Antihyperglycemic and antihyperlipidemic activities of 2-(4-[(2- hydroxybenzyl) amino]-phenyl amino-methyl)-phenol in STZ induced diabetic rats

European Journal of Medicinal Chemistry

Volumn 66, Issue , 2013, Pages 400-406

  Sirasanagandla, Swapna ^a   Kasetti, Ramesh Babu ^a   Shaik, Abdul Nabi ^a   Natava, Rajesh ^a   Surtineni, Venkata Prasad ^a   Cirradur, Suresh Reddy ^a   Chippada, Apparao ^a  

^a SRI VENKATESWARA UNIVERSITY   (India)

Author keywords

HBPMP; Hypoglycemic activity; Hypolipidemic; STZ

Indexed keywords

2 [4 [(2 HYDROXYBENZYL) AMINO] PHENYL AMINO METHYL] PHENOL; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ANTIDIABETIC AGENT; ANTILIPEMIC AGENT; ASPARTATE AMINOTRANSFERASE; CREATININE; GLIBENCLAMIDE; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; STREPTOZOCIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; UREA; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL; 2 [4 [(2 HYDROXYBENZYL)AMINO]PHENYLAMINOMETHYL]PHENOL; CHOLESTEROL; LOW DENSITY LIPOPROTEIN; ORAL ANTIDIABETIC AGENT;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; KIDNEY INJURY; LIVER INJURY; MALE; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; RAT; STREPTOZOCIN DIABETES; TRIACYLGLYCEROL BLOOD LEVEL; UREA BLOOD LEVEL; BODY WEIGHT; DRUG EFFECT; GLUCOSE TOLERANCE TEST; HYPOGLYCEMIA; LIVER FUNCTION; LIVER PROTECTION; LIVER TOXICITY; LONG TERM CARE; RENAL PROTECTION; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; TREATMENT OUTCOME;

EID: 84879813102     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.05.014     Document Type: Article

References (47)

