Insulin resistance in dairy cows

Veterinary Clinics of North America - Food Animal Practice

Volumn 29, Issue 2, 2013, Pages 299-322

  De Koster, Jenne D ^a   Opsomer, Geert ^a  

^a GHENT UNIVERSITY   (Belgium)

Author keywords

Adipose tissue; Dairy cow; Glucose metabolism; Insulin resistance; Insulin sensitivity tests; Pregnancy and lactation

Indexed keywords

GLUCOSE; INSULIN;

ADIPOSE TISSUE; ANIMAL; CATTLE; CATTLE DISEASE; FEMALE; INSULIN RESISTANCE; LACTATION; LIVER; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; PREGNANCY; REVIEW; SECRETION (PROCESS); SKELETAL MUSCLE;

ADIPOSE TISSUE; ANIMALS; CATTLE; CATTLE DISEASES; FEMALE; GLUCOSE; INSULIN; INSULIN RESISTANCE; LACTATION; LIVER; MUSCLE, SKELETAL; PREGNANCY;

BOS;

EID: 84879793478     PISSN: 07490720     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cvfa.2013.04.002     Document Type: Review

References (119)

1. Aschenbach J.R., Kristensen N.B., Donkin S.S., et al. Gluconeogenesis in dairy cows: the secret of making sweet milk from sour dough. IUBMB Life 2010, 62(12):869-877.
2. Annison E.F., White R.R. Glucose utilization in sheep. Biochem J 1961, 80:162-169.
3. Kaske M., Elmahdi B., von Engelhardt W., et al. Insulin responsiveness of sheep, ponies, miniature pigs and camels: results of hyperinsulinemic clamps using porcine insulin. JComp Physiol B 2001, 171(7):549-556.
4. Hayirli A. The role of exogenous insulin in the complex of hepatic lipidosis and ketosis associated with insulin resistance phenomenon in postpartum dairy cattle. Vet Res Commun 2006, 30(7):749-774.
5. Brockman R.P., Laarveld B. Hormonal-regulation of metabolism in ruminants-a review. Livest Prod Sci 1986, 14(4):313-334.
6. Bell A.W., Bauman D.E. Adaptations of glucose metabolism during pregnancy and lactation. JMammary Gland Biol Neoplasia 1997, 2(3):265-278.
7. Sasaki S. Mechanism of insulin action on glucose metabolism in ruminants. Anim Sci J 2002, 73(6):423-433.
8. Drackley J.K., Overton T.R., Douglas G.N. Adaptations of glucose and long-chain fatty acid metabolism in liver of dairy cows during the periparturient period. JDairy Sci 2001, 84:E100-E112.
9. Slyter L.L. Influence of acidosis on rumen function. JAnim Sci 1976, 43(4):910-929.
10. Nocek J.E. Bovine acidosis: implications on laminitis. JDairy Sci 1997, 80(5):1005-1028.
11. Kuhla B., Nurnberg G., Albrecht D., et al. Involvement of skeletal muscle protein, glycogen, and fat metabolism in the adaptation on early lactation of dairy cows. JProteome Res 2011, 10(9):4252-4262.
12. Bell A.W. Regulation of organic nutrient metabolism during transition from late pregnancy to early lactation. JAnim Sci 1995, 73(9):2804-2819.
13. Reynolds C.K., Aikman P.C., Lupoli B., et al. Splanchnic metabolism of dairy cows during the transition from late gestation through early lactation. JDairy Sci 2003, 86(4):1201-1217.
14. Adewuyi A.A., Gruys E., van Eerdenburg F.J. Non esterified fatty acids (NEFA) in dairy cattle. A review. Vet Q 2005, 27(3):117-126.
15. Drackley J.K. Biology of dairy cows during the transition period: the final frontier?. JDairy Sci 1999, 82(11):2259-2273.
16. Bell A.W., Burhans W.S., Overton T.R. Protein nutrition in late pregnancy, maternal protein reserves and lactation performance in dairy cows. Proc Nutr Soc 2000, 59(1):119-126.
17. Cox M., Nelson D.L. Principles of biochemistry 2004, Palgrave Macmillan, New York, ISBN-10.
18. Veenhuizen J.J., Drackley J.K., Richard M.J., et al. Metabolic changes in blood and liver during development and early treatment of experimental fatty liver and ketosis in cows. JDairy Sci 1991, 74(12):4238-4253.
19. Herdt T.H. Ruminant adaptation to negative energy balance. Influences on the etiology of ketosis and fatty liver. Vet Clin North Am Food Anim Pract 2000, 16(2):215-230. v.
