Soy isoflavone alleviates Aβ1-42-induced impairment of learning and memory ability through the regulation of RAGE/LRP-1 in neuronal and vascular tissue

Current Neurovascular Research

Volumn 10, Issue 2, 2013, Pages 144-156

  Xi, Yuan Di ^a   Li, Xiao Ying ^b   Ding, Juan ^a   Yu, Huan Ling ^a   Ma, Wei Wei ^a   Yuan, Lin Hong ^a   Wu, Jian ^b   Xiao, Rong ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Learning and memory ability; LRP 1; Neurovascular protection; NF B; RAGE; Soy isoflavone; amyloid peptide 1 42

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; AMYLOID BETA PROTEIN[1-42]; INTERLEUKIN 1BETA; ISOFLAVONE; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOHISTOCHEMISTRY; LEARNING; LEARNING DISORDER; MALE; MEMORY; MEMORY DISORDER; NERVE CELL; NEUROPROTECTION; NONHUMAN; PLASMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; VASCULAR TISSUE;

EID: 84879816309     PISSN: 15672026     EISSN: 18755739     Source Type: Journal    
DOI: 10.2174/1567202611310020007     Document Type: Article

References (22)

1. Crews L, Masliah E. Molecular Mechanisms of Neurodegeneration in Alzheimer's Disease. Hum Mol Genet 2010; 19(R1): R12-20.
2. Xi YD, Yu HL, Ma WW, et al. Genistein inhibits mitochondrial-targeted oxidative damage induced by beta-amyloid peptide 25-35 in PC12 cells. J Bioenerg Biomembr 2011; 43(4):399-407.
3. Han BH, Zhou M, Abousaleh F, et al. Cerebrovascular Dysfunction in Amyloid Precursor Protein Transgenic Mice: Contribution of Soluble and Insoluble Amyloid-β Peptide, Partial Restoration via γ-Secretase Inhibition. J Neurosci 2008; 28(50): 13542-50.
4. Bell RD, Zlokovic BV. Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease. Acta Neuropathol 2009; 118(1): 103-13.
5. Tong XK, Nicolakakis N, Fernandes P, et al. Simvastatin improves cerebrovascular function and counters soluble amyloid-beta, inflammation and oxidative stress in aged APP mice. Neurobiol Dis 2009; 35(3): 406-414.
6. Stuart B, Melissa MG, Sarah A. Oxidative Stress in Vascular Dementia and Alzheimer's Disease: A Common Pathology. J Alzheimers Dis 2009; 17(2): 245-257.
7. Li W, Frame LT, Hirsch S, Cobos E. Genistein and hematological malignancies. Cancer Lett 2010; 296(1): 1-8.
8. Bitto A, Burnett BP, Polito F, et al. Genistein aglycone reverses glucocorticoid-induced osteoporosis and increases bone breaking strength in rats: a comparative study with alendronate. Br J Pharmacol 2009; 156(8): 1287-95.
9. Si H, Liu D. Phytochemical genistein in the regulation of vascular function: new insights. Curr Med Chem 2007; 14(24): 2581-9.
10. Xi YD, Yu HL, Ding J, et al. Flavonoids Protect Cerebrovascular Endothelial Cells through Nrf2 and PI3K from β-Amyloid Peptide-Induced Oxidative Damage, Curr Neurovas Res 2012; 9(1):32-41.
11. Ma WW, Xiang L, Yu HL, et al. Neuroprotection of soyabean isoflavone co-administration with folic acid against beta-amyloid 1-40-induced neurotoxicity in rats. Br J Nutr 2009; 102(4):502-5.
12. Yu HL, Li L, Zhang XH, et al. Neuroprotective effects of genistein and folic acid on apoptosis of rat cultured cortical neurons induced by beta-amyloid 31-35. Br J Nutr 2009; 102(5):655-62.
13. Ma WW, Yuan LH, Yu HL, et al. Genistein as a neuroprotective antioxidant attenuates redox imbalance induced by β-amyloid peptides 25-35 in PC12 cells. Int J Devl Neurosci 2010; 28(4):289-95.
14. Ding BJ, Ma WW, He LL, Zhou X, Yuan LH, Yu HL, Feng JF, Xiao R. Soybean isoflavone alleviates β-amyloid 1-42 induced inflammatory responseto improve learning and memory ability by down regulation of Toll-like receptor4 expression and nuclear factor-?B activity in rats. Int J Dev Neurosci 2011; 29(5):537-42.
15. Hashimoto M, Hossain S, Tanabe Y, et al. The protective effect of dietary eicosapentaenoic acid against impairment of spatial cognition learning ability in rats infused with amyloid (1-40). J Nutr Biochem 2009; 20(12):965-73.
16. Ding J, Yu HL, Ma WW, et al. Soy isoflavone attenuates brain mitochondrial oxidative stress induced by beta-amyloid peptides 1-42 injection in lateral cerebral ventricle. J Neurosci Res 2013; 91(4):562-7
17. Sheinerman KS, Tsivinsky VG, Crawford F, Mullan MJ, Abdullah L, Umansky SR. Plasma microRNA biomarkers for detection of mild cognitive impairment. Aging 2012; 4(9):590-605.
18. Kuwahara H, Nishida Y, Yokota T. [Blood-brain barrier and Alzheimer's disease]. Brain Nerve 2013; 65(2):145-51.
19. Liu H, Xing A, Wang X, Liu G, Li L. Regulation of β-amyloid level in the brain of rats with cerebrovascular hypoperfusion. Neurobiol Aging 2012; 33(4):826.e31-826. e42.
20. Frommhold D, Kamphues A, Hepper I, et al. RAGE and ICAM-1 cooperate in mediating leukocyte recruitment during acute inflammation in vivo. Blood 2010. 116(5):841-9.
21. Bianchi R, Giambanco I, Donato R. S100B/RAGE-dependent activation of microglia via NF-κB and AP-1 Co-regulation of COX-2 expression by S100B, IL-1β and TNF-α. Neurobiol Aging 2010; 31(4):665-7.
22. Yan SD, Chen X, Fu J, et al. RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease. Nature 1996; 382(6593):685-91.