Gluconeogenesis in dairy cows: The secret of making sweet milk from sour dough

IUBMB Life

Volumn 62, Issue 12, 2010, Pages 869-877

  Aschenbach, Jörg R ^a   Kristensen, Niels B ^b   Donkin, Shawn S ^c   Hammon, Harald M ^d   Penner, Gregory B ^e  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b DANISH INSTITUTE OF AGRICULTURAL SCIENCES   (Denmark)

^c PURDUE UNIVERSITY   (United States)

^d LEIBNIZ INSTITUTE FOR FARM ANIMAL BIOLOGY FBN   (Germany)

^e UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

cellular glucose metabolism; dairy cow; enzyme activity; gene expression; gluconeogenesis

Indexed keywords

FRUCTOSE 1,6 BISPHOSPHATE; GLUCOSE; GLUCOSE 6 PHOSPHATASE; METHYLMALONYL COENZYME A MUTASE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP); PROPIONYL COENZYME A CARBOXYLASE; PYRUVATE CARBOXYLASE;

DAIRY CATTLE; DOUGH; FATTY LIVER; FOOD INTAKE; GLUCONEOGENESIS; GLYCOGEN LIVER LEVEL; HORMONAL REGULATION; KETOACIDOSIS; LACTATION; LIPID METABOLISM; MILK; NONHUMAN; REVIEW; TRANSCRIPTION REGULATION; WEANING;

AMINO ACIDS; ANIMAL FEED; ANIMALS; CATTLE; FATTY LIVER; FEMALE; GENE EXPRESSION REGULATION; GLUCONEOGENESIS; GLUCOSE; GLYCOGEN; HORMONES; HUMANS; KETOSIS; LACTATION; LACTIC ACID; METHYLMALONYL-COA DECARBOXYLASE; METHYLMALONYL-COA MUTASE; MICE; MILK; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PROPIONIC ACIDS; PYRUVATE CARBOXYLASE; RATS;

BOVINAE;

EID: 79952031702     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1002/iub.400     Document Type: Review

References (89)