20. Karcagi R.G., Gaal T., Wagner L., et al. Effect of various dietary fat supplementations on liver lipid and glycogen of high-yielding dairy cows in the peripartal period. Acta Vet Hung 2008, 56(1):57-70.
21. Shepherd P.R., Kahn B.B. Mechanisms of disease-glucose transporters and insulin action-implications for insulin resistance and diabetes mellitus. NEngl J Med 1999, 341(4):248-257.
22. Zhao F.Q., Keating A.F. Expression and regulation of glucose transporters in the bovine mammary gland. JDairy Sci 2007, 90(Suppl 1):E76-E86.
23. Duhlmeier R., Hacker A., Widdel A., et al. Mechanisms of insulin-dependent glucose transport into porcine and bovine skeletal muscle. Am J Physiol Regul Integr Comp Physiol 2005, 289(1):R187-R197.
24. Hanson R.W., Ballard F.J. The relative significance of acetate and glucose as precursors for lipid synthesis in liver and adipose tissue from ruminants. Biochem J 1967, 105(2):529.
25. Komatsu T., Itoh F., Kushibiki S., et al. Changes in gene expression of glucose transporters in lactating and nonlactating cows. JAnim Sci 2005, 83(3):557-564.
26. Ji P., Osorio J.S., Drackley J.K., et al. Overfeeding a moderate energy diet prepartum does not impair bovine subcutaneous adipose tissue insulin signal transduction and induces marked changes in peripartal gene network expression. JDairy Sci 2012, 95(8):4333-4351.
27. Sadri H., Bruckmaier R.M., Rahmani H.R., et al. Gene expression of tumour necrosis factor and insulin signalling-related factors in subcutaneous adipose tissue during the dry period and in early lactation in dairy cows. JAnim Physiol Anim Nutr (Berl) 2010, 94(5):e194-e202.
28. Bauman D.E., Currie W.B. Partitioning of nutrients during pregnancy and lactation-a review of mechanisms involving homeostasis and homeorhesis. JDairy Sci 1980, 63(9):1514-1529.
29. Bertolini M., Moyer A.L., Mason J.B., et al. Evidence of increased substrate availability to invitro-derived bovine foetuses and association with accelerated conceptus growth. Reproduction 2004, 128(3):341-354.
30. Hirayama H., Sawai K., Hirayama M., et al. Prepartum maternal plasma glucose concentrations and placental glucose transporter mRNA expression in cows carrying somatic cell clone fetuses. JReprod Dev 2011, 57(1):57-61.
31. Lucy M.C., Green J.C., Meyer J.P., et al. Short communication: glucose and fructose concentrations and expression of glucose transporters in 4-to 6-week pregnancies collected from Holstein cows that were either lactating or not lactating. JDairy Sci 2012, 95(9):5095-5101.
32. Hay W.W. Placental-fetal glucose exchange and fetal glucose metabolism. Trans Am Clin Climatol Assoc 2006, 117:321.
33. Lemosquet S., Raggio G., Lobley G.E., et al. Whole-body glucose metabolism and mammary energetic nutrient metabolism in lactating dairy cows receiving digestive infusions of casein and propionic acid. JDairy Sci 2009, 92(12):6068-6082.
34. Kronfeld D.S. Major metabolic determinants of milk volume, mammary efficiency, and spontaneous ketosis in dairy-cows. JDairy Sci 1982, 65(11):2204-2212.
35. Hocquette J.F., Balage M., Ferre P. Facilitative glucose transporters in ruminants. Proc Nutr Soc 1996, 55(1B):221-236.
36. Kahn C.R. Insulin resistance, insulin insensitivity, and insulin unresponsiveness: a necessary distinction. Metabolism 1978, 27(12 Suppl 2):1893-1902.
37. Muniyappa R., Lee S., Chen H., et al. Current approaches for assessing insulin sensitivity and resistance invivo: advantages, limitations, and appropriate usage. Am J Physiol Endocrinol Metab 2008, 294(1):E15-E26.
38. Bauman D.E. Regulation of nutrient partitioning during lactation: homeostasis and homeorhesis revisited. Ruminant Physiology 2000, 311-328.
39. American Diabetes Association Diagnosis and classification of diabetes mellitus. Diabetes Care 2004, 27(Suppl 1):S5-S10.
