Ubiquinone and carotene production in the Mucorales Blakeslea and Phycomyces

Applied Microbiology and Biotechnology

Volumn 76, Issue 5, 2007, Pages 991-999

  Kuzina, Vera ^a,b   Cerdá Olmedo, Enrique ^a  

^a UNIVERSITY OF SEVILLE   (Spain)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMEDICAL ENGINEERING; BIOSYNTHESIS; BIOTECHNOLOGY; OXIDATIVE STRESS; STRAIN;

CAROTENE PRODUCTION; DRY MASS; GERANYLGERANYL PYROPHOSPHATE; MUCORALES BLAKESLEA;

FUNGI;

BETA CAROTENE; CARBON; CAROTENE; GAMMA CAROTENE; LEUCINE; NITROGEN; TERPENOID; UBIQUINONE;

BIOCHEMICAL COMPOSITION; FUNGUS; GENETICALLY MODIFIED ORGANISM; MUTATION; TERPENE;

ARTICLE; CELL CULTURE; DRY MASS; FUNGAL STRAIN; FUNGUS CULTURE; FUNGUS MUTATION; LIGHT; MUCORALES; NONHUMAN; OXIDATIVE STRESS; PHYCOMYCETES; SYNTHESIS;

BIOTECHNOLOGY; CAROTENOIDS; CULTURE MEDIA; GENE EXPRESSION REGULATION, FUNGAL; LIGHT; MUCORALES; OXIDATIVE STRESS; PHYCOMYCES; UBIQUINONE;

BLAKESLEA; BLAKESLEA TRISPORA; FUNGI; MUCORALES; PHYCOMYCES; PHYCOMYCES BLAKESLEEANUS; ZYGOMYCOTA;

EID: 34548668711     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-007-1069-7     Document Type: Article

References (46)