1. Cárdenasa, M. L., Cornish-Bowdena, A., and, Uretab, T., (1998) Evolution and regulatory role of the hexokinases. Biochim. Biophys. Acta 1401, 242-264.
2. Cankaya, M., Hernandez, A. M., Ciftci, M., Beydemir, S., Ozdemir, H., Budak, H., Gulcin, I., Comakli, V., Emircupani, T., Ekinci, D., Kuzu, M., Jiang, Q., Eichele, G., and, Kufrevioglu, O. I., (2007) An analysis of expression patterns of genes encoding proteins with catalytic activities. BMC Genomics 8, 2.
3. Mayes, P. A., (1996) Gluconeogenesis and control of the blood glucose. In Harper's Biochemistry, 24th edn. (, Murray, R. K., Granner, D. K., Mayes, P. A., and, Rodwell, V. W., eds.). pp. 194-204, Appleton & Lange, Stanford, CT.
4. Woerle, H. J., Meyer, C., Dostou, J. M., Gosmanov, N. R., Islam, N., Popa, E., Wittlin, S. D., Welle, S. L., and, Gerich, J. E., (2003) Pathways for glucose disposal after meal ingestion in humans. Am. J. Physiol. Endocrinol. Metab. 284, E716-E725. (Pubitemid 36323864)
5. Lemon, P. W., and, Nagle, F. J., (1981) Effects of exercise on protein and amino acid metabolism. Med. Sci. Sports Exerc. 13, 141-149. (Pubitemid 11045713)
6. Madias, N. E., (1986) Lactic acidosis. Kidney Int. 29, 752-774. (Pubitemid 16164586)
7. Leat, W. M. F., (1970) Carbohydrate and lipid metabolism in the ruminant during post-natal development. In Digestive Physiology and Metabolism in the Ruminants (, Phillipson, A. T., ed.). pp. 211-222, Oriel Press, Newcastle Upon Tyne, UK.
8. Donkin, S. S., and, Armentano, L. E., (1995) Insulin and glucagon regulation of gluconeogenesis in preruminating and ruminating bovine. J. Anim. Sci. 73, 546-551.
9. Hostettler-Allen, R., Tappy, L., and, Blum, J. W., (1994) Insulin resistance, hyperglycemia and glucosuria in intensively milk-fed calves. J.Anim. Sci. 72, 160-173.
10. Bergman, E. N., (1990) Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. Physiol. Rev. 70, 567-590. (Pubitemid 20140190)
11. Baird, G. D., Lomax, M. A., Symonds, H. W., and, Shaw, S. R., (1980) Net hepatic and splanchnic metabolism of lactate, pyruvate and propionate in dairy cows in vivo in relation to lactation and nutrient supply. Biochem. J. 186, 47-57. (Pubitemid 10152073)
12. Reynolds, C. K., Huntington, G. B., Tyrrell, H. F., and, Reynolds, P. J., (1988) Net portal-drained visceral and hepatic metabolism of glucose, L -lactate, and nitrogenous compounds in lactating Holstein cows. J. Dairy Sci. 71, 1803-1812.
13. Larsen, M., and, Kristensen, N. B., (2009) Effect of abomasal glucose infusion on splanchnic amino acid metabolism in periparturient dairy cows. J. Dairy Sci. 92, 3306-3318.
14. Reynolds, C. K., Aikman, P. C., Lupoli, B., Humphries, D. J., and, Beever, D. E., (2003) Splanchnic metabolism of dairy cows during the transition from late gestation through early lactation. J. Dairy Sci. 86, 1201-1217. (Pubitemid 39017218)
15. Aschenbach, J. R., Penner, G. B., Stumpff, F., and, Gäbel, G., Role of fermentation acid absorption in the regulation of ruminal pH. J. Anim. Sci., in press; doi 10.2527/jas.2010-3301.
16. Overton, T. R., and, Waldron, M. R., (2004) Nutritional management of transition dairy cows: strategies to optimize metabolic health. J. Dairy Sci. 87 (E Suppl), E105-E119.
17. Young, J. W., (1977) Gluconeogenesis in cattle: significance and methodology. J. Dairy Sci. 60, 1-15.
18. Smith, K. L., Waldron, M. R., Ruzzi, L. C., Drackley, J. K., Socha, M. T., and, Overton, T. R., (2008) Metabolism of dairy cows as affected by prepartum dietary carbohydrate source and supplementation with chromium throughout the periparturient period. J. Dairy Sci. 91, 2011-2020. (Pubitemid 351730904)
19. Allen, M. S., Bradford, B. J., and, Harvatine, K. J., (2005) The cow as a model to study food intake regulation. Annu. Rev. Nutr. 25, 523-547. (Pubitemid 41209012)
