Increased expression of transforming growth factor-β and receptors in primary human airway fibroblasts from chemical inhalation patients

Iranian Journal of Allergy, Asthma and Immunology

Volumn 12, Issue 2, 2013, Pages 144-152

  Mirzamani, Monireh Sadat ^a,c   Nourani, Mohammad Reza ^a   Fooladi, Abbas Ali Imani ^a   Zare, Samad ^c   Ebrahimi, Majid ^a,d   Yazdani, Samaneh ^a,e   Ghanei, Mostafa ^a   Karimfar, Mohammad Hassan ^b  

^a BAQIYATALLAH UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b ILAM UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c URMIA UNIVERSITY   (Iran)

^d YAMAGUCHI UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^e TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Airway remodeling; Fibroblasts; Sulfur mustard; TGF

Indexed keywords

MUSTARD GAS; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2;

ADULT; AIRWAY REMODELING; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG FIBROBLAST; LUNG INJURY; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING;

ADULT; AIRWAY REMODELING; BLOTTING, WESTERN; BRONCHI; BRONCHOSCOPY; CELLS, CULTURED; CHEMICAL WARFARE AGENTS; FIBROBLASTS; HUMANS; INHALATION; MIDDLE AGED; MUSTARD GAS; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 84879756096     PISSN: 17351502     EISSN: 17355249     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Balali-Mood M, Mousavi S, Balali-Mood B. Chronic health effects of sulphur mustard exposure with special reference to Iranian veterans. Emerg Health Threats J 2008; 1:e7.
2. Ghanei M, Panahi Y, Mojtahedzadeh M, Khalili AR, Aslani J. Effect of gamma interferon on lung function of mustard gas exposed patients, after 15 years. Pulm Pharmacol Ther 2006; 19(2):148-53. (Pubitemid 43053003)
3. Nourani MR, Yazdani S, Roudkenar MH, Ebrahimi M, Halabian R, Mirbagheri L, et al. HO1 mRNA and Protein do not Change in Parallel in Bronchial Biopsies of Patients after long term exposure to Sulfur Mustard. Gene Regul Syst Biol 2010; 4:83-90.
4. Nourani MR, Ebrahimi M, Roudkenar MH, Vahedi E, Ghanei M, Imani Fooladi AA. Sulfur Mustard Induces the Expression of Metallothionein-1A in Human Airway Epithelial Cells. Int J Gen Med 2011; 4:413-9.
5. Beheshti J, Mark EJ, Akbaei HM, Aslani J, Ghanei M. Mustard lung secrets: long term clinicopathological study following mustard gas exposure. Pathol Res Pract 2006; 202(10):739-44. (Pubitemid 44356424)
6. Ghanei M, Khalili AR, Arab MJ, Mojtahedzadeh M, Aslani J, Lessan-Pezeshki M, et al. Diagnostic and therapeutic value of short-term corticosteroid therapy in exacerbation of mustard gas-induced chronic bronchitis. Basic Clin Pharmacol Toxicol 2005; 97(5):302-5. (Pubitemid 41608123)
7. Papirmeister B: Medical defense against mustard gas : toxic mechanisms and pharmacological implications. Boca Raton: CRC Press; 1991.
8. Moore B, Murphy RF, Agrawal DK. Interaction of tgf-beta with immune cells in airway disease. Curr Mol Med 2008; 8(5):427-36.
9. Hudon C, Turcotte H, Laviolette M, Carrier G, Boulet LP. Characteristics of bronchial asthma with incomplete reversibility of airflow obstruction. Ann Allergy Asthma Immunol 1997; 78(2):195-202. (Pubitemid 27082227)
10. Brewster CE, Howarth PH, Djukanovic R, Wilson J, Holgate ST, Roche WR. Myofibroblasts and subepithelial fibrosis in bronchial asthma. Am J Respir Cell Mol Biol 1990; 3(5):507-11.
11. Lewis CC, Chu HW, Westcott JY, Tucker A, Langmack EL, Sutherland ER, et al. Airway fibroblasts exhibit a synthetic phenotype in severe asthma. J Allergy Clin Immunol 2005; 115(3):534-40. (Pubitemid 40341707)
12. Eickelberg O, Pansky A, Koehler E, Bihl M, Tamm M, Hildebrand P, et al. Molecular mechanisms of TGF-(beta) antagonism by interferon (gamma) and cyclosporine A in lung fibroblasts. FASEB J 2001; 15(3):797-806. (Pubitemid 32245998)
