Unexpected inhibition of peptidoglycan LD-transpeptidase from Enterococcus faecium by the β-lactam imipenem

Journal of Biological Chemistry

Volumn 282, Issue 42, 2007, Pages 30414-30422

  Mainardi, Jean Luc ^a,b,c   Hugonnet, Jean Emmanuel ^a,b   Rusconi, Filippo ^d,e,f   Fourgeaud, Martine ^a,b   Dubost, Lionel ^d,f   Moumi, Angèle Nguekam ^a,b   Delfosse, Vanessa ^a,b   Mayer, Claudine ^a,b   Gutmann, Laurent ^a,b,c   Rice, Louis B ^g   Arthur, Michel ^a,b  

^a CENTRE DE RECHERCHE DES CORDELIERS   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

^d CNRS   (France)

^e INSERM   (France)

^f MUSÉUM NATIONAL D'HISTOIRE NATURELLE   (France)

^g LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; CATALYST ACTIVITY; DRUG PRODUCTS; GLYCEROL; PEPTIDES; SUBSTRATES;

AMPICILLIN; LACTAM IMIPENEM; PEPTIDOGLYCAN; TRANSPEPTIDASE;

ENZYME INHIBITION;

ALANINE; AMOXICILLIN; AMOXICILLIN PLUS CLAVULANIC ACID; AMPICILLIN; AZTREONAM; BETA LACTAM ANTIBIOTIC; CEFAMANDOLE; CEFEPIME; CEFIXIME; CEFOPERAZONE; CEFOTIAM; CEFOXITIN; CEFSULODIN; CEFTAZIDIME; CEFTRIAXONE; CEFUROXIME; CYSTEINE; GAMMA GLUTAMYLTRANSFERASE; IMIPENEM; OXACILLIN; PENICILLIN G; PEPTIDOGLYCAN; PIPERACILLIN; TRYPSIN;

ACYLATION; AMINO ACID SUBSTITUTION; ARTICLE; BACTERIAL GROWTH; CONCENTRATION RESPONSE; COVALENT BOND; CROSS LINKING; DRUG BINDING; DRUG POTENTIATION; DRUG TARGETING; ENTEROCOCCUS FAECIUM; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME MODIFICATION; GROWTH INHIBITION; INHIBITION KINETICS; MASS; MASS SPECTROMETRY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; STOICHIOMETRY;

ACYLATION; AMINOACYLTRANSFERASES; AMPICILLIN; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAMS; DIPEPTIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENTEROCOCCUS FAECIUM; ENZYME PRECURSORS; GRAM-POSITIVE BACTERIAL INFECTIONS; IMIPENEM; MASS SPECTROMETRY; SUBSTRATE SPECIFICITY; TRYPSIN;

ENTEROCOCCUS FAECIUM;

EID: 35648983979     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M704286200     Document Type: Article

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