40. DeFronzo R.A. Pathogenesis of type 2 diabetes mellitus. Med Clin North Am 2004, 88(4):787-835. ix.
41. Kahn S.E. The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes. Diabetologia 2003, 46(1):3-19.
42. Taniyama H., Shirakawa T., Furuoka H., et al. Spontaneous diabetes-mellitus in young cattle-histologic, immunohistochemical, and electron-microscopic studies of the islets of Langerhans. Vet Pathol 1993, 30(1):46-54.
43. Nazifi S., Karimi T., Ghasrodashti A.R. Diabetes mellitus and fatty liver in a cow: case report. Comp Clin Pathol 2004, 13(2):82-85.
44. Bossaert P., Leroy J.L., De Vliegher S., et al. Interrelations between glucose-induced insulin response, metabolic indicators, and time of first ovulation in high-yielding dairy cows. JDairy Sci 2008, 91(9):3363-3371.
45. Hove K. Insulin secretion in lactating cows: responses to glucose infused intravenously in normal, ketonemic, and starved animals. JDairy Sci 1978, 61(10):1407-1413.
46. Kerestes M., Faigl V., Kulcsar M., et al. Periparturient insulin secretion and whole-body insulin responsiveness in dairy cows showing various forms of ketone pattern with or without puerperal metritis. Domest Anim Endocrinol 2009, 37(4):250-261.
47. Schoenberg K.M., Ehrhardt R.M., Overton T.R. Effects of plane of nutrition and feed deprivation on insulin responses in dairy cattle during late gestation. JDairy Sci 2012, 95(2):670-682.
48. Opsomer G., Wensing T., Laevens H., et al. Insulin resistance: the link between metabolic disorders and cystic ovarian disease in high yielding dairy cows?. Anim Reprod Sci 1999, 56(3-4):211-222.
49. Andersen J.B., Mashek D.G., Larsen T., et al. Effects of hyperinsulinaemia under euglycaemic condition on liver fat metabolism in dairy cows in early and mid-lactation. JVet Med A Physiol Pathol Clin Med 2002, 49(2):65-71.
50. Sjaastad ØV, Sand O, Hove K. Physiology of domestic animals. 2nd edition. Oslo, Scandinavian Veterinary Press: 2010.
51. Bossaert P., De Cock H., Leroy J.L., et al. Immunohistochemical visualization of insulin receptors in formalin-fixed bovine ovaries post mortem and in granulosa cells collected invivo. Theriogenology 2010, 73(9):1210-1219.
52. Sinclair K.D. Declining fertility, insulin resistance and fatty acid metabolism in dairy cows: developmental consequences for the oocyte and pre-implantation embryo. Acta Scientiae Veterinariae 2010, 38(Suppl 2):s545-s557.
53. Vanholder T., Leroy J.L., Dewulf J., et al. Hormonal and metabolic profiles of high-yielding dairy cows prior to ovarian cyst formation or first ovulation post partum. Reprod Domest Anim 2005, 40(5):460-467.
54. Stanley K., Fraser R., Bruce C. Physiological changes in insulin resistance in human pregnancy: longitudinal study with the hyperinsulinaemic euglycaemic clamp technique. Br J Obstet Gynaecol 1998, 105(7):756-759.
55. Barbour L.A., McCurdy C.E., Hernandez T.L., et al. Cellular mechanisms for insulin resistance in normal pregnancy and gestational diabetes. Diabetes Care 2007, 30:S112-S119.
56. Stolic M., Russell A., Hutley L., et al. Glucose uptake and insulin action in human adipose tissue-influence of BMI, anatomical depot and body fat distribution. Int J Obes Relat Metab Disord 2002, 26(1):17-23.
57. Cornier M.A., Dabelea D., Hernandez T.L., et al. The metabolic syndrome. Endocr Rev 2008, 29(7):777-822.
58. De Koster J., Opsomer G. Are modern dairy cows suffering from modern diseases?. Vlaams Diergen Tijds 2012, 81(2):71-80.
59. Vernon R.G., Faulkner A., Hay W.W., et al. Insulin resistance of hindlimb tissues invivo in lactating sheep. Biochem J 1990, 270(3):783-786.
60. Vernon R.G., Taylor E. Insulin, dexamethasone and their interactions in the control of glucose-metabolism in adipose-tissue from lactating and non-lactating sheep. Biochem J 1988, 256(2):509-514.