13. Alcorn JF, Rinaldi LM, Jaffe EF, van Loon M, Bates JH, Janssen-Heininger YM, et al. Transforming Growth Factor-b1 Suppresses Airway Hyperresponsiveness in Allergic Airway Disease. Am J Respir Crit Care Med 2007; 176(10):974-82. (Pubitemid 350127840)
14. Phan SH. Fibroblast phenotypes in pulmonary fibrosis. Am J Respir Cell Mol Biol 2003; 29(3 Suppl):S87-92. (Pubitemid 37070316)
15. Fries KM, Blieden T, Looney RJ, Sempowski GD, Silvera MR, Willis RA, et al. Evidence of fibroblast heterogeneity and the role of fibroblast subpopulations in fibrosis. Clin Immunol Immunopathol 1994; 72(3):283-92. (Pubitemid 24275206)
16. Ihn H, Yamane K, Kubo M, Tamaki K. Blockade of endogenous transforming growth factor beta signaling prevents up-regulated collagen synthesis in scleroderma fibroblasts: association with increased expression of transforming growth factor beta receptors. Arthritis Rheum 2001; 44(2):474-80.
17. Phan SH. The myofibroblast in pulmonary fibrosis. Chest 2002; 122(6 Suppl):286S-289S. (Pubitemid 36043014)
18. Raghu G, Chen YY, Rusch V, Rabinovitch PS. Differential proliferation of fibroblasts cultured from normal and fibrotic human lungs. Am Rev Respir Dis 1988; 138(3):703-8.
19. Baglole CJ, Reddy SY, Pollock SJ, Feldon SE, Sime PJ, Smith TJ, et al. Isolation and phenotypic characterization of lung fibroblasts. Methods Mol Med 2005; 117:115-27.
20. Takashima A. Establishment of fibroblast cultures. Curr Protoc Cell Biol 2001; Chapter 2:Unit 2.1.
21. Ghanei M, Harandi AA. Long term consequences from exposure to sulfur mustard: a review. Inhal Toxicol 2007; 19(5):451-6. (Pubitemid 46364767)
22. Rowell M, Kehe K, Balszuweit F, Thiermann H. The chronic effects of sulfur mustard exposure. Toxicology 2009; 263(1):9-11.
23. Naghibi M. Sulfur mustard intoxication, oxidative stress, and antioxidants. Mil Med 2002; 167(7):573-5.
24. Huber H, . KK: The pathology of bronchial asthma. Arch Intern Med 1992, 30:689-760.
25. Brent E. Parland, Peter T. Macklem, Pare PD. Airway Hyperresponsiveness: From Molecules to Bedside Invited Review: Airway wall remodeling: friend or foe? J Appl Physiol 2003; 95(1):426-34.
26. Boxall C, Holgate ST, Davies DE. The contribution of transforming growth factor-beta and epidermal growth factor signalling to airway remodelling in chronic asthma. Eur Respir J 2006; 27(1):208-29. (Pubitemid 43092684)
27. Aubert JD, Dalal BI, Bai TR, Roberts CR, Hayashi S, Hogg JC. Transforming growth factor beta 1 gene expression in human airways. Thorax 1994; 49(3):225-32. (Pubitemid 24117448)
28. Ohno I, Nitta Y, Yamauchi K, Hoshi H, Honma M, Woolley K, et al. Transforming growth factor beta 1 (TGF beta 1) gene expression by eosinophils in asthmatic airway inflammation. Am J Respir Cell Mol Biol 1996; 15(3):404-9. (Pubitemid 126439908)
29. Magnan A, Retornaz F, Tsicopoulos A, Brisse J, Van Pee D, Gosset P, et al. Altered compartmentalization of transforming growth factor-beta in asthmatic airways. Clin Exp Allergy 1997; 27(4):389-5.
30. Vignola AM, Chanez P, Chiappara G, Merendino A, Pace E, Rizzo A, et al. Transforming growth factor-beta expression in mucosal biopsies in asthma and chronic bronchitis. Am J Respir Crit Care Med 1997; 156(2 Pt 1):591-9. (Pubitemid 27352000)
31. Minshall EM, Leung DY, Martin RJ, Song YL, Cameron L, Ernst P, et al. Eosinophil-associated TGF-beta1 mRNA expression and airways fibrosis in bronchial asthma. Am J Respir Cell Mol Biol 1997; 17(3):326-33. (Pubitemid 127500837)
32. El-Gamel A, Awad MR, Hasleton PS, Yonan NA, Hutchinson JA, Campbell CS, et al. Transforming growth factor-beta (TGF-beta1) genotype and lung allograft fibrosis. J Heart Lung Transplant 1999, 18(6):517-23. (Pubitemid 29291657)
33. Ghanei M, Ghalejooghi NA, Nourani MR, Harandi AA, Fooladi AA. Effect of TGFβ1 and TIMP2 on disease activity in asthma and COPD. Iran J Allergy Asthma Immunol 2010; 9(2):79-86.
