Biosynthesis of gamma-linolenic acid and beta-carotene by Zygomycetes fungi

Biotechnology Journal

Volumn 8, Issue 7, 2013, Pages 794-800

  Klempova, Tatiana ^a   Basil, Eva ^a   Kubatova, Alena ^b   Certik, Milan ^a  

^a SLOVAK UNIVERSITY OF TECHNOLOGY   (Slovakia)

^b CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Carotenoids; Desaturase activity; Mucorales fungi; Polyunsaturated fatty acids

Indexed keywords

BIOLOGICALLY ACTIVE COMPOUNDS; BIOSYNTHETIC PATHWAY; BIOTECHNOLOGICAL PRODUCTION; CAROTENOIDS; DESATURASE ACTIVITY; GAMMA-LINOLENIC ACID; POLYUNSATURATED FATTY ACIDS (PUFAS); UMBELOPSIS ISABELLINA;

BIOACTIVITY; FATTY ACIDS; POLYUNSATURATED FATTY ACIDS;

FUNGI;

ACYL COENZYME A DESATURASE; BETA CAROTENE; CAROTENOID; GAMMA CAROTENE; GAMMA LINOLENIC ACID; GLUCOSE; LINOLEOYL COENZYME A DESATURASE; LYCOPENE; OLEIC ACID;

ACTINOMUCOR ELEGANS; ARTICLE; BIOSYNTHESIS; CARBON SOURCE; ENZYME ACTIVITY; FATTY ACID DESATURATION; FUNGAL CELL; FUNGAL STRAIN; FUNGUS; LIPID STORAGE; MUCOR CIRCINELLOIDES; NONHUMAN; PRIORITY JOURNAL; UMBELOPSIS ISABELLINA; ZYGOMYCETES;

CAROTENOIDS; DESATURASE ACTIVITY; MUCORALES FUNGI; POLYUNSATURATED FATTY ACIDS;

BETA CAROTENE; BIOMASS; FATTY ACID DESATURASES; GAMMA-LINOLENIC ACID; LIPIDS; MUCORALES; SOIL MICROBIOLOGY;

ACTINOMUCOR ELEGANS; FUNGI; MUCORALES; UMBELOPSIS ISABELLINA; ZYGOMYCETES;

EID: 84879772782     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.201200099     Document Type: Article

References (35)