61. Debras E., Grizard J., Aina E., et al. Insulin sensitivity and responsiveness during lactation and dry period in goats. Am J Phys 1989, 256(2):E295-E302.
62. Petterson J.A., Dunshea F.R., Ehrhardt R.A., et al. Pregnancy and undernutrition alter glucose metabolic responses to insulin in sheep. JNutr 1993, 123(7):1286-1295.
63. McCann J.P., Reimers T.J. Glucose response to exogenous insulin and kinetics of insulin metabolism in obese and lean heifers. JAnim Sci 1985, 61(3):612-618.
64. Oikawa S., Oetzel G.R. Decreased insulin response in dairy cows following a four-day fast to induce hepatic lipidosis. JDairy Sci 2006, 89(8):2999-3005.
65. Pires J.A., Souza A.H., Grummer R.R. Induction of hyperlipidemia by intravenous infusion of tallow emulsion causes insulin resistance in Holstein cows. JDairy Sci 2007, 90(6):2735-2744.
66. Pires J.A., Pescara J.B., Grummer R.R. Reduction of plasma NEFA concentration by nicotinic acid enhances the response to insulin in feed-restricted Holstein cows. JDairy Sci 2007, 90(10):4635-4642.
67. Agenas S., Burstedt E., Holtenius K. Effects of feeding intensity during the dry period. 1. Feed intake, body weight, and milk production. JDairy Sci 2003, 86(3):870-882.
68. Holtenius K., Agenas S., Delavaud C., et al. Effects of feeding intensity during the dry period. 2. Metabolic and hormonal responses. JDairy Sci 2003, 86(3):883-891.
69. Ohtsuka H., Koiwa M., Hatsugaya A., et al. Relationship between serum TNF activity and insulin resistance in dairy cows affected with naturally occurring fatty liver. JVet Med Sci 2001, 63(9):1021.
70. Hue L., Taegtmeyer H. The Randle cycle revisited: a new head for an old hat. Am J Physiol Endocrinol Metab 2009, 297(3):E578-E591.
71. LeMarchand-Brustel Y., Gual P., Gremeaux T., et al. Fatty acid-induced insulin resistance: role of insulin receptor substrate 1 serine phosphorylation in the retroregulation of insulin signalling. Biochem Soc Trans 2003, 31:1152-1156.
72. Bergman E.N., Reulein S.S., Corlett R.E. Effects of obesity on insulin sensitivity and responsiveness in sheep. Am J Physiol 1989, 257(5 Pt 1):E772-E781.
73. Gustafson B., Hammarstedt A., Andersson C.X., et al. Inflamed adipose tissue-a culprit underlying the metabolic syndrome and atherosclerosis. Arterioscler Thromb Vasc Biol 2007, 27(11):2276-2283.
74. Ingvartsen K.L., Boisclair Y.R. Leptin and the regulation of food intake, energy homeostasis and immunity with special focus on periparturient ruminants. Domest Anim Endocrinol 2001, 21(4):215-250.
75. Komatsu T., Itoh F., Mikawa S., et al. Gene expression of resistin in adipose tissue and mammary gland of lactating and non-lactating cows. JEndocrinol 2003, 178(3):R1-R5.
76. Lemor A., Hosseini A., Sauerwein H., et al. Transition period-related changes in the abundance of the mRNAs of adiponectin and its receptors, of visfatin, and of fatty acid binding receptors in adipose tissue of high-yielding dairy cows. Domest Anim Endocrinol 2009, 37(1):37-44.
77. Mukesh M., Bionaz M., Graugnard D.E., et al. Adipose tissue depots of Holstein cows are immune responsive: inflammatory gene expression invitro. Domest Anim Endocrinol 2010, 38(3):168-178.
78. Saremi B., Al-Dawood A., Winand S., et al. Bovine haptoglobin as an adipokine: serum concentrations and tissue expression in dairy cows receiving a conjugated linoleic acids supplement throughout lactation. Vet Immunol Immunopathol 2012, 146(3-4):201-211.
79. Kushibiki S., Hodate K., Shingu H., et al. Effects of long-term administration of recombinant bovine tumor necrosis factor-alpha on glucose metabolism and growth hormone secretion in steers. Am J Vet Res 2001, 62(5):794-798.