1. M. Koyuturk, O. Ozsoy-Sacan, S. Bolkent, R. Yanardag, Effect of glurenorm on immunohistochemical changes in pancreatic β cells of rats in experimental diabetes, Indian J. Exp. Biol. 43 (2005) 268-271. (Pubitemid 40359133)
2. A.N. Nagappa, P.A. Thakurdesai, N.V. Rao, J. Singh, Antidiabetic activity of Terminalia catappa Linn. fruits, J. Ethnopharmacol. 88 (2003) 45-50. (Pubitemid 36945347)
3. S.G. Wild, A. Roglic, R. Green, H. King, Global prevalence of diabetes estimated for the year 2000 and projection for 2030, Diabetes Care 27 (2004) 1047-1054.
4. E.J. Verspohl, Recommended testing in diabetes research, Planta Med. 68 (2002) 581-590. (Pubitemid 34827921)
5. E. de Sousa, L. Zanatta, I. Seifriz, T.B. Creczynski-Pasa, M.G. Pizzolatti, B. Szpoganicz, F.R. Silva, Hypoglycemic effect and antioxidant potential of kaempferol-3,7-O-(α)-dirhamnoside from Bauhinia forficata leaves, J. Nat. Prod. 67 (2004) 829-832. (Pubitemid 38702740)
6. J.R. Colca, Insulin sensitizers may prevent metabolic inflammation, Biochem. Pharmacol. 72 (2006) 125-131.
7. M.S. Valiathan, Healing plants, Curr. Sci. 75 (1998) 1122-1126.
8. J.P. Lieu, M. Zhang, W.Y. Wang, S. Grimsgaard, Chinese herbal medicines, for type-2 diabètes mellitus (3), Cochrane Database Syst. Rev. (2004) 3642.
9. V. Vuksan, J.L. Sievenpiper, Herbal remedies in the management of diabetes: lessons learned from the study of ginseng, Nutr. Metab. Cardiovasc. Dis. 15 (2005) 149-160. (Pubitemid 40934158)
10. L. Johnson, H. Strich, A. Taylor, B. Timmermann, D. Malone, N. Teufel-Shone, R. Drummond, R. Woosley, E. Pereira, A. Martinez, Use of herbal remedies by diabetic Hispanic women in the southwestern United States, Phytother. Res. 20 (2006) 250-255.
11. M. Jung, M. Park, H.C. Lee, Y.H. Kang, E.S. Kang, S.K. Kim, Antidiabetic agents from medicinal plants, Curr. Med. Chem. 13 (2006) 1203-1218.
12. T. Matsui, I.A. Ogunwande, K.J.M. Abesundara, K. Matsumoto, Antihyperglycemic potential of natural products, Mini Rev. Med. Chem. 6 (2006) 109-120.
13. M. Brownlee, Biochemistry and molecular cell biology of diabetic complications, Nature 414 (2001) 813-820. (Pubitemid 34000785)
14. T.A. Clark, G.N. Pierce, Cardiovascular complications of non-insulin, dependent diabetes: the JCR: LA-cp rat, J. Pharmacol. Toxicol. Methods 43 (2000) 1-10.
15. K. Ravi, S. Rajasekaran, S. Subramanian, Antihyperglycemic effect of Eugenia jambolana seed kernel on streptozotocin-induced diabetes in rats, Food Chem. Toxicol. 43 (2005) 1433-1439. (Pubitemid 40894640)
16. B.K. Tan, C.H. Tan, P.N. Pushparaj, Anti-diabetic activity of the, semi purified fractions of Averrhoa bilimbi in high fat diet fed-streptozotocin induced STZ rats, Life Sci. 76 (2005) 2827-2839. (Pubitemid 40460328)
17. A.A. Izzo, E. Ernst, Interactions between herbal medicines and prescribed drugs: a systemic review, Drugs 61 (2001) 2163-2175. (Pubitemid 34074799)
18. M. Satyanarayana, P. Tiwari, B.K. Tripathi, A.K. Srivastava, R. Pratap, Synthesis and antihyperglycemic activity of chalcone based aryl oxy propanolamines, Bioorg. Med. Chem. 12 (5) (Mar 1, 2004) 883-889. (Pubitemid 38251280)
19. A. Ranise, O. Spallarossa, S. Schenone, P. Fossa, G. Menozzi, F. Bondavalli, L. Mosti, A. Capuano, F. Mazzeo, G. Falcone, W. Filippelli, Synthesis of N-substituted-N-acylthioureas of 4-substituted piperazines endowed with local anaesthetic, antihyperlipidemic, antiproliferative activities and antiarrythmic, analgesic, antiaggregating actions, Farmaco 58 (9) (2003 Sep) 765-780. (Pubitemid 37122647)
20. 2011 S. Swapna, K. Ramesh Babu, S. Abdul nabi, M. Veera Narayana Reddy, C. Suresh Reddy, C. Appa Rao, Antihyperglycemic and antioxidant activities of 3,3′-(1,4-phenylene)-bis [2-(1-(benzyl carbonyl)-2,3-dihydro-1H- pyrrolidine-2-yl)-2-thiobenzoxaphosphinine in STZ rats, Int. J. Drug Des. Discov. 3 (1) (January-March 2012) 677-682.
21. K. Raju, R. Balaraman, Antidiabetic mechanisms of saponins of Momordica cymbalaria, Phcog. Mag. 4 (15) (2008).
22. T. Szudelski, The mechanism of alloxan and streptozotocin action in B cells of rat pancreas, Physiol. Res. 50 (2001) 536-546.
23. A. Gomes, J.R. Vedasiromoni, M. Das, R.M. Sharma, D.K. Ganguly, Antihyperglycemic effect of black tea (Camellia sinensis) in rat, J. Ethnopharmacol. 27 (2001) 243-275.
