten, A.M., 1994. TAK1: molecular cloning and characterization of a new member of the nuclear receptor superfamily. Mol. Endocrinol., 8(12):1667-1680. [doi:10.1210/me.8.12.1667]
13. Huang, Y.H., Liao, C.H., Chen, R.N., Liao, C.J., Lin, K.H., 2010. Human testicular orphan receptor 4 enhances thyroid hormone receptor signaling. J. Cell. Physiol., 222(2):347-356. [doi:10.1002/jcp.21959]
14. Kang, H.S., Okamoto, K., Kim, Y.S., Takeda, Y., Bortner, C.D., Dang, H., Wada, T., Xie, W., Yang, X.P., Liao, G., et al., 2011. Nuclear orphan receptor TAK1/TR4-deficient mice are protected against obesity-linked inflammation, hepatic steatosis, and insulin resistance. Diabetes, 60(1):177-188. [doi:10.2337/db10-0628]
15. Kim, E., Xie, S., Yeh, S.D., Lee, Y.F., Collins, L.L., Hu, Y.C., Shyr, C.R., Mu, X.M., Liu, N.C., Chen, Y.T., et al., 2003. Disruption of TR4 orphan nuclear receptor reduces the expression of liver apolipoprotein E/C-I/C-II gene cluster. J. Biol. Chem., 278(47):46919-46926. [doi:10.1074/jbc.M304088200] (Pubitemid 37452274)
16. Kim, E., Yang, Z., Liu, N.C., Chang, C., 2005. Induction of apolipoprotein E expression by TR4 orphan nuclear receptor via 5′ proximal promoter region. Biochem. Biophys. Res. Commun., 328(1):85-90. [doi:10.1016/j.bbrc.2004.12.146] (Pubitemid 40164639)
17. Kim, E., Liu, N.C., Yu, I.C., Lin, H.Y., Lee, Y.F., Sparks, J.D., Chen, L.M., Chang, C., 2011. Metformin inhibits nuclear receptor TR4-mediated hepatic stearoyl-COA desaturase 1 gene expression with altered insulin sensitivity. Diabetes, 60(5):1493-1503. [doi:10.2337/db10-0393]
18. Lee, H.J., Lee, Y.F., Chang, C., 2001. TR4 orphan receptor represses the human steroid 21-hydroxylase gene expression through the monomeric AGGTCA motif. Biochem. Biophys. Res. Commun., 285(5):1361-1368. [doi:10.1006/bbrc.2001.5342] (Pubitemid 32912934)
19. Lee, Y.F., Young, W.J., Burbach, J.P., Chang, C., 1998. Negative feedback control of the retinoid-retinoic acid/retinoid X receptor pathway by the human TR4 orphan receptor, a member of the steroid receptor superfamily. J. Biol. Chem., 273(22):13437-13443. [doi:10.1074/jbc.273.22.13437] (Pubitemid 28268382)
20. Lee, Y.F., Young, W.J., Lin, W.J., Shyr, C.R., Chang, C., 1999. Differential regulation of direct repeat 3 vitamin D3 and direct repeat 4 thyroid hormone signaling pathways by the human TR4 orphan receptor. J. Biol. Chem., 274(23):16198-16205. [doi:10.1074/jbc.274.23.16198]
21. Lee, Y.F., Lee, H.J., Chang, C., 2002. Recent advances in the TR2 and TR4 orphan receptors of the nuclear receptor superfamily. J. Steroid Biochem. Mol. Biol., 81(4-5):291-308. [doi:10.1016/S0960-0760(02)00118-8] (Pubitemid 35279114)
22. Lee, Y.F., Liu, S., Liu, N.C., Wang, R.S., Chen, L.M., Lin, W.J., Ting, H.J., Ho, H.C., Li, G., Puzas, E.J., et al., 2011. Premature aging with impaired oxidative stress defense in mice lacking TR4. Am. J. Physiol. Endocrinol. Metab., 301(1):E91-E98. [doi:10.1152/ajpendo.00701.2010]
23. Li, G., Lee, Y.F., Liu, S., Cai, Y., Xie, S., Liu, N.C., Bao, B.Y., Chen, Z., Chang, C., 2008. Oxidative stress stimulates testicular orphan receptor 4 through forkhead transcription factor forkhead box O3a. Endocrinology, 149(7):3490-3499. [doi:10.1210/en.2008-0121] (Pubitemid 351919587)
24. Lin, S.J., Ho, H.C., Lee, Y.F., Liu, N.C., Liu, S., Li, G., Shyr, C.R., Chang, C., 2012. Reduced osteoblast activity in the mice lacking TR4 nuclear receptor leads to osteoporosis. Reprod. Biol. Endocrinol., 10(1):43. [doi:10.1186/1477-7827-10-43]
25. Liu, N.C., Lin, W.J., Kim, E., Collins, L.L., Lin, H.Y., Yu, I.C., Sparks, J.D., Chen, L.M., Lee, Y.F., Chang, C., 2007. Loss of TR4 orphan nuclear receptor reduces phosphoenolpyruvate carboxykinase-mediated gluconeogenesis. Diabetes, 56(12):2901-2909. [doi:10.2337/db07-0359] (Pubitemid 350223624)
26. Liu, S., Lee, Y.F., Chou, S., Uno, H., Li, G., Brookes, P., Massett, M.P., Wu, Q., Chen, L.M., Chang, C., 2011a. Mice lacking TR4 nuclear receptor develop mitochondrial myopathy with deficiency in complex I. Mol. Endocrinol., 25(8):1301-1310. [doi:10.1210/me.2010-0455]