80. Kushibiki S., Hodate K., Shingu H., et al. Insulin resistance induced in dairy steers by tumor necrosis factor alpha is partially reversed by 2,4-thiazolidinedione. Domest Anim Endocrinol 2001, 21(1):25-37.
81. Bradford B.J., Mamedova L.K., Minton J.E., et al. Daily injection of tumor necrosis factor-alpha increases hepatic triglycerides and alters transcript abundance of metabolic genes in lactating dairy cattle. JNutr 2009, 139(8):1451-1456.
82. O'Boyle N., Corl C.M., Gandy J.C., et al. Relationship of body condition score and oxidant stress to tumor necrosis factor expression in dairy cattle. Vet Immunol Immunopathol 2006, 113(3-4):297-304.
83. Chagas L.M., Lucy M.C., Back P.J., et al. Insulin resistance in divergent strains of Holstein-Friesian dairy cows offered fresh pasture and increasing amounts of concentrate in early lactation. JDairy Sci 2009, 92(1):216-222.
84. Balogh O., Szepes O., Kovacs K., et al. Interrelationships of growth hormone AluI polymorphism, insulin resistance, milk production and reproductive performance in Holstein-Friesian cows. Vet Med 2008, 53(11):604-616.
85. Bossaert P., Leroy J.L., De Campeneere S., et al. Differences in the glucose-induced insulin response and the peripheral insulin responsiveness between neonatal calves of the Belgian Blue, Holstein-Friesian, and East Flemish breeds. JDairy Sci 2009, 92(9):4404-4411.
86. Chilliard Y., Ferlay A., Faulconnier Y., et al. Adipose tissue metabolism and its role in adaptations to undernutrition in ruminants. Proc Nutr Soc 2000, 59(1):127-134.
87. Faulkner A., Pollock H.T. Metabolic responses to euglycaemic hyperinsulinaemia in lactating and non-lactating sheep invivo. JEndocrinol 1990, 124(1):59-66.
88. Petterson J.A., Slepetis R., Ehrhardt R.A., et al. Pregnancy but not moderate undernutrition attenuates insulin suppression of fat mobilization in sheep. JNutr 1994, 124(12):2431-2436.
89. Vernon R.G., Doris R., Finley E., et al. Effects of lactation on the signal-transduction systems regulating lipolysis in sheep subcutaneous and omental adipose-tissue. Biochem J 1995, 308:291-296.
90. Smith R.W., Walsh A. Effects of pregnancy and lactation on the metabolism of bovine adipose-tissue. Res Vet Sci 1988, 44(3):349-353.
91. Locher L.F., Meyer N., Weber E.M., et al. Hormone-sensitive lipase protein expression and extent of phosphorylation in subcutaneous and retroperitoneal adipose tissues in the periparturient dairy cow. JDairy Sci 2011, 94(9):4514-4523.
92. Hostens M., Fievez V., Leroy J.L., et al. The fatty acid profile of subcutaneous and abdominal fat in dairy cows with left displacement of the abomasum. JDairy Sci 2012, 95(7):3756-3765.
93. Danfaer A. Nutrient metabolism and utilization in the liver. Livest Prod Sci 1994, 39(1):115-127.
94. Brockman R.P. Effect of insulin on the utilization of propionate in gluconeogenesis in sheep. Br J Nutr 1990, 64(1):95-101.
95. Tesseraud S., Grizard J., Debras E., et al. Leucine metabolism in lactating and dry goats-effect of insulin and substrate availability. Am J Phys 1993, 265(3):E402-E413.
96. Baracos V.E., Brunbellut J., Marie M. Tissue protein-synthesis in lactating and dry goats. Br J Nutr 1991, 66(3):451-465.
97. Overton TR. Substrate utilization for hepatic gluconeogenesis in the transition dairy cow. Proceedings of the 1998 Cornell Nutrition Conference for Feed Manufacturers. 1998. p. 237-46.
98. Rose M.T., Obara Y., Itoh F., et al. Non-insulin- and insulin-mediated glucose uptake in dairy cows. JDairy Res 1997, 64(3):341-353.
99. Ferrell C.L. Maternal and fetal influences on uterine and conceptus development in the cow. 2. Blood-flow and nutrient flux. JAnim Sci 1991, 69(5):1954-1965.
100. Bell A.W., Slepetis R., Ehrhardt R.A. Growth and accretion of energy and protein in the gravid uterus during late pregnancy in Holstein cows. JDairy Sci 1995, 78(9):1954-1961.