1. Spector, A. A., Essentiality of fatty acids. Lipids 1999, 34, S1-S3.
2. Jump, D. B., The biochemistry of n-3 polyunsaturated fatty acids. J. Biol. Chem. 2002, 277, 8755-8758.
3. Horrobin, D. F., Nutritional and medical importance of gamma-linolenic acid. Prog. Lipid Res. 1992, 31, 163-194.
4. Benatti, P., Peluso, G., Nicolai, R., Calvani, M., Polyunsaturated fatty acid: Biochemical, nutritional and epigenetic properties. J. Am. Coll. Nutr. 2004, 23, 281-302.
5. Uemura, H., Synthesis and production of unsaturated and polyunsaturated fatty acids in yeast: Current state and perspectives. Appl. Microbiol. Biotechnol. 2012, 95, 1-12.
6. Britton, G., Liaaen-Jensen, S., Pfander, H. Carotenoids. Natural Functions, Vol. 4, Birkhauser Verlag Basel 2008, pp. 370.
7. Britton, G., Liaaen-Jensen, S., Pfander, H., Carotenoids. Nutrition and Health, Vol. 5, Birkhauser Verlag Basel, 2009, pp. 431.
8. Landrum, J. T., Carotenoids. Physical, Chemical and Biological Functions and Properties. CRC Press Boca Raton 2010, pp. 544.
9. Ratledge, C., Fatty acid biosynthesis in microorganisms being used for single cell oil production. Biochimie 2004, 86, 807-815.
10. Fakas, S., Certik, M., Papanikolaou, S., Aggelis, G. et al., γ-Linolenic acid production by Cunninghamella echinulata growing on complex organic nitrogen sources. Bioresour. Technol. 2008, 99, 5986-5990.
11. Certik, M., Shimizu, S., Biosynthesis and regulation of microbial polyunsaturated fatty acid production. J. Biosci. Bioeng. 1999, 87, 1-14.
12. Dyal, S., Narine, S., Implications for the use of Mortierella fungi in the industrial production of essential fatty acids. Food Res. Int. 2005, 38, 445-467.
13. Amano, N., Shinmen, Y., Akimoto, K., Kawashima, H., Amachi, T., Chemotaxonomic significance of fatty acid compostion in the genus Mortierella (Zygomycetes, Mortierellaceae). Mycotaxon 1992, 44, 257-265.
14. Yurkov, A. M., Vustin, M. M., Tyaglov, B. V., Maksimova, I. A., Sineokiy, S. P., Pigmented basidiomycetous yeasts are a promising source of carotenoids and ubiquinone Q10. Mikrobiologiya 2008, 77, 5-10.
15. El-Banna, A. A. E.-R., El-Razek, A. M. A., El-Mahdy, A. R., Isolation, identification and screening of carotenoid-producing strains of Rhodotorula glutinis. Food Nutr. Sci. 2012, 3, 627-633.
16. Iturriaga, E. A., Velayos, A., Eslava, A. P., Structure and function of the genes involved in the biosynthesis of carotenoids in the Mucorales. Biotechnol. Bioprocess Eng. 2000, 5, 263-274.
17. Dufosse, L., Microbial production of food grade pigments. Food Technol. Biotechnol. 2006, 44, 313-321.
18. Kuzina, V., Cerda-Olmedo, E., Ubiquinone and carotene production in the Mucorales Blakeslea and Phycomyces. Appl. Microbiol. Biotechnol. 2007, 76, 991-999.
19. Nanou, K., Roukas, T., Papadakis, E., Improved production of carotenes from synthetic medium by Blakeslea trispora in a bubble column reactor. Biochem. Eng. J. 2012, 67, 203-207.
20. Del Campo, J. A., García-González, M., Guerrero, M. G., Outdoor cultivation of microalgae for carotenoid production: Current state and perspectives. Appl. Microbiol. Biotechnol. 2007, 74, 1163-1174.
21. Certik, M., Andrasi, P., Sajbidor, J., Effect of extraction methods on lipid yield and fatty acid composition of lipid classes containing γ-linolenic acid extracted from fungi. J. Am. Oil Chem. Soc. 1996, 73, 357-365.
22. Christopherson, S. W., Glass, R. L., Preparation of milk fat methylesters by alcoholysis in an essentially nonalcoholic solution. J. Dairy Sci. 1969, 52, 1289-1290.
23. Sukrutha, S. K., Adamechova, Z., Kunder, R. B., Savitha, J., Certik, M., Endophytic fungi: Are they potential candidates for the production of polyunsaturated fatty acids? Int. J. Appl. Microbiol. Sci. 2012, 2, 44-49.
24. Certik, M., Berhan, S., Sajbidor, J., Lipid production and fatty acid composition of selected strains belonging to Mucorales. Acta Biotechnologie 1993, 13, 193-196.
25. Muhid, F., Nawi, W., Kader, A., Yusoff, W., Hamid, A., Effects of metal ion concentraion on lipid and gamma-linolenic acid production by Cunninghamella sp. 2A1. OnLine J. Biol. Sci. 2008, 8, 62-67.
26. Dyal, S., Bouzidi, L., Narine, S., Maximizing the production of γ-linolenic acid in Mortierella ramanniana var. ramanniana as a function of pH, temperature and carbon source, nitrogen source, metal ions and oil supplementation. Food Res. Int. 2005, 38, 815-829.
27. Hiruta, O., Kamisaka, Y., Yokochi, T., Futamura, T., Takebe, H., Satoh, A., gamma-Linolenic acid production by a low temperature-resistant mutant of Mortierella ramanniana. J. Ferment. Bioeng. 1996, 82, 119-123.
28. Xian, M., Nie, J., Meng, Q., Liu, J. et al., Production of gamma-linolenic acid by disrupted mycelia of Mortierella isabellina. Lett. Appl. Microbiol. 2003, 36, 182-185.
29. Xian, M., Yan, J., Kang, Y., Liu, J. et al., Production of gamma-linoleic acid by Mortierella isabellina grown on hexadecanol. Lett. Appl. Microbiol. 2001, 33, 367-370.
30. Kennedy, M. J., Reader, S. L., Davies, R. J., Fatty acid production characteristics of fungi with particular emphasis on gamma-linolenic aicd production. Biotechnol. Bioeng. 1993, 40, 625-634.
31. Conti, E., Strednansky, M., Strednansky, S., Zanetti, F., gamma-Linolenic acid production production by solid-state culture of Mucorales strains on cereals. Bioresour. Technol. 2001, 25, 101-105.
32. Ward, O. P., Singh, A., Omega-3/6 fatty acid production: Alternative sources of production. Process Biochem. 2005, 40, 3627-3652.
33. Azmi, W., Thakur, M., Kumar, A., Production of betacarotene from deproteinized waste whey filtrate using Mucor azygosporus MTCC414 in submerge fermentation. Acta Microbiol. Immunol. Hung. 2011, 58, 189-200.
34. Laoteng, K., Certik, M., Biotechnological production and application of high-value microbial oils. in: Krause, J. and Fleischer, O. (Eds.), Industrial Fermentation. Nova Science Publishers, Inc., Hauppauge 2010, pp. 187-215.
35. Uttaro, A. D., Biosyntesis of polyunsaturated fatty acids in lower eukaryotes. IUBMB Life 2006, 58, 563-571.