Role of glucose transporters in the intestinal absorption of gastrodin, a highly water-soluble drug with good oral bioavailability

Journal of Drug Targeting

Volumn 21, Issue 6, 2013, Pages 574-580

  Cai, Zheng ^a   Huang, Juan ^a   Luo, Hui ^a   Lei, Xiaolu ^a   Yang, Zhaoxiang ^b   Mai, Yang ^a   Liu, Zhongqiu ^a,c  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b Kunming Pharmaceutical Group Corporation   (China)

^c GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Active transport; Bioavailability; Gastrodin; Glucose transporter; Intestinal absorption; Phenolic glucoside

Indexed keywords

GASTRODIN; GLUCOSE TRANSPORTER 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASOLATERAL MEMBRANE; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG PENETRATION; DRUG SOLUBILITY; EX VIVO STUDY; IN VIVO STUDY; INTESTINE; INTESTINE ABSORPTION; INTESTINE PERFUSION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; BENZYL ALCOHOLS; BIOLOGICAL AVAILABILITY; CACO-2 CELLS; CELL LINE, TUMOR; DIABETES MELLITUS, EXPERIMENTAL; GLUCOSE; GLUCOSE TRANSPORT PROTEINS, FACILITATIVE; GLUCOSIDES; HUMANS; INTESTINAL ABSORPTION; INTESTINES; MALE; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; SODIUM-GLUCOSE TRANSPORTER 1; SOLUBILITY;

EID: 84879778600     PISSN: 1061186X     EISSN: 10292330     Source Type: Journal    
DOI: 10.3109/1061186X.2013.778263     Document Type: Article

References (34)