1. Arrach N, Fernández-Martín R, Cerdá-Olmedo E, Avalos J (2001) A single gene for lycopene cyclase, phytoene synthase, and regulation of carotene biosynthesis in Phycomyces. Proc Natl Acad Sci USA 98:1687-1692
2. Avalos J, Cerdá-Olmedo E (2004) Fungal carotenoid production. In: Arora DK (ed) Handbook of fungal biotechnology, vol 20. Marcel Dekker, New York, pp 367-378
3. Barrero AF, Oltra JE, Poyatos JA, Jiménez D, Oliver E (1998) Phycomysterols and other sterols from the fungus Phycomyces blakesleeanus. J Nat Prod 61:1491-1496
4. Barrero AF, Oltra JE, Robinson J, Burke PV, Jiménez D, Oliver E (2002) Sterols in erg mutants of Phycomyces: metabolic pathways and physiological effects. Steroids 67:403-409
5. Beal MF (2004) Mitochondrial dysfunction and oxidative damage in Alzheimer's and Parkinson's diseases and coenzyme Q10 as a potential treatment. J Bioenerg Biomembranes 36:381-386
6. Bejarano ER, Parra F, Murillo FJ, Cerdá-Olmedo E (1988) End-product regulation of carotenogenesis in Phycomyces. Arch Microbiol 150:209-214
7. Bejarano ER, Avalos J, Lipson ED, Cerdá-Olmedo E (1991) Photoinduced accumulation of carotene in Phycomyces. Planta 183:1-9
8. Bu'lock JD, Osagie AU (1973) Prenols and ubiquinones in single-strain and mated cultures of Blakeslea trispora. J Gen Microbiol 76:77-83
9. Cerdá-Olmedo E (1985) Carotene mutants of Phycomyces. Methods Enzymol 110:220-243
10. Cerdá-Olmedo E (2001) Phycomyces and the biology of light and color. FEMS Microbiol Rev 25:503-512
11. Cerdá-Olmedo E, Lipson ED (Eds) (1987) Phycomyces. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA
12. Choi J-H, Ryu Y-W, Seo J-H (2005) Biotechnological production and applications of coenzyme Q10. Appl Microbiol Biotechnol 68:9-15
13. Ciegler A (1965) Microbial carotenogenesis. Adv Appl Microbiol 7:1-34
14. Cooper JM, Schapira AH (2003) Friedreich's Ataxia: disease mechanisms, antioxidant and coenzyme Q10 therapy. Biofactors 18:163-171
15. Crane FL, Barr R (1971) Determination of ubiquinones. Methods Enzymol 18C:137-237
16. De Boer SR (1928) Respiration of Phycomyces. Recl Trav Bot Néerl 25:117
17. Disch A, Rohmer M (1998) On the absence of the glyceraldehyde 3-phosphate/pyruvate pathway for isoprenoid biosynthesis in fungi and yeasts. FEMS Microbiol Lett 168:201-208
18. El Agamey A, Lowe GM, McGarvey DJ, Mortensen A, Phillip DM, Truscott TG, Young AJ (2004) Carotenoid radical chemistry and antioxidant/pro-oxidant properties. Arch Biochem Biophys 430:37-48
19. Fritz F (1966) Spot tests in organic analysis, 7th edn. Elsevier, Amsterdam, The Netherlands
20. Galland P, Russo VEA (1979) The role of retinol in the initiation of sporangiophores of Phycomyces blakesleeanus. Planta 146:257-262
21. Govind NS, Cerdá-Olmedo E (1986) Sexual activation of carotenogenesis in Phycomyces blakesleeanus. J Gen Microbiol 132:2775-2780
22. Grünler J, Dallner G (2004) Investigation of regulatory mechanisms in coenzyme Q metabolism. Methods Enzymol 378:3-17
23. Hoppe U, Bergemann J, Diembeck W, Ennen J, Gohla S, Harris I, Jacob J, Kielholz J, Mei W, Pollet D, Schachtschabel D, Sauermann G, Schreiner V, Stäb F, Steckel F (1999) Coenzyme Q10, a cutaneous antioxidant and energizer. Biofactors 9:371-378
24. Kemp RJ, Mercer EI (1968) The sterol esters of maize seedlings. Biochem J 110:111-118
25. Kuzina V, Cerdá-Olmedo E (2006) Modification of sexual development and carotene production by acetate and other small carboxylic acids in Blakeslea trispora and Phycomyces blakesleeanus. Appl Environ Microbiol 72:4917-4922
26. Kuzina V, Domenech C, Cerdá-Olmedo E (2006) Relationships among the biosyntheses of ubiquinone, carotene, sterols and triacylglycerols in Zygomycetes. Arch Microbiol 186:485-493
27. Meganathan R (2001) Ubiquinone biosynthesis in microorganisms. FEMS Microbiol Lett 203:131-139
28. Mehta BJ, Cerdá-Olmedo E (1995) Mutants of carotene production in Blakeslea trispora. Appl Microbiol Biotechnol 42:836-838
29. Mehta BJ, Cerdá-Olmedo E (2001) Intersexual partial diploids of Phycomyces. Genetics 158:635-641
30. Mehta BJ, Salgado LM, Bejarano ER, Cerdá-Olmedo E (1997) New mutants of Phycomyces blakesleeanus for β-carotene production. Appl Environ Microbiol 63:3657-3661
31. Mehta BJ, Obraztsova IN, Cerdá-Olmedo E (2003) Mutants and intersexual heterokaryons of Blakeslea trispora for production of β-carotene and lycopene. Appl Environ Microbiol 69:4043-4048
32. Murillo FJ, Cerdá-Olmedo E (1976) Regulation of carotene synthesis in Phycomyces. Mol Gen Genet 148:19-24
33. Obolnikova EA, Yuldasheva LS, Bekhtereva MN, Samokhvalov GI (1971) Isolation and identification of ubiquinone synthesized by the fungus Blakeslea trispora. Prikl Biohim Microbiol 7:47-50
34. Pasto DJ, Johnson CR (1981) Determinación de estructuras orgánicas. Reverté, Barcelona, Spain
35. Quiles-Rosillo MD, Ruiz-Vázquez RM, Torres-Martínez S, Garre V (2005) Light induction of the carotenoid biosíntesis pathway in Blakeslea trispora. Fungal Genet Biol 42:141-153
36. Rodríguez-Sáiz M, Paz B, de la Fuente JL, López-Nieto MJ, Cabri W, Barredo JL (2004) Blakeslea trispora genes for carotene biosynthesis. Appl Environ Microbiol 70:5589-5594
37. Sarter B (2002) Coenzyme Q10 and cardiovascular disease: A review. J Cardiovasc Nurs 16:9-20
38. Shults CW (2003) Coenzyme Q10 in neurodegenerative diseases. Curr Med Chem 10:1917-1921
39. Spiller GH, Threlfall DR, Whistance GR (1968) Biosynthesis of ubiquinone in yeast, Phycomyces blakesleeanus, and Agaricus campestris. Arch Biochem Biophys 125:786-796
40. Stahl W, Sies H (2005) Bioactivity and protective effects of natural carotenoids. Biochim Biophys Acta 1740:101-107
41. Sutter RP (1970) Effect of light on β-carotene accumulation in Blakeslea trispora. J Gen Microbiol 64:215-221
42. Szkopinska A (2000) Ubiquinone. Biosynthesis of quinone ring and its isoprenoid side chain. Intracellular localization. Acta Biochim Pol 47:469-480
43. Torres-Martínez S, Murillo FJ, Cerdá-Olmedo E (1980) Genetics of lycopene cyclization and substrate transfer in β-carotene biosynthesis in Phycomyces. Genet Res 36:299-309
44. Turunen M, Olsson J, Dallner G (2004) Metabolism and function of coenzyme Q. Biochim Biophys Acta 1660:171-199
45. Weinkove D, Poyatos JA, Greiner H, Oltra E, Avalos J, Fuksansky L, Barrero AF, Cerdá-Olmedo E (1998) Mutants of Phycomyces with decreased gallic acid content. Fungal Genet Biol 25:196-203
46. Wilburn AJ, King DS, Glisson J, Rockhold RW, Wofford MR (2004) The natural treatment of hypertension. J Clin Hypertens 6:242-248 (Greenwich)