24. A. Ranise, A. Spallarossa, O. Bruno, S. Schenone, P. Fossa, G. Bondavalli, L. MostiL, A. Capuano, F. Mazzeo, G. Falcone, W. Filippelli, Synthesis of N-substituted-N-acylthioureas of 4-substituted piperazines endowed with local, anesthetic, antihyperlipidemic, antiproliferative activities and antiarrythmic, analgesic, antiaggregating actions, Farmaco 58 (9) (2003) 765-780. (Pubitemid 37122647)
25. E.H. Alberton, R.G. Damazio, L.H. Cazarolli, L.D. Chiaradia, P.C. Leal, R.J. Nunes, R.A. Yunes, F.R. Silva, Influence of chalcone analogues on serum glucose levels in hyperglycemic rats, Chem. Biol. Interact. 171 (3) (2008) 355-362.
26. P.S. Yadav, Devprakash, G.P. Senthilkumar, Benzothiazole: different methods of synthesis and diverse biological activities, Int. J. Pharmaceut. Sci. Drug Res. 3 (1) (2011) 01-07.
27. L. Al-Shamaorry, S.M. Al-khazrajoi, H.A. Twaij, Hypoglycemic effect of Artemisia herba alba. II. Effect of a valuable extract on some blood parameters in diabetic animals, J. Ethnopharmacol. 43 (1994) 167-171. (Pubitemid 24232182)
28. L. Rajkumar, N. Srinivasan, K. Balasubramanian, P. Govindarajulu, Increased degradation of dermal collagen in diabetic rats, Indian J. Exp. Biol. 29 (1991) 1081-1083.
29. P. Kalaiarasi, K.V. Pugalendi, Antihyperglycemic effect of 18β-glycyrrhetinic acid, aglycone of glycyrrhizin on streptozotocin- diabetic rats, Eur. J. Pharmacol. 606 (2009) 269-273.
30. M. Maghrani, A. Lemhadri, N.A. Zeggwagh, M. Amraoui, M. Haloui, H. Jouad, M. Eddouks, Effects of an aqueous extract of Triticumrepens on lipid metabolism in normal and recent-onset STZ rats rats, J. Ethnopharmacol. 90 (2004) 331-337. (Pubitemid 38175422)
31. R. Gupta, H.P. Gupta, N. Kumar, A.K. Joshi, V.P. Gupta, Lipoprotein lipids and prevalence of hyperlipidemia in rural India, J. Cardiovasc. Risk 1 (1994) 179-183.
32. Lipid Research Clinics Programs, The lipid research clinics coronary primary prevention trial results. 11. The relationship of reduction in incidence of coronary heart disease to cholesterol lowering, J. Am. Med. Assoc. 252 (1984) 365-374.
33. J.W. Baynes, Role of oxidative stress in the development of complications in diabetes, Diabetes 40 (1991) 405-.412.
34. R. Yanardag, O. Ozsoy-Sacan, S. Bolkent, H. Orak, O. Karabulut-Bulen, Protective effects of metformin treatment on the liver injury of streptozotocin-STZ rats, Hum. Exp. Toxicol. 24 (2005) 129-135. (Pubitemid 40605153)
35. S. Rajasekaran, K. Ravi, K. Sivagananam, S. Subramanian, Beneficial effects aloevera leaf gel extract on lipid profile status in rats with streptozotocin diabetes, Clin. Exp. Pharmacol. Physiol. 33 (2006) 232-237.
36. U.A. Shinde, R.K. Goyal, Effect of chromium picolinate on histopathological alterations in STZ and neonatal STZSTZ rats, J. Cell Mol. Med. 7 (2003) 332-339.
37. A. Prakasam, S. Sethupathy, K.V. Pugalendi, Antiperoxidative and antioxidant effects of Casearia esculenta root extract in streptozotocin-induced rats, J. Biol. Med. 78 (2005) 15-23.
38. S. Bonnar-Weir, Morphological evidence of pancreatic polarity of beta cells within islets of Langerhans, Diabetes 37 (1998) 616-621.
39. A. Zlatkis, B. Zak, A.J. Boyle, D. Mich, A new method for the direct determination of serum cholesterol, J. Lab. Clin. Med. 41 (1953) 486-492.
40. J.B. Foster, R.T. Dunn, Stable reagents for determination of serum triglycerides by colorimetric Hantzsch condensation method, Clin. Chem. 19 (1973) 338-340.
41. W.T. Friedwald, R.I. Levy, D.S. Fredrickson, Estimation of the concentration of LDL-cholesterol in plasma without the use of the preparative utracentrifuge, Clin. Chem. 18 (1972) 499-502.
42. M. Burstein, H.R. Scholnichk, R. Morin, Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions, J. Lipid Res. 11 (1970) 583-595.
43. T. Suanarunsawat, W.D.N. Ayutthaya, T. Songsak, J. Rattanamahaphoom, Antilipidemic actions of essential oil extracted from Ocimum sanctum L. leaves in rats fed with high cholesterol diet, J. Appl. Biomed. 7 (2009) 45-53.
44. S. Reitman, S. Frankel, Colorimetric method for the determination of serum glutamic oxaloacetic acid and glutamic pyruvic transaminases, Am. J. Clin. Pathol. 28 (1957) 56-63.
45. O.A. Bessey, O.H. Lowry, M.J. Brock, A method for the determination of alkaline phosphatase with five cubic millimeters of serum, J. Biol. Chem. 164 (1946) 321-329.
46. C. Slot, Plasma creatinine determination. A new and specific Jaffe's reaction method, Scand. J. Clin. Lab. Invest. 17 (1965) 381-387.
47. D.R. Wybenga, J. Di Giorgio, V.J. Pileggi, Manual and automated methods for urea nitrogen measurement in whole serum, Clin. Chem. 17 (1971) 891-895.