Kinetic Features of L,D-Transpeptidase Inactivation Critical for β-Lactam Antibacterial Activity

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Triboulet, Sébastien ^a,b   Dubée, Vincent ^a,b   Lecoq, Lauriane ^c,d,e   Bougault, Catherine ^c,d,e   Mainardi, Jean Luc ^a,b,f   Rice, Louis B ^g   Ethève Quelquejeu, Mélanie ^d,h   Gutmann, Laurent ^a,b,f   Marie, Arul ^d,i   Dubost, Lionel ^d,i   Hugonnet, Jean Emmanuel ^a,b   Simorre, Jean Pierre ^c,d,e   Arthur, Michel ^a,b  

^a CENTRE DE RECHERCHE DES CORDELIERS   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c CEA GRENOBLE   (France)

^d CNRS   (France)

^e UNIV GRENOBLE ALPES   (France)

^f HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

^g BROWN UNIVERSITY   (United States)

^h UNIVERSITÉ PARIS DESCARTES   (France)

ⁱ MUSÉUM NATIONAL D'HISTOIRE NATURELLE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; CEFTRIAXONE; ERTAPENEM; GAMMA GLUTAMYLTRANSFERASE; IMIPENEM;

ACYLATION; ANTIBACTERIAL ACTIVITY; ARTICLE; CATALYSIS; CHEMICAL BOND; CONTROLLED STUDY; COVALENT BOND; DRUG PROTEIN BINDING; DRUG SPECIFICITY; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME INACTIVATION; PROTEIN HYDROLYSIS; STRUCTURE ACTIVITY RELATION;

ACYLATION; AMPICILLIN; BACTERIAL PROTEINS; BETA-LACTAM RESISTANCE; CEFTRIAXONE; ENTEROCOCCUS FAECIUM; IMIPENEM; KINETICS; PEPTIDYL TRANSFERASES; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

ENTEROCOCCUS FAECIUM;

EID: 84879815727     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0067831     Document Type: Article

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