34. Takizawa H, Tanaka M, Takami K, Ohtoshi T, Ito K, Satoh M, et al. Increased Expression of Transforming Growth Factorb 1 in Small Airway Epithelium from Tobacco Smokers and Patients with Chronic Obstructive Pulmonary Disease (COPD). Am J Respir Crit Care Med 2001; 163(6):1476-83. (Pubitemid 32506619)
35. Redington AE, Madden J, Frew AJ, Djukanovic R, Roche WR, Holgate ST, et al. Transforming growth factor-beta 1 in asthma. Measurement in bronchoalveolar lavage fluid. Am J Respir Crit Care Med 1997; 156(2 Pt 1):642-7. (Pubitemid 27352007)
36. Aghanouri R, Ghanei M, Aslani J, Keivani-Amine H, Rastegar F, Karkhane A. Fibrogenic cytokine levels in bronchoalveolar lavage aspirates 15 years after exposure to sulfur mustard. Am J Physiol Lung Cell Mol Physiol 2004; 287(6):L1160-4. (Pubitemid 39507192)
37. Bergmann M, Tiroke A, Schafer H, Barth J, Haverich A. Gene expression of profibrotic mediators in bronchiolitis obliterans syndrome after lung transplantation. Scand Cardiovasc J 1998; 32(2):97-103. (Pubitemid 28242924)
38. Khalil N, O'Connor RN, Unruh HW, Warren PW, Flanders KC, Kemp A, et al. Increased production and immunohistochemical localization of transforming growth factor-beta in idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol 1991; 5(2):155-62.
39. Khalil N, O'Connor RN, Flanders KC, Unruh H. TGF-beta 1, but not TGF-beta 2 or TGF-beta 3, is differentially present in epithelial cells of advanced pulmonary fibrosis: an immunohistochemical study. Am J Respir Cell Mol Biol 1996; 14(2):131-8. (Pubitemid 126441385)
40. Hill DJ, Strain AJ, Elstow SF, Swenne I, Milner RD. Bifunctional action of transforming growth factor-beta on DNA synthesis in early passage human fetal fibroblasts. J Cell Physiol 1986; 128(2):322-8. (Pubitemid 16047945)
41. Roberts CJ, Birkenmeier TM, McQuillan JJ, Akiyama SK, Yamada SS, Chen WT, et al. Transforming growth factor beta stimulates the expression of fibronectin and of both subunits of the human fibronectin receptor by cultured human lung fibroblasts. J Biol Chem 1988; 263(10):4586-92.
42. Gold LI, Sung JJ, Siebert JW, Longaker MT. Type I (RI) and type II (RII) receptors for transforming growth factor-beta isoforms are expressed subsequent to transforming growth factor-beta ligands during excisional wound repair. Am J Pathol 1997; 150(1):209-2.
43. Khalil N, Parekh TV, O'Connor RN, Gold LI. Differential expression of transforming growth factor-beta type I and II receptors by pulmonary cells in bleomycin-induced lung injury: correlation with repair and fibrosis. Exp Lung Res 2002; 28(3):233-50. (Pubitemid 34235063)
44. Smith JD, Bryant SR, Couper LL, Vary CP, Gotwals PJ, Koteliansky VE, et al. Soluble transforming growth factor-beta type II receptor inhibits negative remodeling, fibroblast transdifferentiation, and intimal lesion formation but not endothelial growth. Circ Res 1999; 84(10):1212-22. (Pubitemid 29244783)
45. Chen G, Khalil N. In vitro wounding of airway smooth muscle cell monolayers increases expression of TGF-beta receptors. Respir Physiol Neurobiol 2002; 132(3):341-6.
46. Hoshino M, Nakamura Y, Sim JJ. Expression of growth factors and remodelling of the airway wall in bronchial asthma. Thorax 1998; 53(1):21-7. (Pubitemid 28178971)
47. Yazdani S, Karimfar MH, Imani Fooladi AA, Mirbagheri L, Ebrahimi M, Ghanei M, et al. Nuclear factor κB1/RelA mediates the inflammation and/or survival of human airway exposed to sulfur mustard. J Recept Signal Transduct Res 2011; 31(5):367-73.
48. Adelipour M, Imani Fooladi AA, Yazdani S, Vahedi E, Ghanei M, Nourani MR. Smad molecules expression pattern in human bronchial airway induced by sulfur mustard. Iran J Allergy Asthma Immunol 2011; 10(3):147-54.