101. Defronzo R.A., Tobin J.D., Andres R. Glucose clamp technique-method for quantifying insulin-secretion and resistance. Am J Phys 1979, 237(3):E214-E223.
102. Kräft S. Charakterisierung der peripheren Insulin-response und Insulin-sensitivität bei trockenstehenden, laktierenden und leberverfetteten Milchkühe ohne und mit Ketose mittels hyperinsulinämischer, euglycämischer Clamps 2004, [dissertation], Klinik für Rinder der Tierärtzlichen Hochschule Hannover, Hannover (Germany).
103. Kusenda M. Insulin-Sensitivität und Insulin-Response nach einer einmaligen Dexamethasonbehandlung bie Milchkühen in der Frühlaktation 2010, Klinik für Rinder, Tierärtzliche Hochschule Hannover, Hannover (Germany).
104. Haarstrich D. Insulinsensitivität und Insulinresponse nach einer Langzeit-Supplementation von konjugierten Linolsäuren bei laktierenden Milchkühen 2011, Klinik fürRinder, Tierärztliche Hochschule Hannover, Hannover (Germany).
105. Mitrakou A., Vuorinenmarkkola H., Raptis G., et al. Simultaneous assessment of insulin-secretion and insulin sensitivity using a hyperglycemic clamp. JClin Endocrinol Metab 1992, 75(2):379-382.
106. Bergman R.N., Ider Y.Z., Bowden C.R., et al. Quantitative estimation of insulin sensitivity. Am J Physiol 1979, 236(6):E667-E677.
107. Boston R.C., Stefanovski D., Moate P.J., et al. MINMOD Millennium: a computer program to calculate glucose effectiveness and insulin sensitivity from the frequently sampled intravenous glucose tolerance test. Diabetes Technol Ther 2003, 5(6):1003-1015.
108. Cnop M., Vidal J., Hull R.L., et al. Progressive loss of beta-cell function leads to worsening glucose tolerance in first-degree relatives of subjects with type 2 diabetes. Diabetes Care 2007, 30(3):677-682.
109. Ferrannini E., Mari A. How to measure insulin sensitivity. JHypertens 1998, 16(7):895-906.
110. Katz A., Nambi S.S., Mather K., et al. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. JClin Endocrinol Metab 2000, 85(7):2402-2410.
111. Perseghin G., Caumo A., Caloni M., et al. Incorporation of the fasting plasma FFA concentration into QUICKI improves its association with insulin sensitivity in nonobese individuals. JClin Endocrinol Metab 2001, 86(10):4776-4781.
112. Rabasa-Lhoret R., Bastard J.P., Jan V., et al. Modified quantitative insulin sensitivity check index is better correlated to hyperinsulinemic glucose clamp than other fasting-based index of insulin sensitivity in different insulin-resistant states. JClin Endocrinol Metab 2003, 88(10):4917-4923.
113. Leroy J.L., Bossaert P., Opsomer G., et al. The effect of animal handling procedures on the blood non-esterified fatty acid and glucose concentrations of lactating dairy cows. Vet J 2011, 187(1):81-84.
114. Abuelo A., De Koster J., Hernandez J., et al. Quantifying bovine insulin: conversion of units. Vet Clin Pathol 2012, 41(3):308-310.
115. Holtenius P., Holtenius K. Amodel to estimate insulin sensitivity in dairy cows. Acta Vet Scand 2007, 49:29.
116. Schoenberg K.M., Perfield K.L., Farney J.K., et al. Effects of prepartum 2,4-thiazolidinedione on insulin sensitivity, plasma concentrations of tumor necrosis factor-alpha and leptin, and adipose tissue gene expression. JDairy Sci 2011, 94(11):5523-5532.
117. Kruszynska Y.T., Worrall D.S., Ofrecio J., et al. Fatty acid-induced insulin resistance: decreased muscle PI3K activation but unchanged Akt phosphorylation. JClin Endocrinol Metab 2002, 87(1):226-234.
118. Green A., Newsholme E.A. Sensitivity of glucose-uptake and lipolysis of white adipocytes of the rat to insulin and effects of some metabolites. Biochem J 1979, 180(2):365-370.
119. Arner P. Regional adiposity in man. JEndocrinol 1997, 155(2):191-192.