1. Ojemann LM, Nelson WL, Shin DS, et al. Tian ma, an ancient Chinese herb, offers new options for the treatment of epilepsy and other conditions. Epilepsy Behav 2006;8:376-83.
2. Zeng X, Zhang Y, Zhang S, Zheng X. A microdialysis study of effects of gastrodin on neurochemical changes in the ischemic/reperfused rat cerebral hippocampus. Biol Pharm Bull 2007;30: 801-4.
3. Zhao H. Advance in clinical application of gastrodin. Strait Pharm J 2009;21:29-31.
4. Dai JN, Zong Y, Zhong LM, et al. Gastrodin inhibits expression of inducible NO synthase, cyclooxygenase-2 and proinflammatory cytokines in cultured LPS-stimulated microglia via MAPK pathways. PLoS One 2011;6:e21891.
5. Guo Z, Tan T, Zhong Y, Wu C. Study of the mechanism of gastrodin and derivatives of gastrodigenin. J West Chin Univ Med Sci 1991;22:79-82.
6. Wang Q, Chen G, Zeng S. Pharmacokinetics of Gastrodin in rat plasma and CSF after i.n. and i.v. Int J Pharm 2007;341:20-5.
7. Cai Z, Hou S, Li Y, et al. Effect of borneol on the distribution of gastrodin to the brain in mice via oral administration. J Drug Target 2008;16:178-84.
8. Cheng G, Hao XH, Liu GL, et al. Pharmacokinectics of gastrodin in rats. Chin Pharm J 2003;38:127-29.
9. Hua WY, Zhu YF, Zhang QY. Determination of gastrodin in human plasma by LC-MS/MS and its application in pharmacokinetic study. Chin JMAP 2010;27:634-6.
10. Cai Z, Wang Y, Zhu LJ, Liu ZQ. Nanocarriers: a general strategy for enhancement of oral bioavailability of poorly absorbed or presystemically metabolized drugs. Curr Drug Metab 2010;11: 197-207.
11. Smetanova L, Stetinova V, Svoboda Z, Kvetina J. Caco-2 cells, biopharmaceutics classification system (BCS) and biowaiver. Acta Medica (Hradec Kralove) 2011;54:3-8.
12. Mizuma T, Hagi K, Awazu S. Intestinal transport of betathioglycosides by Na\+/glucose cotransporter. J Pharm Pharmacol 2000;52:303-10.
13. Sha X, Fang X. Transport characteristics of 9-nitrocamptothecin in the human intestinal cell line Caco-2 and everted gut sacs. Int J Pharm 2004;272:161-71.
14. Hu M, Chen J, Lin H. Metabolism of flavonoids via enteric recycling: mechanistic studies of disposition of apigenin in the Caco-2 cell culture model. J Pharmacol Exp Ther 2003;307: 314-21.
15. Liu ZQ, Jiang ZH, Liu L, Hu M. Mechanisms responsible for poor oral bioavailability of paeoniflorin: role of intestinal disposition and interactions with sinomenine. Pharm Res 2006;23:2768-80.
16. Hu M, Ge K, Roland L, et al. Determination of absorption characteristics of AG337, a novel thymidylate synthase inhibitor, using a perfused rat intestinal model. J Pharm Sci 1998;87:886-90.
17. Liu H, Xu X, Yang Z, et al. Impaired function and expression of P-glycoprotein in blood-brain barrier of streptozotocin-induced diabetic rats. Brain Res 2006;1123:245-52.
18. Tsujihara K, Hongu M, Saito K, et al. Na(\+)-glucose cotransporter inhibitors as antidiabetics. I. Synthesis and pharmacological properties of 40-dehydroxyphlorizin derivatives based on a new concept. Chem Pharm Bull 1996;44:1174-80.
19. Burant CF, Flink S, DePaoli AM, et al. Small intestine hexose transport in experimental diabetes. Journal of Clinical Investigation 1994;93:578-85.
20. De Miranda P, Blum MR. Pharmacokinetics of acyclovir after intravenous and oral administration. J Antimicrob Chemother 1983; 12:29-37.
21. Ito Y, Kusawake T, Ishida M, et al. Oral solid gentamicin preparation using emulsifier and adsorbent. J Control Release 2005;105:23-31.
22. Hongo R, Nakamura S, Oku T. Utilization of orally administered D-[14C]mannitol via fermentation by intestinal microbes in rats. J Nutr Sci Vitaminol 2010;56:387-95.
23. Johnson DA, Amidon GL. Determination of intrinsic membrane transport parameters from perfused intestine experiments: a boundary layer approach to estimating the aqueous and unbiased membrane permeabilities. J Theor Biol 1988;131:93-106.
24. Krimi RB, Letteron P, Chedid P, et al. Resistin-like molecule-beta inhibits SGLT-1 activity and enhances GLUT2-dependent jejunal glucose transport. Diabetes 2009;58:2032-8.
25. Corpe CP, Basaleh MM, Affleck J, et al. The regulation of GLUT5 and GLUT2 activity in the adaptation of intestinal brush-border fructose transport in diabetes. Pflugers Arch 1996;432:192-201.
26. Stelmanskan E. The important role of GLUT2 in intestinal sugar transport and absorption. Postepy Biochem 2009;55:385-7.
27. Martell RL, Slapak CA, Levy SB. Effect of glucose transport inhibitors on vincristine efflux in multidrug-resistant murine erythroleukaemia cells overexpressing the multidrug resistanceassociated protein (MRP) and two glucose transport proteins, GLUT1 and GLUT3. Br J Cancer 1997;75:161-8.
28. Debnam ES, Smith MW, Sharp PA, et al. The effects of streptozotocin diabetes on sodium-glucose transporter (SGLT1) expression and function in rat jejunal and ileal villus-attached enterocytes. Pflugers Arch 1995;430:151-9.
29. Wang XD, Zeng S. The transport of gastrodin in Caco-2 cells and uptake in Bcap37 and Bcap37/MDR1 cells. Yao Xue Xue Bao 2010;45:1497-502.
30. Kipp H, Khoursandi S, Scharlau D, Kinne RK. More than apical: distribution of SGLT1 in Caco-2 cells. American Journal of Physiology-Cell Physiology 2010;285:737-49.
31. Gilbert ER, Wong EA, Vaughan M, Webb Jr KE,. Distribution and abundance of nutrient transporter mRNA in the intestinal tract of the black bear, Ursus americanus. Comp Biochem Physiol B Biochem Mol Biol 2007;146:35-41.
32. He YX, Liu XD, Wang XT, et al. Sodium-dependent Glucose Transporter Was Involved in Salidroside Absorption in Intestine of Rats. Chin J Nat Med 2009;7:444-8.
33. Mizuma T, Nakamura M, Ina H, et al. Intestinal SGLT1-mediated absorption and metabolism of benzyl beta-glucoside contained in Prunus mume: carrier-mediated transport increases intestinal availability. Biochim Biophys Acta 2005;1722:218-23.
34. Lin LC, Chen YF, Tsai TR, Tsai TH. Analysis of brain distribution and biliary excretion of a nutrient supplement, gastrodin, in rat. Anal Chim Acta 2007;590:173-9.