20. Deodato, F., Boenzi, S., Santorelli, F. M., and, Dionisi-Vici, C., (2006) Methylmalonic and propionic aciduria. Am. J. Med. Genet. C Semin. Med. Genet. 142, 104-112.
21. Zhao, F. Q., Okine, E. K., Cheeseman, C. I., Shirazi-Beechey, S. P., and, Kennelly, J. J., (1998) Glucose transporter gene expression in lactating bovine gastrointestinal tract. J. Anim. Sci. 76, 2921-2929. (Pubitemid 128464900)
22. Aschenbach, J. R., Wehning, H., Kurze, M., Schaberg, E., Nieper, H., Burckhardt, G., and, Gäbel, G., (2000) Functional and molecular biological evidence of SGLT-1 in the ruminal epithelium of sheep. Am. J. Physiol. Gastrointest. Liver Physiol. 279, G20-G27. (Pubitemid 30612681)
23. Aschenbach, J. R., Bhatia, S. K., Pfannkuche, H., and, Gäbel, G., (2000) Glucose is absorbed in a sodium-dependent manner from forestomach contents of sheep. J. Nutr. 130, 2797-2801.
24. Huntington, G. B., and, Reynolds, P. J., (1986) Net absorption of glucose, L -lactate, volatile fatty acids, and nitrogenous compounds by bovine given abomasal infusions of starch or glucose. J. Anim. Sci. 69, 2428-2436.
25. Harmon, D. L., and, McLeod, K. R., (2001) Glucose uptake and regulation by intestinal tissues: implications and whole-body energetics. J. Anim. Sci. 79, E59-E72.
26. Larsen, M., Lund, P., Weisbjerg, M. R., and, Hvelplund, T., (2009) Digestion site of starch from cereals and legumes in lactating dairy cows. Anim. Feed Sci. Technol. 153, 236-248.
27. Taylor, C. C., and, Allen, M. S., (2005) Corn grain endosperm type and brown midrib 3 corn silage: site of digestion and ruminal digestion kinetics in lactating cows. J. Dairy Sci. 88, 1413-1424. (Pubitemid 41431260)
28. Kreikemeier, K. K., and, Harmon, D. L., (1995) Abomasal glucose, maize starch and maize dextrin infusions in cattle: small-intestinal disappearance, net portal glucose flux and ileal oligosaccharide flow. Br. J. Nutr. 73, 763-772.
29. Larsen, M., and, Kristensen, N. B., (2009) Effect of abomasal glucose infusion on splanchnic and whole-body glucose metabolism in periparturient dairy cows. J. Dairy Sci. 92, 1071-1083.
30. Doepel, L., Lobley, G. E., Bernier, J. F., Dubreuil, P., and, Lapierre, H., (2009) Differences in splanchnic metabolism between late gestation and early lactation dairy cows. J. Dairy Sci. 92, 3233-3243.
31. Knowlton, K. F., Dawson, T. E., Glenn, B. P., Huntington, G. B., and, Erdman, R. A., (1998) Glucose metabolism and milk yield of cows infused abomasally or ruminally with starch. J. Dairy Sci. 81, 3248-3258. (Pubitemid 128444875)
32. Lemosquet, S., Delamaire, E., Lapierre, H., Blum, J. W., and, Peyraud, J. L., (2009) Effects of glucose, propionic acid, and nonessential amino acids on glucose metabolism and milk yield in Holstein dairy cows. J. Dairy Sci. 92, 3244-3257.
33. Hammon, H. M., Metges, C. C., Junghans, P., Becker, F., Bellmann, O., Schneider, F., Nürnberg, G., Dubreuil, P., and, Lapierre, H., (2008) Metabolic changes and net portal flux in dairy cows fed a ration containing rumen-protected fat as compared to a control diet. J. Dairy Sci. 91, 208-217. (Pubitemid 351455835)
34. 2 families derived from reciprocal paternal and maternal grandsire crosses. J. Dairy Sci. 93, 3007-3018.
35. Bauman, D. E., Peel, C. J., Steinhour, W. D., Reynolds, P. J., Tyrrell, H. F., Brown, A. C., and, Haaland, G. L., (1988) Effects of bovine somatotropin on metabolism of lactating dairy cows: influence on rates of irreversible loss and oxidation of glucose and nonesterified fatty acids. J. Nutr. 118, 1031-1040.
36. Bergman, E. N., Brockman, R. P., and, Kaufman, C. F., (1974) Glucose metabolism in ruminants: comparison of whole-body turnover with production by gut, liver, and kidneys. Fed. Proc. 33, 1849-1854.
37. Lomax, M. A., and, Baird, G. D., (1983) Blood flow and nutrient exchange across the liver and gut of the dairy cow. Br. J. Nutr. 49, 481-496. (Pubitemid 13028068)
