Structural basis for the inhibition of Mycobacterium tuberculosis l,d-transpeptidase by meropenem, a drug effective against extensively drug-resistant strains

Acta Crystallographica Section D: Biological Crystallography

Volumn 69, Issue 3, 2013, Pages 420-431

  Kim, Hyoun Sook ^a   Kim, Jieun ^a   Im, Ha Na ^a   Yoon, Ji Young ^a   An, Doo Ri ^a   Yoon, Hye Jin ^a   Kim, Jin Young ^b   Min, Hye Kyeoung ^b   Kim, Soon Jong ^c   Lee, Jae Young ^d   Han, Byung Woo ^a   Suh, Se Won ^a  

^a Seoul National University   (South Korea)

^b Korea Basic Science Institute (KBSI)   (South Korea)

^c Mokpo National University   (South Korea)

^d Dongguk University   (South Korea)

Author keywords

antituberculosis drug discovery; carbapenem; l,d transpeptidases; LdtMt2; meropenem; Mt2594; Mycobacterium tuberculosis; peptidoglycans; Rv2518c

Indexed keywords

ANTIINFECTIVE AGENT; CARBAPENEM; ENZYME INHIBITOR; MEROPENEM; PEPTIDYLTRANSFERASE; THIENAMYCIN DERIVATIVE;

ANTIBIOTIC RESISTANCE; ANTITUBERCULOSIS DRUG DISCOVERY; ARTICLE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; L,D-TRANSPEPTIDASES; LDTMT2; MT2594; MYCOBACTERIUM TUBERCULOSIS; PEPTIDOGLYCANS; RV2518C; X RAY CRYSTALLOGRAPHY;

ANTITUBERCULOSIS DRUG DISCOVERY; CARBAPENEM; L,D-TRANSPEPTIDASES; LDTMT2; MEROPENEM; MT2594; MYCOBACTERIUM TUBERCULOSIS; PEPTIDOGLYCANS; RV2518C;

ANTI-BACTERIAL AGENTS; CRYSTALLOGRAPHY, X-RAY; DRUG RESISTANCE, MICROBIAL; ENZYME INHIBITORS; MYCOBACTERIUM TUBERCULOSIS; PEPTIDYL TRANSFERASES; THIENAMYCINS;

BACTERIA (MICROORGANISMS); MYCOBACTERIUM TUBERCULOSIS;

EID: 84875454006     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S0907444912048998     Document Type: Article

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