27. Liu, S., Yan, S.J., Lee, Y.F., Liu, N.C., Ting, H.J., Li, G., Wu, Q., Chen, L.M., Chang, C., 2011b. Testicular nuclear receptor 4 (TR4) regulates UV light-induced responses via cockayne syndrome B protein-mediated transcription-coupled DNA repair. J. Biol. Chem., 286(44): 38103-38108. [doi:10.1074/jbc.M111.259523]
28. Mu, X., Lee, Y.F., Liu, N.C., Chen, Y.T., Kim, E., Shyr, C.R., Chang, C., 2004. Targeted inactivation of testicular nuclear orphan receptor 4 delays and disrupts late meiotic prophase and subsequent meiotic divisions of spermatogenesis. Mol. Cell. Biol., 24(13):5887-5899. [doi:10.1128/MCB.24.13. 5887-5899.2004] (Pubitemid 38787973)
29. Popov, V.M., Wang, C., Shirley, L.A., Rosenberg, A., Li, S., Nevalainen, M., Fu, M., Pestell, R.G., 2007. The functional significance of nuclear receptor acetylation. Steroids, 72(2):221-230. [doi:10.1016/j.steroids.2006.12.001] (Pubitemid 46273505)
30. Robinson-Rechavi, M., Escriva Garcia, H., Laudet, V., 2003. The nuclear receptor superfamily. J. Cell. Sci., 116(Pt 4):585-586. [doi:10.1242/jcs.00247] (Pubitemid 36231296)
31. Shyr, C.R., Kang, H.Y., Tsai, M.Y., Liu, N.C., Ku, P.Y., Huang, K.E., Chang, C., 2009. Roles of testicular orphan nuclear receptors 2 and 4 in early embryonic development and embryonic stem cells. Endocrinology, 150(5):2454-2462. [doi:10.1210/en.2008-1165]
32. Tanabe, O., Katsuoka, F., Campbell, A.D., Song, W., Yamamoto, M., Tanimoto, K., Engel, J.D., 2002. An embryonic/fetal β-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer. EMBO J, 21(13):3434-3442. [doi:10.1093/emboj/cdf340] (Pubitemid 34760575)
33. Tsai, N.P., Huq, M., Gupta, P., Yamamoto, K., Kagechika, H., Wei, L.N., 2009. Activation of testicular orphan receptor 4 by fatty acids. Biochim. Biophys. Acta, 1789(11-12):734-740. [doi:10.1016/j.bbagrm.2009.09.010]
34. Wang, C.P., Lee, Y.F., Chang, C., Lee, H.J., 2006. Transactivation of the proximal promoter of human oxytocin gene by TR4 orphan receptor. Biochem. Biophys. Res. Commun., 351(1):204-208. [doi:10.1016/j.bbrc.2006.10.021] (Pubitemid 44635427)
35. Xie, S., Lee, Y.F., Kim, E., Chen, L.M., Ni, J., Fang, L.Y., Liu, S., Lin, S.J., Abe, J., Berk, B., et al., 2009. TR4 nuclear receptor functions as a fatty acid sensor to modulate CD36 expression and foam cell formation. PNAS, 106(32):13353-13358. [doi:10.1073/pnas.0905724106]
36. Xie, S., Ni, J., Lee, Y.F., Liu, S., Li, G., Shyr, C.R., Chang, C., 2011. Increased acetylation in the DNA-binding domain of TR4 nuclear receptor by the coregulator ARA55 leads to suppression of TR4 transactivation. J. Biol. Chem., 286(24):21129-21136. [doi:10.1074/jbc.M110.208181]
37. Yan, S.J., Lee, Y.F., Ting, H.J., Liu, N.C., Liu, S., Lin, S.J., Yeh, S.D., Li, G., Chang, C., 2012. Deficiency in TR4 nuclear receptor abrogates GADD45A expression and increases cytotoxicity induced by ionizing radiation. Cell Mol. Biol. Lett., 17(2):309-322. [doi:10.2478/s11658-012-0012-9]
38. Yan, Z.H., Karam, W.G., Staudinger, J.L., Medvedev, A., Ghanayem, B.I., Jetten, A.M., 1998. Regulation of peroxisome proliferator-activated receptor alpha-induced transactivation by the nuclear orphan receptor TAK1/TR4. J. Biol. Chem., 273(18):10948-10957. [doi:10.1074/jbc.273.18.10948] (Pubitemid 28204934)
39. Yang, X., Downes, M., Yu, R.T., Bookout, A.L., He, W., Straume, M., Mangelsdorf, D.J., Evans, R.M., 2006. Nuclear receptor expression links the circadian clock to metabolism. Cell, 126(4):801-810. [doi:10.1016/j.cell.2006. 06.050] (Pubitemid 44233631)
40. Zhang, Y., Dufau, M.L., 2000. Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor. J. Biol. Chem., 275(4):2763-2770. [doi:10.1074/jbc.275.4.2763] (Pubitemid 30082047)
41. Zhou, X.E., Suino-Powell, K.M., Xu, Y., Chan, C.W., Tanabe, O., Kruse, S.W., Reynolds, R., Engel, J.D., Xu, H.E., 2011. The orphan nuclear receptor TR4 is a vitamin A-activated nuclear receptor. J. Biol. Chem., 286(4):2877-2885. [doi:10.1074/jbc.M110.168740]