38. Berthiaume, R., Dubreuil, P., Stevenson, M., McBride, B. W., and, Lapierre, H., (2001) Intestinal disappearance and mesenteric and portal appearance of amino acids in dairy cows fed ruminally protected methionine. J. Dairy Sci. 84, 194-203. (Pubitemid 33609601)
39. Kristensen, N. B., and, Harmon, D. L., (2004) Effect of increasing ruminal butyrate absorption on splanchnic metabolism of VFA absorbed from the washed reticulorumen of steers. J. Anim. Sci. 82, 3549-3559. (Pubitemid 39584179)
40. Kristensen, N. B., and, Harmon, D. L., (2004) Splanchnic metabolism of VFA absorbed from the washed reticulorumen of steers. J. Anim. Sci. 82, 2033-2042. (Pubitemid 38893266)
41. Giesecke, D., and, Stangassinger, M., (1977) Rumen acidosis and metabolic kinetics of D (-) lactic acid. In Proceedings of the 3rd International Conference on Production Disease in Farm Animals (, van Adrichem, P. W. M., ed.). pp. 85-87, Pudoc, Wageningen, The Netherlands.
42. 14C) bei Ziegen. Zentralbl. Veterinärmed. A 26, 85-94.
43. Harmon, D. L., Britton, R. A., and, Prior, R. L., (1983) Influence of diet on glucose turnover and rates of gluconeogenesis, oxidation and turnover of D -(-)-lactate in the bovine. J. Nutr. 113, 1842-1850. (Pubitemid 13024435)
44. Kristensen, N. B., and, Raun, B. M. L., (2007) Ruminal and intermediary metabolism of propylene glycol in lactating Holstein cows. J. Dairy Sci. 90, 4707-4717. (Pubitemid 350045154)
45. Reynolds, C. K., and, Tyrrell, H. F., (1991) Effects of mesenteric vein L -alanine infusion on liver metabolism in beef heifers fed on diets differing in forage:concentrate ratio. Br. J. Nutr. 66, 437-450.
46. Bell, A. W., (1995) Regulation of organic nutrients metabolism during transition from late pregnancy to early lactation. J. Anim. Sci. 73, 2804-2819.
47. Ingvartsen, K. L., and, Andersen, J. B., (2000) Integration of metabolism and intake regulation: a review focusing on periparturient animals. J. Dairy Sci. 83, 1573-1597.
48. Meijer, G. A. L., Van der Meulen, J., Bakker, J. G. M., Van der Koelen, C. J., and, Van Vuuren, A. M., (1995) Free amino acids in plasma and muscle of high yielding dairy cows in early lactation. J. Dairy Sci. 78, 1131-1141.
49. Hammon, H. M., Stürmer, G., Schneider, F., Tuchscherer, A., Blum, H., Engelhard, T., Genzel, A., Staufenbiel, R., and, Kanitz, W., (2009) Performance and metabolic and endocrine changes with emphasis on glucose metabolism in high-yielding dairy cows with high and low fat content in liver after calving. J. Dairy Sci. 92, 1554-1566.
50. Lemosquet, S., Raggio, G., Lobley, G. E., Rulquin, H., Guinard-Flament, J., and, Lapierre, H., (2009) Whole-body glucose metabolism and mammary energetic nutrient metabolism in lactating dairy cows receiving digestive infusions of casein and propionic acid. J. Dairy Sci. 92, 6068-6082.
51. Umpleby, A. M., and, Russell-Jones, D. L., (1996) The hormonal control of protein metabolism. Baillieres Clin. Endocrinol. Metab. 10, 551-570. (Pubitemid 27056592)
52. Drackley, J. K., Overton, T. R., and, Douglas, G. N., (2001) Adaptations of glucose and long-chain fatty acid metabolism in liver of dairy cows during the periparturient period. J. Dairy Sci. 84 (E Suppl), 100-112.
53. Hammon, H. M., Sauter, S. N., Reist, M., Zbinden, Y., Philipona, C., Morel, C., and, Blum, J. W., (2003) Dexamethasone and colostrum feeding affect hepatic gluconeogenic enzymes differently in neonatal calves. J. Anim. Sci. 81, 3095-3106. (Pubitemid 38571590)
54. Hammon, H. M., Philipona, C., Zbinden, Y., Blum, J. W., and, Donkin, S. S., (2005) Effects of dexamethasone and growth hormone treatment on hepatic gluconeogenic enzymes in calves. J. Dairy Sci. 88, 2107-2116. (Pubitemid 41431193)
55. Starke, A., Wussow, K., Matthies, L., Kusenda, M., Busche, R., Haudum, A., Beineke, A., and, Rehage, J., (2009) Novel minimal invasive technique for measuring hepatic metabolism quantitatively in dairy cows exemplified by studying hepatic glucose-net production after dexamethasone treatment. In Ruminant Physiology: Digestion, Metabolism, and Effects of Nutrition on Reproduction and Welfare (, Chillard, Y., Glasser, F., Faulconnier, Y., Bocquier, F., Veissier, I., and, Doreau, M., eds.). pp. 664-666, Wageningen Academic Publishers, The Netherlands.
56. Ballard, F. J., and, Francis, G. L., (1983) Effects of anabolic agents on protein breakdown in L6 myoblasts. Biochem. J. 210, 243-249. (Pubitemid 13141437)
57. Watford, M., Hod, Y., Chiao, Y. B., Utter, M. F., and, Hanson, R. W., (1981) The unique role of the kidney in gluconeogenesis in the chicken. The significance of a cytosolic form of phosphoenolpyruvate carboxykinase. J. Biol. Chem. 256, 10023-10027. (Pubitemid 12176199)
58. Peters, J. P., and, Elliot, J. M., (1983) Effect of vitamin B12 status on performance of the lactating ewe and gluconeogenesis from propionate. J. Dairy Sci. 66, 1917-1925.
59. Rollin, E., Berghaus, R. D., Rapnicki, P., Godden, S. M., and, Overton, M. W., (2010) The effect of injectable butaphosphan and cyanocobalamin on postpartum serum β-hydroxybutyrate, calcium, and phosphorus concentrations in dairy cattle. J. Dairy Sci. 93, 978-987.
60. Murondoti, A., Jorritsma, R., Beynen, A. C., Wensing, T., and, Geelen, M. J., (2004) Activities of the enzymes of hepatic gluconeogenesis in periparturient dairy cows with induced fatty liver. J. Dairy Res. 71, 129-134. (Pubitemid 38693287)
61. Greenfield, R. B., Cecava, M. J., and, Donkin, S. S., (2000) Changes in mRNA expression for gluconeogenic enzymes in liver of dairy cattle during the transition to lactation. J. Dairy Sci. 83, 1228-1236.
62. Al-Trad, B., Wittek, T., Penner, G. B., Reisberg, K., Gäbel, G., Fürll, M., and, Aschenbach, J. R., (2010): expression and activity of key hepatic gluconeogenesis enzymes in response to increasing intravenous infusions of glucose in dairy cows. J. Anim. Sci. 88, 2998-3008.
63. Koser, S. L., Thomas, M., and, Donkin, S. S., (2008) Cloning the promoter region for bovine phosphoenolpyruvate carboxykinase gene and identification of propionate responsive region. J. Dairy Sci. 91 (Suppl 1), 424.
64. Karcher, E. L., Pickett, M. M., Varga, G. A., and, Donkin, S. S., (2007) Effect of dietary carbohydrate and monensin on expression of gluconeogenic enzymes in liver of transition dairy cows. J. Anim. Sci. 85, 690-699. (Pubitemid 46651869)
65. Hanson, R. W., and, Reshef, L., (1997) Regulation of phosphoenolpyruvate carboxykinase (GTP) gene expression. Annu. Rev. Biochem. 66, 581-611. (Pubitemid 27274668)
66. Velez, J. C., and, Donkin, S. S., (2005) Feed restriction induces pyruvate carboxylase but not phosphoenolpyruvate carboxykinase in dairy cows. J. Dairy Sci. 88, 2938-2948. (Pubitemid 41096456)
67. Taylor, P. H., Wallace, J. C., and, Keech, D. B., (1971) Gluconeogenic enzymes in sheep. Biochem. Biophys. Acta 237, 179-191.
68. Filsell, O. H., Jarrett, I. G., Taylor, P. H., and, Keech, D. B., (1969) Effects of fasting, diabetes and glucocorticoids on gluconeogenic enzymes in sheep. Biochem. Biophys. Acta 184, 54-63.
69. Smith, R. W., and, Walsh, A., (1982) Effects of pregnancy and lactation on the activities in sheep liver of some enzymes of glucose metabolism. J. Agric. Camb. 98, 563-565.
70. Hartwell, J. R., Cecava, M. J., and, Donkin, S. S., (2001) Rumen undegradable protein, rumen-protected choline and mRNA expression for enzymes in gluconeogenesis and ureagenesis in periparturient dairy cows. J. Dairy Sci. 84, 490-497. (Pubitemid 33609631)
71. Agca, C., Greenfield, R. B., Hartwell, J. R., and, Donkin, S. S., (2002) Cloning of bovine liver cytosolic and mitochondrial phosphoenolpyruvate carboxykinase and characterization during the transition to lactation. Physiol. Genomics 11, 53-63. (Pubitemid 37128722)
72. Loor, J. J., Dann, H. M., Guretzky, N. A., Everts, R. E., Oliveira, R., Green, C. A., Litherland, N. B., Rodriguez-Zas, S. L., Lewin, H. A., and, Drackley, J. K., (2006) Plane of nutrition prepartum alters hepatic gene expression and function in dairy cows as assessed by longitudinal transcript and metabolic profiling. Physiol. Genomics 27, 29-41. (Pubitemid 44511823)
73. Velez, J. C., and, Donkin, S. S., (2004) Bovine somatotropin increases hepatic phosphoenolpyruvate carboxykinase mRNA in lactating dairy cows. J. Dairy Sci. 87, 1325-1335. (Pubitemid 38893352)
74. Baird, G. D., Hibbitt, K. G., and, Hunter, G. D., (1968) Biochemical aspects of bovine ketosis. Biochem. J. 107, 683-689.
75. Grummer, R. R., (1993) Etiology of lipid-related metabolic disorders in periparturient dairy cows. J. Dairy Sci. 76, 3882-3896.
76. Hippen, A. R., She, P., Young, J. W., Beitz, D. C., Lindberg, G. L., Richardson, L. F., and, Tucker, R. W., (1999) Alleviation of fatty liver in dairy cows with 14-day intravenous infusions of glucagon. J. Dairy Sci. 82, 1139-1152. (Pubitemid 129552391)
77. She, P., Lindberg, G. L, Hippen, A. R., Beitz, D. C., and, Young, J. W., (1999) Regulation of messenger ribonucleic acid expression for gluconeogenic enzymes during glucagon infusions into lactating cows. J. Dairy Sci. 82, 1153-1163. (Pubitemid 129552392)
78. Agca, C., Bidwell, C. A., and, Donkin, S. S., (2004) Cloning of bovine pyruvate carboxylase and 5′ untranslated region variants. Anim. Biotechnol. 15, 47-66.
79. Jitrapakdee, S., Vidal-Puig, A., and, Wallace, J. C., (2006) Anaplerotic roles of pyruvate carboxylase in mammalian tissues. Cell. Mol. Life Sci. 63, 843-854. (Pubitemid 43724074)
80. Jitrapakdee, S., St. Maurice, M., Rayment, I., Cleland, W. W., Wallace, J. C., and, Attwood, P. V., (2008) Structure, mechanism and regulation of pyruvate carboxylase. Biochem. J. 413, 369-387.
81. Hazelton, S. M., Bidwell, C. A., and, Donkin, S. S., (2008) Cloning the genomic sequence and identification of promoter regions of bovine pyruvate carboxylase. J. Dairy Sci. 91, 91-99. (Pubitemid 351455822)
82. Agca, C., and, Donkin, S. S., (2007) Differential expression of pyruvate carboxylase 5′UTR variants during transition to lactation. PLoS ONE 2, e1270.
83. White, H. M., Koser, S. L., and, Donkin, S. S., (2009) Regulation of bovine pyruvate carboxylase promoters by fatty acids. J. Dairy Sci. 92 (Suppl 1), 45.
84. White, H. M., Koser, S. L., and, Donkin, S. S., (2009) Heat stress upregulates PC mRNA and promoter expression in bovine primary hepatocytes but not in rat hepatoma model cells. J. Dairy Sci. 92 (Suppl 1), 139.
85. Reynolds, C. K., (1995) Quantitative aspects of liver metabolism in ruminants. In Ruminant Physiology: Digestion, Metabolism, Growth and Reproduction (, Engelhardt, W. v., Leonhard-Marek, S., Breves, G., and, Giesecke, D., eds.). pp. 351-371, Enke, Stuttgart.
86. Al-Trad, B., Reisberg, K., Wittek, T., Penner, G. B., Alkaassem, A., Gäbel, G., Fürll, M., and, Aschenbach, J. R., (2009) Increasing intravenous infusions of glucose improve body condition but not lactation performance in mid-lactation dairy cows. J. Dairy Sci. 92, 5645-5658.
87. Komatsu, T., Itoh, F., Kushibiki, S., and, Hodate, K., (2005) Changes in gene expression of glucose transporters in lactating and nonlactating cows. J. Anim. Sci. 83, 557-564. (Pubitemid 43324064)
88. Tanaka, A., Urabe, S., Takeguchi, A., Mizutani, H., Sako, T., Imai, S., Yoshimura, I., Kimura, N., and, Arai, T., (2006) Comparison of activities of enzymes related to energy metabolism in peripheral leukocytes and livers between Holstein dairy cows and ICR mice. Vet. Res. Commun. 30, 29-38. (Pubitemid 43124255)
89. Seoane, J., Barberà, A., Télémaque-Potts, S., Newgard, C. B., and, Guinovart, J. J., (1999) Glucokinase overexpression restores glucose utilization and storage in cultured hepatocytes from male Zucker diabetic fatty rats. J. Biol. Chem. 274, 31833-31838.